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The Effects of Complex Motor Training on Motor Function and Synaptic Plasticity After Neonatal Binge-like Alcohol Exposure in Rats (복합운동훈련이 신생 흰쥐의 알코올성 소뇌손상 후 운동기능 및 신경연접가소성에 미치는 영향)

  • Lee, Sun-Min;Koo, Hyun-Mo;Kwon, Hyuk-Cheol
    • Physical Therapy Korea
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    • v.12 no.3
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    • pp.56-66
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    • 2005
  • The purposes of this study were to test that complex motor training enhance motor function significantly, to test change in cerebellum, and to test the synaptic plasticity into the immunohistochemistry response of synaptophysin. Using an animal model of fetal alcohol syndrome - which equates peak blood alcohol concentrations across developmental period - the effects of alcohol on body weight during periods were examined. The effect of complex motor training on motor function and synaptic plasticity of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) normal group (NG), via artificial rearing to milk formula and (2) alcohol groups (AG), via 4.5 g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, where they were raised in standard cages (two-and three animals per cage) until they were postnatal 48 days. Rats from alcohol group of postnatal treatment then spent 10 days in one of two groups: Alcohol-experimental group was had got complex motor training (learning traverse a set of 6 elevated obstacles) for 4 weeks. The alcohol-control group was not trained. Before consider replacing with "the experiment/study", (avoid using "got" in writing) the rats were examined during four behavioral tests and their body weights were measured, then their coronal sections were processed in rabbit polyclonal antibody synaptophysin. The synaptophysin expression in the cerebellar cortex was investigated using a light microscope. The results of this study were as follows: 1. The alcohol groups contained significantly higher alcohol concentrations than the normal group. 2. The alcohol groups had significantly lower body weights than the normal group. 3. In alcohol groups performed significantly lower than the normal group on the motor behavioral test. 4. In alcohol-control group showed significantly decreased immunohistochemistric response of the synaptophysin in the cerebellar cortex compared to the nomal group. These results suggest that improved motor function induced by complex motor training after postnatal exposure is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity. Also, these data can potentially serve as a model for therapeutic intervention.

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The Opinion Trend of Members of the Forest Management Cooperatives Concerning Its Management (산림경영협업체(山林經營協業體) 운영(運營)에 관(關)한 회원(會員)의 의식동향(意識動向))

  • Kang, Hag Mo;Kang, Sung Yun;An, Jong Man;Lee, Sang Hyun
    • Journal of Korean Society of Forest Science
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    • v.86 no.2
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    • pp.233-240
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    • 1997
  • This study was carried out to investigate members' affiliation motive to Forest Management Cooperative which is the main managemental body of the private forests and management problems of the organization to find out a solution of the problems and set active promotion plan. The questionnaire about the management of the cooperatives was done by interviewing the members at Seoha Inboh Forest Management Cooperative in Ulsan-gun, Kyongsangnam-do and Sechong Forest Management Cooperative in Chinan-gun, Chollabuk-do from July to August in 1993. Twenty interviewees were selected in the order of their business quantity on the forest from the members who reside in their villages. Integrated matters such as were members' affiliation motive, benefit after their affiliation, management system, incorporation of the organization and other issues concerning to managemental plans questioned. During the survey period, other data about management of the cooperatives were collected from the related organizations and opinions of every president of nine cooperatives in the investigated regions. The majority of the members agreed that the cooperative is an independent forest organization and evaluated the Training and Extension Service Center high. However, their participations in the cooperative such as forest technical training and cooperative forest management were low since they have not earned any income from their forest management.

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Development of analytical method for cyantraniliprole residues in welsh onion (Allium species) (대파(Allium속)에서 살충제 Cyantraniliprole 잔류분석을 위한 시험법 개발)

  • Do, Jung-Ah;Lee, Mi-Young;Chang, Moon-Ik;Hong, Jin-Hwan;Oh, Jae-Ho
    • Analytical Science and Technology
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    • v.28 no.3
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    • pp.175-181
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    • 2015
  • Cyantraniliprole, which is an ananthranilic diamide insecticide that was developed by the DuPont Corporation, was registered in the Republic of Korea in 2012. It offers exceptional insecticidal activity on a broad range of Lepidopera, Coleoptera, Diptera, and Isoptera. The maximum residue limits are set to pepper, peach, apple, sweet pepper, welsh onion, and so on (0.2~2.0 mg/kg). Therefore, an analytical method for determining cyantraniliprole residue in agricultural products was developed to ensure food safety. In previous studies, welsh onions were among vegetables included in the allium species, which is a representative plant with sulfur organic compounds. In this study, the analytical method was developed and evaluated for the elimination of sulfur compounds from the test solution of allium species during pesticide residue analysis. In order to inactivate the enzyme allinase and produce sulfur compounds, sample extraction was made in the base state pH 10 by reducing the activity of the enzyme. The recoveries of the developed method ranged from 81.9% to 83.2%, and the relative standard deviations were less than 10%. Therefore, based on the results, the method developed in this study is accurate and appropriate for use in cyantraniliprole determination. It will be used as the official method for managing the safety of cyantraniliprole residues in agricultural products.

