The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Increased antioxidant enzyme activities and scavenging effect of oxygen free radicals by Jwagyuyeum and Woogyuyeum

좌귀음(左歸飮)과 우귀음(右歸飮)에 의(依)한 활성(活性) 산소류(酸素類)의 소거작용(消去作用)과 항산화(抗酸化) 효소계(酵素系)의 활성(活性) 증가(增加) 효과(效果)에 대(對)한 연구(硏究)

  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Published : 1996.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was undertaken to examine the effect of Jwagyuyeum and Woogyuycum, being known to reinforce Kidney-yin and yang, on the activities of endogenous antioxidant enzymes and the production of oxygen free radicals in the liver and kidney tissues, Alterations in enzyme activities were observed after in vivo treatment in rats, Jwagyuyeum and Woogyuyeum caused a significant increase in the activities of superoxide dismutase(SOD) and catajase Jwagyuyeum significantly increased the activity of glutathione peroxidase in both liver and kidney, but the enzyme activity was not significantly altered by Woogyuyeum. Treatment in vitro of Jwagyuyeum and Woogyuyeum decreased the production of oxygen free radicals in a dose-dependent fashion. These results suggest that Jwagyuyeum and Woogyuyeum stimulate the activities of antioxidant enzymes and inhibit directly the production of oxygen free radicals. These effects of both herbs may contribute to prevent the oxygen free radical-induced impairment of cell function.

