• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.61-73
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• 2021

Metaheuristic search methods have been developed to solve problems with a range of purpose functions in situations lacking information and time constraints. In this study, the Hybrid Vision Correction Algorithm (HVCA), which enhances the performance of the Vision Correction Algorithm (VCA), was developed. The HVCA has applied two methods to improve the performance of VCA. The first method changes the parameters required by the user for self-adaptive parameters. The second method, the CGS structure of the Exponential Bandwidth Harmony Search With a Centralized Global Search (EBHS-CGS), was added to the HVCA. The HVCA consists of two structures: CGS and VCA. To use the two structures, a method was applied to increase the probability of selecting the structure with the optimal value as it was performed. The optimization problem was applied to determine the performance of the HVCA, and the results were compared with Harmony Search (HS), Improved Harmony Search (IHS), and VCA. The HVCA improved the number of times to find the optimal value during 100 repetitions compared to HS, IHS, and VCA. Moreover, the HVCA reduced the Number of Function Evaluations (NFEs). Therefore, the performance of the HVCA has been improved.

• Journal of Oral Medicine and Pain
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• v.37 no.2
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• pp.93-105
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• 2012

Let me introduce a teaching method to improve practice capacity in dental laboratary work. I applied theories of layers of modeling and reflection constituting cognitive apprenticeship and peer tutoring to my class. At internet uploading a file showing a practice procedure a week before the class of a course, I let students preview it. During the class I demonstrated the practice procedure in front of students. A superior student and an inferior student paired according to the previous practice grade and a feedback between a peer tutor and a peer tutee was activated. Late in the class, a student self-evaluated his own practice result and had a check of a professor. Finally he compared his own practice result with that in the file uploaded at internet and reflected. This teaching method led to improvement in students' satisfaction and efficiency of learning.

• Korean Journal of Poultry Science
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• v.42 no.3
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• pp.257-265
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• 2015

Heat conditioning at an early age has been known to help chickens cope with heat stress later in life. The present study was conducted to determine the effects of heat conditioning at 5 days of age in broilers repeatedly exposed to high ambient temperature later in life. A total of 256 day-old Arbor Acre boiler chicks were housed in two identical rooms with a 23-h light/1-h dark cycle and provided with feed and water ad libitum. At 5 days of age, the birds in one room were exposed to $37^{\circ}C$ for 24 hours, while those in the other room served as controls. On day 21, half of the birds in each room were moved into the other room so that each room contained both control and heat-conditioned birds. After a 7-day adaptation period, the birds in one room were exposed to high ambient temperature ($21^{\circ}C{\rightarrow}31^{\circ}C$) for 3 days, whereas those in the other room were kept at normal temperature. The same 3-day exposure to high ambient temperature was repeated two weeks later. Hence, there were four treatment groups (CON+CON: control+control; CON+HS: control+high ambient temperature; HC+CON: heat conditioning+control; and HC+HS: heat conditioning+high ambient temperature). Repeated heat stress resulted in decreased feed intake, water intake, body weight gain, and spleen weight (p<0.05) and increased rectal temperature (p<0.05), mortality, and plasma corticosterone concentrations. The relative weight of the spleen was increased in the heat-conditioned group (p<0.05). Plasma biochemicals were also influenced by high temperature. Thus, no beneficial effects of heat conditioning at an early age were detected in broilers repeatedly exposed to high ambient temperature later in life.

• Journal of Life Science
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• v.29 no.6
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• pp.653-661
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• 2019

The first small interfering RNA (siRNA) therapeutics have recently been approved by the Food and Drug Administration in the U.S., and the demand for a new RNA therapeutics bioanalysis method-which is essential for pharmacokinetics, including the absorption, distribution, metabolism, and excretion of siRNA therapeutics-is rapidly increasing. The stem-loop real-time qPCR (RT-qPCR) assay is a useful molecular technique for the identification and quantification of small RNA (e.g., micro RNA and siRNA) and can be applied for the bioanalysis of siRNA therapeutics. When the anti-HPV E6/E7 siRNA therapeutic was used in preclinical trials, the established stem-loop RT-qPCR assay was validated. The limit of detection was sensitive up to 10 fM and the lower limit of quantification up to 100 fM. In fact, the reliability of the established test method was further validated in three intra assays. Here, the correlation coefficient of $R^2$>0.99, the slope of -3.10 ~ -3.40, and the recovery rate within ${\pm}20%$ of the siRNA standard curve confirm its excellent robustness. Finally, the circulation profiles of siRNAs were demonstrated in rat serum, and the pharmacokinetic properties of the anti-HPV E6/E7 siRNA therapeutic were characterized using a stem-loop RT-qPCR assay. Therefore, the stemloop RT-qPCR assay enables accurate, precise, and sensitive siRNA duplex quantification and is suitable for the quantification of small RNA therapeutics using small volumes of biological samples.

• Journal of the Society of Disaster Information
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• v.14 no.2
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• pp.219-229
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• 2018

Purpose: This research proposes an optimization model for effective evacuation routing and scheduling of civilians near the border area when full-scale war threats heighten. Method: To reflect the reality, administrative unit network is created using Kruscal's Algorithm, Harmony Search, CCRP based on the geographical features, population, and traffic data of real cities, and then, optimal civilian evacuation routes are found. Results: Optimal evacuation routes and schedules are computed by repetitive experiments, and it is found that the scenario that minimizes the average civilian evacuation time is effective for the civilian evacuation plan. Conclusion: By using the civilian evacuation plan this research proposes, at the time of establishing the actual civilian evacuation plan, quantitative analysis is used for the effective plan making rather than only depending.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.24 no.1
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• pp.133-139
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• 2024

In response to the challenges posed by a super-aged society, local authorities are conducting educational programs on smartphone usage tailored for the elderly. However, obstacles such as the limitations of one-to-many education and suboptimal learning outcomes for the elderly have hindered the efficacy of smartphone education. This study suggests an educational service intended for direct application in offline settings, considering the identified problems. Through the utilization of generative AI, the proposed app identifies specific challenges encountered by users during actual smartphone use, offering personalized exercises to facilitate customized and repetitive learning experiences for individual users. When integrated with existing local government education initiatives, this app is anticipated to enhance the efficiency of smartphone education by providing personalized, one-on-one training that is efficient in terms of time and content.

