• Korean Journal of Head & Neck Oncology
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• v.14 no.2
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• pp.191-198
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• 1998

Objectives: We performed an immunohistochemical study to examine the place of neovascularization in the tumorigenic process of follicular thyroid carcinoma and to determine whether tumor angiogenic activity in follicular carcinoma plays a role in tumor aggression. Materials & Methods: We studied 63 follicular thyroid carcinomas and compared with 22 follicular adenomas. The areas of capsular invasion, vascular invasion and cellular atypism of the tumor were confimed on H & E stains. The paraffin embedded tissues were stained by the use of monoclonal antibodies against Ag CD34. Microvesseles were counted in the area of highest vascular density at 200 times magnification. The microvessel densities(MVD) were analized in relation to histologic type and location of the tumors. Results: There were 59 minimal invasive types and 4 widely invasive types of carcinoma. In the histologic specimens of carcinomas, capsular invasion was identified in all the cases, vascular invasion in 46 and cellular atypism in 24. Mean values of the MVDs of the minimal invasive carcinomas, the widely invasive carcinomas and the adenomas were $263.8{\pm}69.2,\;256.l{\pm}49.3\;and\;241.5{\pm}159.4$, respectively and there was no significant difference between each group. In follicular carcinomas, there was a regional difference of the MVDs. The areas of tumor showing cellular atypism and adjacent to or penetrating the capsule, in which represents the tumorigenic process of carcinoma, had a higher rate of vascularization, than other areas of the tumor(p<0.05). However, these features were not noted in the follicular adenomas. Conclusion: Although there was no significant difference of the MVD between follicular carcinomas and adenomas, there was a regional difference of the MVD within the carcinomas and the values were significantly higher in the more malignant areas, as indicated by cellular atypism and capsular invasion. Therefore, tumor angiogenic activity measured by MVD may play a role in tumor aggression in follicular thyroid carcinoma.

• Journal of the Korean Association of Geographic Information Studies
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• v.3 no.3
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• pp.31-44
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• 2000

The purpose of this study is to show how could GIS along with digital maps and census data be used for scientific urban analysis and location analysis for a proposed project. Results are summarized as follows. First. after digital maps being completed, the census tract system being adopted, and major urban data being inputted in the computer file, GIS could be used intensively for various reliable urban analysis. With graphic statistical, and overlay functions of GIS, various physical and socio-economic characteristics of urban areas could be presented for analysis in the form of thematic and datapoint maps on the computer screen. Second, the locational analysis for a proposed project is a major part in the building permit review process, which tends to become disputable and time consuming as society become pluralized. Along with various GIS functions scientific decision-making methods could be developed, and the methods could play an important role for faster and scientific location analysis. As such, GIS would play an important role for faster and reliable urban analysis and location analysis and these functions finally would play important roles to improve public services and administration of local governments.

• The Journal of the Petrological Society of Korea
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• v.18 no.3
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• pp.181-194
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• 2009

The Cheongryangsan Formation was reported to stratigraphically overlie the Gasongdong Formation and underlie the Dogyedong Formation in the northern part of the Yeongyang subbasin, and be divided into the lower Cheongryangsan Member and the Osipbong Member. But the members have more widely called as the Cheongryangsan Conglomerate and the Osipbong Basalt, because the latter have initially meant that thin basalt flows several times intercalate sedimentary rocks in the northern part but later must consider that they have a very dominant volume in the eastern one. Both formations are based on classifying the stratigraphy and play a role of an excellent key bed for stratigraphic correlation between local spaces in the subbasin dominant absolutely for reddish beds. Both formations play a role of excellent key bed in the northern and northwestern areas of the subbasin; the Osipbong Basalt, the midwestern, eastern and southern ones; the Cheongryangsan Conglomerate, the southeastern one.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.1
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• pp.171-180
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• 2013

