• Journal of Gastric Cancer
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• v.17 no.2
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• pp.120-131
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• 2017

Purpose: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. Materials and Methods: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). Results: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. Conclusions: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).

• The Korean Journal of Air & Space Law and Policy
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• v.28 no.2
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• pp.117-144
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• 2013

The MOLIT is also establishing the flight safety standards for UAV within the current Aviation Law. Accordingly the required flight criteria includes operator location, mission operation limit, equipment, etc. which are the principle and standard applied based on the airspace use for UAV. Also, general flight rules, visual flight rules, instrument flight rules are required to be applied to the actual flight. Besides, an appliance regulation needs to be arranged regarding two-way communication, ATC and communication issue, airspace and area in-flight between UAS(Unmanned Aircraft System) users. An operation of the UAV in the air significantly requires the guarantee of the aircraft's capacity, and also the standardized flight criteria. A safe and smooth use is ensured only if this criteria is applied and understood by the entire airspace users. For the purpose, a standardized military UAV flight operations criteria and a law complementary scheme.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.753-766
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• 2013

Even though civilization is developing at a fast rate, human beings and their living environments do not look happy. Given that the civilization comes from the human mind, which is changing in interaction with human body, society, and nature, it is hard to think that the human mind is changing in the desirable direction. This paper described a whole changing paradigm of the human mind and its causes through the cognitive mechanism in the brain from which all the diverse minds are formed. According to the cognitive mechanism, the human mind can change from the first free and peaceful mind through the middle mind to the last obsessive and anguish mind in accordance with the change of one of the factors in the origin of the human mind. Today's unfavorable changes in human beings, society, and the natural environment including the excessive development of civilization are the results of the undesirable changes of the human mind. This paper specified the respective characteristics of the first, middle, and the last mind and discussed where individuals' minds are and where they are going. Lastly, this paper suggested the specific ways to return to the first original mind based on the cognitive mechanism.

• Korean Journal of Environment and Ecology
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• v.28 no.6
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• pp.725-740
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• 2014

To figure out the vegetation situation in the ridge of the Naknam-Jeongmaek, six intensive survey sites were selected considering environmental factors and human interferences, 132 quadrats (area $100m^2$) were installed to survey appearing species of trees and major environmental factors, and the characteristics of vegetation structures were analyzed. The surveyed plots were divided into six groups according to the analysis of classification by TWINSPAN; Quercus mongolica-Q. variabilis community, Pinus densiflora-Q. dentata community, Chamaecyparis obtusa community, Q. mongolica-P. densiflora community, P. densiflora-P. thunbergii community, P. koraiensis community, Rhododendron spp.-Lespedeza cyrtobotrya community. P. densiflora-Q. dentata community, Q. mongolica-P. densiflora community, and P. densiflora-P. thunbergii community are expected to be succeeded by deciduous oaks because the power of deciduous oaks is strong in their lower layer. C. obtusa community, P. densiflora community, and Rhododendron spp.-L.cyrtobotrya community are artificial forests that were artificially formed and are expected to be maintained in the current state for some time because the dominance value of planted species of trees is high. Most vegetations in Naknam-Jeongmaek were secondary forests or artificial forests formed for forest tree production and forestation for erosion control. In particular the top regions and hilly sections of the mountain were mostly dominated by deciduous oaks such as Q. mongolica, Q. variabilis showed some P. densiflora community competing with deciduous oaks. On the other hand, low sections and regions adjacent to the city showed severe artificial interference since exotic species such as P. thunbergiil, C. obtusa, P. koraiensis, and Rhododendron spp. were planted.

• Journal of Service Research and Studies
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• v.9 no.3
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• pp.73-86
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• 2019

The authors of this study conducted research on universities located in China, and the primary purpose of the study was to test whether the quality factors of university education service have a positive (+) effect on student satisfaction. The secondary purpose of the study was to identify and analyze whether university instruction and curriculum variables had a positive regulatory effect on the relationship between quality factors and student satisfaction. First, Research Hypothesis 1, which suggested that university education service quality factors would have a positive effect on student satisfaction, was adopted. As the second analytical process of the study, controlled regression analysis was used to verify whether instruction and the curriculum had a regulatory effect on the relationship between the university education service quality factors and student satisfaction. When the two variables were analyzed as control variables, the results showed that curriculum had a significant positive regulatory effect, and instruction was shown to not be suitable for generating win-win cooperation or synergistic effects. The contributions of the theoretical perspective of this study were the analysis of the relationship between university education service quality factors in Chinese universities and student satisfaction, and systematically linking instructions and the curriculum and analyzing the impact on student satisfaction. The study implies that it would be more effective to analyze additional factors in the operation of universities through in-depth analysis on instruction from a practical standpoint.

• Korean Journal of Optics and Photonics
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• v.24 no.5
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• pp.231-236
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• 2013

We investigated the optical design of a smart headlamp capable of producing various beam patterns through only on/off modulation of light sources. This was implemented by forming a continuous matrix of beams from discontinuous beam patterns by means of a multi-array LED optical system. As one such optical system, the multi-array LED system is a convenient and economical device for implementing beam patterns with the simple on/off modulation of the light sources. A single optical assembly module can be made by combining a multiple-LED array, optical system module, and electronic control with no need for any additional mechanical components. The present optical system was designed to include a secondary lens and a projection lens mounted at the front of each LED in the array to realize accurate lighting patterns as well as the required luminosity at a distance of 25 m in the forward direction. Finally, we identified and analyzed the patterns implemented by the designed optical system that produced satisfactory performance of high beams and adaptive driving beams (ADB).

