We consider the problem of constructing observers for nonlinear systems with unknown inputs. Connectionist networks, also called neural networks, have been broadly applied to solve many different problems since McCulloch and Pitts had shown mathematically their information processing ability in 1943. In this thesis, we present a genetic neuro-control scheme for nonlinear systems. Our method is different from those using supervised learning algorithms, such as the backpropagation (BP) algorithm, that needs training information in each step. The contributions of this thesis are the new approach to constructing neural network architecture and its training.