• Clinical and Experimental Reproductive Medicine
• /
• v.38 no.2
• /
• pp.68-74
• /
• 2011

Objective: Previously, we found that oocyte specific homeobox (Obox) 4 plays significant role in completion of meiosis specifically at meiosis I-meiosis II (MI-MII) transition. The purpose of this study was to determine the mechanism of action of $Obox4$ in oocyte maturation by evaluating downstream signal networking. Methods: The $Obox4$ dsRNA was prepared by $in$ $vitro$ transcription and microinjected into the cytoplasm of germinal vesicle oocytes followed by $in$ $vitro$ maturation in the presence or absence of 0.2 mM 3-isobutyl-1-metyl-xanthine. Total RNA was extracted from 200 oocytes of each group using a PicoPure RNA isolation kit then amplified two-rounds. The probe hybridization and data analysis were used by Affymetrix Gene-Chip$^{(R)}$ Mouse Genome 430 2.0 array and GenPlex 3.0 (ISTECH, Korea) software, respectively. Results: Total 424 genes were up (n=80) and down (n=344) regulated after $Obox4$ RNA interference (RNAi). Genes mainly related to metabolic pathways and mitogen-activated protein kinase (MAPK) signaling pathway was changed. Among the protein kinase C (PKC) isoforms, PKC-alpha, beta, gamma were down-regulated and especially the MAPK signaling pathway PKC-gamma was dramatically decreased by $Obox4$ RNAi. In the cell cycle pathway, we evaluated the expression of genes involved in regulation of chromosome separation, and found that these genes were down-regulated. It may cause the aberrant chromosome segregation during MI-MII transition. Conclusion: From the results of this study, it is concluded that $Obox4$ is important upstream regulator of the PKC and anaphase-promoting complex action for maintaining intact germinal vesicle.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.36 no.4
• /
• pp.245-254
• /
• 2018

Impact of tropospheric correction techniques on accuracy of the GPS (Global Positioning System) derived ellipsoidal heights has been experimentally assessed in this paper. To this end, 247 baselines were constructed from a total of 88 CORS (Continuously Operating Reference Stations) in Korea. The GPS measurements for seven days, acquired from the so-called integrated GNSS (Global Navigation Satellite Systems) data center via internet connection, have been processed by two baseline processing software packages with an application of the empirical models, such as Hopfield, modified Hopfield and Saastamoinen, and the estimation techniques based on the DD (Double-Differenced) measurements and the PPP (Precise Point Positioning) technique; hence a total number of the baseline processed and tested was 8,645. Accuracy and precision of the estimated heights from the various correction schemes were analyzed about baseline lengths and height differences of the testing baselines. Details of these results are summarized with a view to hopefully providing an overall guideline of a suitable selection of the modeling scheme with respect to processing conditions, such as the baseline length and the height differences.

• Journal of Environmental Science International
• /
• v.25 no.5
• /
• pp.737-744
• /
• 2016

For electrolysis process using an insoluble electrode, electrochemical performance was greatly affected by the manufacturing method and procedure, such as the firing temperature, pre-treatment, type of precursor solution, coating method, electrode material, etc. Components of the electrode therein is one of the most important factors in electrochemical reaction. To achieve such characteristics, a appropriate ratio of the electrode material should be carefully chosen. The aim of this research was to apply experimental design method in the optimization of electrode component for the maximum generation of oxidants in electrochemical oxidation process. Mixture design, especially expanded simplex lattice design, in DOME (design of mixture experiments) with Design Expert - commercial software - was used to analyze the data. Analysis of variance (ANOVA) showed a high coefficient of determination ($R^2$) value of 0.9470, thus ensuring a satisfactory adjustment of the $3^{rd}$ order special cubic regression model with the experimental data. The application of response surface methodology (RSM) yielded the following regression equation, which is an empirical relationship between the TRO generation concentration and independent variables(mol ratio of 3 electrode components) in a real unit: TRO generation concentration $(mg/L)=TRO\;conc.=98.25{\times}[Ir]+49.71{\times}[Sn]+95.29{\times}[Sb]-16.91{\times}[Ir]{\times}[Sn]-29.47{\times}[Ir]{\times}[Sb]-22.65{\times}[Sn]{\times}[Sb]+703.19{\times}[Ir]{\times}[Sn]{\times}[Sb]$. The optimized formulation of the 3 component electrode for an high TRO (total residual oxidants) generation was acquired at mol ratio of Ir 0.406, Sn 0.210, Sb 0.384 (desirability d value, 1).

