• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1343-1349
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• 2021

Cockroaches live in places where various pathogens exist and thus are more likely to use antimicrobial compounds to defend against pathogen intrusions. We previously performed an in silico analysis of the Periplaneta americana transcriptome and detected periplanetasin-5 using an in silico antimicrobial peptide prediction method. In this study, we investigated whether periplanetasin-5 has anticancer activity against the human leukemia cell line K562. Cell growth and survival of K562 cells treated with periplanetasin-5 were decreased in a dose-dependent manner. By using flow cytometric analysis, acridine orange/ethidium bromide (AO/EB) staining and DNA fragmentation, we found that periplanetasin-5 induced apoptotic and necrotic cell death in leukemia cells. In addition, these events were associated with increased levels of the pro-apoptotic proteins Fas and cytochrome c and reduced levels of the anti-apoptotic protein Bcl-2. Periplanetasin-5 induces the cleavage of pro-caspase-9, pro-caspase-8, pro-caspase-3, and poly (ADP-ribose) polymerase (PARP). The above data suggest that periplanetasin-5 induces apoptosis via both the intrinsic and extrinsic pathways. Moreover, caspase-related apoptosis was further confirmed by using the caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone (Z-VAD-FMK), which reversed the periplanetasin-5-induced reduction in cell viability. In conclusion, periplanetasin-5 caused apoptosis in leukemia cells, suggesting its potential utility as an anticancer therapeutic agent.

• Journal of the Korea Fashion and Costume Design Association
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• v.20 no.4
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• pp.57-71
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• 2018

Since consumers have become more comfortable with providing and receiving information online, 'online word of mouth' has been gaining consideration as one of the major information sources. Also, the shopping orientation of consumers has been proven to be an important determinant of consumer behavior. Therefore, the study investigated the differences in online WOM behavior based on shopping orientation. Hedonic, loyal, and syntonic styles were the types of shopping orientation considered, and the study focused on information retrieval tendencies, the motivation of online WOM search, searching online WOM sources, and the contents for the online WOM behavior. The research conducted an off-line survey targeting females in their twenties. The total number of data sets used in the empirical study was 125, and these were analyzed by SPSS 20.0: factors analysis, Cronbach's ${\alpha}$, k-means cluster, ANOVA, Duncan's multiple range test, Kruskal-Wallis, Mann-Whitney, and Bonferroni correction. The participants were divided into 3 kinds of shopping orientation groups named 'trend-pursuit', 'passive', and 'loyal'. As a result, there were significant differences in online WOM behavior discovered between the groups. Firstly, the 'trend-pursuit' group had the highest number of ongoing searches while the 'loyal' group had the highest number of pre-purchase search. Secondly, the 'trend-pursuit' and 'loyal' groups both had the motivations of online WOM search, hedonic and utility, whereas the 'passive' group had the lowest motivations for both motivations. Thirdly, the 'loyal' group frequently referred to reviews on shopping malls as online WOM sources. The research provided a better understanding of the online WOM behavior of present consumers and suggests that fashion related corporations map out marketing strategies with the understanding of these behaviors.

• Archives of Plastic Surgery
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• v.50 no.3
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• pp.279-287
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• 2023

Background Hypothenar free flaps (HTFFs) have been widely used for reconstructing palmar defects. Although previous anatomical and clinical studies of HTFF have been conducted, this technique still has some limitations. In this study, we describe some tips for large flap design that allows for easy harvesting of HTFFs with minimal donor site morbidity. Methods A total of 14 HTFF for hand defect reconstruction were recorded. The oblique flap was designed in the proximal HT area following relaxed skin tension line along the axis between fourth web space and 10 mm ulnar side of pisiform. A flap pedicle includes one or two perforators with ulnar digital artery and HT branch of basilic vein. In addition, innervated HTFF can be harvested with a branch of ulnar digital nerve. Electronic medical records were reviewed to obtain data on patients' information, operative details, and follow-up period. In addition, surgical outcome score was obtained from the patient, up to 10 points, at the last follow-up. Results Mean harvest time was 46 minutes, and two perforators were included in 10 cases. The mean flap area was 10.84 cm². There were no problems such as donor site depression, scar contracture, keloids, wound dehiscence, numbness or neuroma pain at donor sites, and hypersensitivity or cold intolerance at flap site, either functionally or aesthetically. Conclusion Palmar defect reconstruction is challenging for hand surgeons. However, large HTFF can be harvested without complications using the oblique axis HTFF technique. We believe our surgical tips increase utility of HTFF for palmar defect reconstruction.

