• Title/Summary/Keyword: 검증시험

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Analytical Method of Multi-Preservatives in Cosmetics using High Performance Liquid Chromatography (HPLC 를 이용한 화장품 중 살균보존제 다성분 동시분석법 연구)

  • Min-Jeong, Lee;Seong-Soo, Kim;Yun-Jeong, Lee;Byeong-Chul, Lee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.4
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    • pp.321-330
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    • 2022
  • This study attempted to establish an optimal multi-compound simultaneous analysis method that can secure reliable results for 15 - preservatives, 2 - sun screens and 1 - antioxidants of cosmetics using HPLC-PDA. Since the potential of hydrogen (pH) in the mobile phase affects the acid dissociation constant (pKa) of the preservatives, and the peak retention time shift and area change were observed. The peak separation condition was established by adjusting the pH to 0.1% H3PO4 addition (mL) when preparing the mobile phase. As a results of method validation, the linearity correlation coefficient (R2) of above 0.999 were obtained, and accuracy 87.9 ~ 101.1%, 0.1 ~ 7.6% precision for two types of cosmetics (cream and shampoo). It was found that the limit of detection (LOD) was 0.1 ~ 0.2 mg/kg and the limit of quantitation (LOQ) was 2.0 ~ 4.0 mg/kg. In addition, it was possible to simultaneously separate p-anisic acid, a natural compound that was difficult to separate in HPLC due to the small difference from methylparaben, a synthetic preservatives. Through this study, it will be effectively used to secure quality control and safety for compound that need restrictions on use cosmetics.

A Study on Inflammation and Itching of Cyperus rotundus Ethyl Acetate Fractions (향부자 에틸아세테이트 분획물의 염증 및 가려움증에 관한 연구)

  • Do Gyu, Kim;Ji Yeon, Lee;Sohyun, Mun;Yukyung, Kim;Nari, Kim;Ah Reum, Jung;Jun-Hwan, Jang;Jae-Soeb, Lee;Sang Bae, Han;Jun-Tae, Bae
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.4
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    • pp.303-312
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    • 2022
  • In this study, Cyperus rotundus (C. rotundus) was fractionated into ethyl acetate to identify α-cyperone, a representative indicator, and its ethyl acetate fraction were evaluated to confirm the possibilityas a functional cosmetic ingredient. As a result of HPLC analysis, it was confirmed that the content of α-cyperone was 5.243%. In order to verify the inflammatory relief effect of the ethyl acetate fraction from C. rotundus (EAFC) and α-cyperone, it was confirmed that nitric oxide (NO) production inhibitory ability in RAW 264.7 macrophages induced an inflammatory reaction with lipopolysaccharide (LPS). Real-time qPCR analysis confirmed inhibition of mRNA expression level of inflammatory factors, IL-1β, IL-6, TNF-α, COX-2 and iNOS. As a results of conducting a clinical study using a simple cosmetic formulation containing EAFC, it was confirmed that the skin irritation stimulated by sodium lauryl sulfate (SLS) was calming and relieving itching. Through these results, it is believed that the C. rotundus can be used as a natural cosmetic ingredient that has the effect of inhibiting inflammation and relieving itching.

A Study on the D-InSAR Method for Micro-deformation Monitoring in Railway Facilities (철도시설물 미소변형 모니터링을 위한 D-InSAR 기법 연구)

  • Kim, Byung-Kyu;Lee, Changgil;Kim, Winter;Yoo, Mintaek;Lee, Ilhwa
    • Journal of the Korean Geotechnical Society
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    • v.38 no.11
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    • pp.43-54
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    • 2022
  • The settlement at the railroad foundation is often the leading cause of track irregularity and potential derailment. The control of such deformation is considered necessary in track maintenance practice. Nevertheless, the monitoring process performed by in situ surveying requires an excessive amount of manpower and cost. The InSAR, a remote sensing technique by RADAR satellite, is used to overcome such a burden. The PS-InSAR technique is preferred for a long-term precise monitoring method. However, this study aims to obtain relatively brief analysis results from only two satellite images using the D-InSAR technique, while a minimum of 25 images are required for PS-InSAR. This study verifies the precision of D-InSAR within a few millimeters by inspecting railroad facilities and land settlements in Korea Railroad Research Institute's test track with images from TerraSAR-X Satellite. Multiple corner reflectors were adopted and installed on an embankment and the building roof to raise the surface reflectivity. Those reflectors were slightly adjusted periodically to verify the detecting performance. The results revealed the optimum distance between corner reflectors. Further, the deformation of railway tracks, slopes, and concrete structures was analyzed successively. In conclusion, this study indicates that the D-InSAR technique effectively monitors the short-term deformation of a broad area such as railway structures.

