• 생물정신의학
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• 제20권3호
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• pp.63-65
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• 2013

The new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is published by the American Psychiatric Association. The diagnostic systems for mental disorders have come under criticism for relying on presenting signs and symptoms with the result that they do not adequately reflect relevant neurobiological and behavioral systems. Finally, the National Institute of Mental Health (NIMH) in the United States has suggested the Research Domain Criteria (RDoC) to develop a research classification system based upon dimensions of neurobiology and behavioral aspect. The present review introduces the RDoC as a new reaseach framework.

• 대한의용생체공학회:의공학회지
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• 제17권2호
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• pp.209-214
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• 1996

The display of biological signals in raster scan monitors often involves a multirate sampling operation which consists of decimation .and interpolation. All electroencephalouaphic (EEG) samples of 10 to 30 seconds (2, 500 to 7, 500 samples at 250[Hz] sampling frequency) must be displayed in the computer screen to keep the aspect ratio of the paper polygraph output. Since the current afrorclable display technology Plots at most 2, 000 Pixels Per row, sDme signal samples need to be discarde4 This Paper studies methods to perform this operation characterizing them from the signal processing viewpoint and compares the display quality among several decimation techniques. Experimental results show that a nonlinear operation such as the peak detection method could be preferable to the canonical linear filtering to reduce aliasing.

• Korea-Australia Rheology Journal
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• 제17권2호
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• pp.35-40
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• 2005

Nanofluid is a novel heat transfer fluid prepared by dispersing nanometer-sized solid particles in traditional heat transfer fluid to increase thermal conductivity and heat transfer performance. In this research we have considered the rheological properties of nanofluids made of CuO particles of 10-30nm in length and ethylene glycol in conjunction with the thermal conductivity enhancement. When examined using TEM, individual CuO particles have the shape of prolate spheroid of the aspect ratio of 3 and most of the particles are under aggregated states even after sonication for a prolonged period. From the rheological property it has been found that the volume fraction at the dilute limit is 0.002, which is much smaller than the value based on the shape and size of individual particles due to aggregation of particles. At the semi-dilute regime, the zero shear viscosity follows the Doi-Edwards theory on rodlike particles. The thermal conductivity measurement shows that substantial enhancement in thermal conductivity with respect to particle concentration is attainable only when particle concentration is below the dilute limit.

• Journal of Plant Biotechnology
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• 제40권3호
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• pp.111-124
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• 2013

Research on the basic interaction of radiation with biological systems has contributed to human society through various applications in pharmaceutical, medicine, agriculture and other technological developments. In the agricultural sciences and food technology sectors, the last few decades have witnessed a large number of pertinent works regarding the utilization of radiation for evolution of superior varieties of agricultural crops of economic importance. This review presents general information about the effect of radiation on plant specificity, dose response, and benefits. There has been summarized of the effects observed after exposure and influenced by several factors including plant characteristics and radiation features. We also report on the effect of ${\gamma}$-irradiations on plants, focusing on metabolic alterations, modifications of growth and development and changes in biochemical pathways.

• 약학회지
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• 제32권6호
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• pp.420-427
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• 1988

Post-translational modification of protein amino acid residues is a well known metabolic phenomenon. One such side chain modification, protein methylation, occur ubiquitously in nature, in organism ranging from prokaryotic to eukaryotic and the biological significance of protein methylation has begun to emerge. The observation that cytochrome C methylation facilitates the binding of this hemoprotein to mitochondria could be placed as the one of the examples along this line. However, the detail biological meaning of cytochrome C methylation is remained to be clarified. In the aspect of such reason this research was done. The results of this experiment were; 1) pure Euglena gracilis cytochrome C552 was isolated, 2) methylarginine and methylmethionine were not found in cytochrome C552 sequence, 3) however, Unknown Peak at 20.78min of retention time was found, and 4) this Unknown Peak was found only from Euglena cytochrome C552, so far.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.311-314
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• 1996

The display of biological signals in monitors often involves a multirate sampling operation which consists of decimation and intenolation. All electroencephalographic (EEG) samples of 10 to 30 seconds must be displayed in the computer screen to keep the aspect ratio of the paper polygraph output. Since the current affordable display technology plots at most 2,000 pixels per row, some samples need to be discarded. This paper studies methods to perform this operation characterizing them from the signal processing viewpoint and compares the display quality among several decimations. Experimental results show that a nonlinear operation such as the peak detection could be preferable than the canonical linear filtering to reduce aliasing.

