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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Role of estrogen and RAS signaling in repeated implantation failure

  • Hong, Kwonho (Department of Stem Cell and Regenerative Biotechnology, Konkuk University) ;
  • Choi, Youngsok (Department of Biomedical Science, CHA University)
  • Received : 2018.02.23
  • Published : 2018.05.31
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Abstract

In humans, hormonal regulation is crucial for the preparation of uterine environment leading to either successful implantation or menstrual cycle. Estrogen is a pivotal female steroid hormone that regulates the uterine dynamics along with progesterone in the estrous and menstrual cycles in humans. Estrogen signals act via nuclear estrogen receptor or membrane-bound receptor. The membrane-bound estrogen receptor plays a crucial role in the rapid response of estrogen in the uterine epithelium. Recently, RASD1 has received attention as a novel signal transducer of estrogen in various systems including female reproductive organs. In this review, we discuss the regulation of estrogen and RASD1 signaling in the uterus and also provide insights into RAS as a novel signaling molecule in repeated implantation failure.

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References

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