• Journal of the Korean Chemical Society
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• v.47 no.2
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• pp.183-188
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• 2003

• Spatial Information Research
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• v.20 no.2
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• pp.93-103
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• 2012

Recently metropolitan cities pursue multi centric urban spatial structure for sustainable development and efficient urban management. Thus, this study calculated population potential using data on population distributed among road nodes for the last 50 years, and based on the results. We measured the spatial variability of the multi centric structure of Busan Metropolitan City. According to the results, the multi centralization process has been continued up to recently in Busan Metropolitan City. As population potential is concentrated on sub centers, Hadan, Gupo and Haeundae areas were playing an increasingly powerful role as the center of the respective district, and Sasang and Dongrae had been losing their role as the center of their respective districts since 2000 and 1990, respectively. Additionally, in all the multi centric districts except Haeundae was observed the increase of oblongity, which is the change of spatial structure in an unbalanced way toward a specific area or direction.

• The Journal of the Korean bone and joint tumor society
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• v.11 no.2
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• pp.183-187
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• 2005

The typical radiologic findings of a small radiolucent nidus with surrounding sclerosis and night pain responding to aspirin make the diagnosis of osteoid osteoma not too difficult. We report a case of multicentric osteoid osteoma with unusual clinical and imaging features which were strongly suggestive of subacute sclerosing osteomyelitis.

• Journal of fish pathology
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• v.2 no.2
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• pp.71-74
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• 1989

Ichthyophonus disease had broken out among rock bream in Dec. 1989. Diseased-fish showed markedly stunted growth and darkish coloration, and anatomically the liver with small white nodules, tumefied spleen with its granulous surface, and the markedly tumefied kidney. Microscopic examination of liver, kidney, spleen and gill from 10 rock bream revealed cyst of the fungus Ichthyophonus sp. Rock bream were heavily infected with the highest concentrations of spherical multinucleate bodies in the liver, the spleen, the kidney and the gills. In heavily infected sectors of tissue a common necrotic zone was formed around spore aggregates. Spherical multinucleate hyphal terminal bodies developed thin hyphae longer than 1mm which divided into many branches.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.33 no.12
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• pp.65-72
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• 2017

Three decades after its establishment in 1946, Seoul National University was transferred to its current location in Gwan-ak District in accordance with the Seoul National University Integration Plan. In the 40 years since Seoul National University transferred to the Gwan-ak area, much quantitative and qualitative growth has taken place, and the university has grown into a world-class research institution. In this process, the campus was expanded externally and internally, and many changes have been made to the campus life bases and facilities which were planned at the beginning of the campus' construction. This study examines the expansion of the facilities at Seoul National University's Gwan-ak campus, as well as the expansion of the campus' boundaries. In addition, through quantitative analysis (Space Syntax), we predicted the location of campus life bases of the present multi-centralized campus and suggested a future developmental direction for the campus.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.616-618
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• 2009

A 5-year-old Pekinese dog was presented for evaluation of a back mass of 1 year duration. Fine needle aspiration cytology of the mass revealed numerous keratinocytes, and a lesser number of multinucleated giant cells along with a low number of spindle cells, which were suggestive of epidermal cyst or hair follicle tumor with secondary granulomatous inflammation. The mass was surgically removed and examined histologically. Microscopically there was partially encapsulated well-demarcated nodule in deep dermis and subcutis. The nodule consisted of central cyst and secondary cysts that were lined by a single or multiple layers of basaloid cells and squamous epitheliums with central laminated keratin. Multifocal aggregation of numerous macrophages and multinucleated giant cells were present. The final diagnosis was keratoacanthoma with granulomatous inflammation. The mass did not recur 5 months after surgery.

• Journal of Veterinary Clinics
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• v.31 no.3
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• pp.258-261
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• 2014

A 4-week-old male piglet being maintained in a research facility was found dead without any previous clinical signs. The piglet had been born from a surrogate mother after somatic nuclear transfer as part of a xenotransplantation study. Ovaries for nuclear transfer were obtained from a private farm outside the research facility. Histopathologically, multifocal to coalescing granulomatous myocarditis was observed in the heart, characterized by infiltration of lymphocytes, macrophages and multinucleated giant cells, and by myocardial necrosis and fibrosis. Lymphoid tissues showed marked lymphoid depletion with infiltration by histiocytes or giant cells. Immunohistochemistry showed PCV-2 antigens in necrotic myocytes, macrophages and multinucleated giant cells in the heart, as well as in macrophages and giant cells in lymphoid depleted areas of lymphoid tissues. Reproductive failure associated with PCV-2 in aborted or stillborn piglets is frequently characterized by myocarditis, and similar lesions were observed in this 4-week-old piglet with PCV-2 infection. The PCV-2 infection in this piglet may have been due to contamination or infection of an ovary from the pig farm.