Control of pH Neutralization Process using Simulation Based Dynamic Programming in Simulation and Experiment (ICCAS 2004)

  • Kim, Dong-Kyu;Lee, Kwang-Soon;Yang, Dae-Ryook
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.620-626
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    • 2004
  • For general nonlinear processes, it is difficult to control with a linear model-based control method and nonlinear controls are considered. Among the numerous approaches suggested, the most rigorous approach is to use dynamic optimization. Many general engineering problems like control, scheduling, planning etc. are expressed by functional optimization problem and most of them can be changed into dynamic programming (DP) problems. However the DP problems are used in just few cases because as the size of the problem grows, the dynamic programming approach is suffered from the burden of calculation which is called as 'curse of dimensionality'. In order to avoid this problem, the Neuro-Dynamic Programming (NDP) approach is proposed by Bertsekas and Tsitsiklis (1996). To get the solution of seriously nonlinear process control, the interest in NDP approach is enlarged and NDP algorithm is applied to diverse areas such as retailing, finance, inventory management, communication networks, etc. and it has been extended to chemical engineering parts. In the NDP approach, we select the optimal control input policy to minimize the value of cost which is calculated by the sum of current stage cost and future stages cost starting from the next state. The cost value is related with a weight square sum of error and input movement. During the calculation of optimal input policy, if the approximate cost function by using simulation data is utilized with Bellman iteration, the burden of calculation can be relieved and the curse of dimensionality problem of DP can be overcome. It is very important issue how to construct the cost-to-go function which has a good approximate performance. The neural network is one of the eager learning methods and it works as a global approximator to cost-to-go function. In this algorithm, the training of neural network is important and difficult part, and it gives significant effect on the performance of control. To avoid the difficulty in neural network training, the lazy learning method like k-nearest neighbor method can be exploited. The training is unnecessary for this method but requires more computation time and greater data storage. The pH neutralization process has long been taken as a representative benchmark problem of nonlin ar chemical process control due to its nonlinearity and time-varying nature. In this study, the NDP algorithm was applied to pH neutralization process. At first, the pH neutralization process control to use NDP algorithm was performed through simulations with various approximators. The global and local approximators are used for NDP calculation. After that, the verification of NDP in real system was made by pH neutralization experiment. The control results by NDP algorithm was compared with those by the PI controller which is traditionally used, in both simulations and experiments. From the comparison of results, the control by NDP algorithm showed faster and better control performance than PI controller. In addition to that, the control by NDP algorithm showed the good results when it applied to the cases with disturbances and multiple set point changes.

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Study for Residue Analysis of Pinoxaden in Agricultural Commodities

  • Kim, Ji Young;Yoon, Eun Kyung;Kim, Jong Soo;Seong, Nu Ri;Yun, Sang Soon;Jung, Yong Hyun;Oh, Jae Ho;Kim, Hyochin
    • Korean Journal of Environmental Agriculture
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    • v.38 no.4
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    • pp.321-331
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    • 2019
  • BACKGROUND: Pinoxaden is the phenylpyrazoline herbicide developed by Syngenta Crop Protection, Inc. and marketed on 2006. The maximum residue levels for wheat and barley were set by import tolerance. Thus, Ministry of Food and Drug Safety (MFDS) official analytical method determining Pinoxaden residue was necessary in various food matrixes. Satisfaction of international guideline of CODEX (Codex Alimentarius Commission CAC/GL 40) and National Institute of Food and Drug Safety Evaluation-MFDS (2017) are additional pre-requirements for analytical method. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was investigated to analyze residue of Pinoxaden (M4), which is defined as pesticide residue in Korea, in foods. METHODS AND RESULTS: Pinoxaden (M4) was extracted followed by acid digestion (2hr reflux with 1N HCl) and pH adjusting (pH 4-5 with 3% ammonium solution). To remove oil, additional clean-up step with hexane saturated with acetonitrile was required to high oil contained sample before purification. HLB cartridge and nylon syringe filter were used for purification. Then, samples were analyzed by LC-MS/MS using reserve phase column C18. Five agricultural group representative commodities (mandarin, potato, soybean, hulled rice, and red pepper) were used to verify the method in this study. The liner matrix-matched calibration curves were confirmed with coefficient of determination (r2) > 0.99 at calibration range 0.002-0.2 mg/kg. The limits of detection and quantitation were 0.004 and 0.01 mg/kg, respectively, which were suitable to apply Positive List System (PLS). Mean average accuracies of pinoxaden (M4) were shown to be 74.0-105.7%. The precision of pinoxaden and its metabolites were also shown less than 14.5% for all five samples. CONCLUSION: The method investigated in this study was suitable to CODEX (CAC/GL 40) and National Institute of Food and Drug Safety Evaluation-MFDS (2017) guideline for residue analysis. Thus, this method can be useful for determining the residue in various food matrixes in routine analysis.

