• Title/Summary/Keyword: 피하

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Ara - C유도체의 항암작용에 관한 연구 (1) : 암세포에 대한 Ara-C 유도체의 항암효과에 대한 in vivo 연구

  • Lee, Hyung-Hwan;Cho, Dong-In;Ji, Yong-Hoon;Lee, Chul-Kyu;Kang, Heon;Choi, Hee-Baek;Lee, Hye-Yeol;Kim, Eun-Tae;Kanter, P.M.;Creaven, P.J.;West, C.R.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.199-199
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    • 1994
  • Thioglycerol과 glycerol로부터 rac-1-S-octa-decyl-2-O-palmitoyl-1-S-thioglycerol-3-phosphate (DL -PTBA-P)와 rac-1-O-octadecyl-2-O-palmitoyl-g1ycerol-3-phosphate (DL-PBA-P)등을 합성하였고, 이들에 ara-C 유도체인 ara-CMP morpholidate를 반응시켜 최종 산물인 ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara-CDP-DL-PTCA 및 ara-CDP-DL-PTBA등을 합성하였다. 이들 최종산믈의 항암효과는 L1210 lymphoid leukemia, colon 26 carcioma, M5076 sarcoma, C-1300 neuroblastoma, 3-Lewis lung carcinoma, WEHI-3B leukemia, human colon cancer, hum an pancreatic cancer 등의 암세포주를 사용하여 실험하였다. L1210를 DB/2J의 뇌막 또는 복강, DBA/1J의 복강내에 이식하여 ara-C, Ehss thioether lipid의 ara-C 유도체 (ara-CDP-L-DP, ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara -CDP-DL-PTCA, ara-CDP-D-PTBA, ara-CDP-L-PTBA, ara-CDP-DL-PTBA)를 단일 투여 또는 중복 투여하였고, 3-Lewis는 C57BL/6 의 발바닥 피하, colon26은 BALB/C의 견갑상부 히아조직, M5076은 C57BL/6의 피하, WEHI-3B는 BALB/C의 복강, C-1300는 A/strong Ros에 각각 이식한 후 ara-C 또는 ara-CDP-DL-PTBA를 단일 또는 중복 투여하였다.

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Production of the Functional Egg to Strengthen Isoflavone : Improvement of Transfer Efficiency of Genistein into the Egg Yolk (Isoflavone 강화 기능성 계란 생산 : 난황내 Genistein 전이 효율 개선)

  • HwangBo, J.;Lee, B.S.;Lee, H.J.;Chung, W.T.;Cho, S.B.;Hong, E.C.;Bae, H.D.;Chang, J.S.
    • Korean Journal of Poultry Science
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    • v.33 no.3
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    • pp.211-215
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    • 2006
  • This study was carried out to determine whether genistein implants in laying hens could be transferred into their eggs. 250 mg genistein pellet was implanted two or four subcutaneously in the neck of laying hens. The contents of genistein in egg yolk transferred were analyzed with HPLC-MS. In 500 mg genistein pellets, it was detected as 395 ng/egg yolk on the day 18 after implanting and maintained as 546 ng/egg yolk after the day 59. In 1,000 mg, genistein was detected as 240 ng/egg yolk on the day 13, as 514 ng/egg yolk on the day 30 and maintained over 59 days. In conclusion, the direct genistein implants could be more twenty times efficiently transferred to egg yolks than dietary supplement.

Measurement-based Face Rendering reflecting Positional Scattering Properties (위치별 산란특성을 반영한 측정기반 얼굴 렌더링)

  • Park, Sun-Yong;Oh, Kyoung-Su
    • Journal of Korea Game Society
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    • v.9 no.5
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    • pp.137-144
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    • 2009
  • This paper predicts 6 facial regions that may have sharply different scattering properties, rendering the face more realistically based on their diffusion profiles. The scattering properties are acquired in the form of high dynamic range by photographing the pattern formed around an unit ray incident on facial skin. The acquired data are fitted to a 'linear combination of Gaussian functions', which well approximates the original diffusion profile of skin and has good characteristics as the filter. During the process, to prevent its solutions from converging into local minima, we take advantage of the genetic algorithm to set up the initial value. Each Gaussian term is applied to the irradiance map as a filter, expressing subsurface scattering effect. In this paper, to efficiently handle the maximum 12 Gaussian filterings, we make use of the parallel capacity of CUDA.

