• The Journal of KAIRB
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• v.2 no.1
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• pp.6-22
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• 2020

Purpose: Clinical studies require institutional review board (IRB) approval based on the ethical principle and regulations. While the number of clinical studies has been increased and diversified, duplicated IRB review for multi-center studies has become a major issue. Therefore, single IRB system has been suggested in revised Common Rule. This study aimed to identify and assess the current status of single IRB in Korea and the anticipated needs of single IRB from researchers and IRB member or administrators. Methods: We developed 14 questions including perceived advantages and disadvantages of single IRB, and anticipated problems. The online survey collected opinions on single IRB from researchers, IRB members and IRB administrators. We also interviewed five IRB administrators who have an experience of single IRB. Results: A total of 80 responses were analyzed in this study. Although efficiencies were suggested for the advantages of single IRB in terms of reducing burden of duplicated review, respondents also perceived that the different review criteria between single IRB and each IRB would be a major hurdle for adopting single IRB system. Therefore, the standardization of standard of procedures (SOP) and the standardization of IRB submission materials should be preceded. According to the small group experiences of single IRB in Korea, we also observed the similar anticipated problems of single IRB. Conclusion: Single IRB system has many advantages for conducting multi-center trial. However, many specialists still have a lot of concerns about introducing a single IRB system in Korea. Therefore, a gradual, step-by-step process for conducting a single IRB system in Korea will be needed. Many studies for improving currently suggested single IRB system and the improvement of awareness about the essential of single IRB system would be needed.

• Analytical Science and Technology
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• v.20 no.5
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• pp.393-399
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• 2007

In principle, the blood galactose level may be determined conveniently with a strip-type biosensor similar to that for glucose. In this study, we describe the development of a disposable galactose biosensor strip for point-of-care testing. The sensor strip is constructed with screen-printed carbon paste electrode (SPCE) and sample amount (< $100{\mu}L$). The developed strip the galactose level in less than 90 s using bienzymatic system of galactose oxidase (GAO) and horseradish peroxidase (HRP). The effects of pH, mediator (1,1-ferrocenedimethanol) concentration, ratio of enzymes, and applied potential were determined preliminarily with glassy carbon electrodes, and optimized further with the strip-type electrodes. The sensor exhibits linear response in the range of $0{\sim}400{\mu}M$ ($r^2$ = 0.997, S/N = 3). Since a low working potential, in principle, the fabricated disposable galactose biosensor has -100 mV (vs. Ag/AgCl), it is applied for the detection of galactose, interfering responses from common interferents such as ascorbic acid, uric acid and acetaminophen could be minimized. The sensor has been used to determine the total galactose level in standard samples with satisfactory reproducibility (CV = 5 %).

• The Journal of the Korea Contents Association
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• v.22 no.5
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• pp.203-213
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• 2022

This study aims to examine the impact of decline in quality of life on perceived fairness and support for real estate deregulation. The rise of dissatisfaction due to the deterioration in the quality of life can increase the blame for the unfairness of the external social system, which may boost support for government-led market regulation to correct such unfairness. This impact of perceived fairness on quality of life furthermore could be more pronounced when the prospect of upward social mobility is pessimistic. That is, when people expect that they are more likely to be the socially underprivileged who are to be more vulnerable to the fallout from the unfair operation of social system, the possibility of associating the deterioration in quality of life and the decrease in perceived fairness could be more pronounced. To test these predictions, this study used the dataset comprising a total of 6,300 survey responses and substantiated such predictions. Overall, these results not only offer an opportunity to take a more detailed look at the underlying causes of the recent rise of the issue of fairness, but also contribute to broadening the understanding of how individual support for government's deregulation of real estate varies as a function of perceived fairness and prospect of upward social mobility.

• 한국노년학
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• v.29 no.1
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• pp.117-134
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• 2009

The purpose of this study was designed to develop an questionnaire for healthy aging. The subjects of this study were total 335 people who participated in regular exercise and went to welfare centers in Seoul. The validity and reliability were tested for verifying the developed questionnaire for healthy aging. The data were collected between June 12, 2006 and October 27, 2006. The mean, standard deviation, kurtosis, skewness, reliability, exploratory factor analysis and confirmatory factor were analyzed for statistical purpose using by SPSS-Win 12.0 program. The results were as follows; First, to obtain content validity, the results of previous research and the value system responses were submitted to a judgement group. Second, the results of the factor analysis of the 20 items making up the questionnaire were classified into the following 3 factors; physiological health(6 items), cognitive-mental health(6 items), social-support health(8 items). Third, the reliability of the questionnaire for healthy aging was 0.891(Cronbach's alpha). In the factor analysis Cronbach's alpha correlations for the 4 factors ranged from 0.642 to 0.885. Fourth, the results of confirmatory factor analysis, all the index values(NFI, RFI, CFI, Delta 2 IFI) were close to 1. Thus, this questionnaire demonstrated good reliability and validity and therefore it was an appropriate measurement of healthy aging.

