• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.4
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• pp.323-330
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• 2008

High cycle bending fatigue of socket welded small bore pipe was characterized, and also the fatigue crack initiation of small bore pipe was monitored in situ by the acoustic emission (AE) technique. The STS 316L stainless steel specimens were prepared by gas tungsten arc welding (GTAW) process having the artificial defect (i.e., lack of penetration) and defect free at the root. The fatigue failure was occurred at the loc for high stress and root for relatively low stress. The crack initiation cycles ($N_i$) was defined to the abrupt increase in AE counts during the fatigue test, and then the cracks were observed by the radiographic test and electron microscope before and after the fatigue crack initiation cycles. The socket welded pipe damaged by bending fatigue was studied regarding the welding defect, failure mode, and crack initiation cycles for the diagnosis and monitoring.

• Clinical and Experimental Reproductive Medicine
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• v.51 no.1
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• pp.75-84
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• 2024

Objective: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients. Methods: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF). Results: PGT-A was associated with significant improvements in the implantation rate (IR) and the ongoing pregnancy rate/live birth rate (OPR/LBR) per embryo transfer cycle in the AMA (39.3% vs. 16.2% [p<0.001] and 42.0% vs. 21.8% [p<0.001], respectively), RIF (41.7% vs. 22.0% [p<0.001] and 47.0% vs. 28.6% [p<0.001], respectively), and RPL (45.6% vs. 19.5% [p<0.001] and 49.1% vs. 24.2% [p<0.001], respectively) groups, as well as the IR in the SMF group (43.3% vs. 26.5%, p=0.011). Additionally, PGT-A was associated with lower overall incidence rates of early pregnancy loss in the AMA (16.7% vs. 34.3%, p=0.001) and RPL (16.7% vs. 50.0%, p<0.001) groups. However, the OPR/LBR per total cycle across all PGT-A groups did not significantly exceed that for the non-PGT-A groups. Conclusion: PGT-A demonstrated beneficial effects in high-risk patients. However, our findings indicate that these benefits are more pronounced in carefully selected candidates than in the entire high-risk patient population.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.1
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• pp.123-131
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• 2020

There have been a lot of studies in the past for the method of predicting the failure of a machine, and recently, a lot of researches and applications have been generated to diagnose the physical condition of the machine and the parts and to calculate the remaining life through various methods. Survival models are also used to predict plant failures based on past anomaly cycles. In particular, special machine that reflect the fluid flow and process characteristics of chemical plants are connected to hundreds or thousands of sensors, so there are not many factors that need to be considered, such as process and material data as well as application of derivative variables. In this paper, the data were preprocessed through time series anomaly detection based on unsupervised learning to predict the abnormalities of these special machine. Next, clustering results reflecting clustering-based data characteristics were applied to produce additional variables, and a learning data set was created based on the history of past facility abnormalities. Finally, the prediction methodology based on the supervised learning algorithm was applied, and the model update was confirmed to improve the accuracy of the prediction of facility failure. Through this, it is expected to improve the efficiency of facility operation by flexibly replacing the maintenance time and parts supply and demand by predicting abnormalities of machine and extracting key factors.

• BMB Reports
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• v.51 no.5
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• pp.225-229
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• 2018

In humans, hormonal regulation is crucial for the preparation of uterine environment leading to either successful implantation or menstrual cycle. Estrogen is a pivotal female steroid hormone that regulates the uterine dynamics along with progesterone in the estrous and menstrual cycles in humans. Estrogen signals act via nuclear estrogen receptor or membrane-bound receptor. The membrane-bound estrogen receptor plays a crucial role in the rapid response of estrogen in the uterine epithelium. Recently, RASD1 has received attention as a novel signal transducer of estrogen in various systems including female reproductive organs. In this review, we discuss the regulation of estrogen and RASD1 signaling in the uterus and also provide insights into RAS as a novel signaling molecule in repeated implantation failure.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.17 no.32
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• pp.227-232
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• 1994

In the performance domain, physical performance is a measure that represents some degree of system, subsystem, component or device success in a continuous sense, as opposed to a classical binomial sense (success or failure). If applicable sensing and monitoring means exist, physical performance can be observed over time, along with explanatory variables or covariables. Performance-based reliability represents the probability that performance will remain satisfactory over a finite period of time or usage cycles in the future when a performance critical limit (which represents an appropriate definition of failure in terms of performance) is set at a fixed level, based on application requirements. In the case of inadequate knowledge of the failure mechanics, this physical based empirical modeling concept along with performance degradation knowledge can serve as an important analysis tool in reliability work in product and process improvement.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.15 no.4
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• pp.63-68
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• 2006

This research presents the reliability analysis of the pneumatic actuator within the tape feeder that is used to transfer the correct force to linked parts during l.0E+7 cycles. First, the degradation analysis for thrust and air leakage is executed to obtain the failure data of a product based on its performance over time. Second, once the parameters has been calculated using the weibull 2-parameter distribution and MLE(Maximum Likelihood Estimation), information related to life such as reliability, failure rate, probability density function is estimated. Finally, MTTF(Mean Time To Failure) and $B_{10}$ life of actuators are calculated. MTTF means the mean life at the confidence level and $B_{10}$ life refers to the time by which 10% of the product would fail. In this study, failure causes and solutions are examined using the reliability analysis.

