The seismic performance of the tall building equipped with a tuned mass damper (TMD) considering soil-structure interaction (SSI) effects is well studied in the literature. However, these studies are performed on the nominal model of the seismic-excited structural system with SSI. Hence, the outcomes of the studies may not valid for the actual structural system. To address the study gap, the reliability theory as a useful and powerful method is utilized in the paper. The present study aims to carry out reliability analyses on tall buildings equipped with TMD under near-field pulse-like (NFPL) ground motions considering SSI effects using a subset simulation (SS) method. In the presence of uncertainties of the structural model, TMD device, foundation, soil, and near-field pulse-like ground motions, the numerical studies are performed on a benchmark 40-story building and the failure probabilities of the structures with and without TMD are evaluated. Three types of soils (dense, medium, and soft soils), different earthquake magnitudes (Mw = 7,0. 7,25. 7,5 ), different nearest fault distances (r = 5. 10 and 15 km), and three seismic performance levels of immediate occupancy (IO), life safety (LS), and collapse prevention (CP) are considered in this study. The results show that tall buildings built near faults and on soft soils are more affected by uncertainties of the structural and ground motion models. Hence, ignoring these uncertainties may result in an inaccurate estimation of the maximum seismic responses. Also, it is found the TMD is not able to reduce the failure probabilities of the structure in the IO seismic performance level, especially for high earthquake magnitudes and structures built near the fault. However, TMD is significantly effective in the reduction of failure probability for the LS and CP performance levels. For weak earthquakes and long fault distances, the failure probabilities of both structures with and without TMD are near zero, and the efficiency of the TMD in the reduction of failure probabilities is reduced by increasing earthquake magnitudes and the reduction of fault distance. As soil softness increases, the failure probability of structures both with and without TMD often increases, especially for severe near-fault earthquake motion.