Korean Journal of Veterinary Pathology (한국수의병리학회지)

Korean Society of Veterinary Pathology (한국수의병리학회)
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Effects of Opuntia ficus-indica extract on the activation of immune cells with special reference to autoimmune disease models

손바닥선인장 추출물이 면역계세포의 활성화에 미치는 영향

  • Shin, Tae-Kyun (Department of Veterinary medicine, Cheju National Univerity,Institute of Life Science, Cheju National Univerity) ;
  • Lee, Sun-Joo (Department of Chemistry, Cheju National Univerity) ;
  • Kim, Sae-Je (Department of Biology, Cheju National Univerity,Institute of Life Science, Cheju National Univerity)
  • 신태균 (제주대학교 수의학과,제주대학교 생명과학연구소) ;
  • 이선주 (제주대학교 화학과) ;
  • 김세재 (제주대학교 생물학과,제주대학교 생명과학연구소)
  • Published : 1998.06.01
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Abstract

The Opuntia ficus-indica extract(OFE) has been claimed to have several therapeutic properties including anti-inflammation and anti-rheumatoid arthritis in oriental medicine but little is known about their effect on macrophages. This study demonstrated that OFE could stimulate TNF-alpha production in cultured macrophages. which is one of important mediators in autoimmune diseases including experimental autoimmune encephalomyelitis(EAE). In vivo study showed that oral administration of OFE exacerbate the onset of clinical paralysis. This finding suggests that OFE stimulates cytokine production and exacerbates autoimmune inflammatory diseases including EAE.

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