Keywords

References

  1. Biochem. J. v.131 Milk xanthine oxidase type D(dehydrogenase) and type O(oxidase) : Purification and interconversion and some properties Batteli, N.G.;Lorenzoni, E.;Stirpe, F.
  2. FASEB J. v.4 Role of oxygen free radicals in carcinogenesis and brain ischemia Floyd, R.A.
  3. Proc Soc Expo Biol Med. v.209 Mechanisms of oxidant stress-induced acute tissue injury Jaeschke, H.
  4. FASEB J. v.9 Oxidative processes and antioxidative defense mechanisms in the aging brain Reiter, R.J.
  5. J Clin Invest v.81 Evidence of the role of hydroxyl radical in gentamicin-induced acute renal failure in rats Walker, P.D.;Shah, S.V.
  6. J. Biol. Chem. v.244 Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) Fridovich, I.;McCord, J.M.
  7. Arch. Biochem. Biophys. v.147 Metabolism of vitamine $B_6$ in the 1-strain mouse Bell, R.R.;Blanchard, C.A.;Haskell, B.E.
  8. Science v.185 Free radical and inflammation : Protection of synovial fluid by superoxide dismutase McCord, J.M.
  9. Exposes Annuels de Biochamie Medicale v.29 Aebi, H.
  10. Biochem. Biophys. Res. Comm. v.31 An intracellular GSH-peroxidase with lipid peroxide substrate Little, C.;O'Brien, P.J.
  11. 생화학뉴스 v.5 no.3 노화의 메카니즘과 연구방향 최진호
  12. Free radical theory of aging ; Role of free radicals in the organization and evolution of life, aging and disease processes Harman, D.;Johnson, J.E.(et al.)(ed.)
  13. Free Radicals in Chemistry and Biology Milan, L.;Jozef, R.;Vilian, K.;Peter, P.;Ladislav, V.
  14. Chem. and Phys. of Lipid v.45 Lipid peroxides and diseases Yagi, K.
  15. 中醫雜誌 v.30 no.2 老年腎虛證血漿過氧化脂質高密度脂蛋白膽固醇及其亞組分水平準化 張文彭(外)
  16. 中國中西醫結合雜誌 v.12 no.1 五子衍宗液延緩衰老的臨床觀察 王學美(外)
  17. 陜西中醫 v.14 no.4 自由基衰老學說, 腎虛與衰老及補腎抗衰老硏究 余月明(外)
  18. 中西醫結合雜誌 v.15 no.3 中醫藥硏究中有關自由基硏究近況 許浦虎(外)
  19. 中西醫結合雜誌 v.10 no.8 腎虛, 衰老與自由基的關係以及補腎葯對自由基的影響 梁曉春(外)
  20. 中醫雜誌 v.30 no.4 腎虛與超氧化物化酶關系初探 陳晏珍(外)
  21. 中國中西醫結合雜誌 v.12 no.1 還少丹膠抗衰老及治療腎陽虛臨床觀察 杜辛(外)
  22. 中醫雜誌 v.30 no.3 淸宮長春丹對老年腎虛證血漿過氧化脂質高密度脂蛋白膽固醇水平影響的硏究 張文彭(外)
  23. 中醫長壽學 王基飛(外)
  24. 景岳全書(下) 張介賓
  25. 大韓韓方內科學會誌 v.16 no.1 左歸飮과 右歸飮이 老化 Rat의 肝 過酸化脂質 生成 및 活性 酵素 生成系 酵素 活性에 미치는 影響 尹哲浩;鄭智天
  26. 大韓韓醫學會誌 v.16 no.2 左歸飮과 右歸飮이 老化 Rat의 肝 過酸化脂質 生成 및 活性 酵素 生成系 酵素 活性에 미치는 影響 尹哲浩;鄭智天;朴宣動
  27. 東醫生理學會誌 v.6 no.1 命門動氣의 生理作用에 對한 實驗的 硏究-左歸飮과 右歸飮가 肉蓯蓉이 飢俄 白鼠 血中 호르몬 및 SOD 活性에 미치는 影響 申興黙;金吉萱
  28. Arch. Biochem. v.255 Negative and positive assays of superoxide dismutase based on hematoxylin autooxidation Martin, J.P.;Dailey, M.;Sugarman, E.
  29. J. Lab. Clin. Med. v.70 Studies on the quantitative and qulitative characterization of erythrocytes glutathione peroxidase Paglia, E.D.;Valentine, W.N.
  30. Anal. Biochem. v.118 Superoxide dependent formation of hydroxyl radicals : Detection of hydroxyl radicals by the hydroxylation of aromatic compounds Richmond, R.;Halliwell, B.;Chauhan, J.;Darbre, A.
  31. Biochem. Biophy. Res. Commun. v.65 The use of acetylated ferricytochrome c for the detection of superoxide radicals produced in biological membranes Azzi, A.;Montecucco, C.;Richter, C.
  32. J. Biol. Chem. v.193 Protein measurement with folin phenol rreagent Lowry, O.H.;Reosebrough, N.J.;Farr, A.L.;Randall, R.J.
  33. FASEB. J. v.1 Oxidants and human disease : Some new concepts Barry, H.
  34. J. Pharm. Pharmacol. v.41 Mechanistic toxicology : A radiicalperspective David, R.
  35. J. Biol. Chem. v.266 Hydrogen peroxide cause the fatal injury to human fibroblasts exposed to oxygen radicals Simon, R.H.;Scogging, C.M.;Patterson, D.
  36. Biochem. Biophys. Res. Comm. v.36 The production of superoxide anion radicals in the reaction of reduced flavins and flavoprotein with molecular oxygen Massey, V.;Strickland, S.;Mayhew, S.G.;Howell, L.G.;Engel, P.C.
  37. Lab. Invest. v.47 Biology of disease. Free radicals and tissue injury Freemann, B.A.;Crapo, J.D.
  38. Biochem. Pharmacol. v.31 Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity Trush, A.M.;Mimnaugh, E.G.;Gram, T.E.
  39. J. Biol. Chem. v.252 Singlet oxygen as a mediator in hematoporphyrin-catalyzed photooxidation of NADPH to NADP in deuterium oxide Bodanes, R.S.;Chan, P.C.
  40. Robbins pathologic basis of disease Corfran, R.S.;Kumar, V.;Robbins, S.L.
  41. 臟腑辨證論治 金完熙;崔達永
  42. 東醫腎系學(上) 杜鎬京
  43. 黃帝內經素問譯釋 南京中醫學院醫經敎硏組
  44. 醫學正傳 虞搏
  45. 古今名方 楊蘊祥
  46. 中醫名方精釋 于世良
  47. 浙江中醫學院學報 v.15 no.6 中藥的抗衰延年作用 馬瑞玶
  48. 山東中醫學院學報 v.15 no.3 27種中藥及SOD對體外大白鼠賂均漿過氧化脂質生成的影響 舒守琴(外)
  49. 中西醫結合雜誌 v.11 no.8 四大懷藥延緩衰老作用的硏究 李獻平(外)
  50. 中草藥 v.22 no.6 口服枸杞子對老年人血中超氧化物岐化酶, 血紅蛋白和過氧化脂質含量的動態觀察 李爲(外)
  51. 中醫雜誌 v.29 no.1 中國傳統延緩衰老藥物的現代硏究槪述 李春生
  52. 四川中醫 v.10 補腎抗衰口服液抗自由基損傷的實驗硏究 會一飛(外)
  53. 中草藥 v.24 no.7 抗衰延壽方對家蠅壽命的影響 莫新民(外)
  54. 四川中醫 v.7 枸杞的抗衰藥理硏究與臨床應用槪述 劉小英
  55. SOD and active oxygen modulators Oyanagui, Y.
  56. Am J. Kidney Dis. v.8 Cisplatin nephrotoxicity Safirstein, R.;Winston, J.;Glodstein, M.(et al.)
  57. Am. J. Med. v.69 Oxygen toxicity Frank, L.;Massaro, D.
  58. Physiol. Res. v.59 Hydroperoxide metabolism in mammalian organs Chance, B.;Sies, H.;Boveris, A.