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Assessment of the Cerebrospinal Fluid Effect on the Chemical Exchange Saturation Transfer Map Obtained from the Full Z-Spectrum in the Elderly Human Brain

  • Park, Soonchan;Jang, Joon;Oh, Jang-Hoon;Ryu, Chang-Woo;Jahng, Geon-Ho
    • Progress in Medical Physics
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    • v.30 no.4
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    • pp.139-149
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    • 2019
  • Purpose: With neurodegeneration, the signal intensity of the cerebrospinal fluid (CSF) in the brain increases. The objective of this study was to evaluate chemical exchange saturation transfer (CEST) signals with and without the contribution of CSF signals in elderly human brains using two different 3T magnetic resonance imaging (MRI) sequences Methods: Full CEST signals were acquired in ten subjects (Group I) with a three-dimensional (3D)-segmented gradient-echo echo-planar imaging (EPI) sequence and in ten other subjects (Group II) with a 3D gradient and spin-echo (GRASE) sequence using two different 3T MRI systems. The segmented tissue compartments of gray and white matter were used to mask the CSF signals in the full CEST images. Two sets of magnetization transfer ratio asymmetry (MTRasym) maps were obtained for each offset frequency in each subject with and without masking the CSF signals (masked and unmasked conditions, respectively) and later compared using paired t-tests. Results: The region-of-interest (ROI)-based analyses showed that the MTRasym values for both the 3D-segmented gradient-echo EPI and 3D GRASE sequences were altered under the masked condition compared with the unmasked condition at several ROIs and offset frequencies. Conclusions: Depending on the imaging sequence, the MTRasym values can be overestimated for some areas of the elderly human brain when CSF signals are unmasked. Therefore, it is necessary to develop a method to minimize this overestimation in the case of elderly patients.

The Effect of the Heel Rest on Braking Reaction Time while Driving Vehicle with Automatic Transmission (오토 차량 운전시 보조 발판이 제동 시간에 미치는 영향)

  • Kim, Jeong-Ryong;Jo, Yeong-Jin;Park, Ji-Su;Seo, Gyeong-Bae
    • Journal of Korean Society of Transportation
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    • v.24 no.1 s.87
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    • pp.53-58
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    • 2006
  • The purpose of this study was to test the safety of the heel rest which was made for reducing the automobile driver's muscle fatigue with automatic transmission. Sixty subjects participated in the test, including ten males and ten females in 30s, 40s, 50s, respectively. Simulator consisted of automobile cockpit, accelerator and brake pedal sensor, heel rest. and driving displays. 30 seconds were given to subjects to be accustomed to the simulator environment. They also had one pre-trial to use the brake pedal according to the experimental scenario. They were told to step on the brake pedal immediately as soon as the red light was on the display The reaction time representing the foot travel time between accelerator and brake pedal was measured with/without the heel rest. In results, there was no significant difference in reaction time between conditions with/without heel rest. The result indicated that the heel rest used in this study would be a safe accessory for drivers who need to reduce the fatigue of the muscle or joint during driving.

The Effect of Foot Bath on Blood Pressure Following Treadmill Exercise (트레드밀 운동 후 족욕이 혈압에 미치는 영향)

