• 대한의생명과학회지
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• 제16권2호
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• pp.113-118
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• 2010

The purpose of this study was to investigate the effects of angular velocity on muscle strength and blood constituent. Subjects was classified into two groups, which were $60^{\circ}/sec$ angular velocity group (n=8), and $240^{\circ}/sec$ angular velocity group (n=8). Each group was applied to perform the isokinetic exercises on extensor muscle group for each 7 times in 10 set (3 days per a week for 3 weeks). Muscle strength was measured using peak torque of quadriceps femoris and blood constituent was measured using RBC, WBC and Hb. The peak torque was more significantly increased after 3 weeks application of $60^{\circ}/sec$ angular velocity group than $240^{\circ}/sec$ angular velocity group. The RBC and Hb were more significantly increased after 3 weeks application of $60^{\circ}/sec$ angular velocity group than $240^{\circ}/sec$ angular velocity group. But WBC was more significantly increased after 3 weeks application of $240^{\circ}/sec$ angular velocity group than $60^{\circ}/sec$ angular velocity group. These results indicate that $60^{\circ}/sec$ angular velocity isokinetic exercise application were effective treatment strategy on increase of muscle strength. But $240^{\circ}/sec$ angular velocity isokinetic exercise application were effective treatment strategy on immune protect system.

• 한국분무공학회지
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• 제16권3호
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• pp.134-139
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• 2011

Recent research has focused on engine combustion technology as well as application of after-treatment in order to comply with emission regulation. However, it is much more efficient way to control emissions from engine itself and furthermore research on engine control will provide the direction of after-treatment technology in future. Furthermore, emission standard regulation for passenger diesel vehicles has been stringent compared to others and nano-particles will be included in EURO6 regulation in Europe and similar emission standard will be introduced in Korea. A 3.0 liter high speed diesel engine equipped with by CRDI system of 160MPa injection pressure, and an intake/exhaust system of V type 6 cylinder turbo-intercooler was applied. The injection duration and injection quantity, pilot injection types which are related to CRDI and air/fuel ratio control applied by EVGT were changed simultaneously. Standard experiment procedure constituted dilution apparatus and CPC system to collect nano-particles and these test results were compared with regulated materials of CO, HC, NOx and investigated their relations and characteristics of nano-particles.

• Bulletin of the Korean Chemical Society
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• 제30권11호
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• pp.2574-2576
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• 2009

In this work, we describe a new sensor that specifically responds to biothiols, i.e., glutathione (GSH), in solution. An electrochemical transducing strategy was utilized and cyclic voltammetry (CV) was employed to monitor the presence of GSH in real time. Our approach harnessed self-assembled monolayers (SAMs) on gold consisting of an alkanethiolate which was terminated by electroactive quininoid moiety. Prior to thiol molecule treatment, the characterisitc reversible redox peaks of the electroactive quininoid group was observed, while the reduction peak was dramatically shifted upon a treatment of GSH. This sensor showed the capability to detect the GSH in solution in the range of 1 mM $\sim$ 100 aM. We believe that this strategy will provide an important tool for accurate, sensitive, rapid, and low-cost determination of GSH.

• 동의신경정신과학회지
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• 제22권3호
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• pp.101-113
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• 2011

Objectives : Trend of R&D of herbal medicine for dementia treatment was examined based on the quantitative information analysis for establishing the national strategy of research on dementia treatment with oriental medicine. Methods : Definition was made to clarify the technology for development of herbal medicine for dementia treatment. Based on the initial keyword provided by experts in the field, queries were compounded to conduct search in the search engines of WoS and DWPI. The raw data (papers or patents) extracted from the initial search were examined by expert-review before objects of analysis were determined. Then, the accumulated data was analyzed in terms of year, country and organization, which led to examination of the trend of R&D. And the research performance evaluation for dementia treatment technologies was also made in terms of country, organization and researcher based on the forward citation analysis. The international cooperation intensity was examined on the basis of analysis of network by researcher before analysis results were put together to select lead researchers. Results : According to the quantitative information analysis of 1,330 articles that were selected as analysis objects, the number of papers on natural products research for dementia treatment has increased by around 4.6 times in recent five years. This indicates that the intensive studies have been underway recently. It was found to be the US that had the highest level in research filed of herbal medicine for dementia treatment and the highest capacity of international cooperation for that purpose. On the contrary, Korea had the share of papers at 5.1%, the number of countries in cooperation research at 8, and the article quality index at 0.40, showing that the qualitative level was insufficient, compared to the quantitative outcome. In particular, Korea was found to have no intensity of international cooperation among researchers. In case of patent, the results of information analysis of 305 patents selected as analysis objects demonstrated that China had the highest share while Korea had the very low frequency of patent application quantitatively. Conclusions : In this study, the research to develop herbal medicine for dementia treatment has recently drawn much attention that has spread around the globe. Therefore, these results suggest establishing the strategy to develop technology for dementia treatment with oriental medicine in the future based on quantitative information analysis.

