• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.259-259
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• 1994

Protein kinase C (PKC) participates in many cellular signal transduction. Previously we found that PKC activity of whole rat brain was altered after an exposure to cold temperature of 4 $^{\circ}C$ (Lee and Choi, Exp. Neurobiol., 2, 6, 1993). In this time PKC activity in each region of rat brain was investigated in order to know each regions is affected mostly by the stress.

• 대한기계학회논문집A
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• 제20권6호
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• pp.1784-1797
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• 1996

The disk/blade assembly of a turbine engine is made in the shape of a dovetail type or a fir-tree type. Since disk fillet regions or contact surfaces undergo high stress comcentration, fatigue cracks frequentrly occur in the disk/blade assembly. Therefore, it is necessary to analyze the stress distributions in the fir-tree type disk/balde assembly and predict the region of fatigue failure. The stress distributions of the disk/blade assembly were investigated by using the photoelastic method and the finite element method. Two dimensional photoelastic techniques were used to investigate the stress distributions of contact surfaces and fillet regions. TH stress distributions were obtained by the shear-difference method and were compared to the finite element results. It was found that maximum tensile stresses were higher in the fillet region thatn in the contact surfaces of the fir-tree models. The finite element results showed good agreement with the experimental results.

• 한국지반공학회논문집
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• 제21권5호
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• pp.103-110
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• 2005

이 논문에서는 현장 수압파쇄시험에서 얻어진 500개 이상의 측정 자료들을 이용하여 국내 과잉 수평응력의 분포 특성에 대한 연구를 수행하였다. 현장 자료를 바탕으로 수평응력 성분의 크기와 작용방향성, 측압계수 분포에 대한 상세 분석을 하였다. 또한 심도에 따른 수평응력 성분들의 상관식과 측압계수 분포 영역의 상, 하한 경계식을 제안하였다. 심도 310m 미만 영역에서 측압계수는 심도 증가에 따라 감소되고 안정화되는 경향을 나타내지만 지역에 따라 심도 loom 이상의 영역에 3.0에 가까운 측압계수를 가지는 과잉 수평장이 형성되어 있는 것으로 조사되었다. 과잉 수평응력장 분포지역에 대한 평가 결과 국내 여러 지역의 심도 310m 이내 구간에서 암반 구조물 굴착시 응력에 의한 취성파괴의 가능성이 있는 것으로 분석되었다.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제1권1호
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• pp.68-73
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• 2020

Korean fir (Abies koreana) is an evergreen coniferous tree species that is unique to South Korea. A. koreana is found in a limited sub-alpine habitat and is considered particularly vulnerable to climate change. Identification of populations vulnerable to climate change is an important component of conservation programs. In this study, a heat stress-induced transcriptome RNA-seq dataset was used to identify a subset of six genes for assessment as candidate marker genes for ecologically vulnerable populations. Samples of A. koreana were isolated from ecologically stable and vulnerable regions of the Halla and Jiri mountains, and the expression levels of the six candidate markers were assessed using quantitative real-time polymerase chain reaction. All six of the candidate genes exhibited higher expression levels in samples from vulnerable regions compared with stable regions. These results confirm that the six high temperature-induced genes can be used as diagnostic markers for the identification of populations of A. koreana that are experiencing stress due to the effects of climate change.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 추계학술대회논문집
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• pp.819-822
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• 2006

This paper has the objects of deciding dynamic instability regions of thick plates on inhomogeneous Pasternak foundation by finite element method and providing kinematic design data for mats and slabs of building structures. In this paper, dynamic stability analysis of tapered opening thick plate is done by use of Serendipity finite element with 8 nodes considering shearing strain of plate. To verify this finite element method, buckling stress and natural frequencies of thick pate with or without in-plane stress are compared with existing solutions. The results are as follow that this finite element solutions with $4{\times}4$ meshes are shown the error of maximum 0.56% about existing solutions, and the larger foundation parameters, the farther dynamic instability regions are from vertical axis of graph presented relation of ${\beta}\;and\;\overline{\omega}/\omega$.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.315-320
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• 2003

Two different strength types of plain concrete plate specimens (200$\times$200$\times$60mm) were tested under different biaxial load combinations. The specimens were subjected to biaxial combinations covering the three regions of compression-compression, compression-tension, and tension-tension. The loading platens with Teflon pads were used to reduce a confining effect in boundary surface between the concrete specimen and the solid platen. The principal deformations in the specimens were recorded, and the failure modes along with each stress ratio were examined. Based on the strength data, the failure envelops were developed for each type of plain concrete. The biaxial stress-strain responses of concrete plate specimens for three biaxial loading regions were also plotted. The test data indicated that the strength of concrete under biaxial compression ($f_2 / f_1$$_1$=-1/-1) is about 17 percent larger than under uniaxial compression.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.323-326
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• 1996

Dental implant is increasingly used to recover the mastication function of tooth. Several types of implant were designed to give an optimal stress distribution in surrounding bony regions. In this study, six types of implant were investigated using finite element method and it was studied i) how the variation of cortical bone thickness affects the stress distribution in surrounding bony regions depending upon implant types, ii) which type gives the best characteristics in the sence of stress distribution and stability. The hybrid-type implant with cylinder and screw gave the optimum properties in view of stability and response to the variation of cortical bone thickness.

