• 한국조경학회지
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• 제30권4호
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• pp.1-8
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• 2002

The place of South Weol Dynastys authorities exhumed in the region of KangChoWu, China lies adjacent to a stone ditch through which water streams crookedly, and a dark trough of stone pond in the north side. There is a sharply curved stone ditch and a crescent-shaped water entrance made by stones. The place was separated by using stone columns and stone walls. There is a beam of ditch, a crooked entrance, a flat bridge of slate, a stepping-stone, a sluice gate, and a crooked corridor. There are big and small artificial islands, and reinforcing stone drainage way in the palace pond recently exhumed at the building site for the pavilion of Hwang-Yong Temple in Kuhwang-Dong, Gyeongju city, Korea. There are four facilities assumed to be entrance and exits at four corners and an open space on which gravel was spread extensively. A narrow road and a middle road with indefinite curves at the south of Asukakyoseki exhumed by the first, second and third and two stone buckets which one is to fill with water and the other is to drain water off like fountain are there, and besides wave protecting dam and north pond and the part that water pass were excavated. Palace ponds that were extensively distributed at old residential cities are a general phenomenon of countries in eastern Asia. Anap pond of Silla and Gungnam pond of Baekje were in Kroea. We believe that Asutnkyoseki is on the extension. Although more investigations in the background of thought and the genealogical relation about the palace pond are required, it seems that an idea was surely received from China.

• 한국지반공학회논문집
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• 제15권6호
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• pp.155-165
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• 1999

화강편마암으로 된 풍화암이 기반암인 암반에 소켓된 말뚝의 지지 거동을 알기 위하여 직경 40cm인 현장타설말뚝 8개를 시공하고 말뚝 재하 시험을 실시하였다. 지반 조사는 예비조사, 본조사, 그리고 시험후 조사 등 3차례에 걸쳐서 이루어 졌으며, 이 때 BX와 NX 보링(12개소) 조사와 탄성파 탐사 등이 시행되었다. 암반 소켓 말뚝의 지지 거동을 주면부와 선단부로 분리하여 평가하기 위하여 암반 소켓 깊이를 3m, 6m 그리고 9m등으로 다양하게 하고, 선단부 지지력의 영향을 배제하기 위하여 말뚝 선단부에 스타이로폼(styrofoam)을 매설하기도 하였다. 그리고 말뚝 깊이에 따른 하중 전이 해석을 위하여 말뚝 철근에 변형률 게이지 등을 설치하고 재하 시험을 수행하였다. 상기의 재하 시험 결과로부터 국내 화강 편마암으로 된 풍화암에 소켓된 현장타설말뚝의 허용 주면지지력과 허용 선단지지력을 각각 $8.6t/m^2 \;와 \;84t/m^2$로 제안하였으며, 일축압축강도를 이용한 풍화암의 탄성계수 산정식을 제안하였다.

• 한국측량학회지
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• 제30권1호
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• pp.67-73
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• 2012

인간의 활동뿐만 아니라 연안 지역의 경제적 피해와 환경 보존에 미치는 해안 침식의 영향은 여러 국가 정책 중에서 주요 관심사 중 하나이다. 본 연구에서는 거진항 지역에 위치한 해변을 대상으로 해안 침식의 영향을 판단하기 위한 해안선 변화 및 해빈 단변에 대한 물리적 조사를 실시하였다. 조사 결과는 해수면 상승, 폭풍, 고파랑 및 인위적 건축물에 의한 복잡한 원인들에 의하여 거진 해변에서 명확한 해안 침식이 일어나고 있는 것을 보여주었다. 특히, 자산천 하구 부근에서는 표사 유입으로 인한 안정된 해빈폭을 유지하고 있었으나, 나머지 구간에서는 해빈폭의 전진 현상보다는 후퇴 현상이 증가를 하고 있는 것으로 나타났다. 따라서 본 GW04 지역은 해안침식에 대하여 불안정한 상태에 놓여 있다고 판단되며, DGPS와 다양한 측량 조사 방법에 의한 지속적인 모니터링 관찰이 필요하다고 본다.

