• Title/Summary/Keyword: time-delay effect

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Anti-tumor Effect of Combined Betacarotene with X-irradiation in the Mouse Fibrosarcoma : Cytotoxicity and Tumor Growth Delay (쥐 섬유육종에서 베타카로틴과 방사선조사 병용의 항종양 효과: 세포독성 및 종양성장 지연에 미치는 영향)

  • Kwon Hyoung-Cheol;Yang Moon-Sik
    • Radiation Oncology Journal
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    • v.18 no.2
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    • pp.133-137
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    • 2000
  • Purpose :To investigate whether combined beta-carotene with X-Irradiation has more enhanced radition response than X-irradiation or not, we peformed a experiment about in vitro cytotoxlcity of beta-carotene and/or X-irradiation in the fibrosarcoma cells, tumor growth delay of combined beta-caroten with/or X-irradiation in the mouse fibrosarcoma. Materials and Methods : 2$\%$ emulsion of beta-carotene was serially diluted and used. X-Irradiation was given by 6 MeV linear accelerator. The cytotoxicity of beta-carotene in vitro was evaluated from clonogenic assay. To compare the cytotoxiclty between combined beta-carotene with X-irradiation and X-irradiation group, 2 mg/ml of beta-carotene was contacted to fibrosarcoma (FSall) cells for 1 hour before X-irradiation. For the tumor growth delay, single 20 Gy was given to FSall tumor hearing C3H/N mice whic was classified as beta-crotene with X-irradiation group (n=5) and X-irradiation alone group (n=5). 0.2 ml of 20 mg/kg of beta-carotene were i.p. injected to mice 30 minute before X-irradiation in the beta-crotene with X-irradiation group. The tumor growth delay defined as the time which reach to 1,000 mm$^{3}$ of tumor volume. Results : (1) Cytotoxicity in vitro: 1) survival fraction at beta-carotene concentration of 0.002,0.02,0.2 and 2 mg/ml were 0.69$\pm$0.07, 0.59$\pm$0.08, 0.08$\pm$0.008 and 0.02$\pm$0.006, respectively. 2) each survival fraction at 2, 4, 6 and 8 Gy in the 2 mg/ml of beta-carotene + X-irradiation group were 0.13$\pm$0.05, 0.03$\pm$0.005, 0.01 $\pm$0.002 and 0.009$\pm$0.0008, respectively. But each survival fraction at same irradiation dose in the X-irradiation group were 0.66$\pm$0.05, 0.40$\pm$0.04, 0.11$\pm$0.01 and 0.03$\pm$0.006, respectively(p<0.05). (2) The time which reach to 1,000 mm$^{3}$ of tumor volume of beta-carotene + X-irradiation group and X-irradiation alone group were 18, 19 days, respectively(p>0.05) Conclusion : The contact of beta-caroten to Fsall cells showed mild cytotoxicity which 띤as increased according to concentration. The cytotoxicity of combined beta-carotene with X-irradiation more increased than that of X-irradiation, additionally, And there was significant difference of cytotoxicity between two groups. But there were no significant difference of the growth delay of fibrosarcoma between two groups.

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Application of Multi-Server Queuing Theory to Estimate Vehicle Travel Times at Freeway Electronic Toll-Collection Systems (고속도로 자동요금징수시스템의 차량 통행시간 산정을 위한 다중서비스 대기행렬이론 연구)

  • Sung, Hyun-Jin;Choi, Jai-Sung;Kim, Sang-Youp
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.10 no.2
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    • pp.22-34
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    • 2011
  • This paper presents the investigation results of a research on how engineers can analyze the economic effect of the ETCS(Electronic Toll Collection System) installed to minimize the vehicle delays on freeway tollgates during toll payments. This research considered this economic effect to occur in the form of vehicle passing time reductions at the ETCS, and the multi-service queuing theory was applied to estimate these values. This research found: 1) When vehicles approaching tollgates show Poisson distribution and the service time of the ETCS shows Exponential distribution, the multi-service queuing theory would be applicable for estimating vehicle passing times at toll-gates, 2) Despite the ETCS placement, exit sections of tollgates give a greater reduction of vehicle passing times than entering sections due to more delays at conventional toll payments, and 3)The ETCS would not guarantee vehicle passing time reductions all the time, because in such a case as many vehicles were queuing at the ETCS, the total delay level for a toll gate would increase greatly. In addition, in order to examine the accuracy of the estimated vehicle passing values, this research compared the values from the multi-service queuing theory with the observed values from a set of field survey values at freeway toll-gates, and found that the two values were in a good agreement with a very low error range of 1-3 seconds per vehicle. Based on this result, the multi-service queuing theory was recommended for practice.