Analysis of Citizen's Attitude to the Foodwaste (II) (음식쓰레기에 관한 실태조사(II))

  • Jang, Won;Kim, Mikyeong;Kang, Changmin;Park, Youngsuk
    • Journal of the Korea Organic Resources Recycling Association
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    • v.5 no.1
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    • pp.53-61
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    • 1997
  • This study was conducted to analysis citizen's attitude and style to the foodwaste from l0th Sept. to 30th Sept. in 1996. The research was used questionare method and analysis was used prequency analysis and cross table method by SPSS (scientific statistics). The foodwaste of householdwaste account for 24.8%, and the magnitude by the kinds of garbage were waste from pre-cocking stage, fruitshell, foodwaste remained after eating, septic foodwaste during storage. The more the housewives'age are young, foodwaste volumne were much. Most remained foodwaste after eating were soup and pot stew. The main cause of foodwaste production was overvolumne cooking. 88.8% of answers think that a menu can be useful to reduce foodwaste. The survey showed that 87.3% of answers put into the meter-rate bag after removed wetness of garbage. 84.1% of answers thought that the recycling of foodwaste needed, but the practical housewife was only 21%. For the suitable treatment of foodwaste, Survey showed that the consistent policy of goverment and continuous publicity was needed essentially, and that the public notice of TV or radio was effective. All of answers would like to participate in recycling of foodwastes whether public-posting or personal-posting. To set up vessel of posting at household, the proper purchase price and space of institution are needed, also the solution of sanitory & aesthetic problem and the collection of composting-product must be achieved smoothly.

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Development and Applyment Selection Standards of Physical Computing Teaching Aids for Elementary SW Education According to the 2015 Revised Curriculum (2015 개정 교육과정의 초등학교 소프트웨어 교육을 위한 피지컬 컴퓨팅 교구 선택 기준 개발 및 적용)

  • Lee, Young-jae;Jeon, Hyung-gi;Kim, Yungsik
    • Journal of The Korean Association of Information Education
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    • v.21 no.4
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    • pp.437-450
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    • 2017
  • This study derived optimized teaching aids that use the physical computing method as the solution for effective software education at the elementary level. We set standard for selecting physical computing teaching aids in elementary-level by gathering the opinions from previous studies and think tanks and then applied the standard to some aids and choose one. We also made lesson plan and tried it to the experimental group. Subsequently, students' logical thinking skills showed a statistically significant improvement in terms of the t-test. Also, in the analysis of the effect size, it was shown to have a positive influence on the improvement of the students' logical thinking skills. Additionally, survey of satisfaction evaluation from the students showed that the teaching aid selection standard was effective in selecting suitable teaching aids for elementary students and that the classroom activities utilizing physical computing teaching aids were at a suitable level for elementary students.

The Policy Guideline of Outdoor Advertising Signs Design Study for Street Scened of City (도시의 가로경관 향상을 위한 옥외광고물 디자인 정책 방향 연구)