  • Lee, Sang-Youl;Lee, Myung-Hee;Yun, Chang-Goo;Bae, Sung-Soo
    • Journal of the Korean Society of Physical Medicine
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    • v.3 no.2
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    • pp.97-102
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    • 2008
  • Purpose : The purpose of this study was to find the effect of foot bath on blood pressure(BP) following treadmill exercise. Methode : Subject of study were forty healthy males without any cardiovascular, musculoskeletal, and neurologic diseases. Following twenty minutes walking at a speed of 5m/s on the treadmill, ten twenty subjects in experimental group received foot bath, on the dominant lower limb while sitting in chair. Foot bath was applied to the level of the lateral and medial malleoli keeping the temperature of the paraffin bath at $40{\pm}0.5^{\circ}C$. Twenty subjects in control group took a rest sitting in chair in a comfortable position. BP was measured in right brachial artery. BP was measured five times(before exercise, immediately after exercise, 5 minutes, 10 minutes, and fifteen minutes after exercise). Results : The study showed that for diastolic blood pressure, there was no significant difference between the experimental and the control group. However, systolic blood pressure(SBP) increased significantly after exercise compared with SBP before exercise (p<.05). In addition, SBP in five minutes after exercise decreased significantly compared with SBP in immediately after exercise (p<.05). On the other hand, the control group had significant difference between SBP measured before exercise and SBP measured at the other measure time (p<.05). In five minutes after exercise, SBP in experimental group had significant difference with SBP in control group (p<.05). Similarly, in ten and fifteen minutes after exercise, SBP in experimental group had significantly difference with SBP in control group (p<.05). Conclusion : Consequently it was confirmed that when foot bath was applied, the increased BP induced by the exercise returned to normal range rapidly.

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The Learning Behavior of K-MOOC Learners and K-MOOC Service Recommendations (K-MOOC 학습자의 학습행태 분석 및 서비스 방향성 연구)

  • Ahn, Jun Hoo;Lee, Jee Yeon
    • Journal of the Korean Society for information Management
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    • v.37 no.3
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    • pp.221-252
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    • 2020
  • According to the participants, the current K-MOOC (Korean Massive Open Online Course) has a few problems, such as too few courses, low content quality, and useless learner management system compared to MOOCs abroad. These problems caused diminished learner motivation. Consequently, the K-MOOC service has recorded a low course completion rate despite high expenses spent to develop the contents and thus requires remedies to fix the issues. This study drew research subjects from a pool of college and graduate students representing the primary users of the K-MOOC. This study limited the research scope to the four categories: motivation, learning experience, recognition, and performance of the Biggs' 3P Learning System Model. Based on the literature review, ten variables were selected and explored how the subjects perceived four categories using the survey questionnaire. This study also examined the relationship between ten variables and generated suggestions for the instructors, course managers, and platform developers to make the K-MOOC better.

Present and Prospect of Clothing Construction Research - Focus on academic associations' publication - (의복구성학 분야의 연구 현황과 전망 - 학회지를 중심으로 -)

  • Kim, Seonyoung
    • Journal of Fashion Business
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    • v.20 no.5
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    • pp.102-114
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    • 2016
  • The purpose of this study is to enable a scientific and rational approach for future research agenda setting in the clothing construction field. Through analysis of research papers on clothing construction published in domestic academic journals during the recent decade, the research trend of clothing construction in respective academic journals, research subjects, and research contents were grasped thoroughly. From all domestic academic associations' publication on garment/clothing and textiles/fashion, 7 academic journals were selected as subjects of research, in order to compare and analyze the research trend in the last ten years. The ten-year period ranged from April 2006 to March 2016, and a total of 735 papers published on clothing construction were used for analysis. The number of publications in the clothing construction area during the last decade has decreased, which is due to the increase in the number of clothing and textiles fashion-related academic journals, other than the 7 journals analyzed, and since the number of papers published in international academic journals has also increased. Body type, patterns, fitting test, and functional clothing accounted for the highest proportion of research themes in clothing construction. In terms of body type, there was an increasing tendency towards usage of 3D body measurement. In the patterns area, the 3D virtual dressing system was actively used. For functional clothing, sportswear, protective clothes, and innerwear were most widely researched, and ergonomic design together with smartwear was actively studied.

