Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Epstein-Barr Virus Infection with Acute Pancreatitis Associated with Cholestatic Hepatitis

  • Kang, Seok-Jin (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Yoon, Ka-Hyun (Department of Pediatrics, Keimyung University School of Medicine) ;
  • Hwang, Jin-Bok (Department of Pediatrics, Keimyung University School of Medicine)
  • Received : 2012.09.15
  • Accepted : 2012.10.11
  • Published : 2013.03.30
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Abstract

Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient's symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases.

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References

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Cited by

  1. Cholestatic Hepatitis Induced by Epstein-Barr Virus in a Pediatric Population vol.54, pp.12, 2013, https://doi.org/10.1177/0009922815570618
  2. Epstein-Barr virus-associated acute pancreatitis vol.12, pp.11, 2019, https://doi.org/10.1136/bcr-2019-231744