Pediatric Infection and Vaccine
- Volume 3 Issue 2
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- Pages.200-206
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- 1996
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- 2384-1079(pISSN)
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- 2384-1087(eISSN)
A Case of Epstein Barr Virus-Associated Hemophagocytic Syndrome Confirmed by mRNA In Situ Hybridization and Polymerase Chain Reaction
mRNA In Situ Hybridization으로 확인된 Epstein Barr Virus-Associated Hemophagocytic Syndrome 1례
- Kim, Chung Han (Department of Pediatrics, Yonsei University College of Medicine) ;
- Yang, Chang Hyun (Department of Pediatrics, Yonsei University College of Medicine) ;
- Sohn, Young Mo (Department of Pediatrics, Yonsei University College of Medicine) ;
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Kim, Hoguen
(Department of Pathology, Yonsei University College of Medicine)
- 김정한 (연세대학교 의과대학 소아과학교실) ;
- 양창현 (연세대학교 의과대학 소아과학교실) ;
- 손영모 (연세대학교 의과대학 소아과학교실) ;
-
김호근
(연세대학교 의과대학 병리학교실)
- Published : 1996.11.20
Abstract
Virus associated hemophagocytic syndrome(VAHS), a class II histiocytosis syndrome, is characterized by high fever, liver dysfunction, coagulation abnormalities, and generalized histiocytic proliferation with marked hemophagocytosis in bone marrow and lymph nodes. VAHS is associated with several viral infections including Epstein Barr virus which has a relatively high mortality rate. We report a fatal case of Epstein Barr virus associated hemophagocytic syndrome and its diagnosis by mRNA in situ hybridization and polymerase chain reaction. A brief review of related literaure is also presented.