As the second-largest 1st degree of ecological zone in Kangwon Province, Pyeongchang County is expected to play an important role in expanding the protected areas of the Republic of Korea. However, Pyoungchang County is expected to experience an increase in demand for development due to the 2018 Winter Olympics. Problems related to various stakeholders and limited budget will arise regarding the issue of expanding the protected areas. In this study, in order to effectively control these problems, we designed expansion plans for the 1st degree ecological zoning map areas and the observed data of threatened species I and II in Pyoungchang County by using the MARXAN Software. As for the methods, we first set the planning units(PUs) for the spatial analysis. The PUs include boundary length, land cost, land status, etc. Then, we made the input data by controlling the conservation features, BLM(Boundary Length Modifier) and iteration numbers. There are two measures for the establishment of the protected areas, one of which only concerns with the ecological priority, and the other with combining the land cost on forest. The one illustrated shows that the larger patches that include the conservation feature was selected as a candidate of the protected areas. The other one presented shows that inexpensive land cost areas were selected. As this study produces visual results and enables an efficient application of various values in selecting protected areas, we believe that it will be useful to various stakeholders in spatial decision-making process.

• Journal of the Korean Institute of Rural Architecture
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• v.14 no.1
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• pp.9-19
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• 2012

The object of this study is to investigate the satisfaction level of group homes for the elderly living alone in rural areas. Sixty-four elderly people, living alone, were selected from ten regions operated by the Gimje city council in Jeonlabuk-do, and then a survey was conducted during January 17 to 26 in 2011. The results of the investigation are as follows: first, roughly 90.6 percent of the participants responded that they were satisfied with cohabitation. Second, average point of satisfaction was going to bed together, which is 4.39, also each unit in all the ten regions was recorded above 4.00. Third, the satisfaction of eating together averaged highly at 4.37. Fourth, 95 percent of them were satisfied with the conditions of the residential space. Fifth, the satisfaction with the amenities, such as electricity, phone, heating and sanitation, averaged 96.9 and 98.4 percent each, which was rated highest. Through analytical research, elderly people who live in 'group homes' are satisfied with their lives. It is thought that this 'group home' can play the role of an alternative family better than existing 'senior citizen centers' and 'welfare centers for the elderly'. The study means that 'group homes' in rural areas could be established successfully.

• Journal of Ecology and Environment
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• v.34 no.3
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• pp.269-278
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• 2011

Carabid beetle community changes in paddy fields, abandoned paddy fields, and mountains were investigated to understand differences in species diversity and composition of different habitat types in small agricultural landscapes in South Korea. A total of 2,938 individuals from 37 species were identified and classified from the studied habitats. Diversity in the mountains was higher than that in abandoned paddy fields. As the number of years since abandonment increased, the diversity and stability of the carabid beetle community also increased. Abandoned paddy fields in some paddy field areas and adjoining mountainous areas, left with preconditions for management and control, have provided the opportunity to improve the diversity and habitat of small agricultural landscapes. Species composition changed continuously from the paddy fields to the mountains, in accordance with individual species habitat preferences. Abandoned paddy fields in small agricultural landscapes are believed to play an important role as transitional buffer zones between paddy fields and the adjacent mountainous areas.

• Journal of Technology Innovation
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• v.16 no.2
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• pp.125-145
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• 2008

The paper evaluates the Korean science, technology, and innovation policy(STIP) in terms of an individual firm. The firm is Viromed(Ltd), a new technology-based venture company in the field of biotechnology. The case is compared with the 'Hwang Project', which is known as a typical failure case in Korea. In order to evaluate the Korean STIP, we establish 6 areas, which are technological infrastructure, institutional infrastructure, human capital infrastructure, technology market, industrial base, and innovation networks. The study shows that the policy schemes relating with technological infrastructure, institutional infrastructure, human capital infrastructure, and industrial base play a positive role in the start-up, development and innovation of Viromed(Ltd). However, we can hardly find the role of Korean government in fostering the technology market, transferring the technological output to economic performance. Although the international networks with the British, American, and Japanese firms or investors were a key success factor of the growth of Viromed(Ltd), the role of the government in this policy area was not enough. As for the 'Hwang Project', we suggest that the government should consider the possibility of commercialization in choosing R&D projects and determining the size of financial aids. Since the evaluation of the Korean STIP is based on an individual firm, the results of the paper need to be confirmed by a systematic comparison with other cases or industries.