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.666-676
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• 2006

Gangliosides are widely distributed in mammalian cells and play important roles in various functions such as cell differentiation and growth control. In addition, diabetes and obesity cause abnormal development of reproductive processes in a variety of species. However, the mechanisms underlying these effects, and how they are related, are not fully understood. This study examined whether the differential expression of gangliosides is implicated in the abnormal follicular development and uterine architecture of streptozotocin (STZ)-induced and db/db diabetic mice. Based upon the mobility on high-performance thin-layer chromatography, mouse ovary consisted of at least five different ganglioside components, mainly gangliosides GM3, GM1, GD1a and GT1b, and diabetic ovary exhibited a significant reduction in ganglioside expression with apparent changes in the major gangliosides. A prominent immunofluorescence microscopy showed a dramatic loss of ganglioside GD1a expression in the primary, secondary and Graafian follicles of STZ-induced and db/db diabetic mice. A significant decrease in ganglioside GD3 expression was also observed in the ovary of db/db mice. In the uterus of STZ-induced diabetic mice, expression of gangliosides GD1a and GT1b was obviously reduced, but gangliosides GM1, GM2 and GD3 expression was increased. In contrast, the uterus of db/db mice showed a significant increase in gangliosides GM1, GD1a and GD3 expression. Taken together, a complex pattern of ganglioside expression was seen in the ovary and uterus of normoglycemic ICR and $db/^+$ mice, and the correspoding tissues in diabetic mice are characterized by appreciable changes of the major ganglioside expression. These results suggest that alterations in ganglioside expression caused by diabetes mellitus may be implicated in abnormal ovarian development and uterine structure.

• Journal of The Korean Association For Science Education
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• v.34 no.6
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• pp.559-569
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• 2014

In this case study, we investigated teaching strategies of science teacher's teaching in science museum. Two secondary science teachers who completed a teacher training course on teaching in science museums participated in this study. We conducted interviews about their perceptions on teaching in science museum and their teaching plans before teaching. Then, we observed and recorded their teaching practices in the science museum throughout one semester, and collected all of the teaching materials. The interviews were also conducted after every lessons and at the end of the semester. For the analysis of teaching strategies, we used a framework that was revised from the framework for museum practice (FMP). The analysis of results revealed that the teachers understood the significance of planning the activities in a series of pre-visit, during-visit, and post-visit, so that they structured their teaching as continuous activities, not as an one-time event. However, they showed differences in the extent of connecting the activities with the national science curriculum according to their teaching objectives. In addition, there were differences in strategies such as promoting social interaction, evoking students' curiosity and interest, providing students with choices and control, and inducing engagement and challenge depending on each teacher's perceptions and experiences on teaching in science museum. These results suggest that science teacher education for the professional development of teaching in science museum should systematically provide knowledge and experiences on teaching strategies based on appropriate perceptions on teaching in science museum.

• Korean Journal of Medicinal Crop Science
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• v.2 no.1
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• pp.1-6
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• 1994

These studies were carried out to investigated effect of cultural environment and of plant growth regulator on Macrocarpium officinale NAKAI. The flowering and fruitage were significantly different with location of cultivated area. Generally, suitable cultivation area was the basin of the mountains of 200-400m above the sea. The diurnal temperature change of GURYE was greater than KWANGSAN. The soil conditions of main cultivation area were sandy loam of slightly acid (pH 6.2-6.6). Dry fruit weight without seed of Macrocarpium officinale NAKAl was increased 18% in primary treatment of Gibberellin W.P (200g/10a) 15days before and secondary GA3 50ppm(6g /10a) 15 days after flowering compared with the control.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.79-85
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• 2015

Objectives: A vertebral compression fracture (VCF) is characterized by back pain and fracture of a vertebral body on spinal radiography. VCFs of the thoraco lumbar spine are common in the elderly. In general, appropriate analgesics should be prescribed to reduce pain and, thus, promote early mobilization. The ideal treatment approach for VCFs has not been determined. In Korea, acupuncture and herbal medication have been used to treat VCFs for many years. There is empirical evidence that acupuncture might benefit patients with a VCF. However, no randomized, controlled, clinical trials evaluating the efficacy and the safety of acupuncture for treating a VCF have been published. Therefore, we designed a randomized, controlled, pilot, clinical trial to obtain information for the design of a further full scale trial. Methods: A five week protocol for a randomized, controlled, pilot, clinical trial is presented. Fourteen patients will be recruited and randomly allocated to two groups: a control group receiving interlaminar epidural steroid injections once a week for three weeks, and an experimental group receiving interlaminar epidural steroid injections plus acupuncture treatment (three acupuncture sessions per week for three weeks, nine sessions in total). The primary outcomes will be the pain intensity (visual analogue scale and PainVision$^{TM}$ system). The secondary outcome measurements will be the answers on the short form McGill pain questionnaire and the oswestry disability index. Assessments will be made at baseline and at one, three, and five weeks. The last assessment (week five) will take place two weeks after treatment cessation. This study will provide both an indication of feasibility and a clinical foundation for a future large scale trial. The outcomes will provide additional resources for incorporating acupuncture into existing treatments, such as nonsteroidal anti-inflammatory medications, narcotics and vertebral augmentation. This article describes the protocol.