• Molecules and Cells
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• 제25권2호
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• pp.211-215
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• 2008

To gain a better understanding of the methylation imprinting changes associated with heat stress in early development, we used bisulfite sequencing and bisulfite restriction analysis to examine the DNA methylation status of imprinted genes in early embryos (blastocysts). The paternal imprinted genes, H19 and Igf-2r, had lower methylation levels in heat-stressed embryos than in control embryos, whereas the maternal imprinted genes, Peg3 and Peg1, had similar methylation pattern in heat-stressed embryos and in control embryos. Our results indicate that heat stress may induce aberrant methylation imprinting, which results in developmental failure of mouse embryos, and that the effects of heat shock on methylation imprinting may be gene-specific.

• 대한한방체열의학회지
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• 제3권1호
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• pp.27-35
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• 2004

Today, everybody lives in the stress. So 50% to 80% or 60% to 80% of the modern diseases are estimated what is caused by the stress. And one of the most important point of the stress is a too serious and continuos tension state. Therefore the best way to promotion, persistence, prevention and treatment of the modern man's health will be the relaxion from the tension state. The relax therapy as known as am effective method to the disease which as concerned with stress. that can be adapted to the treatment of anxiety-related diseases, insomnia, hypertension, tension headache, migraine, asthma, preparation of delivery, G-I disorders and menstrual disorders. Until now we guess the change of a relaxed state by the observation to the change of autonomic nervous system(ANS) and EEG. From the point of the ANS, sympathetic nervous system progresses slowly but parasympathetic nervous system increases the activity. In the EEG, both the alpha-wave concerned with the deep physical relaxed state and emotional stability and the theta-wave appeared in the state of meditation are increased. Current studies show that among the biochemical changes, especially serotinin like body hormone is increased by the feeling of the stability or the happiness. So, to see the change of the relaxed state in the image of the D.I.T.I., we used the deviational differences between the pre-relaxed state and the post-relaxed state of 70 people. As a result, the portional deviation of the face is decreased in the image of the D.I.T.I. So it can be thaught that we can determine the changes of the relaxed state by the D.I.T.I.

• International Journal of Precision Engineering and Manufacturing
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• 제6권3호
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• pp.24-28
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• 2005

Stress state of chip formation zone is one of the main problems in metal cutting mechanics. In two-dimensional case this process is usually considered as consistent shears of work material along one of several shear surfaces, separating chip from workpiece. These shear planes are assumed to be trajectories of maximum shear stress forming corresponding slip-line field. This paper suggests a new approach to the constriction of slip-line field, which implies uniform compression in chip formation zone. Based on the given model it has been found that imaginary shear line in orthogonal cutting is close to the trajectory of maximum normal stress and the problem about its determination has been considered as well. It has been shown that there is a second central slip-line field inside chip, which corresponds well to experimental data about stress distribution on tool rake face and tool-chip contact length. The suggested model would be useful in understanding mechanistic problems in machining.

• Structural Engineering and Mechanics
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• 제33권5호
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• pp.635-647
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• 2009

For the calculation of foundation settlement it is recommended to take into account so called influence zone inside the subsoil bellow the foundation structure. Influence zone inside the subsoil is the region where the load has a substantial influence on the deformation of the soil skeleton. The soil skeleton is pre-consolidated or over consolidated due to the original geostatic stress state. An excavation changes the original geostatic stress state and it creates the space for the load transferred from upper structure. The theory of elastic layer in Westergard manner is selected for the vertical stress calculation. The depth of influence zone is calculated from the equality of the original geostatic stress and the new geostatic stress due to excavation combined with the vertical stress from the upper structure. Two close formulas are presented for the influence zone calculation. Using ADINA code we carried out several numerical examples to verify the proposed analytical formulas and to enhance their use in civil engineering practice. Otherwise, the FEM code accuracy can be control.