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Extraction of Lumbar Multifidus Muscle using Ultrasound Imaging (초음파 영상에서 다열근 추출)

  • Kim, Kwang-Baek;Shin, Sang-Ho
    • Journal of the Korea Society of Computer and Information
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    • v.16 no.2
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    • pp.55-60
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    • 2011
  • In this paper, we propose a new method for extracting muscles from lumbar images. The proposed method sets areas without distortions with field expert's assistance as areas of measuring interest and removing noises from initial ultrasonic videos. Then, the method emphasizes the brightness contrast with Ends-in search stretching algorithm and separate thoracic vertebra from subcutaneous fat area using morphological characteristics. 4-directions contour tracing algorithm is applied to extract the bottom of subcutaneous fat area. Extracting thoracic vertebra area requires noise removal and morphological characteristics as well among candidate areas obtained by controlling min-max brightness. The thickness of muscles is then defined as the length between subcutaneous fat area and extracted thoracic vertebra. The experiment which consists of 368 image analysis verifies that the proposed method is more effective in measuring the thickness of muscles than before.

Clinical Presentation of Paraganglioma in Orthopaedics - Report of Two Cases - (정형외과 영역에서의 부신경절종의 임상 양상 - 2례 보고 -)

  • Lee, Sang-Lim;Oh, Joo-Han;Lee, Sang-Hoon;Kim, Han-Soo;Kim, Hyung-Ho;Kim, June-Hyuk
    • The Journal of the Korean bone and joint tumor society
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    • v.11 no.1
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    • pp.94-99
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    • 2005
  • Paraganglioma is a neoplasm consisting of sympathetic neuroendocrine cells, which arise from neural ectoderm of extra-adrenal paraganglia. It often occurs in thyroid, carotid body, mediastinum, lung, duodenum, the retroperitoneal area and periaortic area. Malignant paraganglioma is defined not by the histological diagnosis, but by spread to regional lymph nodes or distant metastasis. Rare bone metastasis mostly occurs in the base of skull or spine, and even it rarely metastasizes to pelvis or femur. We would like to report two cases of paraganglioma; one in the subcutaneous fat layer that was mistaken for a vascular tumor, and the other in the retroperitoneal space with early bone metastasis.

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Case comments on the Korean Supreme Court's Judgment Involved in a Vessel Not to Impede. (Supreme Court Case No.2000 chu 43 Dated 28 November 2000) (통행불방해의무선박 관련 대법원 판결에 대한 평석 (대법원 2000. 11. 28, 선고 2000추43판결))

  • 김인현
    • Journal of the Korean Institute of Navigation
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    • v.25 no.1
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    • pp.61-75
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    • 2001
  • There are two different groups of vessels which have a duty to avoid the other vessel in the Collision Regulations; one is a vessel to keep out of the way and the other is a vessel not to impede the passage. The definition and duty of a vessel not to impede was clarified by IMO's adoption of rule 8(f) of 1972 COLREG in 1987 revision. However, the Korean government has not inserted rule 8(f) of 1972 COLREG into Korean national collision regulations to date and so the definition and application for a vessel not to impede has not been discussed in even academic circle. Recently Korean Supreme Court rendered a verdict on a collision case involved with a vessel not to impede. The writer expresses his view on the duty of a vessel not to impede and criticizes the Supreme Court's judgment, consulting with foreign scholar's article and the relevant IMO's papers.

