• Biomolecules & Therapeutics
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• 제4권4호
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• pp.419-427
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• 1996

To solubilize practically insoluble biphenyl dimethyl dicarboxylate (DDB), which has been used for the treatment of chronic hepatitis as tablets or hard capsules, the solubilities of DDB in various hydrophilic, oily and hydrocarbon vehicles, and aqueous surfactant solutions were measured by high performance liquid chromatography. It was found that, among the vehicles studied, polyethylene glycol (PEG) 300 revealed the best solvency, and the solubility reached 17.6 mg/ml at 37$^{\circ}C$. The addition of glycyrrhizic acid ammonium salt (GAA) to DDB-PEG 300 solution (5-20 mg/g) inhibited the formation of precipitates, and at the concentration of 10 mg/g, any precipitaction was not observed even after 2 years at 4$^{\circ}C$. Furthermore, GAA markedly enhanced the permeation of DDB through the rabbit duodenal mucosa in a concentration dependent manner. The addition of copolyvidone (ca. 1.0%) to DDB-GAA-PEG 300 system (1 : 0.5 97.5 w/w) was most effective in preventing the considerable precipitation of DDB-PEG 300 solution (7.5 mg/750 mg) when mixed with water of 300-900 ml at 37$^{\circ}C$. GAA showed a synergistic effect in the prevention of precipitate formation. This finding suggests that this DDB formulation may form less precipitation when DDB soft capsules disintegrate and diffuse into the gastrointestinal fluid, resulting in improving the bioavailability Dissolution rate of DDB (7.5 mg) from sort elastic capsules of DDB-GAA-PEG 300 system was rapid. The supersaturation state was maintained for 2 hr at the concentration of 7.35$\pm$3.3 mg in 900 ml of water without precipitation. The total amount of DDB dissolved from this new formulation was 5.3 and 6.1 times higher, when compared to marketed DDB tablets (25 mg) and capsules (7.5 mg), respectively.

• 한국의사학회지
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• 제25권1호
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• pp.11-22
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• 2012

This study is about King Kyung-jong's medical history written on "The Daily Records of Royal Secretariat of Chosun Dynasty". Kyung-jong, the 20th King of Chosun was born in 1688 as a prince and passed away in 1725. When he was prince, his main diseases were some infectious things; for example, smallpox, measles, a sort of malaria, a sort of mumps etc. But the time he was king, his main diseases were related unenergetic(虛證). According to "The Daily Records of Royal Secretariat of Chosun Dynasty" yak-bang(藥房) records, some informations about his health are different from general knowledges. At first, His father's dead is more related his health than his mother's dead. Second, he was fat, not thin(or desiccate). Third, his infertility was not caused his mother when she died. Fourth, he was regarded as one of psychological healthy person. And not exactly related Kyung-jong's health, in "The Daily Records of Royal Secretariat of Chosun Dynasty" at Kyung=jong's era, there are some meaningful informations at medical history. One is a doctor who was smallpox specialist. His name is Yoo-Sang, he treated three of Chosun's King very perfectly and his family worked for the royal family's health for 150 years, especially treating smallpox. the other is prescription Gamijojungtang(加味調中湯), Kyung-jong's favorite prescription. This prescription is considered royal special prescription at Chosun.

• 한국과학교육학회지
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• 제15권3호
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• pp.291-302
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• 1995

Most middle school and high school students learns under the same study plans and educational courses. Such an equal level education policies prevent the science-gifted from developing and promoting their ability. So it is severely necessary to sort out the gifted in science and make them develop their ability. In this paper, the attitudes of teachers and parents toward the science-gifted student in middle school were investigated as well as the characteristics of the gifted. One hundred science teachers of middle school who recommended the gifted in science and their parents in Seoul area were questionnaired. The follows are the consequences of investigation. 1. Most teachers and parents of the gifted considered that the school should do a special care for the gifted in science. That is, they prefer the enrichment course to the acceleration course for it. 2. The teachers play the role of motivating the study and promotion very well, but do not well as either the advisor or the cooperator with the parents because of their excessive work and lack of professional knowledgement about education of the gifted. 3. The parents play the role of the advisor or the counselor well, but do not well as the cooperator with school. 4. Among the characteristics of the gifted, there are not any differences between boys and girls in conduct characteristics. But there are meaningful difference in emotion characteristics. 5. The education of the gifted is very important for developing of country and personal promotion. So the administrative and financial support are necessary in order to sort out the gifted in science earlier and provide various programs.