• 터널과지하공간
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• 제10권4호
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• pp.506-515
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• 2000

최근 30년간 경제적, 사회적 및 군사적인 목적으로 국내에 많은 지하구조물의 건설이 수행되었다. 그 결과 지질조사, 실험실 및 현장시험, 계측 등을 통하여 많은 양의 자료가 얻어졌으나 지금가지 이 귀중한 자료들은 체계적으로 축적되지 못하였고 활용되지도 못하였다. 이는 막대한 돈과 시간의 낭비라 할 수 있다. 본 연구에서는 Microsoft Access 97을 개발 도구로 하여 지하 구조물의 건설중에 얻어진 자료를 효과적으로 저장 및 운용할 수 있는 데이터베이스인 GeoINFO를 개발하였다. GeoINFO는 주요 지반 구조물인 터널, 지하저장시설 및 사면의 구축 시 얻어진 자료의 저장 및 운용에 유용하도록 구성되어 있으며 자료 입력을 위해서는 다층의 트리 (tree)군조를, 자료의 검색을 위해서는 Visual Basic을 활용한 고유의 검색 시스템을 갖추고 있다.

• Biomolecules & Therapeutics
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• 제6권1호
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• pp.95-110
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• 1998

A 13-week dermal toxicity test was conducted to assess the toxicity of DA-5018, a capsaicin derivative. Three groups of Sprague-Dawley rats (10-15 males and 10-15 females) were treated with DA-5018 cream daily by dermal application at concentrations of 0.1%, 0.3% or 0.9% as 500 mg/kg for 13 weeks. One further group of rats (15 males and 15 females) received cream base at 500 mg/kg/day and acted as controls. One male receiving 0.3% DA-5018 cream died during the treatment period. But the animal did not show any signs of treatment-related toxicity until death. There were no local skin reaction of application site and systemic reaction to the treatment of DA-5018 creams in all experimental groups throughout treatment and recovery period. Weight gain and food consumption in animals that received DA-5018 creams appeared to be comparable to that of the controls. Laboratory analyses (hematology, urinalysis and opthalmoscopic examination) did not revealed pathological values. In biochemical investigations, an increase of glucose level associated with increased food consumption and some other significant changes were noted in the animals of both sexes received DA-5018 creams. But these changes were not considered to be of toxicological importance. Postmortem examination did not show macroscopic or histological alterations attributable to the DA-5018 treatments. Based on these results, NOAEL(no-observable-adverse-effect level) of DA-5018 cream if estimated to be over 500 mg/tg/day as 0.9% cream.

• 한국지하수토양환경학회지:지하수토양환경
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• 제25권1호
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• pp.37-52
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• 2020

Sensitivity analysis of hydrodynamic and reaction parameters in conceptual model reflecting aquifer characteristics of Korea was performed to evaluate the uncertainty in the predicted concentrations. Among the hydrodynamic input parameters, both hydraulic conductivity (K_x) and hydraulic gradient (I) affected transport behaviors of contaminants, and resulted in same convergence concentrations with continuous injections of contaminant. However, longitudinal dispervisity (α_L) affected both transport behaviors and the convergence concentrations of contaminants. Compared to the hydrodynamic parameters, growth kinetic and degradation parameters (μ_m & K_c) more significantly affected both transport behaviors and the convergence concentrations of contaminants, indicating those parameters had higher sensitivity indices causing the uncertainties of model predictions. Considering that the sensitivity indices of both hydrodynamic and reaction parameters were a function of transport distance of groundwater, the parameters with higher sensitivity indices, a priori, need to be investigated using conceptual model reflecting site-specific aquifer characteristics before field investigation. After determining the parameters with higher sensitivity indices, the detail field investigations for the selected hydrodynamic and reaction parameters were warranted to reduce the uncertainties of model predictions.