Effects of Equilibration Time, Precooling and Straw Loading Method on Survival of Mouse Embryos Frozen by Vitrification (생쥐 수정란의 유리화 동결보존에 있어서 동결전 처리방법에 관한 연구)

  • Gong, Il-Geun;Lee, Eun-Bong;Gang, Dae-Jin;Park, Chung-Saeng
    • Korean Journal of Animal Reproduction
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    • v.15 no.1
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    • pp.49-57
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    • 1991
  • This study was carried out to investigate the effect of equilibration time, precooling and straw loading method on the post-thaw survival rates of mouse embryos cryopreserved by vitrification method. The effect of the vitrification procedure on the damage of the embryos was also examined by the straining of nuclei using Hoechst 33342. The results obtained were summarized as follows; 1. The equilibration in Medium-1 for 10 minutes was considered to be the optimum equilibration time. Embryos equilibrated in Medium-1 for 10 minutes(81.0%) showed significantly(P<0.05) higher survival rates than those equilibrated for 5 minutes(40.0%) or 15 minutes(74.1%). 2. The survival rate of embryos cryopreserved using the double Medium-2 column(81.0%) was significantly(P<0.01) higher than that using the single Medium-2 column, whish was considered to be due to the double Medium-2 column method being more reliable for preventing contamination of diluent solution of 1M sucrose. 3. The survival rate of compacted morula stage embryos cryopreserved with the precooled and non-precooled Medium-2 was not significantly(P<0.05) different. 4. The number of blastomeres of embryos at late blastocyst stage after culture of mouse morulae for 24 to 28hours was significantly(P<0.05) decreased by freezing embryos using vitrification(53.3${\pm}$1.6 vs 41.4${\pm}$1.5), which was considered to be due to the damage of embryos during vitrification and the delay of embryo development by handling in vitro. 5. The vitrification procedure is considered to be a very simple and efficient method for cryopreservation of embryos at early developmental stage.

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Studies on the ecological characteristics of the rice varieties in Korea. III. Effect of the different seeding times on the yield factors, and its varietal differences (수도품종의 생태적 특성에 과한 연구. III. 파종기의 차이가 수량구성요소에 미치는 영향 및 품종간의 차이)

  • Eun-Woong Lee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.2
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    • pp.11-26
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    • 1964
  • The studies reported herein are on the varietal differences of rice in the effects of seeding times and nursery periods on the components such as, culm length, ear length, number of ears, ear weight, straw weight, and grain/straw ratio following the first series of studies on heading date. In the present investigations, 50 rice varieties, as the preceding studies, were seeded nine times at the interval of 15 days from March 15 to July 28 in 1963. Each variety seeded at respective time was transplanted in 40 days in nursery after seeded. Reviewing the result obtained from the first series of the studies on heading date, the number of days required to heading from seeding were decreased by delaying the seeding time. Most varieties tended to decrease in the number of days from seeding to heading by the 8th planting time. Some of varieties seemed to be decreased in the number of days from seeding to heading by 9th seeding time. However most varieties were failed to show heading delaying the seeding date at the 10th seeding. The results on the effects of altering the seeding time on the components and varietal differences of the response are summarized as follows; 1) Culm length; It appeared that culm length was shortened when the number of days from seeding to heading was decreased by delaying the seeding date. The varieties which needed many days to heading were also shortened in their culm length. 2) Ear length; Ear length was also shortened when the number of days needed tocheading was decreased, by delaying the seeding time. The varieties which needed many days for heading were also shortened in their ear length, while those which headed earlier seemed to be lengthened in their ear lengths. 3) Number of ears; It was shown that the number of ears was increased with the delay of the heading date, whereas, at the 9th seeding the number of ears was decreased when delayed the heading date. 4) Ear weight; Ear weight per hill was also likely to be heavy throughout the seeding times and varieties except the 7th and 8th seedings in which it appeared to be light on the contrary. 5) Straw weight; Straw weight became heavier as delayed the seeding date throughout all the varieties and seeding dates. 6) The grain/straw ratio; The grain/straw ratio was gradually increased by the 5th seeding time, reaching the pick at 5th. An examination of the varieties at each seeding date showed that the grain/straw ratio was low from 1st to 3rd seeding and from 7th to 9th seeding, when the number of days required to heading from seeding are increased. At the 4th seeding time-which is standard seeding time-5th, and 6th seeding times the ratio was high with the delay of heading.

