• International Journal of Naval Architecture and Ocean Engineering
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• v.3 no.1
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• pp.37-52
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• 2011

The present paper introduced a computer program, called WISH, which is based on a time-domain Rankine panel method. The WISH has been developed for practical use to predict the linear and nonlinear ship motion and structural loads in waves. The WISH adopts three different levels of seakeeping analysis: linear, weakly-nonlinear and weak-scatterer approaches. Later, WISH-FLEX has been developed to consider hydroelasticity effects on hull-girder structure. This program can solve the springing and whipping problems by coupling between the hydrodynamic and structural problems. More recently this development has been continued to more diverse problems, including the motion responses of multiple adjacent bodies, the effects of seakeeping in ship maneuvering, and the floating-body motion in finite-depth domain with varying bathymetry. This paper introduces a brief theoretical and numerical background of the WISH package, and some validation results. Also several applications to real ships and offshore structures are shown.

• Journal of Families and Better Life
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• v.27 no.6
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• pp.141-153
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• 2009

This study is focused on the residential spaces that the elderly wish to renovate and their willingness to improve residential environment as they grow old. The analysis shows, first, the most inconvenient places as they grow old are the stairs, following by the toilet and the bath. Second, the place that the elderly most wish to renovate is the floor, upgrading floors with non-slippery materials. And they wish to remove the height differences on the floor to protect them from tripping over, upgrade the floor plan for their convenience and renovate the storage and working spaces at the kitchen and dining areas. The more the government supports the costs of the residential renovation service, the more the elderly are willing to use the renovation service. The factors influencing their willingness to residential renovation are health, residential environment, experience to accidents and their allowances. The elderly who experienced accidents inside their residence are more willing to renovate their house. Even though the elderly wish to renovate their houses, it's not carried out due to the financial difficulties and the lack of information. Thus, the government should share the useful information about residential renovation for the safety of the elderly and find a way to raise money to cover the costs of the renovation.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.5
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• pp.369-376
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• 2022

Background: Nonobstetric surgery is sometimes required during pregnancy, and neck abscess or facial bone fracture surgery cannot be postponed in pregnant women. However, dental surgery can be stressful and can cause inflammation, and the inflammatory response is a well-known major cause of preterm labor. Propofol is an intravenous anesthetic commonly used for general anesthesia and sedation. Studies investigating the effect of propofol on human amnion are rare. The current study investigated the effects of propofol on lipopolysaccharide (LPS)-induced inflammatory responses in human amnion-derived WISH cells. Methods: WISH cells were exposed to LPS for 24 h and co-treated with various concentrations of propofol (0.01-1 ㎍/ml). Cell viability was measured using the MTT assay. Nitric oxide (NO) production was analyzed using a microassay based on the Griess reaction. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE 2), p38, and phospho-p38 was analyzed using western blotting. Results: Propofol did not affect the viability and NO production of WISH cells. Co-treatment with LPS and propofol reduced COX-2 and PGE₂ protein expression and inhibited p38 phosphorylation in WISH cells. Conclusion: Propofol does not affect the viability of WISH cells and inhibits LPS-induced expression of inflammatory factors. The inhibitory effect of propofol on inflammatory factor expression is likely mediated by the inhibition of p38 activation.

• Journal of Hospice and Palliative Care
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• v.18 no.2
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• pp.148-155
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• 2015

Purpose: The purpose of this study is to examine how wish granting influences children with life-threatening medical conditions when it comes to their adaptation to disease with a focus on the mediating effect of resilience and stress caused by disease. Methods: From January 2, 2015 through January 12, 2015, a survey was conducted on 292 children with life-threatening diseases whose wishes were granted through Make-A-Wish Korea. The data were collected using the impact of a wish scale, the Children's Adjustment to Cancer Inventory, the Childhood Cancer Stressor Inventory, and the resilience scale in children with chronic illness. The data were analyzed using SPSS/WIN 20.0 and Amos 21.0. Results: Satisfaction with the wish granting program enhances resilience, and resilience affects stress caused by medical conditions as well as adaptation to disease. Also, stress caused by medical conditions influences adaptation to disease. Conclusion: Wish granting is effective in both facilitating chronically ill children to adjust to disease and reduce their stress from disease. Thus, children with life-threatening medical conditions could be assisted or motivated to adjust to disease by improving satisfaction achieved by wish granting.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.4
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• pp.277-287
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• 2022

Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a widely used sedative in the dental field, but research on the effect of DEX on pregnancy is currently insufficient. In this study, we investigated the effects of co-treatment with DEX and lipopolysaccharide (LPS) on inflammatory responses in human amnion-derived WISH cells. Methods: Human amnion-derived WISH cells were treated with 0.001, 0.01, 0.1, and 1 ㎍/mL DEX with 1 ㎍/mL LPS for 24 h. Cytotoxicity of WISH cells was evaluated by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E₂ (PGE₂), p38, and nuclear factor kappa B (NF-𝜅B) was examined by western blot analysis. The mRNA expression of pro-inflammatory cytokines such as interleukin (IL)-1𝛽 and tumor necrosis factor (TNF)-𝛼 was analyzed by real-time quantitative polymerase chain reaction. Results: Co-treatment with DEX and LPS showed no cytotoxicity in the WISH cells. The mRNA expression of IL-1𝛽 and TNF-𝛼 decreased after co-treatment with DEX and LPS. DEX and LPS co-treatment decreased the protein expression of COX-2, PGE₂, phospho-p38, and phospho-NF-𝛋B in WISH cells. Conclusion: Co-treatment with DEX and LPS suppressed the expression of COX-2 and PGE₂, as well as pro-inflammatory cytokines such as IL-1𝛽 and TNF-𝛼 in WISH cells. In addition, the anti-inflammatory effect of DEX and LPS co-treatment was mediated by the inhibition of p38/NF-𝜅B activation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.1
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• pp.285-293
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• 2013

This study was to investigate which predictors influenced the wish to undergo cosmetic surgery according to experience of cosmetic surgery in female college students. A cross-sectional descriptive design was used with self-report questionnaires, which were completed by 254 subjects. Data was analyzed with t-test and regression. There were statistically significant differences in acceptance and social motivation of cosmetic surgery and the wish to undergo cosmetic surgery in the future between the two groups. Body area satisfaction and acceptance of cosmetic surgery were significant predictors to the wish to undergo cosmetic surgery in the non-experienced group. The significant predictor of the wish to undergo cosmetic surgery for the experienced group was acceptance of cosmetic surgery. The findings from this study suggest that there is need to different approaches to discuss or council for wish to undergo cosmetic surgery according to individual cosmetic surgery experience.

• Journal of Dental Anesthesia and Pain Medicine
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• v.19 no.5
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• pp.253-260
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• 2019

Background: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that can cause inflammation. Inflammatory responses are a well-known major cause of preterm labor and preterm birth. Here we demonstrate the effects of remifentanil on the factors related to preterm labor and its mechanism of action on amniotic-derived epithelial cells (WISH cells). Methods: WISH cells were exposed to lipopolysaccharide (LPS) for 24 h and co-treated with various concentrations of remifentanil. MTT assays were performed to measure cell viability. To explain the effects of remifentanil on the factors related to inflammation in WISH cells, activation of nuclear factor kappa B ($NF-{\kappa}B$) and p38 and the expression of interleukin $(IL)-1{\beta}$, tumor necrosis factor $(TNF)-{\alpha}$, cyclooxygenase (COX)2, and prostaglandin E $(PGE)_2$ were quantified using western blotting and RT-PCR, respectively. Results: Remifentanil did not affect WISH cell viability. In western blot analysis, co-treatment with remifentanil resulted in decreased phosphorylation of $NF-{\kappa}B$, and expression of COX2 and $PGE_2$ in LPS-induced inflammation, but the results were statistically significant only at low concentrations. Reduction of $IL-1{\beta}$ and $TNF-{\alpha}$ expression was also observed with RT-PCR. Conclusion: Co-treatment with remifentanil does not affect the viability of WISH cells, but reduces the expression of the factors related to inflammation, which can induce uterine contraction and preterm labor. These findings provide evidence that remifentanil may inhibit uterine contraction and preterm labor in clinical settings.

• International Commerce and Information Review
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• v.11 no.1
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• pp.407-440
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• 2009

I wish to examine plan about megalopolis formation with Japan and Busan, possess location condition that can be injured to center hub of North-east Asia. First for this, through competitive analysis of Korea and Japan in industrial structure, I will search competition relation. Second, examine what exports and specialization industry of two area are, through industrial structure of Busan and Kyushu area of Japan. Third, to form megalopolis, wish to present what business belt that can bind two area. Fourth, I wish to present preview point about this study in the conclusion. Examine from 2004 to 2007 through exports, degree of trade join(combination), index of trade specialization degree, index of Revealed comparative advantage, and etc, for analysis of this study how in changed industry competitive between two countries or two area have changed.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.141-142
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• 2008

According as USN's application field is magnified, various results are appearing. Efforts to apply this results in life are progressing. In car field, is used in control that level of significance is less. In home network, is used in a household electric appli-ance control and electric lamp control, security etc.. In factory, is used in process control, and is used in various application because is involved with RFID leader recently. In this paper, patient's status monitoring, USN use wish to. Because USN can utilize existent network, it is system that can transmit various data as that change passed information.Wish to send information that get in health-care board. Information that can get in health-care board is blood pressure, blood sugar, stroke, SPO2, ECG, the activity amount, position. Also, wish to forecast use possibility to involved various service, silver industry with database.

• Proceedings of the Korean Society for Quality Management Conference
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• 2010.04a
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• pp.283-290
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• 2010

This paper suggest that the derivation of good and practical ideas is important for the successful use of Kano model. Wish List, Bug List and Forced Connection Method as well as Brainstorming were applied to PMP(Portable Multimedia Player) in order to derive customer attributes. Wish List and Bug List are variants of Brainstorming, which are contrary to each other. Forced Connection Method is designed to bring about bisociation which is a typical characteristic of creative thinking.