The Effect of Virtual Reality Program Combining Transcranial Direct Current Stimulation on Depression, Hand Function, Cognition, and Daily Life Activities of Patients with Mild Cognitive Disorders (경두개직류전류자극을 결합한 가상현실프로그램이 경도인지장애환자의 우울, 손기능, 인지와 일상생활활동에 미치는 영향)

  • Ko-Un Kim;Bo-Ra Kim;Tae-Gyu An
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.1
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    • pp.53-62
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    • 2023
  • Purpose : This study evaluated the effects of transcranial direct current stimulation and a virtual reality program on the depression, hand functions, cognitive function, and activities of daily living of patients with mild cognitive impairment by dividing 20 patients with mild cognitive impairment and depression. The 20 patients were divided into a treatment group (transcranial direct current stimulation + a virtual reality program) and a control group (placebo transcranial direct current stimulation + a placebo virtual reality program). Methods : This study allocated ten subjects to the treatment group and ten subjects to the control group. The treatment was given five times per week for six weeks (30 sessions), and each session was 30 minutes. This study screened depression by using SGDS-K, a short geriatric depression scale, to examine depression before and after treatment intervention. This study also used the box and block test, NCSE, and FIM to evaluate hand functions, cognitive function, and activities of daily living, respectively. Results : The results showed that depression significantly decreased, hand functions significantly increased, cognitive function significantly improved, and activities of daily living significantly increased after intervention in the treatment and control groups. The magnitude of changes in depression, hand functions, cognitive function, and activities of daily living was significantly different between the two groups after intervention (p>.05). Conclusion : The results showed that the application of transcranial direct current stimulation and a virtual reality program could improve cognitive function, hand functions, and activities of daily living by decreasing depression. Therefore, it can be concluded that the simultaneous application of transcranial direct current stimulation and a virtual reality program is an intervention method, which can be applied for decreasing depression, enhancing hand functions, improving cognitive function, and increasing activities of daily living in patients with mild cognitive impairment.

The Influence of the Landscape Meaning Illustrated to Subjects on their Landscape Preference (경관의미에 대한 정보전달이 경관선호에 미치는 영향)

  • 노재현
    • Journal of the Korean Institute of Landscape Architecture
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    • v.26 no.4
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    • pp.14-24
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    • 1999
  • The objective of this study is to test the influence of the landscape meaning illustrated to subjects on their landscape preference and to investigate the difference of the response(Influence Value;IV) between cultural landscape and natural landscape. For this, color-slide surrogates for cultural and natural landscape are shown to Experimental Group(EG) and Control Group(CG)(between-subject design). And Experimental Group is divided into meaning illustrated Before and After Group(within-subject design). For given 45 slide scenes of cultural and natural landscape, the subjects were asked to measure their preference on ten point scale. The results are as follows; 1. The influence of value illustration is positive in the preference. Specifically, this effect was more powerful for the low beauty landscape than for the high beauty landscape. 2. The relation between the IV and the preference of non illustrated group was deeply correlated. And IV of cultural landscape was higher than that of natural landscape. 3. It is identified that the meaning illustration about high naturalness landscape such as the swamp and alpine landscape is more effective than other natural landscape. 4. Also, the preference was more influenced by the personal task associated with landscape experience. But the statistical significance between the preference and experience about landscape didn't exist. Accordingly, it was suggested by this study that the illustrated meanings of landscape and perceived landscape form were also major influential factors on the landscape preference.

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HORIZONTAL PLANE JAW MOVEMENTS IN EDENTULOUS PATIENTS BY USE OF EXTRAORAL TRACING DEVICE (구외 묘기장치를 이용한 무치악 환자의 수평면상 하악운동에 관한 연구)

