Korean Journal of Bronchoesophagology (대한기관식도과학회지)
- Volume 8 Issue 1
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- Pages.29-34
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- 2002
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- 1226-0916(pISSN)
The Histologic Findings and the Expression of Laminin in the Mucosa of the Rat Trachea During
백서 기관 점막의$SO_2$ 노출 후 회복과정의 조직학적 관찰 및 laminin의 발현에 관한 연구
- Lee, Hyung-Seok (Department of Otolaryngology, College of Medicine, Hanyang University) ;
- Tae, Kyung (Department of Otolaryngology, College of Medicine, Hanyang University) ;
- Cho, Seok-Hyun (Department of Otolaryngology, College of Medicine, Hanyang University) ;
- Han, Jang-Hee (Department of Otolaryngology, College of Medicine, Hanyang University) ;
- Jeong, Jin-Suck (Department of Otolaryngology, College of Medicine, Hanyang University)
- 이형석 (한양대학교 의과대학 이비인후과학교실) ;
- 태경 (한양대학교 의과대학 이비인후과학교실) ;
- 조석현 (한양대학교 의과대학 이비인후과학교실) ;
- 한장희 (한양대학교 의과대학 이비인후과학교실) ;
- 정진석 (한양대학교 의과대학 이비인후과학교실)
- Published : 2002.06.01
Abstract
Background and Objectives : Sulfur dioxide gas is one of the major airborne Pollutants noxious to human in industrialized countries. The most vulnerable areas in the human respiratory system were the trachea and main bronchi and a gradient of decreasing damage was observed in the peripheral tracheobronchial tree. Induced functional alteration was increased mucosal permeability, and morphological changes were epithelial sloughing, intracellular edema, mitochondrial swelling, widened intercellular spaces, and ciliary cytoplamic extrusions. The laminins are a family of extracellular matrix glycoproteins localized in the basement membrane. Their primary role is cell-matrix attachment, but many additional biologic activities, including Promoting cell growth and migration, tumor growth and metastasis, wound repair, and graft survival, have been demonstrated. Materials and Methods : Histologic changes and expression of laminin in tracheal mucosa sacrificed at 1 day, 2 day, 3 day, 1 week, 2 weeks, and 3 weeks after continued SO2 exposure of 250 ppm for 30 minutes a day(to 7week) were studied in rats. In this study, mild immune reaction for laminin was noted at the apical cytoplasm of epithelial cells and basement membrane one day after a 7 week