• Communications for Statistical Applications and Methods
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• 제14권1호
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• pp.205-213
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• 2007

In this paper, the normal mixture model subjected to general linear restriction for component-means based on linear regression is proposed, and its fitting method by EM algorithm and Lagrange multiplier is provided. This model is applied to gene clustering of microarray expression data, which demonstrates it has very good performances for real data set. This model also allows to obtain the clusters that an analyst wants to find out in the fashion that the hypothesis for component-means is represented by the design matrices and the linear restriction matrices.

• 충청수학회지
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• 제23권2호
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• pp.197-206
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• 2010

We study the restriction estimate of Fourier transform to arbitrary convex curves in $R^2$ with no regularity assumption. Assuming that the convex curve has the lower bound of curvatures, we extend the restriction results from smooth convex curves to arbitrary convex curves. Our work has been motivated by the lecture notes of Terence Tao. The bilinear approach and geometric observations play an important role.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.4-11
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• 2023

Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction. Moreover, intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects. In this review, the beneficial effects of intermittent fasting are discussed.

• Journal of Nutrition and Health
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• 제46권5호
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• pp.410-417
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• 2013

본 연구는 만 19~60세의 BMI $23kg/m^2$ 이상 여성 61명을 대상으로 12 주간 열량 섭취 제한 시 체중 감량에 영향을 미치는 요인을 분석하고 이들의 상관성을 알아보고자 하였다. 12주간의 열량 섭취 제한으로 하루 평균 451.9 kcal가 감소하였고 열량 제한 후 체중은 평균 4.5% 감소하였고, 내장지방량은 11.9%, 피하지방량은 8.2% 감소하였으며, 혈압도 유의하게 감소하였다 (p < 0.01). 혈액지표 중 GPT 농도는 감소하였으며 (p < 0.05), 아디포넥틴 농도는 증가하였다 (p < 0.01). 연령이 증가함에 따라 섭취 열량 감소량이 낮게 나타났다 (r = 0.31, p = 0.02). 젊은 연령에서 열량 섭취량 감소가 컸으며, 연령이 증가할수록 열량 섭취량 감소가 낮게 나타났다. 연령은 독립적으로 신체 조성 변화와 유의한 관련이 있었으며 (p < 0.05), 연령이 증가함에 따라 열량 섭취 제한에 따른 체중 및 내장지방과 피하지방의 감소량이 낮았으며, 특히, 내장지방 감소량이 낮게 나타났다 (p < 0.05). 또한, 연령이 증가함에 따라 열량 섭취 제한에 따른 렙틴 농도 감소량도 낮았다 (p < 0.05).

• Journal of Nutrition and Health
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• 제36권9호
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• pp.924-932
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• 2003

In middle-aged men, abdominal obesity has been an important risk factor of coronary artery disease (CAD) as well as a predictor of hypertension, dyslipidemia, insulin resistance and glucose intolerance. Particularly, risks from abdominal obesity increase when adipose tissue accumulates in visceral compartment. Many studies showed that weight reduction by caloric restriction improves abdominal obesity and reduces lots of cardiovascular risk factors. Testosterone treatment also results in a significant decrease in visceral fat area and normalizes endocrine metabolism. However there is no study that compare the effect of caloric restriction with that of testosterone treatment. The purpose of this study is to investigate the effect of caloric restriction and that of testosterone treatment on body fat distribution, serum lipids and glucose metabolism in male patients with CAD. Forty five middle-aged overweight-obese men with CAD participated in 12 weeks' program. They were matched with age, body weight, body mass index (BMI) and divided into three groups : control group (n = 15) , caloric restriction group (-300 kcal/day, n = 15) and testosterone treatment group (testosterone undecanoate tablets, n = 15) . After 12 weeks, control group did not have any changes in anthropometries, lipid profile, body fat distribution, glucose metabolism and hormonal status. Expectedly, caloric restriction group showed decreases in body weight, BMI, waist to hip ratio, ％ body fat. Ten percentage of total cholesterol and 23% of triglyceride in serum were also decreased. In body fat distribution, total fat areas at both L1 and L4 levels were significantly reduced in this group without reduction in muscle of thigh and calf. However, testosterone treatment group did not have any significant changes in body weight, ％ body fat, serum lipid profile and abdominal fat distribution. In conclusion, weight reduction by caloric restriction is more beneficial in body fat distribution and serum lipid level than testosterone treatment in overweight male patients with CAD. This result suggests that modest weight reduction is possible to help decrease risk factors of CAD.