• Journal of Korea Water Resources Association
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• v.50 no.8
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• pp.521-535
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• 2017

Acoustic Doppler Current Profilers (ADCPs) have been widely utilized for assessing streamflow discharge, yet few comprehensive studies were conducted to evaluate discharge uncertainty in consideration of individual uncertainty components. It could be mostly because it was not easy to determine which uncertainty framework can be appropriate to rigorously analyze streamflow discharge driven by ADCPs. In this regard, considerable efforts have been made by scientific and engineering societies to develop a standardized theoretical framework for uncertainty analysis in hydrometry. One of the well-established UA methodology based on sound statistical and engineering concepts is Guide to the Expression of Uncertainty Measurement (GUM) adopted widely by various scientific and research communities. This research fundamentally adapted the GUM framework to assess individual uncertainty components of ADCP discharge measurements, and subsequently provided results of a customized experiment in a controllable real-scale artificial river channel. We focused particularly upon sensitivities of uncertainty components in the GUM framework driven by ADCPs direct measurements such as depths, edge distance, submerged depth, velocity gap, sampling time, repeatability, bed roughness and so on. Section-by-Section method for ADCP discharge measurement was applied for uncertainty analysis for this study. All of measurements were carefully compared with data using other instrumentations such as ADV to evaluate individual uncertainty components.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.3
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• pp.37-46
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• 2024

This study investigates the evolution of concrete damage due to chloride-induced steel corrosion through Impact-echo (IE) testing. Three reinforced concrete specimens, each measuring 1500 mm in length, 400 mm in width, and 200 mm in thickness, were fabricated using three concrete mixture proportions of blended cement types: ordinary Portland cement, ground granulated blast-furnace slag and fly ash. Steel corrosion in the concrete was accelerated by impressing a 0.5 A current following a 35-day cycle of wet-and-dry saturation in a 3% NaCl solution. Initial IE data collected during the saturation phase showed no significant changes, indicating that moisture had a minimal impact on IE signals and highlighting the slow progress of corrosion under natural conditions. Post-application of current, however, there was a noticeable decline in both IE peak frequency and the P-wave velocity in the concrete as the duration of the impressed current increased. Remarkably, progressive monitoring of IE proves highly effective in capturing the critical features of steel-corrosion induced concrete deterioration, such as the onset of internal damages and the rate of damage propagation. These results demonstrate the potential of progressive IE data monitoring to enhance the reliability of diagnosing and prognosticating the evolution of concrete damage in marine environment.

• Sleep Medicine and Psychophysiology
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• v.17 no.1
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• pp.34-40
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• 2010

Objectives: This study aimed to evaluate the clinical efficacy of individual cognitive behavioral therapy (CBT) for Patients with Primary or Secondary Insomnia. Methods: Participants were recruited from a primary care sleep clinic from January 2008 to June 2009. The study sample included 64 outpatients with primary insomnia (n=30) and secondary insomnia (n=34) according to the criteria of DSM-IV. Participants completed sleep diaries, Dysfunctional Beliefs and Attitudes about Sleep Scale-16 (DBAS), State-Trait Anxiety Inventory (STAI) before CBT and shortly after completion of CBT. CBT was provided in 7 weekly, 40-50-minute individual therapy sessions. Results: Both groups of patients with primary and secondary insomnia showed significant improvement in the DBAS and sleep parameters including sleep onset latency, total sleep time, and sleep efficiency. Repeated-measures ANOVA of the DBAS and sleep parameters showed no significant group-by-time interactions between patients with primary and secondary insomnia, suggesting the efficacy of CBT for patients with secondary insomnia was equivalent to that of CBT for patients with primary insomnia. Conclusion: This study suggests that CBT is effective for the management of primary and secondary insomnia in a primary care setting.

• Tuberculosis and Respiratory Diseases
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• v.55 no.1
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• pp.98-106
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• 2003

Background : To evaluate the efficacy and safety of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer (NSCLC). Materials and Methods : Forty patients (21 men, 19 women ; age range, 37 to 73 years; median, 63 years) with unresectable stage IIIB to IV NSCLC were evaluated. Patients received cisplatin $60mg/m^2$ (Day 1), gemcitabine $1200mg/m^2$ (Day 1 and 8) every 21 days. Eighteen patients had stage IIIB disease and 22 had stage IV. There were 28 patients of adenocarcinoma (70.0%), 11 of squamous cell carcinoma (27.5%), and one of large cell carcinoma (2.5%). Results : Of 40 patients, no patients showed complete response while 15(37.5%) showed partial response, 7(17.5%) had stable diseases, 18(45%) had progressive diseases. During a total of 195 courses of chemotherapy, grade 3 or more granulocytopenia and thrombocytopenia occured in 12.5% and 2.5% of patients respectively. Non-hematologic toxicity was mild and easily controlled. There was one case of treatment-related death by pneumomia. The median survival was 55 weeks (95% CI, 34~75weeks), and the time to progression was 19 weeks (95% CI, 16~23weeks). One year survival rate was 55% and 2 year survival rate was 10%. Conclusion : The efficacy of cisplatin and gemcitabine combination chemotherapy was acceptable in the treatment of advanced NSCLC.