• IMMUNE NETWORK
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• v.2 no.2
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• pp.86-90
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• 2002

Background: Host genetic polymorphisms in the HIV-1 co-receptor CCR5 and CCR2b and SDF-1, ligand for co-receptor CXCR4, have been known to be associated with the resistance of HIV infection and/or the delayed disease progression in HIV-infected patients. Methods: We examined the frequencies of SDF1-3'A and CCR2b-64I alleles of 354 Koreans including 100 HIV-uninfected persons, 13 discordant spouses of HIV-infected persons, and 241 HIV-infected persons. The genotyping assays of SDF1 and CCR2b genes were carried out by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequencies of CCR2b-64I and SDF1-3'A alleles in Koreans were very high compared with Caucasians and blacks. Observed frequencies of CCR2b-64I and SDF1-3'A allelic variants were 25.1% and 28.7%, respectively. The frequency of the CCR2b-64I allele in Koreans was 2~4 times higher than those of other ethnic groups with the exception of Asian. The frequencies of CCR2b-64I and SDF1-3'A genotypes did not show the significant difference between HIV-infected and uninfected Koreans. However, the prevalence of CCR2b-64I genotype of the LTNP group was about two times higher than that of the remainder group (P< 0.05). Four (45%) out of 9 LTNPs (long-term nonprogressors) showed having the SDF1-3'A allele and 7 (78%) out of 9 LTNPs carried the CCR2b-64I allele. 3 (33%) out of 9 LTNPs had both SDF1-3'A and CCR2b-64I alleles. But none of 5 RPs (rapid progressors) appeared to have both SDF1-3'A and CCR2b-64I alleles. Conclusion: The different genetic backgrounds in study populations may affect the disease progression and the AIDS epidemic in each country. Further studies need to define whether high frequencies of CCR2b-64I and SDF1-3'A allelic variants may affect the HIV disease progression.

• BMB Reports
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• v.52 no.9
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• pp.548-553
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• 2019

Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between elevated expression of Ets-1 in cancer biopsies and poor survival. CCR7 is a chemokine that binds to specific ligand CCL21/CCL19. CCR7 expression is associated with tumor metastasis and infiltration into lymph nodes. The objective of this study was to test whether Ets-1 could regulate CCR7 expression and enhance tumor metastasis. Our data showed that CCR7 expression was downregulated in Ets-1-deficient T cells upon T-cell stimulation. Overexpression of Ets-1 increased CCR7 expression in breast cancer cell lines. In contrast, knockdown of Ets-1 reduced CCR7 expression. Ets-1 could directly bind to CCR7 promoter and mediate CCR7 expression in luciferase reporter assays and chromatin immunoprecipitation assays. Transactivation activity of Ets-1 was independent of the Pointed domain of Ets-1. Ets-1 could also enhance $NF-{\kappa}B$ and CBP transactivation of CCR7 promoter. Our results also showed that Ets-1 could modulate cancer cell transmigration by altering CCR7 expression in transwell assay and wound healing assay. Taken together, our data suggest that Ets-1 can enhance CCR7 expression and contribute to tumor cell migration.

• Biomedical Science Letters
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• v.12 no.3
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• pp.145-151
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• 2006

Leukotactin-l (Lkn-l )/CCL15 has been known as a potent chemoattractant of leukocytes. However, the precise function of Lkn-l in human neutrophils has not been explained well. In the present study, we investigated the contribution of Lkn-1 in chemotactic activity of human neutrophils. Both CCR1 and CCR3 mRNA expressions are strongly expressed in human neutrophils but CCR2 protein expression was uniquely detected on the cell surface. Lkn-l binding to CCR1 and CCR3 induced chemotactic activity of neutrophils. Chemotactic index of Lkn-l was comparable to that of IL-8. $MIP-1{\alpha}/CCL3$ binding to CCR1 and CCR5 has no effect on neutrophil migration. Cell migration, in response to Lkn-l, was blocked by pertussis toxin (Ptx), a $G_o/G_i$ protein inhibitor, and U73122, a phospholipase C(PLC) inhibitor but not by protein kinase C inhibitor such as rottlerin, and Ro-31-8425. Taken together, our results demonstrate that Lkn-l transduces the chemotaxis signal through $G_o/G_i$ protein and PLC. This finding provides the molecular mechanism by which Lkn-l may contribute to neutrophil movement into the site of inflammation.

• Journal of Korea Society of Industrial Information Systems
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• v.14 no.1
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• pp.32-42
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• 2009

Information and communication industry, which has been growing rapidly, is now leading the global economic growth, contributing a ripple effect on general business and economic structure. It is said that information and communication industry enables swift economic growth taking a role as a basic industry of information-oriented society. Especially, rapid technical innovation promotes mutual growth of other related industries and it is technology-intensive. The purpose of this research is to analyze the management efficiency of information and communication industry using DEA method, and finally suggests numerical value for inefficient organizations to improve their efficiency. CCR-I, BCC-I efficiency and RTS(Returns to scale) of 29 companies engaged in information and communication industry was evaluated. With the results, we suggested the model companies for benchmarking in information and communication industry. To summarize, 7 companies were selected with CCR-I efficiency rate 1, and 12 companies with BCC-I efficiency rate 1. RTS was finalized with 8 IRS companies, 10 DRS companies, and 11 CRS companies.