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Implementation of an Intelligent Automatic Parking Assist System (지능형 자동 주차 지원 시스템의 구현)

  • Park Cheong-Sool;Han Min-Hong
    • Journal of the Institute of Convergence Signal Processing
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    • v.6 no.4
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    • pp.182-190
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    • 2005
  • In the paper, we propose an intelligent automatic parking assist system. To realize an automatic parking, first, the prospective parking position and the location of a vehicle should be recognized. Second, the system should compute a path which introduces the parking position precisely with avoiding any obstacles. Third, the handle should be controlled so that the vehicle moves through the path. To calculate the location of the vehicle and its surroundings, the system applies the camera image method to transforming input images to the plane map. It also uses the inertial navigation method which recognizes the position and the direction of a moving vehicle by using a kinematic model of the vehicle. To generate a path of the vehicle, the simple path method and the Bezier spline method are tested. The divided arc method which generates multiple paths is also tested. We apply a method which makes the system choose the best path with multiple objective functions. We introduce the virtual road method, as a solution for the problem of mechanical time delay, to have the vehicle followed the designated path.

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Meniscal Repair with Meniscal Arrows (반월상연골 화살을 이용한 반월상연골 봉합술)

  • Kim Jung-Man;Oh In-Soo
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.1 no.2
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    • pp.124-130
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    • 2002
  • Purpose: The results of meniscal repair of peripheral tear of meniscus with meniscal arrow was analysed. Materials and Methods: Peripheral tears of posterior 1/2 of menisci of 25 cases including 18medial, 6 lateral and 1 both menisci were repaired with meniscal arrows. One to six meniscal arrows were used for each meniscus according to the length of tears. Concurrent tears of ACL were noted in14 cases. The follow-up period was 3.4 years in average. The findings of physical examination and MRI which were taken once or twice in 1$\~$5 years after operation were evaluated. Results: Healing of the tear was achieved in all cases. However, a vertical longitudinal tear of body occurred in two medial menisci along the line of insertion of arrows. An arrow migrated subcuta-neously in two cases, respectively. Conclusions: The meniscal arrow was effective in the treatment of the peripheral tear of menicus. However, there was a chance of occurrence of longitudinal tear of the meniscus in case of insertion of arrows in a row. Migration of the arrow may occur.

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A Handoff Mechanism to Avoid Congestion in Wireless Cells (무선 셀에서의 혼잡 발생을 피하는 핸드오프 방안)

  • 변해선;이미정
    • Journal of KIISE:Information Networking
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    • v.30 no.5
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    • pp.595-603
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    • 2003
  • To provide mobile nodes with continuous communication services, it is important to reduce the packet losses during handoffs. The handoffs of mobile nodes cause packet losses and decrease of TCP throughput on account of a variety of factors. One of those is the congestion in the new cell. Due to the congestion, not only the node moving into the cell but also the already existing nodes that were successfully communicating in the cell suffer the performance degradation. In this paper we propose a new handoff mechanism called‘packet freeze control’, which avoids the congestion caused by handoffs by regulating the influx of traffic burst into the new cell. Packet freeze control is applicable to a wireless network domain in which FAs(Foreign Agents) are connected hierarchically and constitute a logical tree. It gradually increases the number of packets transferred to the new cell by buffering packets in the FAs on the packet delivery path over the wireless network domain. The simulation results show that the proposed mechanism not only reduces the packet losses but also enhances the TCP throughput of other mobile nodes in the cell.

A Study on Characteristics of Lateral Wheel Path Distributions in Different Traffic Lanes (차로위치에 따른 차량의 횡방향 이격거리 분포 특성에 관한 연구)

  • Jo, Myounghwan;Park, Hyunsik;Jin, Jung Hoon;Kim, Nakseok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.3D
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    • pp.339-346
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    • 2008
  • The research was conducted to investigate the characteristics of lateral wheel path distributions (wandering) in different traffic lanes. The lateral wheel path distributions may affect pavement life and various distress types. The results presented that the normal distribution curve with symmetry was observed in the 2-lane and 3-lane roads. In the case of the 2-lane road (on one direction), the wanderings were 70-95cm, and 70-85cm for the 1st and 2nd lanes, respectively, while in the case of the 3-lane road (on one direction), 50-60cm, 65-85cm, and 80-95cm for the 1st, 2nd, and 3rd lanes, respectively. In addition, the 1st lane vehicles tended to pass on the right side to avoid the opposite side vehicles, while the outside lane vehicles tended to pass on the left side to avoid the walkway.