• Journal of Korean Medicine Rehabilitation
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• v.32 no.1
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• pp.107-124
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• 2022

Objectives This study aimed to identify optimal combinations of acupoints used to treat chemotherapy-induced peripheral neuropathy (CIPN). Methods We searched four international databases (MEDLINE, EMBASE, the Allied and Complementary Medicine Databases [AMED], and China National Knowledge Infrastructure [CNKI]) and five Korean databases (DBpia, Research Information Sharing Service [RISS], Korean Studies Information Service System [KISS], Oriental Medicine Advanced Searching Integrated System [OASIS], and KoreaMed) to identify randomized controlled trials (RCTs) that used acupuncture to treat CIPN. Network analysis was performed on the acupoints used in more than three included articles. We constructed a network by calculating the Jaccard similarity coefficient between acupoints and applied minimum spanning tree. Then, modularity analysis, degree centrality (Cd), and betweenness centrality (Cb) were used to analyze properties of the acupoints. Results A total of 25 articles were included. 24 acupoints were extracted from 25 articles. The combinations of acupoints having the highest Jaccard similarity coefficient were {EX-UE9, EX-LE10} and {ST36, SP6}. In the modularity analysis, acupoints were classified to six modules. ST40, EX-UE11, and KI6 had the highest Cd value while ST40, GB34 had the highest Cb value. Conclusions This study found the systematic framework of acupoint combinations used in CIPN studies. This study is expected to provide new perspectives of CIPN treatment to therapists. A RCT is in progress of using the network of this study as a guideline. If significant results are derived from the RCT, it will be possible to lay the groundwork to consider acupuncture for CIPN treatment.

• Ocean and Polar Research
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• v.43 no.4
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• pp.279-293
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• 2021

To investigate the effect of seasonal marine environment conditions on the cyanobacteria abundance and diversity in the South Sea, four-seasonal surveys were conducted along the 127.5°E survey transect line in the central South Sea using flow cytometry and 16S-23S ITS on the Miseq platform from August 2016 to May 2017. The average abundance of Synechococcus varied from 3.3 × 10³ to 7.4 × 10⁴ cells ml^-1. The abundance was the highest in the summer and the lowest in the winter, and the abundance fluctuated according to water temperature. The abundance was high in the outer sea affected by TWC. However, in summer, the Coastal areas affected by the Yangtze River were more populated than the outer sea. Prochlorococcus was rare and could not penetrate into coastal areas due to the fronts, but showed its dominance in the waters influenced by the TWC. Synechococcus clades II, VII, IX, CRD1, and CRD2 were predominant in the outer sea area affected by the TWC. In the coastal area, clades I and IV showed higher dominance whereas clades V, VI, WPC1, and 5.3-MS3 with euryhaline characteristics, showed a high dominance rate in the water masses affected by the low-salinity water of the Yangtze River in the summer. Clade XVI, XVII, CB1, CB5, and 5.3-I/II showed high dominance in nutrient-rich waters in the summer with increased water temperature. The abundance and community composition of cyanobacteria changed in the South Sea due to the influence of the TWC and stratification. In the summer, the abundance and the community composition differed, and were mainly affected by the general influence of the TWC in addition to the influence of the Yangtze River low-salinity water.

• Journal of Radiation Protection and Research
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• v.22 no.3
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• pp.153-160
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• 1997

