• 제목/요약/키워드: the administration

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INHIBITION OF NEURITE OUTGROWTH AND TRANSCRIPTION FACTOR ACTIVATION BY OCHRATOXIN A IN CULTURED PC-12 CELLS

  • Hong, Jin-Tae;Oh, Jae-Ho;Jung, Kyoung-Mi;Lee, Eun-Hee;Park, Ki-Sook;Song, Chi-Won;Jung, Hai-Kwan;Lee, Myung-Koo;Yang, Ki-Hwa;Chung, Soo-Youn
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.168-168
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    • 2001
  • The mycotoxin, ochratoxin A (OTA) has been known to induce microcephaly in animals and in vitro whole embryo. Cytotoxic effect and inhibition of cell differentiation were proposed as underlying mechanisms responsible for OTA-induced microcephaly.(omitted)

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DIETARY RISK ASSESSMENT FOR POLYCYCLIC AROMATIC HYDROCARBONS IN FOOD

  • Hyomin LEE;Eunkyung YOON;Yoonho CHOI;Gunyoung LEE;Yonsook JO;Kisung KWON;Soyoung CHUNG;Myungchul KIM;Jisun YANG
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.136-136
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    • 2002
  • Polycyclic aromatic hydrocarbons(PAHs) vary in their carcinogenic potencies. The more potent PAHs carcinogens are 3-methylcholantheren and 7, 12- dimethyl benzo(a)anthracene, while dibenzo(a, c)anthracene has very little carcinogenic activity. Risk assessment of chemical mixture containing various congeners which toxic potency are each different, are conducted using toxic equivalency factors(TEFs).(omitted)

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Relationship Between the Efficiency and the Redundancy in Public Administration

  • Chung, Sung-Beom
    • 한국정보컨버전스학회:학술대회논문집
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    • 한국정보컨버전스학회 2008년도 International conference on information convergence
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    • pp.157-160
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    • 2008
  • The pursuit of efficiency is taken for granted in today's public administration, and the limit of this study exists in the point that we should carefully deal with combining the redundancy scheme to the public administration. Accordingly, although this study should suggest the specific plans and backgrounds of the needs for the redundancy, it will only find out the applicability of the redundancy to the public administration for its purpose. Redundancy means the excess or superfluity in something, which means the surplusage status ranging from the wasteful and excessive supplies, insignificant additions, to the surplusage in a legal pleading. The emphasis of this study is placed on the changes in the rigidity in believing that the removal of the redundancy from the public administration is the best option in any case of the efficiency. In addition, the necessity of the overlapped organization should not be neglected by the concept of the efficiency. Indeed, it is necessary to correct the overlapped function of superfluity and ambiguity public administration, in order to remove the neglect conflicts between the organizations, to guarantee the inconsistency in the public administration and to ensure the efficiency in the public administration volunteering.

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과량의 미나리 생즙 투여가 HK phenotype 진도견의 혈액상의 미치는 영향 (The Change of Blood Properties of HK Phenotype Jindo dogs Administrated with Excessive Amount of Water Celery Extracts)

  • 안병만;장혜숙;정규식;박승춘;오태호;송재찬;김영홍;권오덕
    • 한국임상수의학회지
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    • 제18권4호
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    • pp.334-340
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    • 2001
  • This study was conducted to investigate changes in blood properties of high potassium (HK) phenotype Jindo dogs (15kg$\pm$2kg) after daily oral administration with water celery extracts (10 ml/kg) for 7 days. Blood samples were collected for three days in a row before administration of water celery extracts. After water celery extracts administration, blood samples were collected at 3h, 6h, 9h and then on daily basis until day 10 post administration (PA). At day 15, final sample was collected. Blood samples were analyzed on the basis of red blood cell (RBC), white blood cell (WBC), packed cell volume (PCV), hemoglobin (Hb) concentration, mean corpuscular volume(MCV), mean corpuscular hemoglobin concentration(MCHC), gluthathione concentration(GSH) and met-hemoglobin(Met-Hb) concentration. The significant changes (p<0.01, p<0.05) of RBCs were shown at 3 h to day 5, and days 7 and 9 after administration. PCV values were decreased form 3 h to day 10 after administration. Mean Hb concentration showed significant increase as 3 h to day 3, and day 6 to day 9 after administration. The significant changes (p<0.05) of WBCs were shown at 9 h and day 1 after administration. The increased numbers of MCV were detected at days 6 to 9 after administration (p<0.05, p<0.01). The significant changes of MCHC were shown at 9h and day 1 after administration. The significant increases (p<0.01, p<0.05) of GSH concentration were detected at days 1, 6 and 7 after administration. In Met-Hb concentration, the significant increases (p<0.05) occurred at only 9h and day 7 after administration, The significant increases (p<0.01, p<0.05) of reticulocyte were detected at days 2, 4, 5, 6 and 7. Data from blood samples collected at day 15 after administration showed that all of blood analysis results returned to normal level, compared to controls.

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Pregnancy rate in Hanwoo cows after timed artificial insemination using different sperm concentrations

  • Sung-Sik Kang;Sang-Rae Cho;Ui-Hyung Kim;Yonghwan Kim;Seok-Dong Lee;Myung-Suk Lee;Eunju Kim;Jeong-Il Won;Shil Jin;Hyoun-Ju Kim;Sungwoo Kim;Sun-Sik Jang;Seunghoon Lee
    • 한국동물생명공학회지
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    • 제39권1호
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    • pp.40-47
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    • 2024
  • Background: Sperm quality and the number of sperm introduced into the uterus during artificial insemination (AI) are pivotal factors influencing pregnancy outcomes. However, there have been no reports on the relationship between sperm concentration at AI and sperm quality in Hanwoo cattle. In this study, we examined sperm quality and pregnancy rates after AI using sperm inseminated at different concentrations. Methods: We evaluated the motility, viability, and acrosomal membrane integrity of sperm at different concentrations (10, 15, 18, and 20 million sperm/straw) in 0.5-mL straws. Subsequently, we compared the pregnancy rates after AI with different sperm concentrations. Results: After freeze-thawing, sperm at the assessed concentrations showed similar viability and acrosomal membrane integrity. After AI, cattle in the 10 million group had significantly lower pregnancy rates compared to those in the 18 and 20 million groups. Conversely, there were no statistically significant variances observed between cattle in the 10 and 15 million groups. Conclusions: Sperm at concentrations of 10, 15, 18 and 20 million per straw exhibited comparable motility, viability, and acrosomal membrane integrity. However, a concentration of at least 18 million sperm per straw is required to achieve a consistent rate of pregnancy rate in Hanwoo cattle after AI.