• Transactions of the Korean hydrogen and new energy society
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• v.19 no.6
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• pp.552-560
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• 2008

In 1997, Korean government established the National Energy and Resources Plan, which targeted from 1997 to 2005 with strategic energy technology development. At the end of 2005, Korean government built a New National Energy and Resources Plan preparing for upcoming 10 years from 2006 until 2015 based on energy technology trees comparing with the previous plan, which based on the energy R&D projects. In this research, we prioritize the relative preferences and efficiency by an AHP/DEA CCR-I and BCC-I integrated model approach considering scale efficiency for well focused R&D and efficiency of developing Greenhouse Gas technologies as an extended research from a view point of econometrics as an extended research.

• The Journal of the Korea Contents Association
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• v.11 no.6
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• pp.397-406
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• 2011

This paper analyzes the efficiency of Korean Financial Investment Institution using DEA model. We evaluate the CCR, BCC efficiency and RTS of 30 Financial Investment Institution. We also suggest the Financial Investment Institution which can be benchmarked based on analyzed information. The result shows that 3 Institution whose values of CCR efficiency are 1, and 7 Institution whose values of BCC efficiency are 1. RTS indicates IRS of 21 Investments, DRS of 6 Investments and CRS of 3 Investments.

• Journal of the Korea Institute of Military Science and Technology
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• v.11 no.6
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• pp.117-126
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• 2008

Recently, the investment and importance have been increasing concerning the researches which are based on fundamental studies. In defense science and technology development, the defense research centers are involved in a large portion of developing the potential capability such as defense applied technology, enhanced human resource, etc. In this paper, we analyzed the relative efficiency of 9 research centers(9 DMU : Decision Making Unit) supported by the defense budget, using DEA(Date Envelopment Analysis) method especially with the CCR-I(Charnes, Cooper, Rhodes-Input) model. Some variables are selected such as budget(input data), patent, article and human resource(output data) to be analyzed. Conclusively, the needs to identify performance-indicators, increase incentives to promote the performance and induce enthusiastic participation in defense science and development projects, are suggested via a relative efficiency analysis.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.328-341
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• 2010

Korea Trucking Transport Business is one of principal national logistics sector, though, so many issues and problems came to arises, which brought cargo transport system crisis over the country such as logistics enormous jam and traffic. This paper analyzes the efficiency of korean trucking transport business firms using DEA model. We evaluate the CCR, BCC efficiency and RTS of 30 trucking transport firms. We also suggest the trucking transport firms which can be benchmarked based on analyzed information. The result shows that seven enterprises whose values of CCR efficiency are 1, and fifteen enterprises whose values of BCC efficiency are 1. RTS indicates IRS of 16 firms, DRS of 5 firms and CRS of 9 firms.

• Proceedings of the Korea Database Society Conference
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• 2008.05a
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• pp.321-338
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• 2008

Information and communication industry, which shows rapid growth rate, is now leading the global economic growth, contributing a ripple effect on general business and economic structure. It is said that information and communication industry enables swift economic growth taking a role as a basic industry of information-oriented society. Especially, rapid technical innovation promotes mutual growth of other related industries and it is technology-intensive. The purpose of this research is to analyze the management efficiency of information and communication industry using DEA method, and finally suggest numerical value for inefficient organizations to improve their efficiency. CCR-I, BCC-I efficiency and RTS(Returns to scale) of 29 companies engaged in information and communication industry was evaluated. With the results, I suggested model companies for benchmarking in information and communication industry. To summarize, 7 companies were selected with CCR-I efficiency rate 1, and 12 companies with BCC-I efficiency rate 1. RTS was finalized with 8 IRS companies, 10 DRS companies, and 11 CRS companies.

• Journal of Yeungnam Medical Science
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• v.5 no.1
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• pp.93-100
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• 1988

In clinical practice, creatinine clearance(Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate(GFR) could be obtained from the simple determinations of plasma creatinine(Pcr) and body length(L) : GFR($m{\ell}/min/1.73m^2$=k L(cm)/Pcr(mg/$100m{\ell}$), (k=constant). The subject of this study were ill children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups; group I, from 1 to 5 years old, group II, from 6 to 10 years old, group III. from 11 to 15 years old. The results were as following ; 1) Measured creatinine clearance($Ccr_M$, $m{\ell}/min/1.73m^2$) were $109.73{\pm}9.97$ in group I, $108.26{\pm}9.02$ in group II, $96.20{\pm}4.72$ in group III and $105.48{\pm}5.23$ in all age group. 2) Measured k($k_M$) obtained from $Ccr_M=k$ Ht/Pcr were $0.49{\pm}0.03$ in group I, $0.48{\pm}0.02$ in group II, $0.43{\pm}0.02$ in group III, and $0.47{\pm}0.02$ in all age group.(Ht ; height) 3) Linear equations and correlation coefficients between Ht/Pcr(x) and Ccr(y) were y=0.822x-65.63(r=0.99) in group I, y=0.61x-23.46(r=0.72) in group II, y=0.18x+54.44(r=0.54) in group III and y=0.58x-22.13(r=0.81) in all age group. 4) $Ccr_E$ was again estiamted from linear equations between Ht/Pcr and $Ccr_M$ and $k_E$ was calculated with Ht/Pcr and $Ccr_E$ were $0.48{\pm}0.01$ in group I, $0.49{\pm}0.01$in group II, $0.43{\pm}0.01$ in group III and $0.47{\pm}0.00$ in all age group. 5) Consistant values of $k_E$ and $k_M$ were highly significant as 95~97.5% in group I and II, 90~95% in group III and 97.5~99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k($k_M$) according to the age in easy and rapid way.