• Journal of the Economic Geographical Society of Korea
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• v.16 no.2
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• pp.167-181
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• 2013

The cross-border flow of workers in EU having the freedom of labor mobility and residence plays a role in the border labor markets as a structural factor of regulation. The regulation role of the cross-border flow of workers on the Grand R$\acute{e}$gion, which is the border among the France-Belgium-Luxemburg-Germany, is as follows. First, the cross-border flow of workers regulates the regional surplus and lack of labor in quantity and quality. Second, the border labor markets are regulated by the regionally segmented supply and demand of labor and are modulated by the flexible employment like a part-time and temporary employment. Third, the residence of the cross-border workers concentrates on the adjacent regions to the border. And the atypical cross-border workers, who have their residence in the neighboring country but works in the existing country, are rising rapidly.

• Molecules and Cells
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• v.28 no.6
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• pp.565-573
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• 2009

The pig could be a useful model to characterize molecular aspects determining several delicate phenotypes because they have been bred for those characteristics. The Korean native pig (KNP) is a regional breed in Korea that was characterized by relatively high intramuscular fat content and reddish meat color compared to other western breeds such as Yorkshire (YS). YS grew faster and contained more lean muscle than KNP. We compared the KNP to Yorksire to find molecular clues determining muscle characteristics. The comparison of skeletal gene expression profiles between these two breeds showed molecular differences in muscle. We found 82 differentially expressed genes (DEGs) defined by fold change (more than 1.5 fold difference) and statistical significance (within 5% of false discovery rate). Functional analyses of these DEGs indicated up-regulation of most genes involved in cell cycle arrest, down-regulation of most genes involved in cellular differentiation and its inhibition, down-regulation of most genes encoding component of muscular-structural system, and up-regulation of most genes involved in diverse metabolism in KNP. Especially, DEGs in above-mentioned categories included a large number of genes encoding proteins directly or indirectly involved in p53 pathway. Our results indicated a possible role of p53 to determine muscle characteristics between these two breeds.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.2
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• pp.314-319
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• 2001

In the present study, effects of $\beta$-alanine, a known taurine antagonist for its structural similarity, on the adaptive regulation and kinetic behavior of the taurine transporter were investigated in the HT-29, human colon carcinoma cell line. Pretreatment of the cell with $\beta$-alanine(10mM) for varying periods from 3 to 30 hrs significantly reduced the taurine uptake compared to the value for control cells. This decrease in the taurine transporter activity was dependent on the incubation time with $\beta$-alanine, and the maximal down-regulation of the transporter activity was observed in cells pretreated with $\beta$-alanine for 24 hrs (25% of the control value, p<0.01). The taurine transporter appears to bind exclusively with $\beta$-alanine in the HT-29 cells since the same concentration of $\alpha$-alanine added in the culture medium for 24 hrs did not influence the taurine uptake. Kinetic analyses of the taurine transporter activity was performed in the HT-29 cell line with varying taurine concentration (5~60$\mu$M) in the uptake medium. Active taurine uptake was significantly lower in $\beta$-alanine pretreated cells compared to the value for control cells in the range of taurine concentration used in the experiment (p<0.001). The cells pretreated with $\beta$-alanine showed a 50% lower maximal velocity (Vmax, 1.7$\pm$2.0 nmole.mg $protein^{-1}$.$30min^{-1}$), and a 99% higher Michaelis constant (Km, 40.3$\pm$7.6$\mu$M) than the control values (3.3$\pm$1.9 nmole.mg $protein^{-1}$.$30min^{-1}$, and 20.3$\pm$2.1$\mu$M, respectively). These results on kinetic data suggest that $\beta$-alanine induced down-regulation of the taurine transporter activity was associated with decreases in both maximal velocity and affinity of the transporter.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.482-498
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• 2019

The purpose of this study is to examine between the social isolation and smart phone addiction in elderly. Under this relationship, we investigated the double-mediation effects of self-regulation and social support. Research data were collected from 404 elderly in DaeJeon, South Korea. The final sample were 404 who fully responded. As a result of structural equation modeling, the social isolation of elderly significantly effected directly in smart phone addiction. Furthermore, self-regulation and social support effected the smart phone addiction indirectly through the double-mediation path. Based on the results of this study, the implications and future studies of the smart phone addiction of elderly are suggested.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.155-161
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• 2014

Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological hallmarks of Alzheimer's disease. Protein phosphatase 2A (PP2A), a major tau protein phosphatase, consists of a structural A subunit, catalytic C subunit, and a variety of regulatory B subunits. The B subunits have been reported to modulate function of the PP2A holoenzyme by regulating substrate binding, enzyme activity, and subcellular localization. In the current study, we characterized regulatory B subunit-specific regulation of tau protein phosphorylation. We showed that the PP2A B subunit PPP2R2A mediated dephosphorylation of tau protein at Ser-199, Ser-202/Thr-205, Thr-231, Ser-262, and Ser-422. Down-regulation of PPP2R5D expression decreased tau phosphorylation at Ser-202/Thr-205, Thr-231, and Ser-422, which indicates activation of the tau kinase glycogen synthase kinase 3 beta ($GSK3{\beta}$) by PP2A with PPP2R5D subunit. The level of activating phosphorylation of the $GSK3{\beta}$ kinase Akt at Thr-308 and Ser-473 were both increased by PPP2R5D knockdown. We also characterized B subunit-specific phosphorylation sites in tau using mass spectrometric analysis. Liquid chromatography-mass spectrometry revealed that the phosphorylation status of the tau protein may be affected by PP2A, depending on the specific B subunits. These studies further our understanding of the function of various B subunits in mediating site-specific regulation of tau protein phosphorylation.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.605-619
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• 2019

This study aimed to examine the mediating roles of self-determined motivations on the effect of class climate perceived by middle school students on self-regulated learning ablility. For this purpose, a total of 589 students were selected as subjects in this research. Structural equation modeling was conducted so as to verify the relationship among all the variables. As a results, first, the perceived autonomous class climate had a direct effect on self-regulated learning ability and an indirect effect on self-regulated learning ability through the mediation effect of identified regulation. Second, the perceived controlled class climate had a direct effect on self-regulated learning ability and an indirect effect on self-regulated learning ability through the mediation effect of identified regulation, introjected regulation, and external regulation. This study implies that facilitating autonomous engagement in learning activities will be a effective educational intervention to improve self-regulated learning ability.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.712-722
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• 2021

The primary purpose of this study was to examine the mediating effect of cognitive emotion regulation strategies in the relationship between adult attachment and interpersonal relationship competence. To achieve the purpose of the study, college students from nationwide completed the questionnaire and analyzed 326 valid ones. Descriptive statistics, Pearson correlation analysis, and structural equation model were performed using SPSS 22.0 and AMOS 23.0. The results are as follows. First, adult attachment(attachment anxiety and attachment avoidance) were negatively correlated with interpersonal relationship competence. Also, attachment avoidance was significantly influenced on interpersonal relationship competence than attachment anxiety. Second, in the relationship between adult attachment and interpersonal relationship competence, attachment anxiety was fully mediated and attachment avoidance was partially mediated with cognitive emotion regulation strategies. Attachment anxiety and attachment avoidance mediated with adaptive cognitive emotion regulation strategies. Based on these results, we verified the importance and the possibility of changing the cognitive emotion regulation for increasing the level of interpersonal relationship competence. Finally, this study may provide an insight in terms of developing education and programs of adaptive cognitive emotion regulation strategies in counseling session.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2005.11a
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• pp.187-190
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• 2005

By the rapid technological advance and social needs, demand of Multi Function Facility is on the increase. The multiplex is an alternative of them. In case of fire, special function of facility nay result in terrible accident. Therefore, literature and regulations survey on the multiplex were enforced, Multiplex facilities in Daejeon City were surveyed, and reformation of regulation and structural system were suggested in this study.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.16-16
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• 1996

Investigation of the structure of the gangliosides has proven to be very important in the understanding of their biological roles such as regulation of differentiation and growth of cells. Unexchanged hydroxyl protons and amide protons in ganglioside are protrude farther from the carbon backbone than the C-linked protons and provides nOe contacts with other protons which can provide additional distance constraints in structural determination. (omitted)

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2009.04a
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• pp.410-414
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• 2009

Performance based fire engineering design should be developed through basic survey and fundamental element such as analytic program for evaluation of fire performance of building. The basic elements will be expressed to the surveys of the structures of building laws, regulation and the fundamental elements consist of technical guidances contained design fires, heat analysis, determination of structural performance.