• Korean Journal of Community Nutrition
• /
• v.13 no.3
• /
• pp.396-404
• /
• 2008

This study aimed to evaluate the amount of patients' satisfaction with hospital foodservices among those who were benefited from national health insurance during their hospitalization. A total of 3,094 inpatients from 191 medical institutions were enrolled in this survey. The survey was carried out from July 23 to September 14, 2007 through the face-to-face interview method. All analyses were made using the SPSS software (version 13.0). The mean age of the participants was 53.3 years, 57.0% were women; 34.7% were high-school graduates. Among the respondents, 30.9% stayed in the hospital for $7{\sim}14$ days long, and 52.0% were hospitalized in multi-patient rooms for six persons. The 87.7% of total population had a general diet, and 9.6% selected the food menu that was notcovered by health insurance. In addition, 38.3% of patients regarded the fee of foodservice as inexpensive. Overall, the satisfaction score with hospital foodservice was 3.63 on a Likert-type scale ranging from 1 (extremely dissatisfied) to 5 (extremely satisfied). However, the limitations were indicated including the lack of providing nutritional information and quality of taste. In conclusion, the quality of hospital foodservice might not deteriorate even after enforcement of national payment of medical insurance. Further efforts are required for the diversification of menus and legislative work for improving quality of food service for a successful hospital foodservice policy.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.22 no.3
• /
• pp.399-410
• /
• 2018

In Android smartphones, many apps are developed as service apps to run in the background. If the memory is insufficient, Android forcibly terminates not only user apps that have not used the CPU for a long time, but also service apps. However, a service app is automatically re-launched after a short period of time, so that it continuously consumes memory space. This paper analyzes the number of running service apps and their memory usage in users' smartphones. The number of service apps accounts for up to 65% of the total number of running apps, and their memory usage accounts for up to 55% of the total memory. Moreover, we investigate the effect of the number of running service apps on the response time of smartphones and apps. As the number of service apps increases, the launching time of user apps increases to 22 times. The booting time and app installation time significantly increase with the number of service apps.

• Journal of the Korea Society of Computer and Information
• /
• v.20 no.8
• /
• pp.121-128
• /
• 2015

This study aimed to investigate the effects of an unplugged robot education system capable of computerless coding education. Specifically, this study compared this education system with PicoCricket, an educational robot that can also be used with elementary students in lower grades, using assessment tools on perceived usefulness and ease. Using random sampling and randomized assignment for more objective validation, 30 participants were assigned to the unplugged robot education system group (experimental group) and 30 participants were assigned to the PicoCricket group (control group), for a total of 60 study participants. The research procedure included verification of the equivalence of the two groups by conducting a pretest after a 2-hour basic training session on algorithms and programming. The experimental and control groups learned the same content using different educational tools in accordance with software training guidelines for a total of 12 hours. Then, the difference in perceived usefulness and ease between the two groups was examined using a post-treatment test. The study results showed that scores on both dependent variables, perceived usefulness and perceived ease, were significantly higher in the experimental group than the control group. Moreover, scores on all sub-variables of the dependent variables were significantly higher in the experimental group than the control group. These results suggest that learners using the unplugged robot education system found it more useful and easier to use than learners using the existing educational robot, PicoCricket. This study's findings are significant, as according to the technology acceptance model, the perceived usefulness and ease of an educational tool are important variables that determine the acceptance of the tool (i.e., persistence of learning).