Study on the Aerodynamic Characteristics of an Wing Depending on the Propeller Mounting Position (프로펠러 장착 위치에 따른 날개의 공력 특성 변화 연구)

  • Inseo, Choi;Cheolheui, Han
    • Journal of Aerospace System Engineering
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    • v.16 no.6
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    • pp.54-63
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    • 2022
  • Recently, electric propulsion aircraft with various propeller mounting positions have been under construction. The position of the propeller relative to the wing can significantly affect the aerodynamic performance of the aircraft. Placing the propeller in front of the wing produces a complex swirl flow behind or around the propeller. The up/downwash induced by the swirl flow can alter the wing's local effective angle of attack, causing a change in the aerodynamic load distribution across the wing's spanwise direction. This study investigated the influence of the distance between a propeller and a wing on the aerodynamic loads on the wing. The swirl flow generated by the propeller was modelled using an actuator disk theory, and the wing's aerodynamics were analysed with the VSPAERO tool. Results of the study were compared to wind tunnel test data and established that both axial and spanwise distance between the propeller and the wing positively affect the wing's lift-to-drag ratio. Specifically, it was observed that the lift-to-drag ratio increases when the propeller is positioned higher than the wing.

Optimal Design for Weight Reduction of Rotorcraft Shaft System (회전익기의 축계 경량화를 위한 최적설계)

  • Kim, Jaeseung;Moon, Sanggon;Han, Jeongwoo;Lee, Geun-Ho;Kim, Min-Geun
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.35 no.4
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    • pp.243-248
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    • 2022
  • Weight optimization was performed for a rotorcraft shaft system using one-dimensional Euler-Bernoulli beam elements. Torsion, shaft support stiffness such as bearings, flange mass are all considered. To guarantee structural dynamic stability, eigenvalue analysis was performed to avoid critical speed and tooth mesh excitation form the gearbox. The weight optimization was performed by adjusting the thickness and radius while the length of the shaft was fixed, and the optimization process was divided into two stages. In the first, the weight is optimized with the torsional strength constraint. In the second, the difference between the primary mode of shaft and the critical speed is maximized so that the primary mode of the shaft can avoid the critical speed while the constraint on the torsional strength of the shaft is satisfied according to the standard for shaft system stability (AMC P 706-201, 1974). The proposed method was verified by comparing the results of the optimal design using the given one-dimensional beam elements with the stress results of the 3D finite element and the actual manufactured shaft.

A Study on the Efficient Compliance Method for Airworthiness Certification in the field of Flying Qualities of Military Aircraft (군용항공기 비행성 분야의 효율적인 감항인증 입증방법에 대한 고찰)

  • Kang, Myungsoo;Kim, Chong-sup;Koh, GiOk;Lim, Sang-soo;Kim, Byoung soo
    • Journal of Aerospace System Engineering
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    • v.16 no.4
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    • pp.95-108
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    • 2022
  • Airworthiness certification is critical, in ensuring the flight safety of military aircraft for development tests and production operations. The MIL-HDBK-516C, latest airworthiness certification document, handles the field of flying qualities in Chapter 6 (flight technology), and refers to specific chapters of MIL-STD-1797B, which is the specification document for developing military aircraft. Since the MIL-STD-1797B released in 2006 by the U.S. Department of Defense is not disclosed to other countries, the Chapter 6 (flight technology) of MIL-HDBK-516B Expanded, the former certification standards pursuant to flying qualities, has to be applied to military aircraft being developed in the Republic of Korea. However the requirements of Chapter 6 of MIL-HDBK-516B Expanded comprise unclear sentences, because of contents from various development specifications. Also, clarification is needed in that the same requirements have to be verified in different criteria. In this paper, the results of this study present an effective verification method, for acquiring the airworthiness certification in field of flying qualities based on MIL-HDBK-516B Expanded.