• Journal of the Korean Geotechnical Society
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• v.23 no.5
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• pp.43-51
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• 2007

Frost action may cause extensive damage to building, structures, roads, railways and utility lines in seasonal frost. The research about frost heave of natural ground has been considerably performed. In late years various structures have become complicated with the development of social infrastructure maintenance. Therefore countermeasure to frost heave becomes a matter of great importance from a new viewpoint. This study was aimed at catching natural ground frost heaving force quantitatively. Frost heaving forces on circular steel plates which were set on ground surface were measured in field test. The frost heaving forces arise at freezing front propagates to the structures through frozen soil layer. Besides, a full scale model of multi-anchored retaining wall was installed in field, and the freezing lines, frost heave pressure to act on a wall block, and so on were measured. Finally, the position and shape of frost line were estimated by using numerical simulation and a method to determine replacement range was suggested with soil properties and weather data.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5C
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• pp.303-312
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• 2006

This study is to evaluate the mechanical characteristics of flowable backfill and offer a guide line of mixture proportion based on soil types for constructing underground power utilities. Flowable backfill is known as soil-cement slurry, void fill, and controlled low-strength material(CLSM). The benefits of CLSM are reduced equipment costs, faster construction, re-excavation in the future, and the ability to place materials in confined spaces, which are narrow parts or perimeters of underground power cables nearly impossible for compaction. The flowable slurry mixed with 17 soils and 6 accelerated mixtures in the laboratory were evaluated for flowability and unconfined compressive strength to meet the target values of this study.

• Convergence Security Journal
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• v.24 no.2
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• pp.133-140
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• 2024

The spread of Direct-to-Consumer (DTC) genetic testing, where users request tests directly, has been increasing. With growing demand, certification systems have been implemented to grant testing qualifications to non-medical institutions, and the scope of tests has been expanded. However, unlike cases in less regulated foreign countries, disease-related tests are still excluded from the domestic regulations. The existing de-identification method does not adequately ensure the uniqueness and familial sharing of genomic information, limiting its practical utility. Therefore, this study proposes the application of fully homomorphic encryption in the analysis process to guarantee the usefulness of genomic information while minimizing the risk of leakage. Additionally, to safeguard the individual's right to self-determination, a privacy preservation model based on Opt-out is suggested. This aims to balance genomic information protection with maintainability of usability, ensuring the availability of information in line with the user's preferences.

• Korean Journal of Remote Sensing
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• v.40 no.3
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• pp.257-268
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• 2024

Drone-mounted hyperspectral sensors (DHSs) have revolutionized remote sensing in agriculture by offering a cost-effective and flexible platform for high-resolution spectral data acquisition. Their ability to capture data at low altitudes minimizes atmospheric interference, enhancing their utility in agricultural monitoring and management. This study focused on addressing the challenges of radiometric and geometric distortions in preprocessing drone-acquired hyperspectral data. Radiometric correction, using the empirical line method (ELM) and spectral reference panels, effectively removed sensor noise and variations in solar irradiance, resulting in accurate surface reflectance values. Notably, the ELM correction improved reflectance for measured reference panels by 5-55%, resulting in a more uniform spectral profile across wavelengths, further validated by high correlations (0.97-0.99), despite minor deviations observed at specific wavelengths for some reflectors. Geometric correction, utilizing a rubber sheet transformation with ground control points, successfully rectified distortions caused by sensor orientation and flight path variations, ensuring accurate spatial representation within the image. The effectiveness of geometric correction was assessed using root mean square error(RMSE) analysis, revealing minimal errors in both east-west(0.00 to 0.081 m) and north-south directions(0.00 to 0.076 m).The overall position RMSE of 0.031 meters across 100 points demonstrates high geometric accuracy, exceeding industry standards. Additionally, image mosaicking was performed to create a comprehensive representation of the study area. These results demonstrate the effectiveness of the applied preprocessing techniques and highlight the potential of DHSs for precise crop health monitoring and management in smart agriculture. However, further research is needed to address challenges related to data dimensionality, sensor calibration, and reference data availability, as well as exploring alternative correction methods and evaluating their performance in diverse environmental conditions to enhance the robustness and applicability of hyperspectral data processing in agriculture.

• Journal of Preventive Medicine and Public Health
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• v.12 no.1
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• pp.13-23
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• 1979