The frequencies of ${\gamma}$-ray-induced micronuclei (MN) in cytokinesis-blocked (CB) lymphocytes at several doses were measured in three donors of human and C57BL/6 mice. Measurements performed after irradiation showed a dose-related increases in MN frequency in each of the donors studied. The relative sensitivity of mouse in spleen lymphocytes (SLs) compared with human peripheral blood lymphocytes (PBLs) was estimated by best fitting linear-quadratic model based on the radiation-induced MN data over the range from 0 cGy to 400 cGy. In the case of MN frequency with 0.2 per CB cell, the relative sensitivity of mouse SLs was 1.67. Compared with the radiation-induced MN formation in the PBLs of human, the SLs of mouse were more radiosensitive. Using this MN assay with human PBLs and mouse SLs, studies were performed to determine whether the water fraction of ginseng (Panax ginseng C.A.Meyer) against radiation-induced MN in human PBLs after in vitro irradiation (3Gy) and in SLs of C57BL/6 mice after in vivo irradiation (3Gy). The frequency of MN in human PBLs was reduced by water fraction of ginseng (0.5mg/ml of medium) both pre-and post treatment (p<0.0l) in vitro. In addition, the frequency of MN in mouse SLs was also reduced by pretreatment of ginseng (2mg/ml of drinking water for 7days) in vivo. The data suggested that the ginseng may reduce cell damage caused by ${\gamma}$-rays in vitro and in vivo. Further studies are needed to characterize better the protective nature of ginseng extract, its fractions and compounds.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.3
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• pp.253-259
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• 2016

Previously, we found that KTH-13 isolated from the butanol fraction of Cordyceps bassiana (Cb-BF) displayed anti-cancer activity. To improve its antiproliferative activity and production yield, we employed a total synthetic approach and derivatized KTH-13 to obtain chemical analogs. In this study, one KTH-13 derivative, 4-(tert-butyl)-2,6-bis(1-phenylethyl)phenol (KTH-13-t-Bu), was selected to test its anti-cancer activity. KTH-13-t-Bu diminished the proliferation of C6 glioma, MDA-MB-231, LoVo, and HCT-15 cells. KTH-13-t-Bu induced morphological changes in C6 glioma cells in a dose-dependent manner. KTH-13-t-Bu also increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, KTH-13-t-Bu increased the levels of cleaved caspase-3 and -9. In contrast, KTH-13-t-Bu upregulated the levels of pro- and cleaved forms of caspase-3, -8, and -9 and Bcl- 2. Phospho-STAT3, phospho-Src, and phospho-AKT levels were also diminished by KTH13-t-Bu treatment. Therefore, these results strongly suggest that KTH-13-t-Bu can be considered a novel anti-cancer drug displaying pro-apoptotic activity.

• Journal of Korean Society of Forest Science
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• v.18 no.1
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• pp.17-22
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• 1973

Using of zymography for identification of same clone of Pinus densiflora, the two year old needle leaves of 48 ramtes including 8 clones (6 ramets per clone) were collected in the clone bank which has been established on the near campus of Institute of Forest Genetics, Suwon, in 1962. All 8 bands are named from cathod to anode, G, H, K, M, N, Q, S and Y. Only CB-1 clone shows all bands, while KW-3 clone reveals only 5 bands. Other 6 clones were found 7 bands but the occurred frequencies of those bands are variable among those clones. Though the grafting stock are used various individuals grown seed propagation of P. densiflora, moreover, three stocks have been different species and that one has been P. rigida and two individuals have been P. koraiensis, the zymograms of the ramets belonging to the same clone reveals the identified patterns. The results show that the stocks for grafting have not been affected on the isoperoxidase patterns of their scions in P. densiflora. Among 48 ramets of 8 clones, 4 ramets are found the different isoperoxidase patterns from that of the remained rametes within same clone. Thus, it is conluded that zymography is useful for testing genuineness of the grafted clones of P. densiflora.

• Weed & Turfgrass Science
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• v.7 no.2
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• pp.148-157
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• 2018

Research was initiated to evaluate four domestic and overseas organic soil amendments (SAs) on turfgrass groundcover and density and to provide basic information on practical sports turf establishment. This study was conducted in Agrostis palustris Huds. (CB) grown in sand-based root zone. A total of 20 treatments of SA+sand were prepared by mixing 10 to 50% (v/v). These amendments were SABP (Berger Peat), SAEP (Eco-Peat), SAGS (G1-Soil), and SAPP (Premier Peat). Turfgrass groundcover and density significantly varied with SAs, its mixing rate to sand and week after seeding (WAS). Cumulative turfgrass density was variable, but a great change occurred between 2 and 4 WAS. Turfgrass density at 2 WAS ranged from 36.7 (SABP 30) to 89.7% (SAGS 20), being 53.0% in differences among treatments. However, CB reached to carrying capacity around 6 WAS. Thus, most treatments were similar to 90% or so in density. At the end of study, overall groundcover ranged between 60.7 (SAEP 10) and 96.7% (SAPP 50). Proper mixing rate was variable with SAs, being 10 and 20% for SABP and SAGS, respectively. But the optimum rate was 50% for both SAEP and SAPP.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.5
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• pp.275-282
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• 2018