• 대한기계학회논문집B
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• 제26권5호
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• pp.629-639
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• 2002

In-vitro flow characteristics downstream of a polyurethane artificial heart valve and a Bjork-Shiley Monostrut mechanical valve have been comparatively investigated in pulsatile flow using particle image velocimetry (PIV). With a triggering system and a time-delayed circuit the velocity distributions on the two perpendicular measurement planes downstream of the valves are evaluated at any given instant in conjunction with the opening behaviors of valve leaflets during a cardiac cycle. The regions of stasis and high shear stress can be found simultaneously by examining the entire view of the instantaneous velocity and Reynolds shear stress fields. It is known that high shear stress regions exist at the interface between strong axial jet flows along the wall and vortical flows in the central area distal to the valves. In addition. there are large stagnation or recirculation regions in the vicinity of the valve leaflet, where thrombus formation can be induced by accumulation of blood elements damaged in the high shear stress zones. A correlation between the unsteady flow patterns downstream of the valve and the corresponding opening postures of the polyurethane valve membrane gives useful data necessary for improved design of the frame structure and leaflet geometry of the polyurethane valve.

• Steel and Composite Structures
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• 제22권6호
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• pp.1239-1259
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• 2016

The modified couple stress-based third-order shear deformation theory is presented for sigmoid functionally graded materials (S-FGM) plates. The advantage of the modified couple stress theory is the involvement of only one material length scale parameter which causes to create symmetric couple stress tensor and to use it more easily. Analytical solution for dynamic instability analysis of S-FGM plates on elastic medium is investigated. The present models contain two-constituent material variation through the plate thickness. The equations of motion are derived from Hamilton's energy principle. The governing equations are then written in the form of Mathieu-Hill equations and then Bolotin's method is employed to determine the instability regions. The boundaries of the instability regions are represented in the dynamic load and excitation frequency plane. It is assumed that the elastic medium is modeled as Pasternak elastic medium. The effects of static and dynamic load, power law index, material length scale parameter, side-to-thickness ratio, and elastic medium parameter have been discussed. The width of the instability region for an S-FGM plate decreases with the decrease of material length scale parameter. The study is relevant to the dynamic simulation of micro structures embedded in elastic medium subjected to intense compression and tension.

• 대한의용생체공학회:의공학회지
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• 제13권4호
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• pp.339-352
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• 1992

A numerical simulation of the steady and pulsatile flow across the end-to-side anastomosis was performed In order to understand the role of flow dynamics in the preferential bevel opment of distal anastomotic intimal hyperplasla. The finite element technique was employed to solve two-dimensional unsteady pulsatile flow in that region. The results of the steady flow revealed that low shear stresses occur at the proximally occluded host artery and at the recirculation region in the Inner wall just distal to the toe region of the anastomosis. The nor- mal;zed wall shear rate was increased, as was the recirculation zone size in the host artery of the by-pass graft anastomosis, with increased anastomotic junction angle. In order to min imize the size of the low wall shear region which might result in the intimal hyperplasia in the by-pass graft anastomosis, a smaller anastomotic junction angle is recommended. The pulsatile flow simulation revealed flow that regions of low and ascillating mali shear do exist near the anastomosis as In the steady simulation. The shift of stagnation point depends on the pulsation of the flow. As the flow was accelerated at systole, the stagnation point moved downstream, disappered at early diastole and reappeared during late diastole. Low shear stress was also found along both walls of the occluded proximal artery. However, the diastolic flow behavior is quite different from the steady results. The vortex near the occluded artery moved downstream and inwardly during late systole, and disappeared during diastole. Recirculations proximal to the toe and heel regions were significant during diastole. Shear stress oscillation was found along the opposite wall. The results of the present study revealed that tow shear occurs at the proximally occluded host artery aud the recirculation region in the inner wall Just dlstal to the toe region of the anastomosis. The present study suggested that the regions of fluctuated wall shear stress wit flow separation is correlated with the preferential developing regions of anastomosis neointial fibrous hyperplasia.