A study was carried out from October 1977 to September 1978 in order to develope health care delively system which will meet to rural area in Korea. For the study objective a model of health care delivery system of Myun (township) area was developed which is adopted the net-work of village health voluntary worker who will play the role of bridge for communication related with health and illness between families or village people and health subcenter, and :he model health care delivery system net-work was set in the area of Soodong Myun, Yangju Gun. which is the rural health demonstration area of Ewha Womans University since 1972. The activities and attitude of 22 village health voluntary workers were observed and analized. during the study period. The results are as follows; 1. For the field activities of village health voluntary workers. a guide line which is described with specific behavioral objectives was developed and used for not only training of the workers but also evaluation of their field activities. 2. During the study period, the number of 971 village people were served primary health care service by village health voluntary worker and the service was classified largely into symptomatic medications (92%) and preventive measures (8%). 3. Comparative percentage of the number of 894 symptomatic cases cared by village health voluntary workers to 5,695 cases of patient treated by Soodong Health Subcenter during the same period was 15.7%. 4. Annual utility rate of village health voluntary worker by Myun total people was 16.1% but utility rate by Rie was varied from 38.2% to 2.8% which shown there were considerable differences in each Rie. In order to settle the village health care service, the obstructive factors of utility should be detected and their counter measure must be taken. 5. As the health need of village people increases, it is expected that the supplement of drug excluding present sit basic drugs is inevitable, but considering the ability of village health voluntary worker, the selection of additional drugs and education, plan should be carefully studied. 6. It is desirable that a financial resource for supplementary purchase of first aid kit, drugs and materials whould be alloted from village public fund like Saemaeul Women's Club fund, which has already practiced in a few villages in the study area. 7. As pointed out by village health voluntary workers, in order to improve the village health, village leaders should be in the center of it and the cooperation of whole village people is a core of healthful village development, and it is reasonable that the health subcenter backs up these voluntary health activities by village people in techniques. 8. It seems effective that a supplementary education for village health voluntary worker be accomplished by a planned education through regular meetings like worker's monthly meeting and irregular post guide when Myun Health Workers can handle the problems found during the round trip of villages. 9. It is desirable that village health voluntary workers, who are recommended by a civil voluntary organization like Saemael Woman's Club, are charged by natural villagc unit, are given a function of village health care service and used through basic education at health subcenter. 10. It is advisable that the village health voluntary worker's service is compensated not by a form of money, but by other way such as an exemption of medical fee of worker herself or her families in health subcenter can be one method. 11. Daily health activities of each village health voluntary worker should be reported to health subcenter by biweekly or monthly in order to get not only for basic data of the program but also for evaluation the program. It is recomandable that the report form should be simple and clear enough for village health voluntary worker to fill it effectively. 12. Village health care service should be developed into a Saemaeul Movement in which village people actively participate. For this, the appointed function of village health voluntary worker should be absorbed into those of living Environment Betterment Section or Family Planning Section of Saemaeul Women's Club or it is desirable that establish a new section, Village Health Promoting Section and make it involve the appointed functions of those sections mentioned above.

• Journal of radiological science and technology
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• v.38 no.3
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• pp.229-235
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• 2015

Mammoplasty is currently increasing not only for cosmetic surgery, but as well as for the recovery after breast cancer surgery. The prostheses inserted into the breasts of women who have undergone mammoplasty, hide the breast substances and it is becoming increasingly difficult to diagnose breast disease, and fear is growing by the concern of the prostheses bursting by the strap. So we want to develop a strap applicable to women with prostheses inserted, to determine the usefulness, and we also want to compare the utility by comparing the total area of the Inner and Outer parts of the breast and Posterior Nipple Line (PNL), after obtaining video by applying the existing strap and the developed strap to phantom of the prostheses inserted patient shape. When the pressure by the developed pressure, the total area increased by 10.09% from CC view to $9,813.797mm^2$, 3.88% from CC-ID view to $7,621.531mm^2$, PNL increased by 3.41% from CC view to $90.916mm^2$, 1.64% from CC-ID view to$75.357mm^2$. And the breast tissue of the thorax side increased 3.53% from CC view to $177.725mm^2$, and 6.57% from CC-ID view to $152.510mm^2$, and we could verify that the prostheses were completely eliminated in the CC-ID images of developed strap, compared with the existing strap.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6159-6164
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• 2013

Background: Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to investigate the potential effcts of thymoquinone, caffeic acid phenylester (CAPE) and resveratrol on inflammatory markers, oxidative stress parameters, mRNA expression levels of proteins and survival of lung cancer cells in Vitro. Materials and Methods: The A549 cell line was treated with benzo(a)pyrene, benzo(a)pyrene plus caffeic acid phenylester (CAPE), benzo(a)pyrene plus resveratrol (RES), and benzo(a)pyrene plus thymoquinone (TQ). Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and anti-apoptotic proteins and cell viability were assessed and results were compared among study groups. Results: TQ treatment up-regulated Bax and down-regulated Bcl2 proteins and increased the Bax/Bcl2 ratio. CAPE and TQ also up-regulated Bax expression. RES and TQ down-regulated the expression of Bcl-2. All three agents decreased the expression of cyclin D and increased the expression of p21. However, the most significant up-regulation of p21 expression was observed in TQ treated cells. CAPE, RES and TQ up-regulated TRAIL receptor 1 and 2 expression. RES and TQ down-regulated the expression of NF-kappa B and IKK1. Viability of CAPE, RES and TQ treated cells was found to be significantly decreased when compared with the control group (p=0.004). Conclusions: Our results revealed up-regulation of the key upstream signaling factors, which ultimately cause increase in their regulatory p53 levels affecting the induction of G2/M cell cycle arrest and apoptosis. Overall these results provide mechanistic insights for understanding the molecular basis and utility of the anti-tumor activity of TQ, RES and CAPE.