• Coupled systems mechanics
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• v.13 no.2
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• pp.95-113
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• 2024

In this paper, we will analyse the thermo-elastic behavior of the plate element of a structure arranged in a climatically aggressive environment (extreme temperature), we use a refined four-variable thick plate theory to take the shear effect into consideration, the proposed theory less computationally expensive and more accurate so that it incorporates the shear effect into the formulation. The plate is assumed to be simply supported on its four edges, so exact (closed-form) solutions are found according to the Navier expansion, and the governing stability equations and associated boundary conditions of the problem are obtained via the virtual works principle. The plate studied ismade of laminated composite materials, so a parametric study is needed to see the effect of different types of parameters and coupling on the critical temperature value causing thermo-elastic instability of the plate and also on the natural frequency of free vibration, as well as for other parameters such as anisotropy, slenderness and aspect ratio of the plate and finally the lamination angle. Numerical results are obtained for specially orthotropic and antisymmetrical plates and are compared with those obtained by othertheoriesin the literature to validate the analysis approach used.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.4
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• pp.173-181
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• 2018

Recently composite materials have dominated most engineering fields, owing to their better performance, increased durability and flexibility to be customized and designed for a specific required property. This has given them unprecedented superiority over conventional materials. With the help of the ever increasing computational capabilities of computers, researchers have been trying to develop accurate material models for the complex and integrated properties of these composites. This has led to advances in virtual testing of composite materials as a supplement or a possible replacement of laboratory experiments to predict the properties and responses of composite materials and structures. This paper presents a review on the complex multi-scale modelling framework of the virtual testing machines, which involve computational mechanics at various length-scales starting with nano-mechanics and ending in structure level computational mechanics, with a homogenization technique used to link the different length scales. In addition, the paper presents the features of some of the biggest integrated virtual testing machines developed for study of concrete, including a multiscale modeling scheme for the simulation of the constitutive properties of nanocomposites. Finally, the current challenges and future development potentials for virtual test machines are discussed.

• Journal of Software Assessment and Valuation
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• v.17 no.2
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• pp.109-116
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• 2021

Traditionally, the engineering field has been dominated by face-to-face education focused on experimental practice, but demand for online learning has soared due to the rapid development of IT technology and Internet communication networks and recent changes in the social environment such as COVID-19. In order for efficient online education to be conducted in the engineering field, where the proportion of experimental practice is relatively high compared to other fields, virtual laboratory practice content that can replace actual experimental practice is very necessary. In this study, we developed a line tracer model and a virtual experimental software to simulate it for efficient online learning of microprocessor applications that are essential not only in the electric and electronic field but also in the overall engineering field where IT convergence takes place. In the developed line tracer model, the user can set various hardware parameter values in the desired form and write the software in assembly language or C language to test the operation on the computer. The developed line tracer virtual experimental software has been used in actual classes to verify its operation, and is expected to be an efficient virtual experimental practice tool in online non-face-to-face classes.

• Toxicological Research
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• v.35 no.4
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• pp.295-301
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• 2019

In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by modeling virtual oral administration in rats. To ensure that a broad range of chemical structures is present among the selected substances, the properties described by 196 chemical descriptors in a chemoinformatics tool were calculated for 50,000 randomly selected molecules in the original chemical space. To allow visualization, the resulting chemical space was projected onto a two-dimensional plane using generative topographic mapping. The calculated absorbance rates of the chemicals based on cell permeability studies were found to be inversely correlated to the no-observed-effect levels for hepatoxicity after oral administration, as obtained from the Hazard Evaluation Support System Integrated Platform in Japan (r = -0.88, p < 0.01, n = 27). The maximum plasma concentrations and the areas under the concentration-time curves (AUC) of a varied selection of chemicals were estimated using two different methods: simple one-compartment models (i.e., high-throughput toxicokinetic models) and simplified physiologically based pharmacokinetic (PBPK) modeling consisting of chemical receptor (gut), metabolizing (liver), and central (main) compartments. The results obtained from the two methods were consistent. Although the maximum concentrations and AUC values of the 53 chemicals roughly correlated in the liver and plasma, inconsistencies were apparent between empirically measured concentrations and the PBPK-modeled levels. The lowest-observed-effect levels and the virtual hepatic AUC values obtained using PBPK models were inversely correlated (r = -0.78, p < 0.05, n = 7). The present simplified PBPK models could estimate the relationships between hepatic/plasma concentrations and oral doses of general chemicals using both forward and reverse dosimetry. These methods are therefore valuable for estimating hepatotoxicity.