  • 이중엽
    • Archives of design research
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    • v.11 no.2
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    • pp.71-81
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    • 1998
  • Outdoor advertising signs of sity is recorgnized as the most basic element forming street scenes of city as well as establishing the citys identity in firsthand and secondhand. It has just started by commercial measure but recntly, in the rapid economical growth and diversified social structure a grent number of business have been generated so that is brings an absoluce increage of kind and quantity in outdoor advertising signs. Such quantitative increase has caused now envirenmental city problems so a more effective control of outdoor advertising signs and sophisticatided and logical design is needed. Thus, I would like to set up the direction with street scenes of city can be formed through this study. Firstly, understanding the concept, special features, and strong, weark points of street scenes of city and outdoor advertising signs. Secondly, in present sitiation analysis, studing and comparing the chracteristic of our present outdoor advertising regulations with those of Japanese regulations. Thirdly performing the reserch upon now advertising signs can be influentia in city scenes and thereafter, issuing possible problem censequantly, I would like to suggest the direction of control policy of outdoor advertising signs as following (1). Leading differentiation of each reggion for the solution of environmental and scenic problem. (2). Non-realistic advertising regulation are needed to be amended for uping changing outdoor advertising signs. (3). Advertising problems should be settleed through effectiveness of outdoor advertising signs administration. (4). The problem of advertising agenics should be leaded short term and long term plan. (5). Collection of scenic pollution should be operated for building up a scenic and community consciousness. Therefore, with these suggestion of clear direction of polish, the improvement of city scenes and regional differentiation followed by activated local autonomy system can be induced so that a more beautiful city scenes can be achiveved.

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Appropriate Daily Last Irrigation Time in Coir Bag Culture for Tomato (토마토 코이어 자루재배시 적정 급액마감시각 구명)

  • Kim, Sung-Eun;Sim, Sang-Youn;Lee, Moon-Hang;Kim, Young-Shik
    • Journal of Bio-Environment Control
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    • v.21 no.1
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    • pp.12-19
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    • 2012
  • This research was performed to determine the appropriate daily last irrigation time to enhance the plant growth and the water and fertilizer use efficiencies in coir bag culture for tomato plant. The time to finish the daily irrigation was set by 1, 2, 3 and 4 hours before the sunset. The water content in the substrate was greatly affected by the last irrigation time. The earlier the last time, the greater the daily fluctuation of water contents in the substrate. The daily irrigation times were not affected by using irrigation management system controlled by drainage electrodes or the physiochemical properties of coir. The growth characteristics were not significantly different among the treatments. The highest marketable yields were obtained in the treatment finishing two hours before sunset, and the lowest yields were obtained in the the treatment finishing 4 hours before sunset. Based on the result from surveying quantity of irrigated water for 128 days of the experiment period, the water and fertilizer use efficiencies were lowest in the treatment finishing 4 hours before sunset, and the highest in the treatment finishing 2 hours before sunset. In terms of plant growth, yields, water and fertilizer use efficiencies, 2 hours before sunset treatment was determined as the most economical and desirable irrigation schedule.

An Analysis of Cognitive Demands of Tasks in Elementary Mathematical Instruction: Focusing on 'Ratio and Proportion' (수학 교수${\cdot}$학습 과정에서 과제의 인지적 수준 분석 - 초등학교 '비와 비율' 단원을 중심으로 -)

  • Kim, Hee-Seong;Pang, Suk-Jeong
    • Journal of Educational Research in Mathematics
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    • v.15 no.3
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    • pp.251-272
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    • 2005
  • Given that cognitive demands of mathematical tasks can be changed during instruction, this study attempts to provide a detailed description to explore how tasks are set up and implemented in the classroom and what are the classroom-based factors. As an exploratory and qualitative case study, 4 of six-grade classrooms where high-level tasks on ratio and proportion were used were videotaped and analyzed with regard to the patterns emerged during the task setup and implementation. With regard to 16 tasks, four kinds of Patterns emerged: (a) maintenance of high-level cognitive demands (7 tasks), (b) decline into the procedure without connection to the meaning (1 task), (c) decline into unsystematic exploration (2 tasks), and (d) decline into not-sufficient exploration (6 tasks), which means that the only partial meaning of a given task is addressed. The 4th pattern is particularly significant, mainly because previous studies have not identified. Contributing factors to this pattern include private-learning without reasonable explanation, well-performed model presented at the beginning of a lesson, and mathematical concepts which are not clear in the textbook. On the one hand, factors associated with the maintenance of high-level cognitive demands include Improvising a task based on students' for knowledge, scaffolding of students' thinking, encouraging students to justify and explain their reasoning, using group-activity appropriately, and rethinking the solution processes. On the other hand, factors associated with the decline of high-level cognitive demands include too much or too little time, inappropriateness of a task for given students, little interest in high-level thinking process, and emphasis on the correct answer in place of its meaning. These factors may urge teachers to be sensitive of what should be focused during their teaching practices to keep the high-level cognitive demands. To emphasize, cognitive demands are fixed neither by the task nor by the teacher. So, we need to study them in the process of teaching and learning.

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