• Journal of Veterinary Science
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• v.24 no.5
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• pp.73.1-73.16
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• 2023

Background: Highly pathogenic avian influenza virus (HPAIV) is considered a global threat to both human health and the poultry industry. MicroRNAs (miRNA) can modulate the immune system by affecting gene expression patterns in HPAIV-infected chickens. Objectives: To gain further insights into the role of miRNAs in immune responses against H5N1 infection, as well as the development of strategies for breeding disease-resistant chickens, we characterized miRNA expression patterns in tracheal tissues from H5N1-infected Ri chickens. Methods: miRNAs expression was analyzed from two H5N1-infected Ri chicken lines using small RNA sequencing. The target genes of differentially expressed (DE) miRNAs were predicted using miRDB. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were then conducted. Furthermore, using quantitative real-time polymerase chain reaction, we validated the expression levels of DE miRNAs (miR-22-3p, miR-146b-3p, miR27b-3p, miR-128-3p, miR-2188-5p, miR-451, miR-205a, miR-203a, miR-21-3p, and miR-200a3p) from all comparisons and their immune-related target genes. Results: A total of 53 miRNAs were significantly expressed in the infection samples of the resistant compared to the susceptible line. Network analyses between the DE miRNAs and target genes revealed that DE miRNAs may regulate the expression of target genes involved in the transforming growth factor-beta, mitogen-activated protein kinase, and Toll-like receptor signaling pathways, all of which are related to influenza A virus progression. Conclusions: Collectively, our results provided novel insights into the miRNA expression patterns of tracheal tissues from H5N1-infected Ri chickens. More importantly, our findings offer insights into the relationship between miRNA and immune-related target genes and the role of miRNA in HPAIV infections in chickens.

• Korean Journal of Psychosomatic Medicine
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• v.31 no.2
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• pp.72-78
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• 2023

Objectives : This study aims to identify various psychiatric symptoms and psychosomatic symptoms caused by COVID-19 infection and investigate their long-term impact. Methods : A systematic literature review was conducted, selecting papers from domestic and international databases using keywords such as "COVID-19" and "psychosomatic." A total of 16 papers, including those using structured measurement tools for psychosomatic symptoms, were included in the final analysis. Results : Psychiatric symptoms such as anxiety, depression, and somatic symptoms have been reported in acute COVID-19 infection, while long-term post-COVID symptoms include chest pain and fatigue. The frequency of long-term psychosomatic symptoms has been estimated to be 10%-20%. Factors contributing to these symptoms include psychological and social stress related to infectious diseases, gender, elderly age, a history of psychiatric disorders, and comorbid mental illnesses. It is suggested that systemic inflammation, autoimmune responses, and dysregulation of the autonomic nervous system may be involved. Conclusions : Psychosomatic symptoms arising after COVID-19 infection have a negative impact on quality of life and psychosocial functioning. Understanding and addressing psychiatric aspects are crucial for symptom prevention and treatment.

• Journal of Food Hygiene and Safety
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• v.38 no.6
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• pp.442-448
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• 2023

This study aimed to prepare kombucha, a fermented tea beverage, containing Dendropanax morbiferus (DM) leaves and roots, and analyze its antioxidant and intracellular activities. We compared the pH change, total acidity, radical scavenging activity, and oxygen radical absorbance capacity (ORAC) of kombucha fermented with black tea alone and that with added DM leaves or roots during fermentation. Using RAW 264.7, we evaluated the effects of kombucha containing different DM parts on nitric oxide (NO) production and inflammation-related cytokine content in cells. Kombucha containing ethanol extracts of DM leaves (BTK-E-DML) and roots (BTK-E-DMR) showed higher radical scavenging activity and ORAC 3 d after fermentation than that prepared from black tea alone (BTK-Ori). In an in vitro experiment using RAW 264.7, samples were treated with 8 mg/mL kombucha considering cytotoxicity; the lipopolysaccharide (LPS)-induced NO content significantly reduced after BTK-E-DML and BTK-EDMR treatments compared with that after BTK-Ori treatment. Additionally, the levels of interleukin-6 and tumor necrosis factor-alpha, which were LPS-stimulated inflammatory cytokines, significantly decreased in cells treated with BTK-E-DML and BTK-E-DMR 15 d after fermentation compared with those treated with BTK-Ori. In conclusion, these results demonstrate that kombucha fermented with the leaves and roots of DM increases antioxidant activity and can significantly regulate inflammatory responses at the cellular level.