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Effect of Bonding Process Conditions on the Interfacial Adhesion Energy of Al-Al Direct Bonds (접합 공정 조건이 Al-Al 접합의 계면접착에너지에 미치는 영향)

  • Kim, Jae-Won;Jeong, Myeong-Hyeok;Jang, Eun-Jung;Park, Sung-Cheol;Cakmak, Erkan;Kim, Bi-Oh;Matthias, Thorsten;Kim, Sung-Dong;Park, Young-Bae
    • Korean Journal of Materials Research
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    • v.20 no.6
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    • pp.319-325
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    • 2010
  • 3-D IC integration enables the smallest form factor and highest performance due to the shortest and most plentiful interconnects between chips. Direct metal bonding has several advantages over the solder-based bonding, including lower electrical resistivity, better electromigration resistance and more reduced interconnect RC delay, while high process temperature is one of the major bottlenecks of metal direct bonding because it can negatively influence device reliability and manufacturing yield. We performed quantitative analyses of the interfacial properties of Al-Al bonds with varying process parameters, bonding temperature, bonding time, and bonding environment. A 4-point bending method was used to measure the interfacial adhesion energy. The quantitative interfacial adhesion energy measured by a 4-point bending test shows 1.33, 2.25, and $6.44\;J/m^2$ for 400, 450, and $500^{\circ}C$, respectively, in a $N_2$ atmosphere. Increasing the bonding time from 1 to 4 hrs enhanced the interfacial fracture toughness while the effects of forming gas were negligible, which were correlated to the bonding interface analysis results. XPS depth analysis results on the delaminated interfaces showed that the relative area fraction of aluminum oxide to the pure aluminum phase near the bonding surfaces match well the variations of interfacial adhesion energies with bonding process conditions.

A Low Latency Handoff Scheme with Lossless Remote Subscription for Real-time Multimedia Communications in Mobile IP Environments (모바일 IP환경에서의 실시간 멀티미디어 통신을 위한 무손실 원격지 가입 저 지연 핸드오프)

  • Kim Ho-cheal;Kim Young-tak
    • Journal of KIISE:Information Networking
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    • v.31 no.6
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    • pp.620-632
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    • 2004
  • IP is not suitable for mobile nodes by network-based routing because mobile nodes are dynamically change their network attachment point. Mobile-IP is an IETF standard providing continuous access to the Internet for mobile nodes, but it has the triangle routing problem. Also it has a performance degradation problem by massive packet loss during layer 3 handoff of mobile nodes. Especially, two IETF multicast support schemes for Mobile-IP do not guarantee the quality of realtime multimedia services because they have several problems such as long routing path, packet duplication(hi-directional tunneling) and massive packet loss(remote subscription). In this paper, we propose a lossless remote subscription scheme that guarantees the quality of realtime multimedia services over Mobile-IP. From the result of simulation, we verified that the proposed scheme in this paper can reduce the delay time of remote subscription by the effect of the low latency handoff scheme that is extended to apply to the multicast group management and it requires only 0.58% buffer spaces of the previously proposed lossless remote subscription scheme.

