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A comparative study for guided bone regeneration of silk fibroin nanomembrane(NanoGide-$S^{TM}$) (실크 피브로인 나노 차폐막(나노가이드-에스)을 이용한 치조골 유도재생능력에 관한 비교 연구)

  • Han, Dae-Hyun;Hong, Ki-Seok;Chung, Chin-Hyung;Yim, Sung-Bin
    • Journal of Periodontal and Implant Science
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    • v.38 no.3
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    • pp.475-482
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    • 2008
  • Purpose: To evaluate the safety and efficiency of bone regenerative abilities of silk fibroin nanomembrane(Nanoguide-S) Material and Methods: The objects were 38 patients who had large defect at extraction sockets caused by chronic periodontitis and silk fibroin nano matrix were used on experimental group(N=19) and PLA/PLGA matrix were used on control group(N=19). The width, height, and length by crown-apical direction(socket depth) of defects were measured with the occlusal plane as a reference plane, and tooth axis direction, perpendicular to tooth axis direction were measured on radiographs at 3 months pre-operative, 3 months post-operative. Result: Tissue response to silk fibroin nano matrix and Biomesh were clinically satisfactory and complications such as swelling, exudation, ulceration and vesicles were not found except the ordinary discomfort of operated portion. 3 months later, the width, height, and length by crown-apical direction (socket depth) of defects were clinically improved in both groups with no significant difference. 3 months later radiolucency of tooth axis direction and perpendicular to tooth axis direction were all increased in both groups with no significant difference. Conclusion: By these results biodegradadable silk fibroin nano matrix was efficient in GBR on alveolar bone resorption caused by periodontitis compared to Biomesh.

Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs

  • Lee, Jung-Seok;Park, Weon-Yeong;Cha, Jae-Kook;Jung, Ui-Won;Kim, Chang-Sung;Lee, Yong-Keun;Choi, Seong-Ho
    • Journal of Periodontal and Implant Science
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    • v.42 no.2
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    • pp.50-58
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    • 2012
  • Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model. Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral $4{\times}{\times}4{\times}5$ mm (buccolingual width${\times}$mesiodistal width${\times}$depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations. Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone. Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.

A Real-Time RPWM Inverter for Reduction of Switching Frequency Band Noise in the Induction Motor (유도전동기의 스위칭 주파수대 소음 저감을 위한 실시간 RPWM 인버터)

  • 나석환;최창률;양승학;김광헌;임영철;박종건
    • The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.11 no.6
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    • pp.64-73
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    • 1997
  • RPWM(Random Pulse Width Modulation) techniques have been attracting an interest as an excellent reduction method of acoustic noise on the inverter drive system. Using randomly changed switching fre-quency of the inverter, the power spectrum of the electromagnetic acoustic noise can be spread out into the wide-band area. The wide band noise is much more comfortable and less annoying than the narrow-band one. This paper describes an implementationof the triangular carrier frequency modultde RPWM inverter drive system The poweer soedtrum of the noise emittde from the induction motro was measured in the anechoic chamber. The analysis of the sources for the acoustic noise and the effects of the noise reduction are confirmed by the ceasured dpectra of the noise. Real-time RPWM along with the speed control was achieved by high speed DSP(Digital Signal Processor ) TmS320C31, By changing the center frequency and the bandwidth of the carrier, theis real-time RPWM scheme can be used as an efficient switching frequency band acoustic noise reduction method for the inverter system with variant load conditions.

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Effect of X-Irradiation in Vitro on the Pulmonary Surfactant in Rabbits (In Vitro X선조사(線照射)가 가토폐포표면(家兎肺胞表面) 활성물질(活性物質)에 미치는 영향(影響))

  • Cho, Joong-Hwan;Choo, Young-Eun
    • The Korean Journal of Physiology
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    • v.5 no.1
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    • pp.51-58
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    • 1971
  • In an attempt to further clarify the effect of X·irradiation on the activity of surfactant in rabbits, X-ray in dose of 900r was irradiated to the lung tissues of rabbits in vitro. Tension-area diagram of the lung extract was recorded automatically by a modified Langmuir-Wilhelmy balance with a synchronized recording system designed in this department. The surface tension of the lung extract was measured at 1,3,5,24 and 48 hours post-irradiation, and the results were compared with the non·irradiated normal group. The result$ thus obtained are summarized as follows: I The maximal surface tension, minimal surface tension, width of the tension·area diagram at the surface area of 40% in the lung extract and stability index of the normal rabbit long extract were 40.73 dynes/cm, 8.96 dynes/cm, 20.71 dynes/cm and 1.28, respectively. II. When 900r of X-ray was irradiated to the lung in vitro, 1) The maximal and minimal surface tensions did not differ noticeably from the normal at 1,3, and 5 post-irradiation hours, but the minimal surface tension increased significantly at 24 and 48 hours Post-irradiation. 2) The width of the tension area at the surface area of 40% showed a tendency of decrease throughout the experiment. 3) The stability index showed no significant change at 1,3 and 5 post-irradiation hours,but at 24 and 48 hours post-irradiation a significant decrease was observed comparing with the control. III. Activity of surfactant was significantly depressed by X·irradiation in vitro especially at 24 and 48 hours post-irradiation.