• Archives of Plastic Surgery
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• 제36권3호
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• pp.269-276
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• 2009

Purpose: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust formation, skin necrosis, and ulceration. Even though several treatment options have been proposed for extravasation injury, there is still controversy regarding the management of such lesions. Thus the aim of this study was to compare the efficacy of saline injection(Group 1), hydrocortisone injection(Group 2), propranolol injection(Group 3) and early surgical excision as a treatment(Group 4) in a rat extravasation model. Methods: The authors planned forty mature male Sprague - Dawley rats were divided into 4 groups and each group contained 10 rats. Administration of adriamycin($1.0mg/m{\ell}$) $1.5m{\ell}$ by subcutaneous injection on the dorsal side of the rats was followed by protocol. The treatment options were applied 2 hours after adriamycin injection. At the end of the 5th days, the presence and size of ulcers at the injection site were measured. 3 weeks after injection, a histopathologic examination was performed for each treatment and control group. T - tests were used to analyze the differences between the measurements. Results: Propranolol significantly improved tissue recovery compared with control group and other groups. These data suggest that there is little role for saline and hydrocortisone in the treatment of adriamycin extravasation injury. Conclusion: In this study, we compared some treatment methods in adriamycin extravasation model. The findings support the propranolol injection may prevent extravasation injury. However this study was performed in the laboratory using rats, and the results could be different in clinical application. Thus, more needs further investigations and clinical application.

• 한국도로학회논문집
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• 제7권2호
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• pp.87-95
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• 2005

동절기에 대기온도가 영하로 내려감에 따라 포장하부층의 동결 및 응해가 반복되어 포장체의 구조적 성능이 저하된다. 이를 방지하기 위하여 동상에 대한 많은 연구가 수행되었으며, 그 결과, 우리나라 전역의 동결지수선도가 작성되어 동상방지층 설계 등의 도로건설에 이용되고 있다. 하지만, 포장층의 두께와 재료, 그리고 지형에 따른 동결심도의 변화에 대한 조사가 체계적으로 이루어지지 않아 현행 동상방지층 설계의 유효성에 대한 평가가 시급한 실정이다. 본 논문에서는 한국도로공사 시험도로에서 측정되는 대기온도 자료와 콘크리트 및 아스팔트 포장의 깊이별 온도 및 함수량 자료를 이용하여, 시험도로의 동결지수 및 동결가능 깊이를 조사하였다. 또한, 조사된 결과를 기존의 동결심도 추정식에 의한 결과와 비교하였다. 본 연구는 시험도로에서 측정된 동결 관련자료에 대한 초기연구로서 , 장기적인 자료의 축적과 분석을 통하여 보다 신뢰성 있는 결과가 도출될 수 있을 것으로 판단된다.

• Interdisciplinary Bio Central
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• 제2권3호
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• 한국안전학회지
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• 제25권3호
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• pp.40-44
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• 2010

North Korea's discharge of water from a dam into the Imjin River that flows through the inter-Korean border swept away a riverside camping site early Sunday morning, killing six people. This tragic incident might have been prevented if the North had given prior notice of the release from its Hwanggang Dam to the South. Investigations are under way to determine the reasons behind the unexpected act. This incident was a man-made disaster not least death of six people. A water level monitoring system(WLMS) of the Imjin River was installed the bridge of Pilseung that operate three public institutions. The WLMS of the A institution set up warning siren and broadcasting as the water level has been rising the bridge of Pilseung in the Imjin River. But the A institution's system was already out of side before discharged of water a dam into the Imjin River and the operators were culpable negligence. The B institution's office employee on charges of negligence that might have contributed to the tragedy and one of the A institution's employees ignored 26 warning messages on the WLMS. This tragic incident was a man-made disaster not least death of six people and might have been prevented if the WLMS was normally operated and the system operators must be worked a tight.