• 대한수의학회지
• /
• 제61권1호
• /
• pp.8.1-8.10
• /
• 2021

The purpose of this retrospective study was to describe cases of feline intermediateto high-grade alimentary lymphoma regarding signalment, clinical presentation, laboratory findings, response to therapy (modified 25-week University of Wisconsin-Madison [UW-25] vs. COP [cyclophosphamide, vincristine, prednisone]), toxicosis, and outcomes and to identify prognostic factors. Sixteen cats were treated with chemotherapy protocols. Response rates and survival did not differ statistically between the two protocols. The progression-free interval (PFI) and median survival time (MST) in cats achieving a response to therapy were longer than in those with no response [NR] (complete remission [CR] vs. partial remission [PR] vs. NR; PFI, 124 vs. 49 vs. 12 days, p < 0.001; MST, 361 vs. 118 vs. 16 days, p < 0.001). Clinical stage was another prognostic factor for PFI and MST. The PFI and MST in cats in stage I were longer than in those in other stages (PFI, 107 days vs. 30 days; MST, 193 days vs. 54 days). Hematologic and gastrointestinal toxicosis was mostly low grade. In comparing the modified UW-25 protocol with the COP protocol, there was not much difference in the number of neutropenic episodes and grade levels.

• 대한정형도수물리치료학회지
• /
• 제29권1호
• /
• pp.81-93
• /
• 2023

Purpose: The current case study focuses on identifying the effects of manual therapy and home self-therapeutic exercise including on mouth opening and pain relief in patients with continuous neck pain with myofascial temporomandibular disorders (TMDs) accompanied by headache induced by masticatory myalgia Subjects: The study participant was a 27-year-old woman who was treated a year ago for pain related to TMDs accompanied by a headache. Methods: Manual therapy of the cervical spine with upper cervical spine posterior-to-anterior mobilization (C1~C2), upper cervical spine flexion mobilization (C0~C2), upper cervical spine lateral flexion mobilization (C0~C1), upper cervical spine thrust manual therapy (C1~C2) and manual therapy of the temporomandibular joint and muscles with transverse medial accessory temporomandibular joint mobilization, manual therapies for the temporal, the masseter, and medial pterygoid muscles were performed twice a week for about 30 minutes for 4 weeks. This protocol included 3 sessions in total. The home self-therapeutic exercise was to be performed two to three times a day. Results: The values more improved MMO increased to 41.4 mm, left masseter muscle PPT to 2.9 kgf/cm², right masseter muscle PPT to 3.1 kgf/cm², KHIT-6 to 46 points, neck pain intensity (by NRS) to 2 points, headache frequency to per weeks, cervical kyphotic angle to -8.06%, and GCPS to grade 1 (low-intensity pain without pain-related disorder). Conclusion: Manual therapy and home self-therapeutic exercise can be helpful for mouth opening and pain relief in patients with myofascial TMDs accompanied by secondary headaches induced by masticatory myalgia.

• 대한핵의학회:학술대회논문집
• /
• 대한핵의학회 2001년도 제40차 춘계학술대회 및 연수교육
• /
• pp.4-10
• /
• 2001

The radionuclide therapy is a protocol for tumor control by administering radionuclides as the cytotoxic agents. Radionuclides concentrated at the site of cancerous lesion are expected to kill the cancerous cells with minimal injury to the normal tissue. The efficacy of every radionuclide treatment can be evaluated by examining the toxicity to the lesion differentiated from that to the normal tissue. Radiation dosimetry is the procedure of quantitating the energy absorbed by target volumes of interest. Dosimetric information plays an indicator of the expected radiation damage and thus the therapeutic efficacy. This paper summarizes the dosimetric aspects in radionuclide therapy in terms of radionuclides of use, radiation dosimetry methodology and considerations for each treatment in practical use.

• 한국산학기술학회논문지
• /
• 제17권7호
• /
• pp.144-153
• /
• 2016

본 연구의 목적은 감각통합 중재 효과에 관해 체계적 고찰을 통해 최근 연구 동향을 살펴보고, 감각통합 중재가 어떤 영역에서 효과가 나타나는지 객관적인 근거를 찾고자 함이다. 연구 분석을 위해 데이터베이스 Medline과 EMBASE에 "Occupational therapy", "Sensory integration therapy", "Sensory processing", "Weighted vest", "Wilbarger protocol"를 검색하였다. 2010년부터 2015년까지의 연구 중 감각통합 중재 효과를 보고한 14개의 연구를 분석하여 PICO원리에 따라 정리하였다. 연구결과 근거수준I과 근거수준V의 연구가 각각 4개(28.6%)로 가장 많았고, 중재 효과를 측정하기 위해 사용된 평가도구를 빈도 분석한 결과 GAS와 VABS-II가 4개(11.8%)의 연구에서 사용되었다. 분석 연구들에서 자폐스펙트럼 장애 아동들이 71.4%로 주요 대상군이었으며, 감각통합 중재가 운동수행, 감각처리, 행동, 학습과 관련한 교육, 작업수행영역에서 효과가 있었다. 본 연구결과를 통해 작업치료 임상에서 감각통합을 중재 계획으로 수립하는데 유용한 자료로 활용할 수 있을 것이다. 향후 연구에서는 폭넓은 재활 분야에서 사용되고 있는 감각통합 중재 효과에 대한 연구를 포함하여 감각통합 중재의 효과성 검증에 대한 연구가 이루어져야 할 것으로 사료된다.

• 재활치료과학
• /
• 제8권4호
• /
• pp.7-18
• /
• 2019

목적 : 경두개 직류 자극과 강제 유도 운동 치료의 결합된 중재를 적용한 뇌졸중 환자의 회복과 관련된 연구 동향을 알아보고, 중재 계획 시, 도움이 될 수 있는 정보 및 근거를 제시하는 데 목적이 있다. 연구방법 : 전자 데이터베이스 PubMed, NDSL 등을 이용하여 2009년 1월부터 2018년 12월까지 10년간 온라인 데이터에 등록된 논문을 검색하였다. 주요 검색어로 'Transcranial direct current stimulation' or 'tDCS', 'Constraint-induced movement therapy' or 'CIMT', 'Upper extremity function', 'Upper limb', 'Stroke'을 혼용하여 사용하여 본 연구의 선정기준과 배제기준에 부합하는 6편의 논문을 최종 선정하여 분석하였다. 결과 : 경두개 직류 자극의 적용 전류의 세기, 적용시간 등과 강제 유도 운동 치료의 프로토콜은 다양한 방법으로 이루어져 있었지만, 경두개 직류 자극 직 후 CIMT를 시행하는 중재 절차는 동일하게 시행되었다. 중재 효과를 알아보기 위해 상지기능, 일상생활동작, 대뇌피질 활성도 평가 등이 사용되었다. 경두개직류 자극과 강제 유도 운동 치료의 결합된 중재는 뇌졸중 환자의 상지기능과 일상생활동작 개선에 효과적인 것으로 나타났으며, 대뇌피질의 활성화에도 유의미한 효과가 있는 것으로 나타났다. 결론 : 본 연구를 통해 경두개 직류 자극과 강제 유도 운동 치료의 결합된 중재 적용에 필요한 정보 제공 및 근거를 마련하였다. 추후 연구를 통해, 경두개 직류 자극의 자극시간과 전류의 세기, 전극의 부착 위치 등에 대한 일반화가 필요할 것이며 가장 적절한 강제 유도 운동 치료 프로토콜을 사용하여 큰 모집단을 대상으로 장기간 추적 관찰을 포함한 무작위 대조군 실험연구가 필요하다.

• The Journal of Korean Physical Therapy
• /
• 제14권4호
• /
• pp.28-44
• /
• 2002

The purpose of this study is to discuss and analyze the effect of blood glucose on treadmill exercise, functional food and their combined treatment protocol on diabetic rats. These group were divided treadmill exercise group(n:12), functional food feeding group(n:12), treadmill exercise with functional food feeding group(n:12) and control group. The following results were obtained from this study. 1. The blood glucose level was showed significantly different in several group, treadmill exercise with functional food feeding group are most significantly on other group. 2. The inhibitory rate of body weight was not significantly different on each group. 3. The amount of feeding was not significantly in several group. 4. The Islets size and Connective tissue proliferation was showed significantly different except control group, treadmill exercise with functional food feeding group are more significantly than other group. These results show that treadmill exercise with functional food feeding and their several protocols can retard the setreptozotocin-induced dibetic rat.

• 대한예방한의학회지
• /
• 제12권2호
• /
• pp.185-195
• /
• 2008

The purpose of this investigation is comparing two groups one applied with taping therapy the other with controlled causes variation in pain substances of blood ${\beta}$-endorphin, serotonin with taping therapy. 12 male students of S college divided into two groups each 6 experimental and controlled with no history of flexion and extention of lower extremity focused on knee joint. Experimental group applied with elastic taping before experiment at quadriceps, calf muscles, hamstrings and tibialis anterior, controlled group didn't applied any taping therapy. Bruce protocol of maximal progressive loading exercise implemented 5 minutes after blood samples were extracted. And 5 minutes after the exercise blood samples also were taken and made investigation. Data before and after investigation were operated on SPSS Ver. 12.0 for Window(Kor.). P value 0.05. The affirmative effects of this investigation was proved with increased ${\beta}$-endorphin and decreased serotonin that cause reducing pain.

• International Journal of Advanced Culture Technology
• /
• 제9권4호
• /
• pp.29-39
• /
• 2021

Cognitive behavioral therapy (CBT) is effective for people with an addiction tendency. This study aims to implement a CBT program for college students at high risk of smartphone addiction and investigate the impact of the program on their desire to use a smartphone, depression, impulsivity, and anxiety. Baseline/post-intervention evaluation and the ABA' single-case experimental design were used. The study consisted of the baseline phase (A), pre-evaluation, intervention phase (B), post-evaluation, and baseline phase (A'). Six participants were enrolled, and the main outcome variables were daily changes in the desire to use a smartphone and changes in depression, impulsivity, and anxiety after the program. Prior to the intervention, all six participants had mild to moderate depression, but after the intervention, three were normal, two had mild depression, and only one had moderate depression. Impulsivity and anxiety scores decreased after the intervention, with anxiety scores showing the most dramatic change. The percentage of non-overlapping data for the baseline phase (A)-intervention phase (B) was more than 75% and that for baseline phase (A)-baseline phase (A') was 100% for all 6 participants. This study presented a good protocol for people with low access to psychological therapy. We expect the findings will be highly useful for people suffering from psychological difficulties due to smartphone addiction.

• International Journal of Stem Cells
• /
• 제17권2호
• /
• pp.204-211
• /
• 2024

With recent advances in adeno-associated virus (AAV)-based gene therapy, efficacy and toxicity screening have become essential for developing gene therapeutic drugs for retinal diseases. Retinal organoids from human pluripotent stem cells (hPSCs) offer a more accessible and reproducible human test platform for evaluating AAV-based gene therapy. In this study, hPSCs were differentiated into retinal organoids composed of various types of retinal cells. The transduction efficiencies of AAV2 and AAV8, which are widely used in clinical trials of inherited retinal diseases, were analyzed using retinal organoids. These results suggest that retinal organoids derived from hPSCs serve as suitable screening platforms owing to their diverse retinal cell types and similarity to the human retina. In summary, we propose an optimal stepwise protocol that includes the generation of retinal organoids and analysis of AAV transduction efficacy, providing a comprehensive approach for evaluating AAV-based gene therapy for retinal diseases.

• 대한방사선기술학회지:방사선기술과학
• /
• 제47권4호
• /
• pp.271-278
• /
• 2024

This study aimed to evaluate the impact of changes in beam arrangement and arc counts on dosimetric factors in volumetric modulated arc therapy (VMAT) inverse radiation therapy planning for hippocampal-avoidance whole brain radiation therapy (HA-WBRT) by using the Elekta Monaco radiation therapy planning system (RTPs). For coplanar VMAT, both the arc per beam (APB) method and the beam determined arc(BDA) method, which is determined by the number of beams, were applied. For non-coplanar VMAT, the BDA method was utilized, and a total of 9 treatment plans were established by varying the arc counts. All radiation therapy plans met the radiation oncology group (RTOG) 0933 protocol standards, and 14 dosimetric factors were compared and analyzed. The results showed that the BDA-NC VMAT method demonstrated superior performance in terms of planning target volume (PTV) coverage and protection of normal organs, while APB-VMAT was advantageous in terms of hippocampal protection, monitor unit and delivery time. This study is expected to contribute to the efficient establishment of HA-WBRT plans considering the changes in beam arrangement and rotation arc numbers in Monaco RTPs.