• The Korea Journal of Herbology
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• v.30 no.3
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• pp.55-61
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• 2015

Objectives : This study aimed to investigate the effects of Shingi-whan(SG) on the male reproductive and sexual function, so we measured the spermatogenesis and the testicular toxicity in mice and the vasorelaxation in isolated rabbit corpus cavernosum smooth muscle. Methods : To evaluate effect on the spermatogenesis in mice, we prepared two groups, control group and SG group that was orally administered SG(1,000mg/kg) for 20 days, and compared. To analyze testicular toxicity in mice, we also prepared two groups, doxo group that was injected with doxorubicin (3mg/kg) on three times and doxo + SG group that was injected with doxorubicin and SG for 20 days, and compared. To investigate sexual function of SG in mice, we prepared three groups, normal group and aging elicited group consisting of 18-month-old mice, SG treated aging group that was orally administered SG for 60 days, and compared using histochemical staining on mice corpus cavernous tissues. In order to define the relaxation effects of SG, rabbit corpus cavernous tissues were prepared in $2{\times}2{\times}6mm$ sized strip. Then the dose-dependent relaxation responses of SG at 0.01-3.0 mg/ml in contracted strips induced by phenylephrine were measured. Results : The sperm density in dutus epididymis and the diameter of seminiferous tubules of SG group was significantly increased when compared to control group. The testicular weight and the diameter and height of epithelial layer of seminiferous tubules of doxo + SG group was significantly increased when compared to doxo group. The cavernous strips were significantly relaxed by SG extract In SG treated aging group, ratio of smooth muscles to collagen fibers and red blood cell count in venous sinus was increased as compared to aging elicited group. Conclusions : Our findings have shown that SG extract have effect on spermatogenesis and mitigating effect on doxo-induced testicular toxicity. Further, it also have the vasorelaxant effect on rabbit corpus cavernosum.

• Journal of the Korean Institute of Intelligent Systems
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• v.25 no.4
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• pp.412-417
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• 2015

Kinect sensor has two output data which are produced from red green blue (RGB) sensor and depth sensor, it is called color image and depth map, respectively. Although this device's prices are cheapest than the other devices for three-dimensional (3D) reconstruction, we need extra work for reconstruct a smooth 3D data and also have semantic meaning. It happened because the depth map, which has been produced from depth sensor usually have a coarse and empty value. Consequently, it can be make artifact and holes on the surface, when we reconstruct it to 3D directly. In this paper, we present a method for solving this problem by using implicit surface representation. The key idea for represent implicit surface is by using radial basis function (RBF) and to avoid the trivial solution that the implicit function is zero everywhere, we need to defined on-surface point and off-surface point. Based on our simulation results using captured face as an input, we can produce smooth 3D face and fill the holes on the 3D face surface, since RBF is good for interpolation and holes filling. Modified anisotropic diffusion is used to produced smoothed surface.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.7 s.172
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• pp.112-121
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• 2005

This paper is concerned with smooth trajectory generation of biped robot which has inverted pendulum type balancing weight. Genetic algorithm is used to generate the trajectory of the leg and balancing weight. Balancing trajectory can be determined by solving the second order differential equation under the condition that the reference ZMP (Zero moment point) is settled. Reference ZMP effect on gait pattern absolutely but the problem is how to determine the reference ZMP. Genetic algorithm can find optimal solution under the high order nonlinear situation. Optimal trajectory is generated when use genetic algorithm which has some genes and a fitness function. In this paper, minimization of balancing joints motion is used for the fitness function and set the weight factor of the two balancing joints at the fitness function. Inverted pendulum type balancing weight is very similar with human and this model can be used fur humanoid robot. Simulation results show ZMP trajectory and the walking experiment made on the real biped robot IWR-IV.

• International Journal of Control, Automation, and Systems
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• v.5 no.3
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• pp.283-294
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• 2007

In this paper, a nonlinear controller based on adaptive sliding-mode method which has a sliding surface vector including new boundizing function is proposed and applied to a two-wheeled welding mobile robot (WMR). This controller makes the welding point of WMR achieve tracking a reference point which is moving on a smooth curved welding path with a desired constant velocity. The mobile robot is considered in view of a kinematic model and a dynamic model in Cartesian coordinates. The proposed controller can overcome uncertainties and external disturbances by adaptive sliding-mode technique. To design the controller, the tracking error vector is defined, and then the sliding surface vector including new boundizing function and the adaptation laws are chosen to guarantee that the error vector converges to zero asymptotically. The stability of the dynamic system is shown through the Lyapunov method. In addition, a simple way of measuring the errors by potentiometers is introduced. The simulations and experimental results are shown to prove the effectiveness of the proposed controller.