• Journal of Veterinary Science
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• v.22 no.6
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• pp.41.1-41.14
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• 2021

Background: Our previously prepared ceftiofur (CEF) hydrochloride oily suspension shows potential wide applications for controlling swine Streptococcus suis infections, while the irrational dose has not been formulated. Objectives: The rational dose regimens of CEF oily suspension against S. suis were systematically studied using a pharmacokinetic-pharmacodynamic model method. Methods: The healthy and infected pigs were intramuscularly administered CEF hydrochloride oily suspension at a single dose of 5 mg/kg, and then the plasma and pulmonary epithelial lining fluid (PELF) were collected at different times. The minimum inhibitory concentration (MIC), minimal bactericidal concentration, mutant prevention concentration (MPC), post-antibiotic effect (PAE), and time-killing curves were determined. Subsequently, the area under the curve by the MIC (AUC_0-24h/MIC) values of desfuroylceftiofur (DFC) in the PELF was obtained by integrating in vivo pharmacokinetic data of the infected pigs and ex vivo pharmacodynamic data using the sigmoid E_max (Hill) equation. The dose was calculated based on the AUC_0-24h/MIC values for bacteriostatic action, bactericidal action, and bacterial elimination. Results: The peak concentration, the area under the concentration-time curve, and the time to peak for PELF's DFC were 24.76 ± 0.92 ㎍/mL, 811.99 ± 54.70 ㎍·h/mL, and 8.00 h in healthy pigs, and 33.04 ± 0.99 ㎍/mL, 735.85 ± 26.20 ㎍·h/mL, and 8.00 h in infected pigs, respectively. The MIC of PELF's DFC against S. suis strain was 0.25 ㎍/mL. There was strong concentration-dependent activity as determined by MPC, PAE, and the time-killing curves. The AUC_0-24h/MIC values of PELF's DFC for bacteriostatic activity, bactericidal activity, and virtual eradication of bacteria were 6.54 h, 9.69 h, and 11.49 h, respectively. Thus, a dosage regimen of 1.94 mg/kg every 72 h could be sufficient to reach bactericidal activity. Conclusions: A rational dosage regimen was recommended, and it could assist in increasing the treatment effectiveness of CEF hydrochloride oily suspension against S. Suis infections.

• Structural Engineering and Mechanics
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• v.68 no.4
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• pp.409-421
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• 2018

In the present paper, functionally graded (FG) materials are presented to investigate the bending analysis of simply supported plates. It is assumed that the material properties of the plate vary through their length according to the power-law form. The displacement field of the present model is selected based on quasi-3D hyperbolic shear deformation theory. By splitting the deflection into bending, shear and stretching parts, the number of unknowns and equations of motion of the present formulation is reduced and hence makes them simple to use. Governing equations are derived from the principle of virtual displacements. Numerical results for deflections and stresses of powerly graded plates under simply supported boundary conditions are presented. The accuracy of the present formulation is demonstrated by comparing the computed results with those available in the literature. As conclusion, this theory is as accurate as other shear deformation theories and so it becomes more attractive due to smaller number of unknowns. Some numerical results are provided to examine the effects of the material gradation, shear deformation on the static behavior of FG plates with variation of material stiffness through their length.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.2
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• pp.324-332
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• 2007

In this paper, we developed remote control devices that can be controlled passive component e.g. resistor, inductor, capacitor that is a basic element in the electric circuit. We embodied a remote laboratory for basic circuit theory which learners can experiment controlling element value to remote through the internet. It was seen that is useful applying passive component developing to a remote laboratory. Because developed passive components can response in an experiment altering several element values to remote, they will be used very usefully in a remote experiment that equip various experiment theme. Therefor the proposed laboratory will be solved problems of virtual laboratory which students do not handle instruments in engineering experiment. With our proposed system, students can experiment any time, anywhere.