• 건축역사연구
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• 제18권1호
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• pp.7-29
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• 2009

In understranding the essence of the Korea traditional Architecture, it is important to consider the jointing methods of architectural members, architectural technologies, etc. Especially the purpose of this study is understanding on the Jointing Method of Wooden Members in the period of Unified Silla Architecture. It's conclusion is summarized as follows. 1. A section of column has very close to do with the foundation stone. The structures of foundation stone and column are generally concluded by butt joint, arrow-head joint, housed joint by Grang-e method. Judu is structured by arrow-head joint And, in general, beam is structured by Sagaematchum Chumcha and sagaljudu of Don direction. At the head of Pyungju and the body of Goju, Changbang is structed by Jangbumachum with arrow-head joint or by jumukchang-machum. Also, it is surmised that Gyisoseum and Anssolim methods had been applied to columns from former ages. The example can be found at Bagjae Mireuksaji stone pagoda. Bagjae Mireuksaji stone pagoda taking wooden-pagoda form adopts Gyisoseum and Anssolim methods. We can also find such a sort of methods from other stone constructions like Budo, etc. 2. Injahwaban is structured by short Changbumachum with arrowed-head joint at upper members, and by Anjangmachum at the lower part. This sort of Gongpo style can be seen in the mural painting of tomb of Koguryo and in Buplyungsa, Buplyunsa, Bupkisa-located in Japan, which are influenced by Bakjae or Unified Silla. It is considered that at the end of the late United Silla, Injawhaban had been replaced with Chumcha and Soro on the Pyungbang under influence of Dapo style from China.

• 수산해양교육연구
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• 제28권5호
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• pp.1358-1364
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• 2016

Maritime accidents caused by a ship include collisions, sinking, stranding and fire etc. This study is intending to consider fire accidents among such diverse marine accidents. It is much likely that various sorts of fires break out because crewmen are living in a narrow space for long periods of time consequent on the ship's characteristic of sailing on the sea. According to the ship fire survey, about 50% of the total fire accidents occurred at an engine room, and the main fire origin was analyzed to be oil. In addition, ship fire breaks out in the order of baggage racks and living quarter. In short, the survey indicates that all sorts of fires belonging to A, B, C and D-class have occurred. This study, targeting an actual passenger ship 'A', found the response time to evacuation, during which the people on board a ship recognize the outbreak of fire, and act, and the travel time for evacuation which is the actual travel time. In addition, this study carried out a simulation through the special program for fire analysis - FDS (Fire Dynamics Simulator) in order to find the effective evacuation time, i.e. life survival time. Particularly, this study did comparative analysis of the influence on the survival of passengers and crew based on the collected simulation data by fire size and sort. As a result of the analysis, it was found that when examining the only actual evacuation movement time excepting the response time to evacuation, people are safe by completing evacuation before the effective evacuation time only in case fire size is 100Kw among all sorts of fires. In other words, in case of the outbreak of fire more than 1 MW, it was found to fail to meet evacuation safety regardless of fire size.

• 전자공학회논문지CI
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• 제42권3호
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• pp.9-16
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• 2005

정규화(normalization)는 데이터의 불필요한 중복의 정도를 최소화찰 뿐만 아니라 데이터의 무결성을 높이는데 기여하기 때문에 데이터베이스를 효율적으로 설계하기 위해 수행하고 있다. 그러나 정규화를 깊숙이 수행한 데이터베이스인 경우 자료 검색 시 필요에 따라 테이블 간의 조인을 해야 하기 때문에 자료 처리 속도의 저하 현상이 발생될 수도 있다. 이러한 정규화의 부작용을 다소나마 해소하기 위한 수단으로 기업에서는 궁여지책으로 역정규화를 함으로써 어느 정도 완화시킬 수 있다고 보는 견해가 있다. 본 논문에서는 정규화와 역정규화와의 성능 평가를 위해 고객관련업무 시스템에 대해 두 가지 방법을 적용하여 데이터베이스 시스템을 구축하고 분석하여 비교하였다. 실험 결과 데이터베이스 크기에 따른 응답 시간은 전체적으로 역정규화 모델이 정규화 모델보다 더 길게 나왔다. 역정규화가 데이터의 중복을 발생시키기 때문에 시스템 성능 향상에 기여하는 바가 거의 없는 것으로 나타났다.

• 한국조경학회지
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• 제31권6호
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• pp.95-103
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• 2004