• Journal of Preventive Medicine and Public Health
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• 제54권4호
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• pp.259-264
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• 2021

Traditional epidemiological studies have identified a number of risk factors for various diseases using regression-based methods that examine the association between an exposure and an outcome (i.e., one-to-one correspondences). One of the major limitations of this approach is the "black-box" aspect of the analysis, in the sense that this approach cannot fully explain complex relationships such as biological pathways. With high-throughput data in current epidemiology, comprehensive analyses are needed. The network approach can help to integrate multi-omics data, visualize their interactions or relationships, and make inferences in the context of biological mechanisms. This review aims to introduce network analysis for systems epidemiology, its procedures, and how to interpret its findings.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.276.2-276.2
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• 2002

Glycosaminoglycans(PT -Gag) were isolated from the porcine testis. From the PT -Gag. we obtained two different types of Gag fractions using Dowex macroporous Resin MSA-1 column. PT-Gag-1.5% NaCl and PT -Gag-16% NaCl. Various biological activities of the GAGs were examined in aspect of anticoagulant and immunomodulating activity. The anticoagulant activity of the GAGs was evaluated by activated partial thromboplastin time (aPTT ) assay and thrombin time (TT) assay. The GAGs of porcine testis markedly increased the clotting times of both of aPTT and TT. showing that PT-Gag-16% NaCl was more effective than PT-Gag-1.5% NaCl. The immunomodulating activity of the GAGs was examined in relation to regulation of cytokine production of mutine peritoneal macrophages. Treatment with the GAGs promonently enhanced the prodution of cytokines. IFN-${\gamma}$, from macrophages. Taken together. GAGs isolated from porcine testis possess biological functions such as anticoagulant and immunomodulating activity.

• Biotechnology and Bioprocess Engineering:BBE
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• 제10권5호
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• pp.432-443
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• 2005

Microarray technology has contributed Significantly to the understanding of bacterial genetics and transcriptional regulation. One neglected aspect of this technology has been optimization of microarray-generated signals and quality of generated information. Full genome microarrays were developed for Clostridium acetobutylicum through spotting of PCR products that were designed with minimal homology with all other genes within the genome. Using statistical analyses it is demonstrated that Signal quality is significantly improved by increasing the hybridization volume. possibly increasing the effective number of transcripts available to bind to a given spot, while changes in labeled probe amounts were found to be less sensitive to improving signal quality. In addition to Q-RT-PCR, array validation was tested by examining the transcriptional program of a mutant (M5) strain lacking the pSOL1 178-gene megaplasmid relative to the wildtype (WT) strain. Under optimal conditions, it is demonstrated that the fraction of false positive genes is 1% when considering differentially expressed genes and 7% when considering all genes with signal above background. To enhance genomic-scale understanding of organismal physiology, using data from these microarrays we estimated that $40{\sim}55%$ of the C. acetobutylicum genome is expressed at any time during batch culture, similar to estimates made for Bacillus subtilis.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
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• pp.270-278
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• 2000

A machine vision system using charge coupled device(CCD) camera for the weed detection in a radish farm was developed. Shape features were analyzed with the binary images obtained from color images of radish and weeds. Aspect, Elongation and PTB were selected as significant variables for discriminant models using the STEPDISC option. The selected variables were used in the DISCRIM procedure to compute a discriminant function for classifying images into one of the two classes. Using discriminant analysis, the successful recognition rate was 92% for radish and 98% for weeds. To recognize radish and weeds more effectively than the discriminant analysis, an artificial neural network(ANN) was used. The developed ANN model distinguished the radish from the weeds with 100%. The performance of ANNs was improved to prevent overfitting and to generalize well using a regularization method. The successful recognition rate in the farms was 93.3% for radish and 93.8% for weeds. As a whole, the machine vision system using CCD camera with the artificial neural network was useful to detect weeds in the radish farms.