• Journal of Communications and Networks
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• v.16 no.5
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• pp.548-558
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• 2014

Load distribution is vital to the performance of multipath transport. The task becomes more challenging in real-time multimedia applications (RTMA), which impose stringent delay requirements. Two key issues to be addressed are: 1) How to minimize end-to-end delay and 2) how to alleviate packet reordering that incurs additional recovery time at the receiver. In this paper, we propose sub-packet based multipath load distribution (SPMLD), a new model that splits traffic at the granularity of sub-packet. Our SPMLD model aims to minimize total packet delay by effectively aggregating multiple parallel paths as a single virtual path. First, we formulate the packet splitting over multiple paths as a constrained optimization problem and derive its solution based on progressive approximation method. Second, in the solution, we analyze queuing delay by introducing D/M/1 model and obtain the expression of dynamic packet splitting ratio for each path. Third, in order to describe SPMLD's scheduling policy, we propose two distributed algorithms respectively implemented in the source and destination nodes. We evaluate the performance of SPMLD through extensive simulations in QualNet using real-time H.264 video streaming. Experimental results demonstrate that: SPMLD outperforms previous flow and packet based load distribution models in terms of video peak signal-to-noise ratio, total packet delay, end-to-end delay, and risk of packet reordering. Besides, SPMLD's extra overhead is tiny compared to the input video streaming.

• Structural Engineering and Mechanics
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• v.74 no.3
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• pp.365-380
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• 2020

The focus of this paper is to develop an analytical approach based on an efficient shear deformation theory with stretching effect for bending stress analysis of cross-ply laminated composite plates subjected to transverse parabolic load and line load by using a new kinematic model, in which the axial displacements involve an undetermined integral component in order to reduce the number of unknowns and a sinusoidal function in terms of the thickness coordinate to include the effect of transverse shear deformation. The present theory contains only five unknowns and satisfies the zero shear stress conditions on the top and bottom surfaces of the plate without using any shear correction factors. The governing differential equations and its boundary conditions are derived by employing the static version of principle of virtual work. Closed-form solutions for simply supported cross-ply laminated plates are obtained applying Navier's solution technique, and the numerical case studies are compared with the theoretical results to verify the utility of the proposed model. Lastly, it can be seen that the present outlined theory is more accurate and useful than some higher-order shear deformation theories developed previously to study the static flexure of laminated composite plates.

• Steel and Composite Structures
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• v.43 no.6
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• pp.821-837
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• 2022

This research is devoted to study the effects of humidity and temperature on the bending behavior of functionally graded (FG) ceramic-metal porous plates resting on Pasternak elastic foundation using a quasi-3D hyperbolic shear deformation theory developed recently. The present plate theory with only four unknowns, takes into account both transverse shear and normal deformations and satisfies the zero traction boundary conditions on the surfaces of the functionally graded plate without using shear correction factors. Material properties of porous FG plate are defined by rule of the mixture with an additional term of porosity in the through-thickness direction. The governing differential equations are obtained using the "principle of virtual work". Analytically, the Navier method is used to solve the equations that govern a simply supported FG porous plate. The obtained results are checked by comparing the results determined for the perfect and imperfect FG plates with those available in the scientific literature. Effects due to material index, porosity factors, moisture and thermal loads, foundation rigidities, geometric ratios on the FG porous plate are all examined. Finally, this research will help us to design advanced functionally graded materials to ensure better durability and efficiency for hygro-thermal environments.