• Geomechanics and Engineering
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• 제23권6호
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• pp.587-600
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• 2020

Shear-induced instability of jointed rock mass has greatly threatened the safety of underground openings. To better understand the failure mechanism of surrounding rock mass under shear, the flawed specimens containing a circular opening and two open joints are prepared and used to conduct direct shear tests. Both experimental and numerical results show that joint inclination (β) has a significant effect on the shear strength, dilation, cracking behavior and stress distribution around flaws. The maximum shear strength, occurring at β=30°, usually corresponds to a unifrom stress state around joint and an intense energy release. However, a larger joint inclination, such as β=90°~150°, will cause a more uneven stress distribution and a stronger stress concentration, thus a lower shear strength. The stress distribution around opening changes little with joint inclination, while the magnitude varys much. Both compression and tension around opening will be greatly enhanced by the 30°-joints. In addition, a higher normal stress tends to enhance the compression and suppress the tension around flaws, resulting in an earlier generation and a larger proportion of shear cracks.

• 보건교육건강증진학회지
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• 제24권3호
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• pp.21-34
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• 2007

Objectives: This study aims to examined whether physical activity prevent the negative effect of psychological stress on cardiovascular reactivity by reducing stress induced sympathetic output and preventing norepinephrine depletion negative psych-affective responses. It is assumed that physical activity reduces the magnitude of cardiovascular responses and psychological responses to stress which threaten individuals' physical and mental health. The result of investigating the effect of physical activity on reducing negative physiological and psychological responses would suggest useful information health for practitioners who want to prevent stress-induced diseases, especially coronary heart disease. Methods: participants of this study were 30 students (10 males & 20 females), whose mean age was 21.30 (SD=2.29). Fifteen students (5 males & 10 females) were assigned for in each group, treatment and control groups. They were interviewed and given a survey that included a consent form, demographics sheet and psychological tests, such as State-Trait Anger Expression Inventory and State-Trait Anxiety Inventory. Before the application of psychological stress, participants in treatment group were going through with a course of physical exercise, running on treadmill 15minutes, while participants in control group were not physically active. After exercise, there was 15 minutes resting period before applying cognitive stress. During the experiment, all participants performed challenging cognitive tasks for 20minutes in situations that were designed to experience learned helplessness and measured their cardiovascular reactivity including blood pressure and heart rate every 5 minutes, until 10 minutes after finishing the application of psychological stress(recovering state). In the end of experiment, they were given some psychological test again. Results: Heart rates of exercise group were significantly higher than non-exercise group, especially, five minute after applying cognitive stress and at the end of recovery, in other word 10 minutes after stressful event. Systolic blood pressures of exercise group were lower than those of non-exercise group during the stressful event, but this differences in borderline level of significance. state anger level of exercise group decreased even experiencing stress, while those of non-exercise group increase. And state anxiety level of exercise group decreased in borderline level of significance. Conclusion: This study reiterate health benefits of physical activity and suggest that regular moderate exercise may regulate cardiovascular reactivity and psycho-affective responses from stress by reducing stress induced sympathetic output.

• Perspectives in Nursing Science
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• 제11권2호
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• pp.87-93
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• 2014

Purpose: The use of salivary biomarkers for stress research is increasing based on the convenience of collection, affordability and scientific merit. This short review provides an overview of the state of the science of salivary biomarkers utilized in research related to stress. Methods: An integrative review was conducted. Results: The trend of utilizing salivary biomarkers in stress research was reviewed, specifically, focusing on the use of endocrine and inflammatory biomarkers incorporated in previous stress research. Then, a review of sampling procedures for salivary biomarkers and the analytic methods is provided. Finally, a discussion on the strengths and areas for improvement in the use of salivary biomarkers in stress research is included. Conclusion: Salivary biomarkers as an alternative to blood biomarkers are increasingly being recognized as a legitimate source for analyzing the stress response in humans.

• 터널과지하공간
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• 제18권2호
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• pp.134-148
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• 2008

암반의 초기응력 상태는 방사성 폐기물 지층 처분장의 적합성을 판단하는데 중요한 요소이다. 본 연구에서는 3차원 개별요소법을 이용하여 스웨덴 방사성 폐기물 처분장 후보지 중 하나인 오스카샴 지역에서 대규모 변형대가 초기응력에 미치는 영향을 살펴보았다. 수치해석에서는 부지조사 과정에서 확인된 변형대를 모델에 포함시켰으며 원거리 지각응력을 경계조건으로 사용하였다. 현지 암반에서 관찰되는 초기응력값의 변화 양상이 수치해석에서도 재현이 됨으로써 수치해석이 암반의 초기응력상태를 이해하는데 유용하게 쓰일 수 있음을 확인하였다. 수치해석을 통한 예측값과 초기응력 측정값과의 차이는 측정된 자료의 양호한 정도, 지질모델 및 변형대의 물성치의 불확실성 등에 기인하는 것으로 생각된다.