• 한국어병학회지
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• 제26권3호
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• pp.275-282
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• 2013

활성처리제는 40~200배의 희석액에 최단시간 1분, 최장시간 3분 침지 후의 방사무늬김과 파래의 사세포율은 방사무늬김은 유엽 및 성엽 모두 100~150배 희석율이 사세포율이 낮게 나타났으며, 파래는 희석배율과 침지시간에 관계없이 90%이상 파래가 사멸하였다. 현장시험에서 방사무늬김 세포의 사세포율은 처리시기에 따라 차이가 나지만 처리 전은 2.1~17.6%였으며, 처리 후에는 2.1~15.0%로 처리 전후의 사세포율에는 차이가 없었다. 파래의 사세포율은 처리전에는 0~4.6%였지만, 처리 후에는 99.0~100%로 활성처리제의 처리는 파래 제거에 매우 효과적이었다. 또한 활성처리제 처리는 엽체의 부착 규조류는 33.3-97.2%, 부착 생균수는 1/10~1/100,000로 감소시킨 반면 엽체의 색택에는 영향을 미치지 않았다. 그러므로 방사무늬김 엽체의 상태와 수온 등을 고려하여 본 활성처리제를 100~150배의 희석농도에 1~3분간 처리함으로써 파래의 제거, 부착 규조류의 탈락, 엽체 부착 생균수의 감소 효과가 있으며, 방사무늬김의 색택에는 별다른 영향을 미치지 않아 방사무늬김 활성처리제로서 유효한 것으로 나타났다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.291-294
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• 2010

$CO_2$ is known as the major source of the green house effect and the volume produced from electricity generation and transportation sector in Korea constitutes the large portion. In order to reduce the green house effect, several treatment methods can be the major research topics such as the scheme to fundamentally restrict the production of $CO_2$ creation, to perfectly sequestrate the produced $CO_2$, to reuse the separated $CO_2$, or to permanently dispose $CO_2$ in an appropriate storage site. Among of them, R&D strategy and geotechnical research issues are explored in this paper in an effort to realize geological storage for the sequestrated $CO_2$ in local storage sites. $CO_2$ is known as the major source of the green house effect and the volume produced from electricity generation and transportation sector in Korea constitutes the large portion. In order to reduce the green house effect, several treatment methods can be the major research topics such as the scheme to fundamentally restrict the production of $CO_2$ creation, to perfectly sequestrate the produced $CO_2$, to reuse the separated $CO_2$, or to permanently dispose $CO_2$ in an appropriate storage site. Among of them, R&D strategy and geotechnical research issues are explored in this paper in an effort to realize geological storage for the sequestrated $CO_2$ in local storage sites.

• 대한두경부종양학회지
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• 제27권1호
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• pp.38-41
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• 2011

Background and Objectives : Although it is well established that patients with papillary thyroid microcarcinoma (PTMC) have a highly favorable prognosis, the extent of thyroid surgery for PTMC remains unclear. According to the 2011 revised Korean Thyroid Association guideline, the choice of surgical strategy(total thyroidectomy versus lobectomy) for PTMC depends on solely preoperative diagnostic scrutinies-ultrasonography and fine needle aspiration cytology. We want to know how accurately these preoperative diagnostic scrutinies define the choice of surgical strategy for PTMC. Materials and Methods : For 119 patients who underwent total thyroidectomy with central neck dissection for PTMC, retrospectively, we compared the choice of surgery according to preoperative work up and postoperative pathologic findings. Results : Overall accuracy of the choice of surgery by preoperative work up was 61%. Among patients recommended lobectomy on preoperative work up, completion thyroidectomy on postoperative pathology might be necessary for 60% of patients and hidden central node metastasis was revealed in 31% of patients. Conclusions : The results of this study compel us to reinvestigate the current treatment guideline for PTMC. On current guideline according to the sonography and fine needle aspiration cytology, it might be thought to be better to choose more aggressive surgical strategy.

• 한국과학교육학회지
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• 제21권4호
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• pp.738-744
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• 2001

본 연구에서는 문제 해결 교수 방법의 효과를 조사하였다. 새로운 교수 방법은 계획과 검토 단계를 강조한 4단계 문제 해결 전략과 학생들의 문제 해결 수행을 점검하기 위한 해결자 청취자 활동으로 구성되어 있다. 고등학교 이과 2학년 2개 학급을 처치 집단과 통제 집단으로 무선 배치하였다. 수업 전에 수업참여도에 대한 인식과 자아효능감 검사를 실시하여 그 점수를 공변인으로 사용하였다. 수업 후에는 학생들의 화학 문제 해결력, 수업 참여도에 대한 인식, 자아효능감을 조사하였다. 연구 결과, 화학 문제 해결력 검사와 수업 참여도에 대한 인식 검사에서는 처치 집단의 접수가 통제 집단에 비해 유의미하게 높았다. 그러나 자아효능감 검사에서는 두 집단 간에 유의미한 차이가 없었다.

• 대한후두음성언어의학회지
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• 제30권1호
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• pp.15-20
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• 2019

Background and Objectives : The goal of this study is to present a strategy for improving the self-regulation (SR) ability and facilitating the change of vocal behavior by applying voice therapy using the SR concept to the patients with vocal cord nodule and muscle tension dysphonia. Materials and Method : The subjects were 80 patients and 80 patients who were diagnosed with muscle tension dysphonia and vocal nodules. As a control group, the results were compared among patients with the same dysphonia without using SR strategies. The concept of SR before voice therapy was explained to the patients, and the treatment was divided into three stages according to the goal of voice therapy. The treatment stages consist of 1) skill acquisition, 2) habit formation, and 3) habit changes. voice therapy was performed by applying SR strategies such as goal implementation intentions and a less routine behavior. Patient's dropout rates were measured to compare the adherence of voice therapy. Results : Significant improvement was seen in all groups receiving voice therapy. However, in the group using the SR strategy, the voice analysis results showed a relatively low dropout rate of voice therapy. In the generalization confirmation stage, patients who applied SR concept showed better results. SR strategy did no longer be necessary to maintain newly adopted vocal behavior. Conclusion : The results of this study show that SR is one of the cognitive factors that can have a significant impact on the outcome of voice therapy, and also has a positive impact on the acquisition and generalization of new skills. A better understanding of SR and the development of therapeutic strategies using it will play an important role in solving voice problems in clinical settings.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.