  • Eun Seong-Sik;Chung Chae-Heon
    • The Journal of Korean Academy of Prosthodontics
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    • v.32 no.3
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    • pp.396-410
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    • 1994
  • Ten subjects who were going to wear conventional complete dentures were selected for this study. Theree subjects were women and seven were men. The average age was 63.1 years(range : 44 to 76 years). With the Height tracer (extraoral tracing device) in place the subject was instructed to go through the entire range of mandibular movements. The extreme lateral pathway of the incisor point, the so-called Gothic arch, was thereby inscribed by the stylus on the tracing plate. The mandibular movements in this study were peformed voluntarily by the subject(self guided technique) and guided by the dentist(chin-point technique and bimanual technique). The Gothic arch tracings were analysed and the Gothic arch angles and eccentric movement distances were measured. The results were as follows : 1. The apex position of the Gothic arch tracings of mandibular movements in edentulous patients varied both anterioposteriorly and mediolaterally. 2. The Gothic arch tracing had some lateral deviation during protrusion. 3. The average Gothic arch tracing angle was $136.7{\pm}12.0^{\circ}$ by subjects self guided technique, $135.7{\pm}5.9^{\circ}$ by chin-point technique, $136.6{\pm}6.5^{\circ}$ by bimanual technique. But there were no statistical differences in the reliability among the three techniques. 4. The average mandibular eccentric movements were irregular and the mandibular eccentric movement distances varied with a wide range.

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Effects on Improvement of Activities of Daily Living Through Short-Term Home Visiting Physical Therapy (단기 가정방문물리치료 시행이 일상생활동작의 개선에 미치는 효과)

  • An, Duk-Hyun
    • Physical Therapy Korea
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    • v.14 no.2
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    • pp.53-60
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    • 2007
  • The objective of this study was to discover the effects of the short-term home visiting physical therapy program involving patients with some chronic brain disorders at Gimhae City, Kyongnam. Recovery of activities of daily living (ADL) is a very important factor of rehabilitative procedures, and Functional Independence Measure (FIM) is a useful standard of evaluation for it. The FIM is widely used in brain disorder research because it measures real functional activities of daily living. We applied the physical therapy exercise program twice per week (10~15 times repeatedly); a warm-up and cool down exercise performed every ten minutes by active & active-assistive ROM and stretching exercises. Main exercises were composed of getting up & laying down in bed, standing training, walking exercise in the room, and window or wall sliding exercise using affected upper limbs for a total duration of 30 minutes. We collected the data from 20 patients with chronic brain disorders at his/her home and analyzed by means of SPSS/PC+ program (Ver. 10.0). After the six week long physical therapy exercise program, the average was $56.10{\pm}22.59$ point compared with initial $50.55{\pm}19.12$ point by FIM, improved functional ADL ability about 5.55 point, and these changed scores were statistically significant (p=.000). We also studied another factor regarding patient's satisfaction. The majority of subjects (10 people) rated the program with the maximum score of ten points (50.0%), and three people rated it a seven point program (15.0%), the other two subjects gave a rating of nine and eight points (10.0%). Because the program was effective at improving the physical ADL ability and satisfaction of each subject, we suggest continual development and implementation of a home visiting physical therapy program. Further study should involve a longer period of observation with a larger population that is involved in an individually designed home physical therapy program.

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Effects of Stimulation Conditions and Waveforms on Muscle Contractile Characteristics

  • Song Tongjin;Khang Gon
    • Journal of Biomedical Engineering Research
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    • v.26 no.2
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    • pp.111-116
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    • 2005
  • This study was designed to apply the stimulation system developed in our laboratory to investigate how the stimulation conditions affect the muscle contractile characteristics in the isometric condition as well as during the FES standing/walking. Four paraplegic and ten healthy subjects participated in this study, and their knee extensors were voluntary contracted or electrically stimulated to measure the muscle force and the fatigue index for different waveforms of the pulse train. We also investigated different combinations of the electrode positions during standing/walking. It was confirmed that continuous and high-frequency stimulation causes faster fatigue than intermittent and low-frequency stimulation. Fatigue resistance was higher around the optimal muscle length than at a stretched position in healthy subjects, whereas the opposite was observed in paralyzed subjects. The paired t-test results with the level of significance at 0.01 indicated that the sinusoidal waveform generated the largest torque among the four typical waveforms. Although statistically not very significant, the sinusoidal waveform also generated, in general, the highest fatigue resistance at an intensity level below the supramaximal stimulation. One of the paraplegic subject who participated in the standing/walking program can now stand up for 1 minute and 50 seconds with the knee extensors, and walk for about 5 minutes at the speed of 12m/sec.