• Journal of the Korean Association of Geographic Information Studies
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• v.9 no.4
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• pp.204-214
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• 2006

The necessity of a management for a metropolitan has long intrigued many urban scholars and researchers who are interested in Busan metropolitan spatial structure and its problems. The purpose of this study is to investigate the dynamic changes of spatial structure in Busan Metropolitan by analyzing the population, employment and Land prices, for the period of 1993, 2001. The major results in this study are as follows; While main-centers have experienced significant loss of population, sub-centers have been growing. Jung-Ang Dong still has high accessibility in population potentials, but its accessibility has declined since 1993. Pu-Jeon Dong had increasing trend of population until 2000, but its population has also descended since that time. Meanwhile, the population of sub-centers has increased in its accessibility. And The spatial pattern of the population in Busan has changed from monocentric to polycentric. This phenomenon was almost spontaneously generated from population dispersion from existing main-centers. In terms of change of land values are there is a spatial and temporal rhythm in the urbanization of Busan. The highest land value in Busan is shown in CBD. The development of Busan proceeded along the north-south belt and extended to west Busan.

• Journal of Periodontal and Implant Science
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• v.37 no.sup2
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• pp.297-310
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• 2007

치조골 흡수는 파골세포와 matrix metalloproteinases (MMPs)에 의한 골의 무기질과 유기질의 파괴로 일어나는 과정이다. 세균성 산물, 주로 내독소는 치은조직 내에서 염증세포의 유주, 사이토카인 생산, 조직파괴 효소 분비 및 파골세포 활성 등의 국소 면역반응을 유도한다. A. actinomycetemcomitans는 급진성 치주염의 원인 균주중 하나로 그 내독소는 치조골의 흡수와 관련된다. MMP-13은 세균성 산물이나 염증성 사이토카인의 자극에 의해 분비되며, 최근의 연구 결과들은 MMP-13이 치주질환의 진행과 골 흡수 과정에서 일정한 역할을 담당하는 것으로 보고하고 있으나, A. actinomycetemcomitans 내독소와 MMP-13과의 관련성에 대한 연구는 미미하다. 이에 이번 연구에서는 A. actinomycetemcomitans 내독소에 의한 MMP-13의 발현과 파골세포 형성을 세포배양을 통하여 관찰하였고, 백서 구개부 치은에 A. actinomycetemcomitans 내독소를 주입하여 흡수가 진행되고 있는 치조골에서 파골세포의 분화와 MMP-13의 발현을 TRAP 염색, 면역조직화학적 방법 등을 통해 관찰하여 다음과 같은 결과를 얻었다. MMP-13 mPNA의 발현은 A. actinomycetemcomitans 내독소 (1ug/ml)로 24시간 자극한 마우스 치주인대 섬유모세포에서 생리식염수로 자극한 세포에 비하여 약 2.6배 증가하였으며 마우스 대식세포에서는 TRAP 양성 세포가 대조군보다 더 많이 나타났다. A. actinomycetemcomitans 내독소를 주입한 백서 치주조직에서는 대조군보다 더 심한 골소실을 보였다. TRAP-양성 다핵 파골세포 유사세포는 치주염군과 대조군 모두 치조골에서 관찰되었다. TRAP-양성 다핵 파골세포 유사세포는 치주염군에서 대조군보다 유의하게 많은 숫자가 관찰되었으며, 치주염군에서 대조군보다 유의하게 많은 숫자가 관찰되었다. MMP-13 면역양성 반응은 치주염군에서 거친 골연을 갖는 치조골상에 배열된 조골세포와 그 인접한 치주인대에서 관찰되었으며 대조군에서는 MMP-13 면역 양성 반응이 치조골 표면에서만 일부 관찰되었다. 이상의 결과는 A. actinomycetemcomitans 내독속가 MMP-13의 발현을 증가시키며 파골세포의 활성을 통하여 치조골의 흡수를 유도함을 시사한다. 또한 A. actinomycetemcomitans 내독소 투여에 의한 실험적 모델은 백서에서 중등도의 골 소실을 동반한 만성 치주염 모델로 향후 치주질환 치료제의 효과를 평가하는데 유용하게 사용될 수 있으리라 기대된다.

• Journal of the Korean Geographical Society
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• v.37 no.1
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• pp.61-74
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• 2002

In late 1980s, many suburban cities in Tokyo metropolitan area have tried to construct office parks, such as Makuhari New Town, Minato Mirai 21 to promote knowledge based economy. As the most important player of this mesa project, the local government mobilized local resources from various private sectors. The local government adopted place marketing strategy to attract companies and consumers with thick pocket. The composition of this strategy embraces publicity, uniqueness, centrality of function and information and comfortability for formation of the office park. Headquarters and producer service offices were relocated in the suburban office parks for the first time in the history of modem Tokyo since 1920s. Although it is the ongoing project that encounters some financial difficulties, the office park Project will be a sound foundation for future growth of knowledge-based economy.