Using isogeometric analysis(IGA) gives more accurate results for higher order mode in eigenvalue problem than using the finite element method(FEM). This is because the FEM has $C^0$ continuity between elements, whereas IGA guarantee $C^{P-1}$ between elements for p-th order basis functions. In this paper, a mode based reduced model is constructed by using IGA and dynamic behavior analysis is performed using this advantage. Craig-Bampton(CB) method is applied to construct the reduced model. Several numerical examples were performed to compare the eigenvalue analysis results for various order of element basis function by applying the IGA and FEM to simple rod analysis. We have confirmed that numerical error increases in the higher order mode as the continuity between elements decreases in the IGA by allowing internal knots multiplicity. The accuracy of the solution can be improved by using the IGA with high inter-element continuity when high-frequency external force acts on the reduced model for dynamic behavior analysis.

• Journal of Powder Materials
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• v.22 no.5
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• pp.315-320
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• 2015

The present work reports a systematic study of using carboxymethylated cellulose (CMC) as water-borne binder to produce $Li_4Ti_5O_{12}$-based anodes for manufacture of high rate performance lithium ion batteries. When the LTO-to-CB-to-CMC mass ratio is carefully optimized to be 8:1:0.57, the special capacity of the resulting electrodes is $144mAh{\cdot}g^{-1}$ at 10 C and their capacity retention was 97.7% after 1000 cycles at 1 C and 98.5% after 500 cycles at 5 C, respectively. This rate performance is comparable or even better than that of the electrolytes produced using conventional, organic, polyvinylidene fluoride binder.

• Journal of Technologic Dentistry
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• v.19 no.1
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• pp.55-61
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• 1997

To observe the difference of the special liquid influencing to the fitness of casting body among the many elements influencing to the die fitness of the casting body, we fit L/P ratio each investment, using two kinds of phosphate bonded investment, divided the density of the special liquid by 5 groups(Density 100, 75, 50, 25, 0), made 10 copying per each group and experiment 10 groups, totally 100 copying and finally we could get the result as following ; 1) In such a case of CB-30, the casting fitness of the density 100 of special liquid, group 6, was the best and in order of the density 75, 50, 25, 0 the fitness is better. 2) In such of Denti-vest, the fitness of the density 100 of the special liquid, group 1, was the best and in order of the density 75, 50, 25, 0 the fitness is better. 3) Therefore we should change the density according to the transformation of the environment as investing because of increasing the expansion of phosphate bonded investment, as increasing the density of the special liquid.

• Journal of Electrical Engineering and Technology
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• v.13 no.1
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• pp.89-96
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• 2018

When a fault occurs in a power system, the existing analytic models for the power system fault diagnosis could generate multiple solutions under the condition of one or more protective relays (PRs) and/or circuit breakers (CBs) malfunctioning, and/or an alarm or alarms of these PRs and/or CBs failing. Therefore, this paper presents an improved analytic model addressing the above problem. It takes into account the interaction between the uncertainty involved with PR operation and CB tripping and the uncertainty of the alarm reception, which makes the analytic model more reasonable. In addition, the existing analytic models apply the penalty function method to deal with constraints, which is influenced by the artificial setting of the penalty factor. In order to avoid the penalty factor's effects, this paper transforms constraints into an objective function, and then puts forward an improved immune clonal multi-objective optimization algorithm to solve the optimal solution. Finally, the cases of the power system fault diagnosis are served for demonstrating the feasibility and efficiency of the proposed model and method.