This paper examines the effects on safety index analysis with Level II Second-Moment Method. The general two variable problem is examined by means of Cornell safety index ${\beta}c$ Rosenblueth-Esteva safety index ${\beta}_{RE}$ Rackwitz-Fiessler safety index by iterative method and Practical FOSM safety index ${\beta}_p$, which based partly on the concepts given by Paloheimo and Hannus, proposed the algorithm in this paper. The calculated examples have shown that safety index by Practical FOSM Method proposed in this paper would be similar to those in the method by Rosenblueth-Esteva or Rackwitz-Fissler and be simpler in calculation than the Rackwitz's Advanced FOSM Method, in which the iterative procedure has to be used.