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Stemphylium Leaf Blight of Garlic (Allium sativum) in Spain: Taxonomy and In Vitro Fungicide Response

  • Galvez, Laura;Gil-Serna, Jessica;Garcia, Marta;Iglesias, Concepcion;Palmero, Daniel
    • The Plant Pathology Journal
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    • v.32 no.5
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    • pp.388-395
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    • 2016
  • The most serious aerial disease of garlic is leaf blight caused by Stemphylium spp. Geographical variation in the causal agent of this disease is indicated. Stemphylium vesicarium has been reported in Spain, whereas S. solani is the most prevalent species recorded in China. In this study, Stemphylium isolates were obtained from symptomatic garlic plants sampled from the main Spanish production areas. Sequence data for the ITS1-5.8S-ITS2 region enabled assignation of the isolates to the Pleospora herbarum complex and clearly distinguished the isolates from S. solani. Conidial morphology of the isolates corresponded to that of S. vesicarium and clearly discriminated them from S. alfalfae and S. herbarum on the basis of the size and septation pattern of mature conidia. Conidial morphology as well as conidial length, width and length:width ratio also allowed the Spanish isolates to be distinguished from S. botryosum and S. herbarum. Control of leaf blight of garlic is not well established. Few studies are available regarding the effectiveness of chemical treatments to reduce Stemphylium spp. incidence on garlic. The effectiveness of nine fungicides of different chemical groups to reduce Stemphylium mycelial growth in vitro was tested. Boscalid + pyraclostrobin (group name, succinate dehydrogenase inhibitors + quinone outside inhibitors), iprodione (dicar-boximide), and prochloraz (demethylation inhibitors) were highly effective at reducing mycelial growth in S. vesicarium with $EC_{50}$ values less than 5 ppm. In general, the effectiveness of the fungicide was enhanced with increasing dosage.

Protective effects of a transgenic carrot vaccine on piglet diarrhea (자돈 설사병에 대한 형질전환 당근백신의 방어 효능 평가)

  • Kim, Yeong-Hun;Nam, Jin-Young;Lee, Hyang-Keun;Hwang, Cheol-Ho;Han, Jeong-Hee
    • Korean Journal of Veterinary Research
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    • v.51 no.2
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    • pp.151-158
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    • 2011
  • The study evaluated whether a transgenic carrot vaccine could induce a K88-specific immune response in sows and whether the resultant maternal antibody could protect piglets against enterotoxigenic Escherichia coli (ETEC) K88ac infection. Sows (n = 15) selected randomly from a farm in Korea were assigned to three groups (n = 5 per group: control [untreated]), group A (orally inoculated with a nontransgenic and transgenic carrot vaccines at 2 and 4 weeks ante partum, respectively), and group B (conventionally vaccinated according to the manufacturer's instructions). After 7 days of lactation, 5 piglets selected randomly from each group were challenged with $1{\times}10^{10}$ colony forming units/mL ETEC K88ac. Group C had the lowest mean fecal consistency score on post-challenge days 1 and 7. Histiologically, On post-challenge day 7, group C showed an increased duodenum and ileum villus:crypt ratio, compared to group A in the duodenum, with group B displaying the highest ratio. Groups B and C had more increased villus width than group A in the jejunum. Group C displayed the greatest increase in villus width in the ileum. The colostrums and serum from groups B and C displayed higher concentrations of IgA and IgG against ETEC K88, compared to group A. Based on the results, it was concluded that the transgenic carrot vaccine in sow per oral may have an effect on preventing piglet diarrhea as good as commercial recombinant vaccine.

A Study on the Smoke control Design parameter of Large Volume space by Fire Dynamic Simulation (화재 시뮬레이션(FDS)을 이용한 대형공간의 제연 설계인자에 관한 연구)

  • Choi, Sang-Gon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.11
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    • pp.237-243
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    • 2018
  • Performance-oriented design has been introduced in fire protection design, and various efforts have been made to minimize the damage caused by fire in the design stage. We conducted a study to provide information for reasonable design factors using a Fire Dynamic Simulation code provided by the NIST on boundary width and amount of supply. This paper shows that using a living-room air-supply system in a large space and dividing the space by a ventilation boundary are the two factors that are considered to have the greatest influence on the design of the living room ventilation. The results show that for performance-based design, the width of the ventilation boundary is designed to be the maximum limit in the initial design. It is judged that reasonable air volume determination should be made through various methods.

