• Title/Summary/Keyword: Epstein-Barr virus

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Acute Epstein-Barr Virus Hepatitis in a 32 Month Old Female Manifesting as Henoch-Sch$\ddot{o}$nlein Purpura

  • Kim, Hee Jin;Jung, Su Jin;Lee, Jun Ho
    • Childhood Kidney Diseases
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    • v.19 no.1
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    • pp.39-42
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    • 2015
  • Henoch-Sch$\ddot{o}$nlein purpura can result from exposure to an antigen after infection with several types of organisms. However, Henoch-Sch$\ddot{o}$nlein purpura caused by a primary Epstein-Barr virus infection has been rarely reported. Here, we report the case of a 32-month-old female patient who presented with Henoch-Sch$\ddot{o}$nlein purpura. Based on abnormal liver function test results and positive results for Epstein-Barr virus infection markers, a diagnosis of Epstein-Barr virus hepatitis manifesting as Henoch-Sch$\ddot{o}$nlein purpura was made. Treatment with methyl-prednisolone and hydration improved the symptoms, and a switch to oral steroids was effective in completely alleviating the purpura. No recurrence was noted and no liver function abnormalities were detected during the follow up period.

A Case of Epstein Barr Virus-Associated Hemophagocytic Syndrome Confirmed by mRNA In Situ Hybridization and Polymerase Chain Reaction (mRNA In Situ Hybridization으로 확인된 Epstein Barr Virus-Associated Hemophagocytic Syndrome 1례)

  • Kim, Chung Han;Yang, Chang Hyun;Sohn, Young Mo;Kim, Hoguen
    • Pediatric Infection and Vaccine
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    • v.3 no.2
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    • pp.200-206
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    • 1996
  • Virus associated hemophagocytic syndrome(VAHS), a class II histiocytosis syndrome, is characterized by high fever, liver dysfunction, coagulation abnormalities, and generalized histiocytic proliferation with marked hemophagocytosis in bone marrow and lymph nodes. VAHS is associated with several viral infections including Epstein Barr virus which has a relatively high mortality rate. We report a fatal case of Epstein Barr virus associated hemophagocytic syndrome and its diagnosis by mRNA in situ hybridization and polymerase chain reaction. A brief review of related literaure is also presented.

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Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

  • Lim, Ji Soo;Kim, Tae Min;Cho, Kwang Hyun
    • Annals of dermatology
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    • v.29 no.5
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    • pp.618-620
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    • 2017
  • Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are characterized by the T-cell immunophenotype. Here, we report the first Korean case of EBV-associated vesiculopapular eruption on the face of a patient with natural killer (NK)/T cell lymphoma. A 32-year-old Korean man presented with a late adolescent-onset recurrent necrotic papulovesicles on his face. The patient was previously diagnosed with EBV-associated NK/T cell lymphoma of the oral cavity and also had childhood-onset hypersensitivity to mosquito bites. Biopsy of his facial skin showed EBV-associated vesiculopapular eruptions, though ultraviolet provocation did not reproduce the skin lesions. EBV viral load in his peripheral blood was detected but low. The patient was treated with systemic chemotherapy. The lymphoma went into remission, but the facial EBV-associated vesiculopapular eruption had a relapsing and remitting course.

Eosinophilic Fasciitis in a 22 Month Old Boy Associated with Epstein-Barr Virus Infection (22개월 남아에서 Epstein-Barr Virus 감염과 연관되어 발생한 호산구성 근막염 1례)

  • Kang, Ju Sung;Jo, Dae Sun
    • Pediatric Infection and Vaccine
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    • v.13 no.2
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    • pp.186-190
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    • 2006
  • Eosinophilic fasciitis(EF) is a very rare clinical syndrome, especially during childhood. It is characterized by diffuse fasciitis and peripheral eosinophilia. Little is known about the pathogenesis of EF, and it is suggested that immunologic alteration may play a role. Epstein-Barr virus(EBV) is known to cause a variety of diseases via immune mechanism. We report a 22 month old boy with EF following EBV infection, which may be associated with pathogenesis of EF.