A turfgrass rootzone foundation is one of the important iufluences on the growth of cool-season turfgrass such as Kentucky bluegrass, which is usually grown on korean golf courses and athletic fields in Korea. This study was carried out to evaluate the growth of Kentucky bluegrass on 4 types of turfgrass root-zone foundations: a 2cm thickness of Sand 90%+Peat humus 8%+Zeolite 2% mixture on a subsoil base (C), a 20cm thickness of Sand 90%+Peat humus 8%+Zeolite 2% mixture (S), a 20cm thickness of Sand 45%+fine sand(a sort of Bomyungsa) 45%+Peat humus 8%+Zeolite 2% mixture (S+F), and a 20cm thickness of Sand 45%+fine sand(a sort of Bomyungsa) 45%+Peat humus 8%+Zeolite 2% mixture on a 20cm thick drainage layer (S+F(G)). Visual ratings of Kentucky bluegrass on the C foundation were low throughout the experiment when compared to S, S+F, and S+F(G) foundations, which contained high contents of sand with a high water infiltration rate. However, poor growth of Kentucky bluegrass in the summer of 1991 on the S foundation was likely to be caused by a too high water infiltration rate (185.8cm/hr). The growth of Kentucky bluegrass on the S+F(G) was good while the growth was a little weak at the developing stage on the S +F foundation. If the cost had to be considered when constructing golf courses and athletic fields, The S+F foundation without the drainage layer would be the best choice in terms of low cost and good quality of Kentucky bluegrass compared to the S+F(G). In this result, the infiltration rate was regarded as the most influential factor to the growth of Kentucky bluegrass on rootzone foundations.

• 한국실내디자인학회논문집
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• 제18권1호
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• pp.3-10
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• 2009

The relationship between light and space is fundamental In an opera stage design. In contemporary stage design, light, color and space themselves became one of tile most important elements to express and symbolize the content of the opera. This was very different compared to the primitive and medieval opera stage design in the past. The designer tried to represent the same periodical background of the opera with exact replica of the buildings as well as costumes. In comtemporary performance art, light became one the most important aspects in design. Max Keller is one of the living pioneers in stage lighting design. This thesis that is based on his lighting experiments and projects attempts to examine how contemporary stage design and light are applied and what kind of characteristics they have. One of the Wagner's opera, "Tristan und Isolde" was selected to be further analyzed. Three different "Tristan und Isolde" opera stage designs were carefully studied in terms of how three designs are differently constructed for specific same contents of the opera. This sort of comparison study is crucial when there is a strict parameter that is the opera itself. It was found that three opera stages have very different stage designs and unique ways of expressing the opera flow and contents. However, in some parts, very similar lightings were used. This sort of multi-disciplinary study can be helpful to re-think the interior environment by applying light as a fundamental medium.

• 한국건축시공학회지
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• 제21권5호
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• pp.397-408
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• 2021

건설업은 업무상 재해 발생빈도와 사망자 수가 다른 산업군에 비해 높아 가장 위험한 산업군으로 불린다. 정부는 건설 현장에서 발생하는 산업 재해를 줄이고 예방하기 위해 CCTV 설치 의무화를 발표했다. 건설 현장의 안전 관리자는 CCTV 관제를 통해 현장의 잠재된 위험성을 찾아 제거하고 재해를 예방한다. 하지만 장시간 관제 업무는 피로도가 매우 높아 중요한 상황을 놓치는 경우가 많다. 따라서 본 연구는 딥러닝 기반 컴퓨터 비전 모형 중 개체 분할인 YOLACT와 다중 객체 추적 기법인 SORT을 적용하여 다중 클래스 다중 객체 추적 시스템을 개발하였다. 건설 현장에서 촬영한 영상으로 제안한 방법론의 성능을 MS COCO와 MOT 평가지표로 평가하였다. SORT는 YOLACT의 의존성이 높아서 작은 객체가 적은 데이터셋을 학습한 모형의 성능으로 먼 거리의 물체를 추적하는 성능이 떨어지지만, 크기가 큰 객체에서 뛰어난 성능을 나타냈다. 본 연구로 인해 딥러닝 기반 컴퓨터 비전 기법들의 안전 관제 업무에 보조 역할로 업무상 재해를 예방할 수 있을 것으로 판단된다.

• 한국콘텐츠학회논문지
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• 제21권7호
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• pp.404-412
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• 2021

본 연구는 육가공식품의 소비자 인식에 대하여 본질적이고 심층적으로 접근하기 위해 질적 분석방법의 하나인 Q연구방법을 이용하여 연구하였다. 이를 위해 긍정과 부정의 질의응답 표를 작성하여 P샘플을 설정하여 응답지를 나누어 주는 작업을 거치는 Q-sort를 PC QUANL프로그램을 사용하고 Q요인 분석을 통해 분석하였다. 분석결과 3가지의단일 유형으로 나뉘었다. 제 1유형(N= 10) : 육가공식품의 선호 유형, 제 2유형(N= 7) : 육가공식품의 기능성 추구유형, 제 3유형(N= 4) : 육가공식품의 비 선호 유형으로 요인명을 설정하였다. 유형마다 각각의 다른 특징이 나타났고 이러한 분석을 통하여 검출된 각 요인의 주관적인 인식은 향후에 다양한 기초 연구 자료로 이용 할 수 있고 연구의 목적으로는 육가공식품을 이용하는 소비자들의 인식을 유형별로 구분하여 구분된 변수 간의 특성을 확인 해 보며 향후 개선 방향을 제시하는데 있다.