• The Journal of the Korea Contents Association
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• v.9 no.4
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• pp.355-363
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• 2009

Increased oxidative stress by abnormal mitochondrial function can damage cell signal transduction and gene expression, and induce insulin resistance or diabetes. Autophagy, however, improve insulin resistance by clearance of malfunctioning mitochondria. Exercise also recovers the muscle dysfunction and degeneration by activating mitochondrial biogenesis. As it seems that exercise and autophagy might act as an orchestrated network to induce mitochondrial biogenesis, we investigated whether autophagy is involved in AMPK signal pathway stimulated by exercise or AICAR to increase mitochondrial biogenesis. And it showed that PGC-1 and mtTFA, but not autophagy marker LC3 mRNA expression were significantly increased by 6 hr of acute exercise. On the other hand, PGC-1 and mtTFA mRNA expression were upregulated by AICAR treatment to C2C12 myotube. However these genes were not inhibited by LC3 siRNA transfection. These results provide the evidence that autopahgy affects on mitochondrial biogenesis through different signal pathway from AMPK signal transduction.

• Korean Journal of Food Science and Technology
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• v.43 no.4
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• pp.458-463
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• 2011

Recent studies have revealed that collagen peptide (CP) plays a protective role in skin by improving the activity of antioxidants and acts as an inducer of skin regeneration by positive feedback. In this study, we focused on the beneficial effect of reinforcing the CP skin barrier. To evaluate the skin barrier, hairless mice were exposed to UVB irradiation and acetone-treatment, with or without oral administration of CP. The effects on skin appearance, trans-epidermal water loss, epidermal thickness, and cytokine content were measured using bioengineering and histochemical methods. In the CP treated group, the skin had better appearance and less damage than that of the control. Furthermore, in HaCaT cells, the amount of serinepalmytoyl transferase (SPT) mRNA increased by about 1.6-fold after treatment (CP, 100 mg/L), reflecting that CP can induce SPT expression and reinforce the recovery of skin barrier function. These results suggest that CP is not only an anti-wrinkling agent but also a potent candidate as an epidermal moisturizer.

• Korean Journal of Social Welfare
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• v.56 no.2
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• pp.53-70
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• 2004

This study is about family discourses of social workers in Korea. The purpose of this study is to gain suggestions of relatedness between discourse and practice by grasping the contents and meaning of discourses in social workers. 10 social workers in various fields were interviewed for this study. The results are followed: First, social workers understand family as a private space which have a meaning of shelter and refuge. Second, there are gaps between consciousness and practice of division of gender role in family. But social workers generally are inclined toward receiving division of gender role in family and applied to their family practice. Third, monolithic family image have a tendency of versatility in family structure, is inclined toward the division of gender role and myth of motherhood. Fourth, social workers perceived emotional tie as important nature of family solidarity and family as natural institution. Also these discourses of social workers were applied to their family practice. The results of this study reveals possibility that social work practice can be discoursive practice or interpretive practice.

• Cross-Cultural Studies
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• v.52
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• pp.1-29
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• 2018

The notion of 'gift' is one of the effective and fruitful codes for understanding Western civilization. In this study, we will shed light on several meanings, especially by comparing among the three French philosophers that expressed interest in this notion: they are Mauss, Derrida and $Ric{\oe}ur$. Called "father of French ethnography", Mauss claims, in his famous article "Essay on the Gift", that the gift is paradoxically a kind of economic exchange dominated by three obligations: to give, receive, and return. But he strives to establish a moral theory based on the obligation to give. Under the influence of Mauss, Derrida deconstructs the theory of Mauss by devoting attention to 'time', one of the determining elements in studies on the gift. Derrida observes that the gift is established just at the extremely short moment of emergence of the act of giving and that this act is transformed into an economic exchange with passing of time. From it, the impossibility of the gift is derived despite its concrete and real emergence and existence. Under the influence of Mauss, $Ric{\oe}ur$, for his part, is interested in the notion of giving as part of the dialectic between 'love' and 'justice'. According to him, whereas justice is dominated by the economy of gift, namely the logic of equivalence, love, by the logic of 'superabundance'. He focuses on establishing 'Supra-ethics' by considering the fact that the gift is at the core of his religious and philosophical vision. Finally, let us point out that in $Ric{\oe}ur$, this notion of gift ('don') is closely linked to forgiveness ('pardon'), that holds in it the secret of understanding regarding the 'fallible' and 'capable' man.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.1
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• pp.11-18
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• 2004

The eruption of permanent teeth represents the movement in the alveolar bone before appearance in oral cavity, to the occlusal plane after appearance in oral cavity, and additive movement after reaching th the occlusal plane. Tooth eruption is mostly controlled by genetic signals. The eruption stage is divided to preeruptive alveolar stage, alveolar bone stage, mucosal stage according to the process of growth and development. If the disturbance is occured in any stage of eruption, tooth does not erupt. The cause of eruption disturbance are ectopic position of the tooth germ, obstruction of the eruption path and defects in the follicle or PDL. In the treatment of eruption disturbance, surgical procedures are commonly used. There are three kind of surgical procedure ; surgical exposure, surgical repositioning, surgical exposure and traction Surgical exposure is basic procedure. This involves removal of mucosa, bone, lesion that are surrounding the teeth, dental sac when necessary to maintain a patent channel between the crown and the normal eruptive path into the oral cavity. To ensure this patency, many techniques including cementation of a celluloid crown, packing with gutta-percha or zinc oxide-eugenol, or a surgical pack, are used. When surgical exposure is conducted, operators should not expose any part of cervical root cement and not injure periodontium or root of adjunct tooth. After surgical exposure, tooth should be surrounded by keratinized gingiva. There is direct relationship between the extent of development of pathophysiologic aberrations and the intensity of the manipulative injury inflicted on the tooth by surgical treatment, so operator should consider this thing. In these cases, surgical exposure is conducted on Maxillary 1st milars that have a eruption disturbance and improve the eruption disturbance effectively.

