• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.4 no.2
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• pp.41-57
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• 2000

In this paper, we consider first order generalized difference scheme for the two-point boundary value problem and one-dimensional second order parabolic type problem. The optimal error estimates in $L_p$ and $W^{1,p}$ ($2{\leq}p{\leq}{\infty}$) as well as some superconvergence estimates in $W^{1,p}$ ($2{\leq}p{\leq}{\infty}$) are obtained. The main results in this paper perfect the theory of GDM.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.4 no.1
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• pp.67-77
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• 2000

In this paper we consider finite element mathods for nonlinear parabolic problems defined in ${\Omega}{\subset}R^d$ ($d{\leq}4$). A new initial approximation is taken. Optimal order error estimates in $L_p$ for $2{\leq}p{\leq}{\infty}$ are established for arbitrary order finite element. One order superconvergence in $W^{1,p}$ for $2{\leq}q{\leq}{\infty}$ are demonstrated as well.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.9 no.1
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• pp.17-29
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• 2005

In this paper we consider finite element methods for nonlinear hyperbolic integro-differential problems defined in ${\Omega}\;{\subset}\;R^d(d\;{\leq}\;4)$. A new initial approximation of $u_t(0)$ is taken. Optimal order error estimates in $L_p$ for $2\;{\leq}\;p\;{\leq}\;{\infty}$ are established for arbitrary order finite element. One order superconvergence in $W^{1,p}$ for $2\;{\leq}\;p\;{\leq}\;{\infty}$ are demonstrated as well.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.9 no.2
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• pp.55-64
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• 2005

In this paper, generalized difference methods(GDM) for one-dimensional viscoelastic problems are proposed and analyzed. The new initial values are given in the generalized difference scheme, so we obtain optimal error estimates in $L^p$ and $W^{1,p}(2\;{\leq}\;p\;{\leq}\;{\infty})$ as well as some superconvergence estimates in $W^{1,p}(2\;{\leq}\;p\;{\leq}\;{\infty})$ between the GDM solution and the generalized Ritz-Volterra projection of the exact solution.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.7 no.2
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• pp.35-49
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• 2003

In this paper, finite volume element methods for nonlinear parabolic integrodifferential problems are proposed and analyzed. The optimal error estimates in $L^p\;and\;W^{1,p}\;(2\;{\leq}\;p\;{\leq}\;{\infty})$ as well as some superconvergence estimates in $W^{1,p}\;(2\;{\leq}\;p\;{\leq}\;{\infty})$ are obtained. The main results in this paper perfect the theory of FVE methods.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.6 no.2
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• pp.85-97
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• 2002

In this paper, finite volume element methods for nonlinear parabolic problems are proposed and analyzed. Optimal order error estimates in $W^{1,p}$ and $L_p$ are derived for $2{\leq}p{\leq}{\infty}$. In addition, superconvergence for the error between the approximation solution and the generalized elliptic projection of the exact solution (or and the finite element solution) is also obtained.

• Smart Structures and Systems
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• v.34 no.2
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• pp.97-116
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• 2024

The standard l₁-norm regularization is recently introduced for impact force identification, but generally underestimates the peak force. Compared to l₁-norm regularization, l_p-norm (0 ≤ p < 1) regularization, with a nonconvex penalty function, has some promising properties such as enforcing sparsity. In the framework of sparse regularization, if the desired solution is sparse in the time domain or other domains, the under-determined problem with fewer measurements than candidate excitations may obtain the unique solution, i.e., the sparsest solution. Considering the joint sparse structure of impact force in temporal and spatial domains, we propose a general l_p-norm (0 ≤ p < 1) regularization methodology for simultaneous identification of the impact location and force time-history from highly incomplete measurements. Firstly, a nonconvex optimization model based on l_p-norm penalty is developed for regularizing the highly under-determined problem of impact force identification. Secondly, an iteratively reweighed l₁-norm algorithm is introduced to solve such an under-determined and unconditioned regularization model through transforming it into a series of l₁-norm regularization problems. Finally, numerical simulation and experimental validation including single-source and two-source cases of impact force identification are conducted on plate structures to evaluate the performance of l_p-norm (0 ≤ p < 1) regularization. Both numerical and experimental results demonstrate that the proposed l_p-norm regularization method, merely using a single accelerometer, can locate the actual impacts from nine fixed candidate sources and simultaneously reconstruct the impact force time-history; compared to the state-of-the-art l₁-norm regularization, l_p-norm (0 ≤ p < 1) regularization procures sufficiently sparse and more accurate estimates; although the peak relative error of the identified impact force using l_p-norm regularization has a decreasing tendency as p is approaching 0, the results of l_p-norm regularization with 0 ≤ p ≤ 1/2 have no significant differences.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Communications for Statistical Applications and Methods
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• v.31 no.5
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• pp.497-519
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• 2024