A Study on Cooling Effect and Power Control of a Mini Ozonizer (소형 오존발생장치의 전력제어와 냉각효과에 관한 연구)

  • Woo, Sung-Hoon;Park, Seung-Cho;Yoon, Sung-Yoon;Park, Jee-Ho;Woo, Jung-In
    • Journal of Korean Society of Environmental Engineers
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    • v.28 no.1
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    • pp.97-103
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    • 2006
  • In this paper, a control method of a mini ozone generator is proposed, and also a cooling technique is described which is cooling down the flowing air gap into a silent discharger to $2^{\circ}C$ to generate ozone of high density and diffusing power. As the digital control system for this method, a double feedback loop is designed which detects the voltage and current of equivalent capacitor of the discharger and compensates for the poor power waveform caused by the noise at high discharging frequency. During the plant modeling of this system, computing time factor is considered as a unique parameter of the power system to improve the transient responses with regard to fluctuating load and to replenish the computing time delay of the controller. Through the experiment, sinusoidal input current for discharger can be acquired and all the effectiveness of this accurate control system over unstable ozone discharger are proved.

A Proactive Approach to Reconstructing Overlay Multicast Trees using Resource Reservation (자원 예약 방식을 사용한 오버레이 멀티캐스트 트리의 구성과 복구 방안)

  • Heo, Kwon;Son, Suung-Chul;Kim, Kyung-Hoon;Song, Ho-Young;Nam, Ji-Seung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.12B
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    • pp.1049-1057
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    • 2006
  • Overlay Multicast is an effective method for efficient utilization of system resources and network bandwidth without using hardware customization. Unlike in IP multicast, multicast tree reconstruction is required when non-leaf node leaves or fails. In this paper, we propose a proactive approach to solve this defect by using a resource reservation of the out degrees. This allows children of non-leaf node to connect to its new parent node immediately when its parent node leaves or fails. In our proposal, a proactive route maintenance gives a fast recovery time and reduces a delay effect in the new route. The simulation results show that our proposal takes shorter period of time than the other algorithms to reconstruct a similar tree and that it is a more effective way to deal with a lot of nodes that have lost their parent nodes.

Component Analysis of Thermally Activated Building System in Residential Buildings

  • Chung, Woong June;Lee, Yu Ji;Yoo, Mi Hye;Park, Sang Hoon;Yeo, Myoung Souk;Kim, Kwang Woo
    • Architectural research
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    • v.16 no.4
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    • pp.203-210
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    • 2014
  • The packaged terminal air conditioner, the typical cooling system for the residential buildings, consumes a large amount of electricity in a short period time during peak hours. In order to reduce the peak load and conserve the electricity, the thermally activated building system can be used as a secondary system to handle the partial cooling load. However, the thermally activated building system may cause condensation and under-cooling. Thus, design of both systems should be performed with careful investigation in characteristics of both systems to amplify the advantages. Since the thermally activated building system has the time-delay effect which may cause under-cooling, the system is designed to handle the base load of the building. Hence, simple simulation with EnergyPlus was performed to observe the characteristics of cooling load in residential buildings. Once the possible range of the load handling ratio of the thermally activated building system was decided, characteristics of system was analyzed in terms of hardware component and operation parameters. The hardware components were analyzed in plant and system aspects and the operation parameter was evaluated in the thermal comfort aspect. As the load handling ratio increased, the thermal comfort increased due to the lower radiant mean temperatures. Within the range of thermal comfort, the several adjustments were made in setpoint temperature and electricity consumptions of difference cases were observed to decide which components and parameters were important for designing the systems.

Design of a Frequency Domain Equalizer Algorithm for MBOK DS-UWB System (MBOK DS-UWB 시스템을 위한 주파수 영역 등화기 알고리즘의 설계)

  • Kang, Shin-Woo;Im, Se-Bin;Choi, Hyung-Jin
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.32 no.10A
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    • pp.1034-1041
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    • 2007
  • In this paper, we propose a FD USE (frequency domain minimum mean square error) equalizer algorithm for MBOK DS-UWB (M-ary bi-orthogonal keying direct sequence UWB) systems considered as a PHY proposal for high-speed wireless communication in IEEE 802.15.TG3a. The conventional FD MMSE equalization scheme has a structural limit due to insertion of the cyclic prefix (CP) in all transmit packets, but the proposed scheme is able to equalize the channel effect without CP. In order to overcome channel estimation error by multipath delay, we introduce a moving FFT and a moving average scheme. Compared with conventional FD MMSE equalizer and the traditional TD (time domain) MMSE-RAKE receiver, the proposed FD MMSE equalizer has better BER performance and we demonstrate this result by computer simulation.