Development and Validation of an Analytical Method for β-Agonists in Livestock and Fishery Products Using LC-MS/MS (LC-MS/MS를 이용한 축·수산물 중 β-agonist계 시험법 개발 및 검증)

  • Lee, Tae Ho;Kim, Yu Ra;Park, Su Jeong;Kim, Ji Young;Choi, Jang Duck;Moon, Gui Im
    • Korean Journal of Environmental Agriculture
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    • v.41 no.2
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    • pp.135-151
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    • 2022
  • BACKGROUND: The β-agonists known as phenyl ethanolamine derivatives have a conjugated aromatic ring with amino group. They are used as tocolytic agents and bronchodilator to human and animal generally, and some of them are used as growth promoters to livestock. METHODS AND RESULTS: β-agonists in samples were extracted by 0.4 N perchloric acid and ethyl acetate. The target compounds were analyzed by liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). Validation of method was performed according to CODEX guidelines (CAC/GL-71). The matrix matched calibration gave correlation coefficients>0.98, and the obtained recoveries were in the range of 62.0-109.8%, with relative standard deviation ≤ 20.1%. In addition, a survey was performed to inspect any residual β-agonist from 100 samples of livestock and fishery products and ractopamine was detected in one of the 100 samples. CONCLUSION(S): In this study, we established the analytical method for β-agonists through using the expanded target compounds and samples. And we anticipate that the established method would be used for analysis to determine veterinary drug residues in livestock and fishery products.

Line Tracer Modeling for Educational Virtual Experiment (교육용 가상실험 라인 트레이서 모델링)

  • Ki, Jang-Geun;Kwon, Kee-Young
    • Journal of Software Assessment and Valuation
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    • v.17 no.2
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    • pp.109-116
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    • 2021
  • Traditionally, the engineering field has been dominated by face-to-face education focused on experimental practice, but demand for online learning has soared due to the rapid development of IT technology and Internet communication networks and recent changes in the social environment such as COVID-19. In order for efficient online education to be conducted in the engineering field, where the proportion of experimental practice is relatively high compared to other fields, virtual laboratory practice content that can replace actual experimental practice is very necessary. In this study, we developed a line tracer model and a virtual experimental software to simulate it for efficient online learning of microprocessor applications that are essential not only in the electric and electronic field but also in the overall engineering field where IT convergence takes place. In the developed line tracer model, the user can set various hardware parameter values in the desired form and write the software in assembly language or C language to test the operation on the computer. The developed line tracer virtual experimental software has been used in actual classes to verify its operation, and is expected to be an efficient virtual experimental practice tool in online non-face-to-face classes.

Evaluation on the Bending Behavior After Yield of RC Beam by Using Image Processing Method(II): Focused on the Tensile Part (영상 분석 기법을 이용한 RC 부재의 항복 후 휨 거동 분석(II): 인장부를 중심으로)

  • Kim, Kun-Soo;Park, Ki-Tae;Woo, Tae-Ryeon
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.26 no.6
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    • pp.47-53
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    • 2022
  • As the limit state design method is applied as a method of designing concrete structures, the ultimate state is considered in the analysis or design. In fact, when the reinforced concrete member bears tensile force, the force is transmitted from the rebar to the concrete, and the structure bears the tensile force to the ultimate state even after yield. Therefore, the accurate evaluation of behavior after yield, it is necessary to study the tension stiffening effect after yield of the flexural member. In this study, a 4-point bending test was conducted on the RC simple beam having a rectangular cross section of the double reinforcement, and the behavior of the member was analyzed in detail using the image analysis method. Using the analysis results, the estimation formula for the tension stiffening effect after yield was proposed, and the applicability of this was verified through the experimental results of existing study. The difference between the ultimate strain and the yield strain representing the ductile behavior of the member is similar to the experimental results. The prediction of the proposed formula is relatively accurate.

A Study on the Introduction and Application of Core Technologies of Smart Motor-Graders for Automated Road Construction (도로 시공 자동화를 위한 스마트 모터 그레이더의 구성 기술 소개 및 적용에 관한 연구)

  • Park, Hyune-Jun;Lee, Sang-Min;Song, Chang-Heon;Cho, Jung-Woo;Oh, Joo-Young
    • Tunnel and Underground Space
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    • v.32 no.5
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    • pp.298-311
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    • 2022
  • Some problems, such as aging workers, a decreased population due to a low birth rate, and shortage of skilled workers, are rising in construction sites. Therefore research for smart construction technology that can be improved for productivity, safety, and quality has been recently developed with government support by replacing traditional construction technology with advanced digital technology. In particular, the motor grader that mainly performs road surface flattening is a construction machine that requires the application of automation technology for repetitive construction. It is predicted that the construction period will be shortened if the construction automation technology such as trajectory tracking, automation work, and remote control technology is applied. In this study, we introduce the hardware and software architecture of the smart motor grader to apply unmanned and automation technology and then analyze the traditional earthwork method of the motor grader. We suggested the application plans for the path pattern and blade control method of the smart motor grader based on this. In addition, we verified the performance of waypoint-based path-following depending on scenarios and the blade control's performance through tests.