• 대한한방부인과학회지
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• 제22권4호
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• pp.1-18
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• 2009

Purpose: This study was performed to elucidate the inhibitory effect of Mibaeksan (MB) on melanin synthesis in B16F10 mouse melanoma cell. Methods: To demonstrate the inhibitory effects of MB on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma cell. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, MMP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma cells. Results: 1. MB decreased the release and production of melanin in B16F10 melanoma cells. 2. MB decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. MB decreased the expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$ and MMP-2 in B16F10 melanoma cells. 4. MB increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 5. MB decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that MB has the antimelanogenetic effects.

• 대한한방부인과학회지
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• 제36권4호
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• pp.121-139
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• 2023

Objectives: This study was performed to analyze randomized controlled trial, which studied the effect of Saenghwa-tang treatment on postpartum prolonged lochia and uterine subinvolution. Methods: Researchers searched for randomized controlled trial of based on postpartum prolonged lochia, uterine subinvolution and Saenghwa-tang. The paper search was conducted through 6 online databases on August 10, 2023. Results: 8 studies were included after selection and exclusion criteria. 5 studies compared Saenghwa-tang alone with western medicine. 3 studies compared combined treatment of Saenghwa-tang and western medicine, with western medicine alone. Comparing with control group, the treatment group showed statistically significant improvement on total effective rate, uterine involution, serum fibrinogen, D-dimer, viscosity of blood and plasma, Erythrocyte aggregation, and various symptoms. Conclusions: This study suggests that Saenghwa-tang has benefit for treating prolonged lochia and uterine subinvolution. For reliable evidence, further research is needed to establish safety of Saenghwa-tang, standardize diagnosis criteria and specify the treatment course.

• 대한한방부인과학회지
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• 제37권3호
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• pp.85-106
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• 2024

Objectives: This study was performed to analyze randomized controlled trial, which studied the effect of korean herbal medicine on premature ovarian insufficiency. Methods: Researchers searched for randomized controlled trial of based on korean herbal medicine and premature ovarian insufficiency. The paper search was conducted through 7 online databases on April 20, 2024. Results: 12 studies were included after selection and exclusion criteria. 4 studies compared herbal medicine with hormone replacement therapy or placebo. 8 studies compared combined treatment of herbal medicine and hormone replacement therapy, with hormone replacement therapy alone. All studies reported significant improvement on hormone, antral follicle count (AFC), total effective rate and associated symptoms. There were no serious adverse effects. Conclusions: This study suggests that herbal medicine has benefit for treating symptoms and ovarian function of premature ovarian insufficiency. For reliable evidence, further research on pregnancy or long-term follow-up is needed.

• 대한한방부인과학회지
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• 제34권3호
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• pp.79-95
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• 2021

Objectives: The purpose of this review is to analyze the domestic study trends on climacteric syndrome treated with pharmacopuncture. Methods: We investigated the studies on pharmacopuncture for climacteric syndrome via searching 6 online databases. Results: 18 studies were selected. There were 2 case reports, 1 randomised controlled trial, and 15 animal experiments. There were 14 studies about osteoporosis, 1 study about hot flush and sweating, 1 study about abdominal obesity, 1 study about neck pain, and 1 study about learning disability and memory disorder. Nokyong was most frequently used for pharmacopuncture, followed by Honghwa. 陰谷 (KI10) was most frequently used for acupuncture point, followed by 腎兪 (BL23). Conclusions: This study shows that pharmacopuncture could be one of the effective treatments for climacteric syndrome. More well-designed clinical studies using pharmacopuncture for climacteric syndrome will be needed.

• 대한한방부인과학회지
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• 제32권3호
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• pp.162-173
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• 2019

Objectives: The purpose of this review was to overview and evaluate the efficacy of acupoint sticking therapy for women with endometriosis. Methods: We searched for randomized controlled clinical trials (RCTs) using acupoint sticking therapy on endometriosis in 5 electronic databases such as EMBASE, Pubmed, and CAJ. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias tool. Results: Two RCTs were included for analysis. In the selected studies, Treatment group was higher effective cure rate than any control group. In one RCT, Acupoint sticking therapy was only used, but the other RCT was treated acupoint sticking therapy combined with acupuncture. So, Interventions in 2 studies were not same, Quantitative synthesis was impossible. Conclusion: The limitation of this review is that the number of studies included is small. However, our systematic review provides a basis for acupoint sticking therapy for endometriosis. Acupoint sticking therapy was considered as one of external treatment method for patients with endometriosis.