• Korean Journal of Occupational Health Nursing
• /
• v.28 no.1
• /
• pp.12-20
• /
• 2019

Purpose: This descriptive study aimed to explore the effects of bullying, health promotion lifestyles, and physical symptoms on the occupational stress of new nurses in general hospitals. Methods: The participants of this study were 157 new nurses in fivegeneral hospitals with 100 to 399 beds in Gyeonggi-do. Data were collected from January to February, 2018, using a structured questionnaire and analyzed using the SPSS software version 20. Results: A total of 60.5% of the participants experienced bullying, and 38.2% experienced bullying more than 10 times a month. The perceived severity of bullying was severe (32.4%) and the nurses' first bullying experience began within the first six months (47.7%). Their occupational stress was scored 3.1. The regression model for occupational stressors was significant (F=23.86, p<.001), and the total explanatory power was 46.8%. The variables affecting occupational stress were bullying awareness (${\beta}=-.30$, p<.001), preceptor satisfaction (${\beta}=-.30$, p<.001), and health promotion lifestyles (${\beta}=-.26$, p=.001). Conclusion: It is important to reduce the incidence of bullying in order to help new nurses with high occupational stress. Stress management programs are needed to improve relationships between new nurses and preceptors and to encourage their health promotion lifestyles.

• Journal of the Korea Convergence Society
• /
• v.9 no.12
• /
• pp.1-7
• /
• 2018

Gentry is responsible for moving the fine chip in the device that mounts the chip on the PCB. However, it is not easy to increase productivity because of the mechanical limitations of the gantry. Therefore, in this paper, we try to solve the method to increase the productivity by software. For this purpose, we propose a method to improve the productivity by shortening the movement time of the gantry. First, we calculated the total travel time for the current method(stop-motion). In addition, the total travel time is also calculated for the travel time reduction method presented in this paper. This method reduces the travel time by checking parts without stopping in front of the camera. As a result, we showed that the proposed method shortened the time of 16%. In the future, we will study time calculation methods for other types.

• Journal of Korean Society for Quality Management
• /
• v.47 no.1
• /
• pp.17-32
• /
• 2019

Purpose: CMMI is a process model used to assess or improve an organization's software development capabilities. This paper deals with the quality indicators when using CMMI and their priorities for possible improvement. Methods: The 22 process areas and 167 practices of CMMI are matched with 60 indicators of Quality Scorecard(QSC) first to analyze the balance of CMMI in terms of prevention, appraisal, and final result categories and second to isolate a set of key areas for quality focused performance measures. Results: A total of 86.2% (144 out of 167) CMMI practices were mapped to QSC. According to the CMMI level of maturity, level 2 and 3 accounted for more than 75% of the total. The practices at the maturity level of 4 and 5 were mapped to more than 52% of the final result's measurements. It has been observed that CMMI practices need further elaboration at higher levels to consider prevention, appraisal, and final results simultaneously. Conclusion: In order to improve the quality performance of the organization by applying CMMI, the final result measures should be refined in metrics, cycles, and methods, and then corrective actions could be conducted to improve the performance of CMMI practices. This strategy would help the practitioners benefit from CMMI in fostering the overall quality level of key activities for the organization's business goals.

• Asian-Australasian Journal of Animal Sciences
• /
• v.32 no.3
• /
• pp.341-349
• /
• 2019

Objective: Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later layer period will allow full utilization of layer hens. Hence, we conducted a genome-wide association study (GWAS) to identify potential quantitative trait loci or genes that potentially contribute to internal organ weight. Methods: A total of 1,512 chickens originating from White Leghorn and Dongxiang Blue-Shelled chickens were genotyped using high-density Affymetrix 600 K single nucleotide polymorphism (SNP) array. We conducted a GWAS, linkage disequilibrium analysis, and heritability estimated based on SNP information by using GEMMA, Haploview and GCTA software. Results: Our results displayed that internal organ weights show moderate to high (0.283 to 0.640) heritability. Variance partitioned across chromosomes and chromosome lengths had a linear relationship for liver weight and gizzard weight ($R^2=0.493$, 0.753). A total of 23 highly significant SNPs that associated with all internal organ weights were mainly located on Gallus gallus autosome (GGA) 1 and GGA4. Six SNPs on GGA2 affected heart weight. After the final analysis, five top SNPs were in or near genes 5-Hydroxytryptamine receptor 2A, general transcription factor IIF polypeptide 2, WD repeat and FYVE domain containing 2, non-SMC condensin I complex subunit G, and sonic hedgehog, which were considered as candidate genes having a pervasive role in internal organ weights. Conclusion: Our findings provide an understanding of the underlying genetic architecture of internal organs and are beneficial in the selection of chickens.