In reliability analysis, the probability P(Y < X) is significant because it denotes availability and dependability in a stress-strength model where Y and X are the stress and strength variables, respectively. In reliability theory, the inverse Lomax distribution is a well-established lifetime model, and the literature is developing inference techniques for its reliability attributes. In this article, we are interested in estimating the stress-strength reliability R = P(Y < X), where X and Y have an unknown common scale parameter and follow the inverse Lomax distribution. Using Bayesian and non-Bayesian approaches, we discuss this issue when both stress and strength are expressed in terms of lower record values. The parametric bootstrapping techniques of R are taken into consideration. The stress-strength reliability estimator is investigated using uniform and gamma priors with several loss functions. Based on the proposed loss functions, the reliability R is estimated using Bayesian analyses with Gibbs and Metropolis-Hasting samplers. Monte Carlo simulation studies and real-data-based examples are also performed to analyze the behavior of the proposed estimators. We analyze electrical insulating fluids, particularly those used in transformers, for data sets using the stress-strength model. In conclusion, as expected, the study's results showed that the mean squared error values decreased as the record number increased. In most cases, Bayesian estimates under the precautionary loss function are more suitable in terms of simulation conclusions than other specified loss functions.

• Asian Spine Journal
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• v.12 no.6
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• pp.1060-1068
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• 2018

Study Design: Retrospective study. Purpose: Lumbar intervertebral disc degeneration is an important cause of low back pain. Overview of Literature: Spinal fusion is often reported to have a good course for adolescent idiopathic scoliosis (AIS). However, many studies have reported that adjacent segment degeneration is accelerated after lumbar spinal fusion. Radiography is a simple method used to evaluate the orientation of the vertebral column. magnetic resonance imaging (MRI) is the method most often used to specifically evaluate intervertebral disc degeneration. The Pfirrmann classification is a well-known method used to evaluate degenerative lumbar disease. After spinal fusion, an increase in stress, excess mobility, increased intra-disc pressure, and posterior displacement of the axis of motion have been observed in the adjacent segments. Methods: we retrospectively secured and analyzed the data of 15 patients (four boys and 11 girls) with AIS who underwent a spinal fusion surgery. We studied the full-length view of the spine (anterior-posterior and lateral) from the X-ray and MRI obtained from all patients before surgery. Postoperatively, another full-length spine X-ray and lumbosacral MRI were obtained from all participants. Then, pelvic tilt, sacral slope, curve correction, and fused and free segments before and after surgery were calculated based on X-ray studies. MRI images were used to estimate the degree to which intervertebral discs were degenerated using Pfirrmann grading system. Pfirrmann grade before and after surgery were compared with Wilcoxon signed rank test. While analyzing the contribution of potential risk factors for the post-spinal fusion Pfirrmann grade of disc degeneration, we used generalized linear models with robust standard error estimates to account for intraclass correlation that may have been present between discs of the same patient. Results: The mean age of the participant was 14 years, and the mean curvature before and after surgery were 67.8 and 23.8, respectively (p<0.05). During the median follow-up of 5 years, the mean degree of the disc degeneration significantly increased in all patients after surgery (p<0.05) with a Pfirrmann grade of 1 and 2.8 in the L2-L3 before and after surgery, respectively. The corresponding figures at L3-L4, L4-L5, and L5-S1 levels were 1.28 and 2.43, 1.07 and 2.35, and 1 and 2.33, respectively. The lower was the number of free discs below the fusion level, the higher was the Pfirrmann grade of degeneration (p<0.001). Conversely, the higher was the number of the discs fused together, the higher was the Pfirrmann grade. Conclusions: we observed that the disc degeneration aggravated after spinal fusion for scoliosis. While the degree of degeneration as measured by Pfirrmann grade was directly correlated by the number of fused segments, it was negatively correlated with the number of discs that remained free below the lowermost level of the fusion.