Fracture resistance of CAD-CAM all-ceramic surveyed crowns with different occlusal rest seat designs

  • Chaturvedi, Saurabh;Alqahtani, Turki;Alsolami, Saleh;Alqahtani, Abdulbari;Das, Gotam;Alsubaiy, Ebrahim
    • The Journal of Advanced Prosthodontics
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    • v.13 no.1
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    • pp.36-45
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    • 2021
  • Purpose. To investigate the fracture resistance of monolithic CAD-CAM all-ceramic surveyed crowns with two different occlusal rest seat designs. Materials and Methods. Two maxillary first premolar were prepared for all-ceramic surveyed crowns with wide (2/3rd of buccolingual width of an unprepared tooth) or narrow (1/3rd of buccolingual width of an unprepared tooth) disto-occlusal rest seat (ORS) designs. Eighty monolithic CAD-CAM all-ceramic surveyed crowns were prepared and divided into 4 groups - Group CR, Composite resin material as a control; Group LDS, Lithium disilicate based material; Group ZIPS, zirconia-material (IPS ZirCAD); and Group ZLHT, zirconia- material (CeramillZolidht+). Crowns were cemented on an epoxy resin die with adhesive resin cement. The fracture resistance of crowns was tested with the universal machine. Univariate regression analysis was used. Results. The mean ± standard deviation of maximum failure force values varied from 3476.10 ± 285.97 N for the narrow ORS subgroup of group ZIPS to 687.89 ± 167.63 N for the wide ORS subgroup of group CR. The mean ± standard deviation of maximum force was 1075 ± 77.0 N for group CR, 1309.3 ± 283.9 N for group LDS, 3476.1 ± 285.97 N for group ZIPS, and 2666.7 ± 228.21 N for group ZLHT, with narrow occlusal rest seat design. The results of the intergroup comparison showed significant differences in fracture strength with various material groups and occlusal rest seat designs (P<.001). Conclusion. The zirconia-based all-ceramic surveyed crowns fractured at more than double the load of Lithium disilicate based crowns. The crowns with narrow base occlusal rest seat design had statistically significantly higher fracture resistance than surveyed crowns with wide occlusal rest seat design. The use of narrow occlusal rest seat design in CAD-CAM all ceramic surveyed crowns provides higher fracture resistance, and therefore narrow occlusal rest design can be used for providing esthetics with high strength.

A Study on the Circuit Design Methodology and Performance Evaluation for Hybrid Gate Driver (하이브리드 게이트 드라이버를 위한 회로 디자인 방법과 성능 평가에 관한 연구)

  • Cho, Geunho
    • Journal of IKEEE
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    • v.25 no.2
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    • pp.381-387
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    • 2021
  • As Head-Mounted Displays(HMDs), which are mainly used to maximize realism in games and videos, have experienced increased demand and expanded scope of use in education and training, there is growing interest in methods to enhance the performance of conventional HMDs. In this study, a methodology to utilize Carbon NanoTubes(CNTs) to improve the performance of gate drivers that send control signals to each pixel circuit of the HMD is discussed. This paper proposes a new circuit design method that replaces the transistors constituting the buffer part of the conventional gate driver with transistors incorporating CNTs and compare the performance of the suggested gate drive with that of a gate driver comprising only conventional transistors via simulations. According to the simulation results, by including CNTs in the gate driver, the output voltage can be increased by approximately 0.3V compared to the conventional gate driver high voltage(1.1V) at a speed of 12.5 GHz and the gate width also can be reduced by up to 20 times.

Case-control study of the treatment of postaxial polysyndactyly of the foot: Comparison of surgical results after removal of the fifth or sixth toe

  • Woo, Soo Jin;Kim, Byung Jun;Kwon, Sung Tack
    • Archives of Plastic Surgery
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    • v.48 no.1
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    • pp.91-97
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    • 2021
  • Background In postaxial polysyndactyly of the foot, the choice of which toe to excise is controversial. It is often treated by resection of the fifth toe to save the lateral neurovascular bundles of the sixth toe. However, the sixth toe is often short and laterally deviated, which may require wedge osteotomy, potentially shortening the phalanx and compromising circulation. This study outlines an individualized method to spare the length and axis of the fifth toe in polysyndactyly with a short and deviated sixth toe. Methods We retrospectively analyzed 38 patients who underwent surgery between 2006 and 2019. The fifth toe was spared in 18 cases, and the sixth toe in 20 cases. The ratios of the forefoot width, angle difference, and toe length were compared between the affected and unaffected sides postoperatively. Complications and subjective judgments on cosmetic results were recorded and compared. Results No significant between-group differences were observed for sex, age at surgery, or the follow-up period. The forefoot width ratio did not significantly differ between the groups. However, the angle difference and toe length ratios showed significantly better results in the fifth toe-spared group than in the sixth toe-spared group (P<0.05 and P<0.01, respectively). There were no cases of impaired circulation, and subjective evaluations revealed satisfactory results in the fifth toe-spared group. Conclusions In cases with short and deviated sixth toes, sparing the fifth toe is an effective method of cosmetic treatment. The surgical results were satisfactory, with an improved appearance and no residual deformities.