• Journal of Nutrition and Health
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• v.53 no.6
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• pp.563-569
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• 2020

Purpose: The vascular smooth muscle cells (VSMCs) in mature animals have implicated to play a major role in the progression of cardiovascular diseases such as atherosclerosis. This study aimed at optimizing the protocol in culturing primary VSMCs (pVSMCs) from rat thoracic aorta and investigating the effect of cellular zinc (Zn) deficiency on cell proliferation of the isolated pVSMCs. Methods: The thoracic aorta from 7-month-old Sprague Dawley rats was isolated, minced and digested by the enzymatic process of collagenase I and elastase, and then inoculated with the culture Dulbecco Modified Eagle Medium (DMEM) at 37℃ in an incubator. The primary cell culture morphology was observed using phase-contrast microscopy and cellular Zn was depleted using Chelex-100 resin (extracellular zinc depletion only) or 3 µM N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN) (extracellular and intracellular zinc depletion). Western blot analysis was used for the detection of SM22α and calponin as smooth muscle cell marker proteins and von Willebrand factor as endothelial cell marker protein to detect the culture purity. Cell proliferation by Zn depletion (1 day) was measured by MTT assay. Results: A primary culture protocol for pVSMCs from rat thoracic aorta was developed and optimized. Isolated cultures exhibited hill and valley morphology as the major characteristics of pVSMCs and expressed the smooth muscle cell protein markers, SM22α and calponin, while the endothelial marker von Willebrand factor was hardly detected. Zn deprivation for 1 day culture decreased rat primary vascular smooth muscle cell proliferation and this pattern was more prominent under severe Zn depletion (3 µM TPEN), while less prominent under mild Zn depletion (Chelexing). Conclusion: Our results suggest that cellular Zn deprivation decreased pVSMC proliferation and this may be involved in phenotypic modulation of pVSMC in the aorta.

• The Mathematical Education
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• v.62 no.4
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• pp.473-490
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• 2023

Previous studies from domestic and abroad are accumulating information on how to reason students' continuous changes through teaching experiments. These studies deal with scenes in which students who make 'smooth reasoning' and 'chunky reasoning' construct mathematical results together in teaching experiments. However, in order to analyze their results in more detail, it is necessary to check what kind of results a student reasoning in a specific way constructs for the tasks of previous studies. According to the need for these studies, the researcher conducted a total of 14 teaching experiments on one first-year high school student who was found to make 'chunky reasoning'. In this study, it was possible to observe a scene in which a student who makes 'chunky reasoning' constructs an output similar to 'a mathematical result constructed by students with various reasoning methods(smooth reasnoning or chunky reasoning) in previous studies.' In particular, the student who participated in this study observed a consistent construction method of constructing the function of 'time-speed' from the function of 'time-distance'. The researcher expected that information on this student's distinctive construction methods would be helpful for subsequent studies.

• Journal of applied mathematics & informatics
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• v.27 no.5_6
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• pp.1087-1095
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• 2009

In this paper, we study approximation method from scattered data to the derivatives of a function f by a radial basis function $\phi$. For a given function f, we define a nearly interpolating function and discuss its accuracy. In particular, we are interested in using smooth functions $\phi$ which are (conditionally) positive definite. We estimate accuracy of approximation for the Sobolev space while the classical radial basis function interpolation applies to the so-called native space. We observe that our approximant provides spectral convergence order, as the density of the given data is getting smaller.

• Proceedings of the Technology Innovation Conference
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• 1996.12a
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• pp.241-264
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• 1996

This article introduces the five functions of the national innovation system (NIS). As the national innovation system is a kind of social systems in the national level, the five generic functions of open system-production boundary spanning, maintenance, adaptation management functions-are applied to the NIS. The production function is the primary process, which produces innovative products and services of the NIS. The boundary spanning function is the function of procuring the input and disposing the innovation output or aiding in these process. Experienced R&D human resources, R&D funds, technology etc. belong to the input of the NIS. The maintenance function is responsible for the smooth operation and upkeep of the system in terms of various conditions. The adaptive function is to help the system change and adapt, scan the environment for problems, opportunities, and technological developments. It faces outward for the survival of the system from the long-term view. The management function carries out planning and controlling the overall activities for the other four functions in order to run the system. Finally it discuses implications for the diagnosis and the decision making process of S&T policy.

• Communications of the Korean Mathematical Society
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• v.30 no.1
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• pp.7-21
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• 2015

We give the characterization of H$\ddot{o}$lder differentiability points and non-differentiability points of the Riesz-N$\acute{a}$gy-Tak$\acute{a}$cs (RNT) singular function ${\Psi}_{a,p}$ satisfying ${\Psi}_{a,p}(a)=p$. It generalizes recent multifractal and metric number theoretical results associated with the RNT function. Besides, we classify the singular functions using the singularity order deduced from the H$\ddot{o}$lder derivative giving the information that a strictly increasing smooth function having a positive derivative Lebesgue almost everywhere has the singularity order 1 and the RNT function ${\Psi}_{a,p}$ has the singularity order $g(a,p)=\frac{a{\log}p+(1-a){\log}(1-p)}{a{\log}a+(1-a){\log}(1-a)}{\geq}1$.

• Journal of applied mathematics & informatics
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• v.5 no.2
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• pp.525-537
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• 1998

In this paper we prove the inequality of subharmonic functions between a non-negative subharmonic function u and a smooth function $\upsilon$satisfying ｜$\upsilon(0)$\mid$\leq u(0), $\mid$\nabla \upsilon $\mid$ \leq$\mid$\nabla u $\mid$\leq c\Delta u $, where 0$\leq$c$\leq$1 is a constant. Here $\mu$is the harmonic measure on $\partial$D with respect to 0.