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Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer (악성 위궤양과 감별이 어려웠던 Epstein-Barr Virus 감염이 동반된 양성 위궤양 증례 1예)

  • Gwak, Jin Wuk;Yoo, Jiwon;Suh, Seong O;Kim, Jaeyeon;Oh, In Soo;Bae, Ji Yoon
    • The Korean Journal of Gastroenterology
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    • v.73 no.3
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    • pp.177-181
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    • 2019
  • Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal pain are non-specific and rarely encountered, which means it is difficult to diagnose gastric involvement of EBV infection without suspicion. The relation between gastric carcinoma and gastric lymphoma associated with EBV infection is well defined, but relations with other EBV-associated gastrointestinal diseases such as gastritis and peptic ulcer disease have rarely been reported. We report a case of benign gastric ulcer with EBV infection confirmed by endoscopic and histological findings.

A Case of Bronchiolitis Obliterans Organizing Pneumonia from Epstein-Barr Virus (BOOP 형태로 발현된 Epstein-Barr Virus 폐렴 1예)

  • Na, Hyoung Jung;Kim, Sueng Up;Kim, Do Hyun;Nam, Dong Hyug;Lee, Sun Min;Kim, Chong Ju;Kie, Jeong-Hae;Hong, Yong Kug
    • Tuberculosis and Respiratory Diseases
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    • v.62 no.1
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    • pp.51-55
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    • 2007
  • In the average adult with a normal immune state, Epstein-Barr virus pneumonia is very rare, especially in the form of interstitial lung disease. According to recent studies, the Epstein-Barr virus is also associated with lymphocytic interstitial pneumonia, AIDS and Langerhans cell histiocytosis, but not with sarcoidosis. BOOP is caused by lung injury due to an infection or drug intoxication, and is related to connective tissue disease or bone marrow transplantation, but is sometimes idiopathic. We experienced a patient with symptoms and signs of interstitial lung disease, with confirmed BOOP and EBV ingection from an open lung biopsy and serologic examination, respectively Herein, this case is reported, with a review of the literature.

A Case of Epstein-Barr Virus Infection with Gall Bladder and Common Bile Duct Stones in an Otherwise Healthy Child

  • Park, Jong-Hyun;Noh, Jin-Chul;Park, Hyang-Mi;Jung, Yu-Soek;Park, Sei-Hyeog;Hong, H. Christian;Shin, Hye-Jung
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.15 no.1
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    • pp.57-61
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    • 2012
  • Cholelithiasis and choledocholithiasis are uncommon pediatric diseases, although clinicians have seen them with increasing frequency in children in recent years. Moreover, no case of Epstein-Barr virus (EBV) infection with cholelithiasis and choledocholithiasis has been previously reported in the English literature. We report a pediatric patient with EBV infection, a gall bladder stone, and a common bile duct stone, may have had GB and CBD stones prior to her EBV infection, whom we successfully treated with antibiotics and laparoscopic cholecystectomy for cholecystitis.

Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice

  • Fujiwara, Shigeyoshi
    • IMMUNE NETWORK
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    • v.14 no.1
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    • pp.1-6
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    • 2014
  • Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new-world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-associated diseases, have not been available. Recently the development of severely immunodeficient mouse strains enabled production of humanized mice in which human immune system components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author's group addressing reproduction of EBV infection and pathogenesis in humanized mice.

Acute gastritis associated with Epstein-Barr virus infection in a child

  • Kim, Ji Mok;Song, Chun Woo;Song, Kyu Sang;Kim, Jae Young
    • Clinical and Experimental Pediatrics
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    • v.59 no.sup1
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    • pp.68-71
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    • 2016
  • Infectious mononucleosis is Epstein-Barr virus (EBV) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. Gastrointestinal symptoms of EBV infection are nonspecific and occur rarely. EBV inducing acute gastrointestinal pathology is poorly recognized without suspicion. Careful consideration is needed to diagnose gastric involvement of EBV infection including gastric lymphoma, gastric cancer, and gastritis. A few recent cases of gastritis associated with EBV infection have been reported in adolescents and adults. However, there is no report of EBV-associated gastritis in early childhood. We experienced a rare case of 4-year-old girl with EBV gastritis confirmed by in situ hybridization.

Epstein-Barr Virus Infection with Acute Pancreatitis Associated with Cholestatic Hepatitis

  • Kang, Seok-Jin;Yoon, Ka-Hyun;Hwang, Jin-Bok
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.16 no.1
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    • pp.61-64
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    • 2013
  • Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient's symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases.