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A retrospective study of 16 cats with intermediate- to high-grade alimentary lymphoma

  • Kwak, Dong-Hyuk (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Cho, Mun-Ju (Beaksan Feline Medical Center) ;
  • Park, Hyung-Jin (Sungsim Animal Medical Center) ;
  • Song, Kun-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • Received : 2021.01.15
  • Accepted : 2021.02.25
  • Published : 2021.03.31

Abstract

The purpose of this retrospective study was to describe cases of feline intermediateto high-grade alimentary lymphoma regarding signalment, clinical presentation, laboratory findings, response to therapy (modified 25-week University of Wisconsin-Madison [UW-25] vs. COP [cyclophosphamide, vincristine, prednisone]), toxicosis, and outcomes and to identify prognostic factors. Sixteen cats were treated with chemotherapy protocols. Response rates and survival did not differ statistically between the two protocols. The progression-free interval (PFI) and median survival time (MST) in cats achieving a response to therapy were longer than in those with no response [NR] (complete remission [CR] vs. partial remission [PR] vs. NR; PFI, 124 vs. 49 vs. 12 days, p < 0.001; MST, 361 vs. 118 vs. 16 days, p < 0.001). Clinical stage was another prognostic factor for PFI and MST. The PFI and MST in cats in stage I were longer than in those in other stages (PFI, 107 days vs. 30 days; MST, 193 days vs. 54 days). Hematologic and gastrointestinal toxicosis was mostly low grade. In comparing the modified UW-25 protocol with the COP protocol, there was not much difference in the number of neutropenic episodes and grade levels.

Keywords

References

  1. Barrs VR, Beatty JA. Feline alimentary lymphoma: 1. Classification, risk factors, clinical signs and non-invasive diagnostics. J Feline Med Surg 2012;14:182-190. https://doi.org/10.1177/1098612X12439265
  2. Rissetto K, Villamil JA, Selting KA, Tyler J, Henry CJ. Recent trends in feline intestinal neoplasia: an epidemiologic study of 1,129 cases in the veterinary medical database from 1964 to 2004. J Am Anim Hosp Assoc 2011;47:28-36. https://doi.org/10.5326/JAAHA-MS-5554
  3. Vail DM, Thamm DH, Liptak JM. Withrow and MacEwen's Small Animal Clinical Oncology. 6th ed. Elsevier, St. Louis, 2020.
  4. Mahony OM, Moore AS, Cotter SM, Engler SJ, Brown D, Penninck DG. Alimentary lymphoma in cats: 28 cases (1988-1993). J Am Vet Med Assoc 1995;207:1593-1598.
  5. Gabor LJ, Malik R, Canfield PJ. Clinical and anatomical features of lymphosarcoma in 118 cats. Aust Vet J 1998;76:725-732. https://doi.org/10.1111/j.1751-0813.1998.tb12300.x
  6. Vail DM, Moore AS, Ogilvie GK, Volk LM. Feline lymphoma (145 cases): proliferation indices, cluster of differentiation 3 immunoreactivity, and their association with prognosis in 90 cats. J Vet Intern Med 1998;12:349-354. https://doi.org/10.1111/j.1939-1676.1998.tb02134.x
  7. Louwerens M, London CA, Pedersen NC, Lyons LA. Feline lymphoma in the post-feline leukemia virus era. J Vet Intern Med 2005;19:329-335. https://doi.org/10.1892/0891-6640(2005)19[329:FLITPL]2.0.CO;2
  8. Stutzer B, Simon K, Lutz H, Majzoub M, Hermanns W, Hirschberger J, Sauter-Louis C, Hartmann K. Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma. J Feline Med Surg 2011;13:81-87. https://doi.org/10.1016/j.jfms.2010.09.015
  9. Vezzali E, Parodi AL, Marcato PS, Bettini G. Histopathologic classification of 171 cases of canine and feline non-Hodgkin lymphoma according to the WHO. Vet Comp Oncol 2010;8:38-49. https://doi.org/10.1111/j.1476-5829.2009.00201.x
  10. Rau SE, Burgess KE. A retrospective evaluation of lomustine (CeeNU) in 32 treatment naïve cats with intermediate to large cell gastrointestinal lymphoma (2006-2013). Vet Comp Oncol 2017;15:1019-1028. https://doi.org/10.1111/vco.12243
  11. Collette SA, Allstadt SD, Chon EM, Vernau W, Smith AN, Garrett LD, Choy K, Rebhun RB, Rodriguez CO Jr, Skorupski KA. Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012). Vet Comp Oncol 2016;14(Suppl 1):136-146. https://doi.org/10.1111/vco.12158
  12. Gieger T. Alimentary lymphoma in cats and dogs. Vet Clin North Am Small Anim Pract 2011;41:419-432. https://doi.org/10.1016/j.cvsm.2011.02.001
  13. Kiselow MA, Rassnick KM, McDonough SP, Goldstein RE, Simpson KW, Weinkle TK, Erb HN. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). J Am Vet Med Assoc 2008;232:405-410. https://doi.org/10.2460/javma.232.3.405
  14. Lingard AE, Briscoe K, Beatty JA, Moore AS, Crowley AM, Krockenberger M, Churcher RK, Canfield PJ, Barrs VR. Low-grade alimentary lymphoma: clinicopathological findings and response to treatment in 17 cases. J Feline Med Surg 2009;11:692-700. https://doi.org/10.1016/j.jfms.2009.05.021
  15. Fondacaro JV, Richter KP, Carpenter JL, Hart JR, Hill SL, Fettman MJ. Feline gastrointestinal lymphoma: 67 cases (1988-1996). Eur J Comp Gastroenterol 1999;4:5-11.
  16. Gouldin ED, Mullin C, Morges M, Mehler SJ, de Lorimier LP, Oakley C, Risbon R, May L, Kahn SA, Clifford C. Feline discrete high-grade gastrointestinal lymphoma treated with surgical resection and adjuvant CHOP-based chemotherapy: retrospective study of 20 cases. Vet Comp Oncol 2017;15:328-335. https://doi.org/10.1111/vco.12166
  17. Gustafson TL, Villamil A, Taylor BE, Flory A. A retrospective study of feline gastric lymphoma in 16 chemotherapy-treated cats. J Am Anim Hosp Assoc 2014;50:46-52. https://doi.org/10.5326/JAAHA-MS-5989
  18. Moore AS, Cotter SM, Frimberger AE, Wood CA, Rand WM, L'Heureux DA. A comparison of doxorubicin and COP for maintenance of remission in cats with lymphoma. J Vet Intern Med 1996;10:372-375. https://doi.org/10.1111/j.1939-1676.1996.tb02083.x
  19. Malik R, Gabor LJ, Foster SF, McCorkell BE, Canfield PJ. Therapy for Australian cats with lymphosarcoma. Aust Vet J 2001;79:808-817. https://doi.org/10.1111/j.1751-0813.2001.tb10923.x