• Animal cells and systems
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• v.7 no.1
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• pp.1-9
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• 2003

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis of higher organisms. Mitochondria, known to play a central role in regulating cellular metabolism, was found to be critical for regulating apoptosis induced under both physiological and pathological conditions. Mitochondria are a major source of reactive oxygen species (ROS) but they can also serve as its target during the apoptosis process. Release of apoptogenic factors from mitochondria, the best known of which is cytochrome c, leads to assembly of a large apoptosis-inducing complex called the apoptosome. Cysteine pretenses (called caspases) are recruited to this complex and, following their activation by proteolytic cleavage, activate other caspases, which in turn target for specific cleavage a large number of cellular proteins. The redox regulation of apoptosis during and after cytochrome c release is an area of intense investigation. This review summarizes what is known about the biological role of ROS and its targets in apoptosis with an emphasis on its intricate connections to mitochondria and the basic components of cell death.

• The KIPS Transactions:PartB
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• v.19B no.1
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• pp.43-52
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• 2012

Semantic role labeling is the research area analyzing the semantic relationship between elements in a sentence and it is considered as one of the most important semantic analysis research areas in natural language processing, such as word sense disambiguation. However, due to the lack of the relative linguistic resources, Korean semantic role labeling research has not been sufficiently developed. We, in this paper, propose an automatic predicate-argument analyzer to begin constructing the Korean PropBank which has been widely utilized in the semantic role labeling. The analyzer has mainly two components: the semantic lexical dictionary and the automatic predicate-argument extractor. The dictionary has the case frame information of verbs and the extractor is a module to decide the semantic class of the argument for a specific predicate existing in the syntactically annotated corpus. The analyzer developed in this research will help the construction of Korean PropBank and will finally play a big role in Korean semantic role labeling.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.163-172
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• 2004

Mast cells (MCs) have been implicated in the pathogenesis of tissue fibrosis. However, the role of MC in the development of liver fibrosis has not been fully elucidated. Stem cell factor (SCF) is known to recruit MCs to the liver following injury as it induces mast cell proliferation, survival and differentiation from resident tissue precursors. This study examines the interaction between activated hepatic stellate cells (HSCs) and MCs in rat fibrotic liver, and SCF production by HSCs during culture in vitro. Rats were studied 4, 7, 14 and 21 days after bile duct ligation (BDL). Fibrogenesis was assessed by a measurement of collagen stained with sirius red F3B. Activated HSCs and MCs were identified by ${\alpha}$-smooth muscle actin (${\alpha}-SMA$) immunohistochemical and alcian blue staining and measured by a computerized image analysis system. SCF production was determined in rat HSC cultures using Western blotting. Mild fibrotic changes were noted in BDL rat livers as early as 4 days after induction of cholestasis. Significant expansion and organization of fibrous tissue has occurred in day 14 BDL rats which progressed to bridging fibrosis by day 21. In BDL rats, both a large number of activated HSCs and MCs were detected in portal tracts and fibrous septa. Both area of activated HSCs infiltration and density of MCs were significantly higher in all BDL group compared with Shams. In BDL rats, both areas of activated HSCs infiltration and density of MCs were no significant difference between day 4 and 7 and were significantly higher in day 14. However, the areas of activated HSCs infiltration were significantly lesser in day 21 and the densities of MCs were significantly higher in day 21 compared with day14 BDL. In BDL rats, both areas of activated HSCs infiltration and density of MCs were highly correlated with areas of fibrosis. Western blotting showed that SCF protein was consistently produced in activated HSCs by culture on plastic and freshly isolated HSCs expressed relatively little 30kD SCF compared to late primary culture activated HSCs (day 14) and passaged HSCs. These results suggest that HSCs activated in vitro produce SCF, and may play an important role in recruiting mast cells to the liver during injury and fibrosis.