• 대한한방부인과학회지
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• 제34권4호
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• pp.62-77
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• 2021

Objectives: This study aimed to anaylze randomized controlled trials on the effectiveness of herbal medicine for hyperemesis gravidarum. Methods: We searched the randomized controlled trials that intervented oral herbal medicine treatment on hyperemesis gravidarum retrieved using seven domestic and foreign databases. Literature search was conducted on April 19, 2021. Results: 185 studies were searched, and 7 were finally selected based on inclusion and exclusion criteria. All subjects were treated with western symptomatic treatment and in treatment group, additional oral herbal medicine was administered. Although the evaluation index was different for each study, all the indexes in the treatment group were significantly improved compared to the control group. Conclusions: Herbal medicine treatment for hyperemesis gravidarum showed significant effectiveness compared to western symptomatic treatment. In the future, additional studies are needed to evaluate the safety of herbal medicine treatment.

• 대한한방부인과학회지
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• 제34권1호
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• pp.82-92
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• 2021

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine treatment on interstitial cystitis. Methods: The patient diagnosed with Interstitial cystitis/Bladder pain syndrome (IC/BPS) was treated with Korean medicine treatment during 22 days of hospitalization. The patient received Korean medicine treatment including herbal medicine, acupuncture, pharmacopuncture, moxibustion, cupping and extracorporeal magnetic stimulation therapy. The effect of treatment on IC/BPS was evaluated through the Numeric Rating Scale (NRS), voiding diary, and Interstitial Cystitis Symptom Index/Problem Index (ICSI/ICPI). Results: After the treatment, the clinical symptoms of IC/BPS such as pelvic pain, pelvic pressure, frequent urination and urinary urgency were improved. Also, the patient had better scores in ICSI/ICPI. Conclusions: This case report proved that the Korean medicine treatment may be effective for improving clinical symptoms of IC/BPS. However, a large-scale clinical study is needed in the future to prove the effectiveness of Korean medicine treatment for IC/BPS.

• 대한한방부인과학회지
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• 제34권2호
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• pp.62-81
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• 2021

Objectives: The purpose of this study is to review clinical studies and evaluate effectiveness of intravaginal administration of oriental medicine on vaginal atrophy in menopausal women. Methods: 'postmenopause', 'menopause', 'vaginal atrophy', 'atrophic vaginitis', 'vaginal cream', 'vaginal gel', 'pessary', 'suppository' were searched on 3 online databases (Pubmed, Cochrane Library, OASIS). The risk of bias was assessed by using Cochrane risk of bias (RoB) 2.0 tool. Results: 9 randominized controlled trials (RCTs) were selected among 489 articles. The types of intervention were intravaginal administration of oriental medicine. 6 studies showed that treatment group was better than placebo control group or both treatment group and western medicine control group improved similarly. 2 studies were not significant effective in some results and 1 study was not statistically significant. Conclusions: Intravaginal administration of oriental medicine can be an effective option in treating menopausal women with vaginal atrophy. but considering the small number and low quality of studies, further well-designed studies are needed to confirm the effectiveness of this treatment.

• 대한한방부인과학회지
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• 제36권1호
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• pp.90-102
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• 2023

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine treatment on postmenopausal syndrome. Methods: The patient with postmenopausal syndrome with palpitation was treated with Korean medicine treatment during 14 days of hospitalization. The patient received Korean medicine treatment including herbal medicine, acupuncture and moxibustion. The effect of treatment on postmenopausal syndrome was evaluated through the Numeric Rating Scale (NRS) and questionnaire. Palpitation and arrhythmia was evaluated by Electrocardiogram (ECG) and manual pulse diagnosis three times a day. Result: After the treatment, the clinical postmenopausal symptoms of palpitation and hot flush were improved. Also, ECG's result was improved ventricular premature contraction to normal ECG. Conclusions: This case report proved that the Korean medicine treatment may be effective for improving postmenopausal syndrome with palpitation and hot flush. However, further clinical study is needed in the future to prove the effectiveness of Korean medicine treatment for postmenopausal syndrome with palpitation and hot flush.

• 대한한방부인과학회지
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• 제22권4호
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• pp.135-148
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• 2009

Purpose: The purpose of this study is to recognize correlation between stress and menstrual pattern among low-income women. Methods: From 5th October to 24th October 2009 we researched 14 low-income mothers by questionnaires to investigate their stress and menstrual patterns. Results: The mean level of their stress was $6.71{\pm}2.92$. The less the income was, the higher the stress was. Among the women, the stress of those who do not had husbands was also high. Most of the women's menarche came late and their menstrual cycle was long. The menstrual color was a little dark and they had blood clots and pain during menstruation. Their mental states also often changed over the period and they had pattern of blood stasis. The study observed that the higher the stress was, the worse the menstrual pain was. Conclusion: Low-income women are under stress by their socioeconomic status and their menstrual patterns often change. Stress has correlation with menstruation.