• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.1
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• pp.61-64
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• 2013

Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient's symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.1909-1912
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• 2014

It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

• 한국생물공학회:학술대회논문집
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• 2002.04a
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• pp.103-106
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• 2002

A gradient LC/MS system was constructed and applied for separation of biological samples. For example, a rapid and simple analytical method without pretreatment based on gradient ${\mu}LC/MS$ with a disposable microcolumn has been developed to determine B group vitamins in urine. Urine samples were directly injected to the disposable home-made microcolumn. The microcolumn can be emptied after being used for a series of urine samples, and repacked with fresh stationary phase. An overdose of vitamin pills were swallowed by healthy volunteers and the urine samples were taken 1,2,3,5, and 8 hours after swallowing. Vitamins immediately showed up in urine, hit the maximum, and disappeared swiftly. This technique is expected to have some application for clinical purposes.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.474-478
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• 2001

A female mixed miniature pinscher dog, about 5 years old, 4 kg, was referred to veterinary teaching hospital of Chungnam National University with chief complaint of excessive hemorrhagic vaginal discharge for a month, partial alopecia and hyperpigmentation. There are no specific change with CBC, blood chemistry and X-ray findings but we figured out high estrogen concentration with hormone analysis and detected a majority of the superficial epithelial cells with pyknotic nuclei by cytologic examination of vaginal smear preparation and multiple ovarian cysts on both ovaries by ultrasonography. Based on the clinical signs, hormone analysis, vaginal smear preparation and ultrasonography, the authors diagnosed this case as hyperestrogenism with ovarian cysts.

• Clinical and Experimental Reproductive Medicine
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• v.8 no.1
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• pp.19-22
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• 1981

정자 아크로좀이나 정액중에서 고순도로 정제된 탄수화물 분해효소들 및 썰파테이스를 개별적으로 또는 여러 조합으로 사용하여 난자막의 용해를 조사하였다. 베타 굴룩유로니데이스와 베타-엔-에시틸글루코사미니데이스가 전혀 없이 정제된 황소 정자의 하이얄유로니데이스는 토끼의 난자막중 큐믈러스층을 쉽게 분해시켰다. 토끼의 정자에서 얻은 아릴썰파테이스와 위의 하이얄유로니데이스는 더욱 빨리 토끼난자의 큐믈러스층을 용해시켰다. 한편 아릴썰파테이스는 하이얄유로니데이스나 베타-엔-에시틸 글루코사미니데이스들도 하이얄 유로니데이스들과 아릴썰파테이스들처럼 큐믈러스츨을 용해시켰으나 모든 경우에 난자의 코로나층이나 조나펠루시다층에는 아무런 변화를 주지 않고 있다.

• Korean Journal of Veterinary Pathology
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• v.2 no.1
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• pp.31-36
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• 1998

The Opuntia ficus-indica extract(OFE) has been claimed to have several therapeutic properties including anti-inflammation and anti-rheumatoid arthritis in oriental medicine but little is known about their effect on macrophages. This study demonstrated that OFE could stimulate TNF-alpha production in cultured macrophages. which is one of important mediators in autoimmune diseases including experimental autoimmune encephalomyelitis(EAE). In vivo study showed that oral administration of OFE exacerbate the onset of clinical paralysis. This finding suggests that OFE stimulates cytokine production and exacerbates autoimmune inflammatory diseases including EAE.

• Journal of Ginseng Research
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• v.42 no.3
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• pp.248-254
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• 2018

Ginseng is a natural product best known for its curative properties in diverse physiological processes such as cancer, neurodegenerative disorders, hypertension, and maintenance of hemostasis in the immune system. In previous decades, there have been some promising studies into the pharmacology and chemistry of ginseng components and the relationship between their structure and function. The emerging use of modified ginseng and development of new compounds from ginseng for clinical studies have been topics of study for many researchers. The present review deals with the anticancer, anti-inflammatory, antioxidant, and chemopreventive effects, and recent advances in microRNA technology related to red ginseng. The review also summarizes the current knowledge on the effect of ginsenosides in the treatment of cancer.

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4137-4140
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• 2012

A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.

• Preventive Nutrition and Food Science
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• v.8 no.1
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• pp.105-112
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• 2003

Animals possess a highly sophisticated mechanism of storing energy in adipose tissue inside their bodies. However, in humans it has been clarified that adipocyte (fat cell), which composes the body fat (adipose) tissues, development and the extent of subsequent fat accumulation are closely associated with the occurrence and advancement of various common diseases (e.g., type-2 diabetes, coronary artery disease, and hypertension) resulting from obesity. Recent exciting progress in clinical and biochemical studies of adipocytes has rapidly clarified the functions of adipocytes and adipose tissue. Interesting findings are the function of white adipocytes as "secreting cells" and the molecular mechanism undelying adipocyte differentiation at the transcriptional level in relation to nuclear receptors. Consequently, the adipose tissue is being targeted for the prevention or treatment of many common diseases. In this review, I will focus on recent information on characteristics of adipocytes and the relationship between obesity and common obesity-related diseases. diseases.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.221-222
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• 1996

In order to prepare the porous hydroxyapatite (HA) ceramics with different porosity, interconnectivity, mechanical properties, surface chemistry and tissue response, several methods have been developed. Of the different forms of Porous HA ceramics which were prepared by various methods, only the coralline HA has undergone major clinical applications in orthopaedic, maxillofacial and ophthalmic surgery. In this study, totally synthetic macroporous HA ceramics with various pore size distribution were prepared. It is shown that the new reticulate HA ceramics, comprised of interconnected voids surmunded by a web of ceramic, have a morphology which mimics that of human trabecular bone.