• Journal of Applied Reliability
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• v.13 no.3
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• pp.207-216
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• 2013

This paper, we classified LED failure mechanisms that occur due to the delamination and analyzed each of the mechanism that gives the LED PKGs the effect. Usually, the LED is composed of several materials which are LED chips, gold wire, phosphor, epoxy resin, adhesive, reflector and lead frame. These different materials are usually delaminated in trouble conditions which are huge temperature difference, hot and humid or mechanical shocked. When the components are delaminated, a luminance will be lost and moisture be absorbed easily, a thermal resistance be increased attendantly. In this paper, we experimented to investigate failure mechanism of the thermal resistance and failure mechanism of the decrease of luminance that occur due to the delamination. A thermal shock test was performed to reproduce this phenomena by subjecting samples to a cold-hot cyclling process between $-30^{\circ}C$(15min) and $110^{\circ}C$(15min). The samples were inspected at 200, 600 and 1,000 cycles. We measured feature of LED using the spatial analyzer, optical microscope, thermal resistance, photometer, scanning electron microscope (SEM). As a result, the progression of the crack and the thermal resistance and decrease in luminance are proportional to number of thermal shock.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.4
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• pp.47-54
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• 2013

The main cause of die failure in hot forging is wear. Die wear directly generates the gradual loss of part tolerances, thereby causing deterioration in the dimensional accuracy of a forged part. It is very important to estimate forging cycles, called as die life, at which the die should be repaired or replaced. In this study, in order to estimate the hot forging die life, the finite element simulation of wear on an asymmetric part like a ball joint socket used in vehicle was carried out based on Archard's model. Finite element simulation results were compared with wear amounts of a used die that were measured using a contact stylus profilometer. The simulation results were in relatively good agreement with measurements obtained from the virtual die which was used by 7,000 forging cycles in a forging industry. Consequently, the die life in the hot forging of the ball joint socket was estimated by 10,500 forging cycles on the finisher die.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.15 no.2
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• pp.19-30
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• 2019

In this study, to evaluate conservatism of various fatigue life evaluation procedures, fatigue tests were conducted using compact tension (CT) specimens with a round notch, made of A516 Gr.70 carbon steel and A240 TP304 stainless steel, under load-controlled cyclic condition. Experimental fatigue failure cycles were measured and compared with predicted fatigue lives using two different life evaluation methods; (1) Design-By-Analysis (DBA) procedure given in ASME B&PV Code, Sec. III, Div. 1, Subsec. NB-3200 and (2) structural stress-based approach provided in ASME B&PV Code, Sec. VIII, Div. 2, Part 5. To predict fatigue failure cycles, three-dimensional elastic finite element analysis was conducted. Fatigue lives were predicted by both design fatigue curve given in ASME B&PV Code, Sec. III, Div. 1, Appendices and best-fit fatigue curve suggested in NUREG/CR-6815 for the DBA procedure. Finally, fatigue lives evaluated by various methods were compared with test results, and then conservatism between each evaluation procedure was discussed.

• Clinical and Experimental Reproductive Medicine
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• v.51 no.3
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• pp.260-267
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• 2024

Objective: This study investigated the metabolic status of the spent culture media from embryos of patients with repeated implantation failure (RIF) undergoing in vitro fertilization-intracytoplasmic sperm injection cycles in comparison with the embryos from healthy fertile women. Methods: Metabolite levels in spent culture media were assessed and compared between embryos from RIF patients (n=35) and oocyte donors as controls (n=15). Protein levels of insulin-like growth factor 1 (IGF-1) were determined using Western blotting. Concentrations of glucose, pyruvate, and lactate were measured using spectrophotometry. Ionic colorimetric assay kits were utilized to analyze the concentrations of sodium, chloride, calcium, and magnesium ions. High-performance liquid chromatography was employed to measure the concentrations of glutamic acid, aspartic acid, methionine, phenylalanine, and histidine. Results: Glucose consumption and lactate secretion were higher in the control group than in the RIF group. The magnesium concentration was significantly higher in the control group than in the RIF group, but glutamic acid and aspartic acid concentrations were lower in the control group than in the RIF patients (p<0.05). The levels of IGF-1, sodium, calcium, chloride, methionine, histidine, and phenylalanine did not show statistically significant differences between the two groups. Conclusion: The metabolic profile of the culture medium of the embryos in the RIF group differed from that of the control group. These findings suggest potential factors that may affect implantation capacity in RIF patients and provide a new perspective on embryo selection.