• Korea Trade Review
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• v.48 no.2
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• pp.45-69
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• 2023

The advent of the 4th industrial technology brought about various changes and innovations in the overall industry, but the digitalization of the logistics industry, which involved complicated paperwork processes and various stakeholders, was somewhat behind compared to other industries. However, changes and innovations related to digitalization in the logistics industry began to accelerate due to the impact of COVID-19. This study is to check the digitalization status of container liners accelerated by these changes, analyze the impact of such changes on customer satisfaction and behavioral intention. In this study, a questionnaire survey was conducted for 30 days targeting workers in the logistics industry who had experience using digitalization products of container shipping companies, and a total of 144 questionnaire responses were used to verify hypotheses. To summarize the results of this study, first, it was confirmed that perceived ease of use has a positive (+) effect on perceived usefulness. Second, perceived ease of use was found to have a positive (+) effect on customer satisfaction. Third, it was found that perceived usefulness had a positive (+) effect on customer satisfaction. Fourth, perceived usefulness has a positive (+) effect on behavioral intention. Fifth, it was found that customer satisfaction had a positive (+) effect on behavioral intention. Summarizing the results of the study, it can be summarized that the digitization of regular shipping companies is convenient to use and has a positive effect on customer satisfaction and behavioral intention if it is useful.

• Journal of Environmental Health Sciences
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• v.49 no.6
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• pp.372-379
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• 2023

Background: Laundry workers are known to be exposed to organic solvents in various works including dry cleaning. Long-term exposure to organic solvents may cause adverse health effects among laundry workers. Objectives: To investigate the association between exposure to organic solvents and symptom of headache or eyestrain among laundry workers. Methods: The subjects were total 267 laundry workers who participated in the 6th Korean Working Conditions Survey (KWCS). Responses to exposure to 'inhalation of vapor from organic solvent' was categorized into two (non-exposed: rarely or absolutely not exposed during working hours; exposed: ≥1/4 working hours) or three (non-exposed; low exposure: 1/4 of the working hours; high exposure: ≥1/2 working hours) groups. Logistic regression analysis was performed to evaluate the association between exposure to organic solvents and symptom of headache or eyestrain in the last 12 months among laundry workers. Odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated for experience of the symptom of headache or eyestrain with adjustment for age, sex, education, workplace size (by the number of workers), working hours per week, and current working period (year). Results: The proportions of exposure groups, i.e., non-exposed, low exposure, and high exposure, were 80.4%, 11.1%, and 8.5%, respectively. The proportion of those who had symptom of headache or eyestrain in the last 12 months was 18.7%. There was a significant association between exposure to organic solvents and experience of headache or eyestrain (OR=3.2, 95% CI=1.4~7.4). And, the proportion of those who experienced symptom of headache or eyestrain tended to increase significantly as the level of exposure to organic solvents increased (P_trend=0.002). Conclusions: Our results suggest that exposure to organic solvents are associated with symptom of headache or eystrain among laundry workers in Korea. However, further studies with more relevant design is needed to replicate the association.

• Journal of Venture Innovation
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• v.6 no.1
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• pp.95-114
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• 2023

As the Fourth Industrial Revolution progresses, the importance of startups is becoming more prominent. Additionally, the role of accelerators in ensuring the sustainability of startups is also being emphasized. Therefore, in this study, among the services provided by accelerators to startups, the mentoring service, education service, funding service, and networking service tried to empirically analyze the structural relationship that affects startup performance through the dynamic capabilities of start-ups. To achieve this, we conducted a survey in February 2023 targeting startup CEOs and executives who had experience with accelerator program services. A total of 238 valid responses were analyzed using structural equation modeling with Amos 24. The results of the empirical analysis were as follows. The accelerator program services, including mentoring, education, funding, and networking services, had a significant positive effect on startup dynamic capabilities. Among the accelerator program sub-factors, networking services had the highest impact on startup dynamic capabilities, followed by mentoring, funding, and education services. Furthermore, startup dynamic capabilities were found to have a significant positive effect on startup performance. On the other hand, startup dynamic capabilities were found to mediate the relationship between mentoring, education, funding, networking services, and startup performance. Dynamic capabilities are a critical factor for startups, and the finding that accelerator programs can have a significant impact on startup performance by mediating these dynamic capabilities is significant both academically and practically.