• 치위생과학회지
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• 제12권6호
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• pp.583-590
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• 2012

본 연구는 경제적 스트레스와 상태 특성불안이 치주질환에 미치는 영향을 파악하여 치주질환의 예방과 발생 및 진행 정도를 미연에 방지할 수 있는 방안을 마련하기 위하여 실시되었다. 연구대상은 일부 지역 치과의원에 내원한 40~50대 성인남녀 총 326명을 대상으로 하여 구조화된 설문지와 치주상태를 측정하여 조사 분석하였다. 수집된 자료는 IBM SPSS ver. 19.0 통계프로그램(IBM Co., Armonk, NY, USA)을 이용하여 빈도와 백분율, t-test (검증), One way ANOVA (일원배치 분산분석), Multiple regression Analysis (다중회귀분석)을 실시하여 분석결과는 다음과 같다. 1. 경제적 스트레스는 치은염 지수의 고($1.12{\pm}0.72$), 중($0.85{\pm}0.62$), 저($0.88{\pm}0.62$)에 따라 통계적으로 유의한 차이를 보였다(p<0.01). 2. 상태 특성불안은 치은염 지수(p<0.001)의 고($1.16{\pm}0.71$), 중($0.81{\pm}0.63$), 저($0.86{\pm}0.60$), 치주낭 깊이(p<0.05)의 고($3.86{\pm}1.12$), 중($3.44{\pm}1.07$), 저($3.57{\pm}1.01$), 임상적 부착소실(p<0.05)의 고($3.86{\pm}1.12$), 중($3.44{\pm}1.07$), 저($3.57{\pm}1.01$)에 따라 통계적으로 유의한 차이를 보였다. 3. 치은염 지수에 영향을 미치는 요인으로 경제적 스트레스($\beta$=0.052, p<0.01)가 높을수록, 상태 특성불안($\beta$=0.052, p<0.01)이 높을수록 영향을 미치는 것으로 조사되었다. 이상의 연구결과에서 치과의료기관은 치주질환으로 힘들어 하는 환자에게 경제적 스트레스와 상태 특성불안이 치주질환에 영향을 미친다는 사실을 인식시킬 필요가 있으며 이에 따른 치주질환의 예방과 발생 및 진행 정도를 방지할 수 있는 스트레스 관리능력배양을 위한 교육프로그램 개발이 마련되어야 할 것이다.

• 한국전산구조공학회논문집
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• 제28권3호
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• pp.309-316
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• 2015

상태 기반 페리다이나믹 모델은 일반적인 재료 구성 모델을 구현할 수 있고 비국부 영역 내에서 연결된 모든 결합의 변형을 통해 각 절점의 재료 응답이 결정되기 때문에 체적 및 전단 변형을 모두 표현할 수 있다. 따라서 상태 기반 모델은 복잡한 동적 취성 파괴 현상(분기균열, 2차 균열, 계단균열, 균열 유착 등)을 해석하는데 유용하다. 본 논문에서는 평면응력 탄성체에 대해 2차원 상태 기반 페리다이나믹 모델을 적용하고 에너지해방율과 페리다이나믹 에너지 포텐셜로부터 손상 모델을 구성하였다. 페리다이나믹 파괴 해석 모델을 통해 취성 유리 재료에 대해 균열 면에 평행한 압축 응력파가 균열 분기 패턴에 미치는 영향에 대해 조사하였다. 실험을 통해 관찰된 동적 균열 진전 및 분기 패턴에 대한 주요 특성들이 페리다이나믹 해석을 통해 확인되었다. 또한 강한 인장 하중 하의 계단균열과 이차균열 등이 상태 기반 페리다이나믹 시뮬레이션을 통해 잘 모사가 되는 것을 확인할 수 있었다.