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.178-185
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• 2005

Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo-HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ${\pm}13$-cis-retinoic acid(CRA) before transplant, and CRA was used, posttransplant, in six patients. Results : Only three patients were in complete remission(CR) at the time of transplantation. Initial chimeric status revealed complete donor chimerism(CC) in five patients, mixed chimerism(MC) in five and autologous recovery(AR) in one. One patient with MC having persistent splenomegaly eventually turned to CC and CR after rapid tapering of cyclosporine, combined with daily use of CRA. An AR case relapsed shortly after transplant but was rescued with second, unrelated cord blood transplantation. Ultimately, six patients are alive, event-free, with a median follow-up of 15.5 months posttransplant. All three deaths occurred in patients who failed to achieve CC, leading to disease progression. Conclusion : We suggest that graft-versus-leukemia effect play an important role and CRA a possible role in posttransplant leukemic involution in JMML. In patients whose leukemic burden is still high with MC after transplant, early tapering of immunosuppressants and introduction of CRA might provide a chance of a cure for some patients.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.5
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• pp.228-235
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• 2016

Nitrite accumulation is essential for constructing an anammox process. As the pH in the reactor exerts a complicated and strong influence on the reaction rate, we investigated its effects upon treatment of an ammonic wastewater (2,000 mgN/L) through modeling and experiment. The modeling results indicated that the reaction stability is strongly affected by pH, which results in a severe reduction of the 'stable region' of operation under alkaline environments. On a coordinate of the total ammonia nitrogen (TAN) concentration vs. pH, the maximal stable reaction rates and the maximal nitrite accumulation potentials could be found on the 'stability ridge' that separates the stable region from the unstable region. We achieved a stable and high ammonia oxidation rate (${\sim}6kgN/m^3-d$) with a nitrite accumulation ratio of ~99% when operated near the 'stability ridge'. The optimum pH that can be observed in experiments varies with the TAN concentrations utilized, although the intrinsic optimum pH is fixed. The direction of change is that the optimum operational pH falls as the TAN concentration increases, which is in excellent accordance with the observations in the literature. The optimum operational pH for 95% nitritation was predicted to be ~8.0, whereas it was ~7.2 for 55% partial nitritation to produce an anammox feed in our experimental conditions.

• Journal of Dental Rehabilitation and Applied Science
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• v.26 no.1
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• pp.59-68
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• 2010

Recently, dental implants extensively inserted on edentulous area show highly clinical success rate. However, clinicians cannot exclude the possibility of failure and it often unexpectively occures. Many possible factors associated with failure of dental implants have been reported but controversy exists over the extent to them. In this study, we collected 212 patients who had been inserted 358 dental implants on mandibular premolar and molar area from 2005 to 2006. The survival rate of fixtures was recorded according to age of patients, implantation site, implant system, diameter and length of fixtures. Multi-variable analysis using SPSS chi-square test was operated to verify relation of each factors and survival rates. Accumulative survival rate was 98.3% for 3 years. Only diameter of fixtures was related to the implant survival rate. This may be thought that wider fixtures had been chosen to rescue implants or used in sites of poor bone quality. Further continuous study will be needed for direct guidance associated with survival rate of implants.

• Korean Journal of Social Welfare
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• v.39
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• pp.322-349
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• 1999

The purpose of the study is to investigate kinds of social support provided by various types of family members, relationships between types of family support and personal variables of the elderly and structural variables of the family network, and the relationships between family support and depression of the elderly. Here, family included a spouse, sons and daughters and their spouses, grandchildren, siblings and parents of an older person. Social support consisted of emotional, instrumental, financial help and social companionship. Two-hundred-eight older persons of age 60 years and over were interviewed. The main results of the study were as follows: an older person's spouse tended to provide more for emotional support, sons for financial help, daughters-in-law for instrumental support, and daughters for emotional and financial support. Some elderly were also provided for emotional support by parents and siblings. Possibility of daughters-in-laws and grandchildren as support providers was also verified. Various factors among personal and network-structural characteristics were significantly related to many types of social support provided by various types of family members. In general, while younger female elders, elders with good IADL ability or more frequent contacts with family members tended to have social support from more family members, support from daughters-in-law was provided to the elderly with less functional abilities. Various types of social support from a spouse were significantly related to depression level of the elderly. Their depression level was more related to whether or not sons and daughters-in-law exist rather than whether or not they provide social support. Practical methods to increase family support for the elderly were discussed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.5B
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• pp.475-481
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• 2011

The TMDL standard flow as applying watershed management regime uses the average low flow of past 10 years. Moreover, the TMDL implementation assessment has been enforced through management of pollutant load satisfied objective water quality. Even though the present allocation and management through averaged low flow are still convenient, they are not enough to solve ultimate goals of watershed management to keep up recovery of water body. To maintain the same water quality concentration, the standard flow is required to consider total discharge in management plan which helps to keep healthy ecosystem. In view of this, it would be possible to approach reasonable assessment by reflecting variably changeable discharge from precipitation-streamflow relation and the TMDL standard establishment considering artificial regulated flow. Therefore, this study attempts to develop the TMDL method using Load Duration Curve (LDC) and Streamflow-Load Rating Curve (QLRC) considering total discharge and finds drawbacks with solutions as applying on Nakdong river TMDL unit watershed. Finally, this research evaluates possibility of application on pollutant load allocating and implementation assessment in Korea.