  20. Teske E, van Straten G, van Noort R, Rutteman GR. Chemotherapy with cyclophosphamide, vincristine, and prednisolone (COP) in cats with malignant lymphoma: new results with an old protocol. J Vet Intern Med 2002;16:179-186. https://doi.org/10.1892/0891-6640(2002)016<0179:CWCVAP>2.3.CO;2
  21. Simon D, Eberle N, Laacke-Singer L, Nolte I. Combination chemotherapy in feline lymphoma: treatment outcome, tolerability, and duration in 23 cats. J Vet Intern Med 2008;22:394-400. https://doi.org/10.1111/j.1939-1676.2008.0057.x
  22. Waite AH, Jackson K, Gregor TP, Krick EL. Lymphoma in cats treated with a weekly cyclophosphamide-, vincristine-, and prednisone-based protocol: 114 cases (1998-2008). J Am Vet Med Assoc 2013;242:1104-1109. https://doi.org/10.2460/javma.242.8.1104
  23. Mooney SC, Hayes AA, MacEwen EG, Matus RE, Geary A, Shurgot BA. Treatment and prognostic factors in lymphoma in cats: 103 cases (1977-1981). J Am Vet Med Assoc 1989;194:696-702.
  24. Milner RJ, Peyton J, Cooke K, Fox LE, Gallagher A, Gordon P, Hester J. Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003). J Am Vet Med Assoc 2005;227:1118-1122. https://doi.org/10.2460/javma.2005.227.1118
  25. Hadden AG, Cotter SM, Rand W, Moore AS, Davis RM, Morrissey P. Efficacy and toxicosis of VELCAP-C treatment of lymphoma in cats. J Vet Intern Med 2008;22:153-157. https://doi.org/10.1111/j.1939-1676.2007.0031.x
  26. Kristal O, Lana SE, Ogilvie GK, Rand WM, Cotter SM, Moore AS. Single agent chemotherapy with doxorubicin for feline lymphoma: a retrospective study of 19 cases (1994-1997). J Vet Intern Med 2001;15:125-130. https://doi.org/10.1892/0891-6640(2001)015<0125:SACWDF>2.3.CO;2
  27. Stein TJ, Pellin M, Steinberg H, Chun R. Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc 2010;46:413-417. https://doi.org/10.5326/0460413
  28. Krick EL, Cohen RB, Gregor TP, Salah PC, Sorenmo KU. Prospective clinical trial to compare vincristine and vinblastine in a COP-based protocol for lymphoma in cats. J Vet Intern Med 2013;27:134-140. https://doi.org/10.1111/jvim.12006
  29. Limmer S, Eberle N, Nerschbach V, Nolte I, Betz D. Treatment of feline lymphoma using a 12-week, maintenance-free combination chemotherapy protocol in 26 cats. Vet Comp Oncol 2016;14 Suppl 1:21-31. https://doi.org/10.1111/vco.12082
  30. Barrs VR, Beatty JA. Feline alimentary lymphoma: 2. Further diagnostics, therapy and prognosis. J Feline Med Surg 2012;14:191-201. https://doi.org/10.1177/1098612X12439266
  31. Taylor SS, Goodfellow MR, Browne WJ, Walding B, Murphy S, Tzannes S, Gerou-Ferriani M, Schwartz A, Dobson JM. Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats. J Small Anim Pract 2009;50:584-592. https://doi.org/10.1111/j.1748-5827.2009.00813.x
  32. Kiupel M, Smedley RC, Pfent C, Xie Y, Xue Y, Wise AG, DeVaul JM, Maes RK. Diagnostic algorithm to differentiate lymphoma from inflammation in feline small intestinal biopsy samples. Vet Pathol 2011;48:212-222. https://doi.org/10.1177/0300985810389479
  33. Cotter SM. Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone. I. Treatment of dogs. J Am Anim Hosp Assoc 1983;19:159-165.
  34. Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1. Vet Comp Oncol 2016;14:417-446. https://doi.org/10.1111/vco.283
  35. Simon D, Nolte I, Eberle N, Abbrederis N, Killich M, Hirschberger J. Treatment of dogs with lymphoma using a 12-week, maintenance-free combination chemotherapy protocol. J Vet Intern Med 2006;20:948-954. https://doi.org/10.1892/0891-6640(2006)20[948:TODWLU]2.0.CO;2
  36. Tidd KS, Durham AC, Brown DC, Velovolu S, Nagel J, Krick EL. Outcomes in 40 cats with discrete intermediate- or large-cell gastrointestinal lymphoma masses treated with surgical mass resection (2005-2015). Vet Surg 2019;48:1218-1228. https://doi.org/10.1111/vsu.13281
  37. Sabattini S, Bottero E, Turba ME, Vicchi F, Bo S, Bettini G. Differentiating feline inflammatory bowel disease from alimentary lymphoma in duodenal endoscopic biopsies. J Small Anim Pract 2016;57:396-401. https://doi.org/10.1111/jsap.12494
  38. Sapierzynski R, Jankowska U, Jagielski D, Kliczkowska-Klarowicz K. Large granular lymphoma in six cats. Pol J Vet Sci 2015;18:163-169. https://doi.org/10.1515/pjvs-2015-0021
  39. Krick EL, Moore RH, Cohen RB, Sorenmo KU. Prognostic significance of weight changes during treatment of feline lymphoma. J Feline Med Surg 2011;13:976-983. https://doi.org/10.1016/j.jfms.2011.08.002