• Journal of Nutrition and Health
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• 제2권1호
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• pp.35-46
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• 1969

임신 전(前) Restricted diet을 먹은 것과 Unrestricted diet을 먹은 group간에 2세의 체중증가에 미치는 영향에는 차이가 없었으며 임신 전(前) 체중변화에 있어서 Restricted diet에 숫컷이 더 예민하였다. 암컷에서는 Recovery diet을 주는 기간에는 Unrestricted group을 거의 쫓아 갔으나 숫컷에서는 그차이가 심하였다. 새끼들의 체중에 있어서 임신동안의 초기와 후기의 식이제한 group은 관계없이 임신전(全)기간 식이제한 group과 Unrestricted group간에 체중의 차이를 나타내었다. 어미의 Nitrogen 배설량에서 보면 섭취량에 대한 배설량의 백분율은 사료섭취량의 증감(增減)에 관계없이 일정하며 배설량은 사료섭취량이 많으면 많이 나가고 적으면 그것에 비례해서 적게 배설되었다. 새끼의 Nitrogen 배설량은 8 group사이에 큰 차이를 보여주지 않고 있다. Birth weight는 임신전(前) Restricted diet이나 Unrestricted diet 영향을 받지 않았으며 임신동안의 Unrestricted group의 새끼가 임신동안 전(全)기간 식이제한을 하였거나 부분적으로 식이제한을 한 group의 새끼보다 Birth weight가 컸다. litter size는 사료섭취량에 영향을 받지 않았다.

• Toxicological Research
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• 제6권2호
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• pp.167-182
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• 1990

Dietary restriction (caloric restriction) is the only intervention which has been reliably shown to extend the maximum life span of warm-blooded animals and delay the many phenomena associated with aging. It is also one of the most effective modulators of toxicity, especially cancer endpoints. In spite of the known modulator effects of caloric restriction, the biological mechanisms responsible for these effects had not been in vestigated until recently. The National Center for Toxicological Research (NCTR), in a collaborative effort with the National Institute of Aging (NIA), initiated a project whereby nine (9) combinations of rodent species/strains and diets were fed both restricted and ad libitum. The NIA's initiative was to identify biomarkers of aging whereas NCTR's initiative was to identify the biological effects associated with the profound effects caloric restriction has in protecting against both spontaneous (age-related) and chemically-induced toxic endpoints. Independent of sex or species, caloric restriction has similar effects on body temperature, oxygen consumption and $CO_2$production. Caloric restriction also decreased lipid glycolysis and metabolism in rats and mice, which suggest decreased production of metabolites which could lead to fatty acid epoxide formation. The age-associated loss of ciradian regulation of intermediate enzymes is also significantly reduced. Moreover, caloric restriction reduced the age-associated feminization of sexually dimorphic liver isozymes, increased several glucocorticoid responsive isozymes, elevated glucagon/insulin ratios, produced less microsomal superoxide and enhanced the capacity for utilzing detoxicating metabolic pathways. Calorically restricted rats have less than half the number of aflatoxin ($AFB_1$)-DNA adducts than ad libitum animals and urinary excretion of $AFB_1$ was increased significantly. Finally, DNA repair mechanisms are enhanced and oncogene expression is decreased in calorically restricted animals.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.485-493
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• 2019

본 연구는 유치원의 자유놀이 제한 규칙에 대한 교사의 인식을 알아봄으로써 유치원 자유놀이 운영을 위한 기초적인 정보를 얻을 목적으로 수행되었다. 이를 위하여 J 지역에 근무하는 유치원 교사 200명을 대상으로 설문 조사를 시행하였다. 연구 도구는 학급 내 자유놀이에 대한 제한 규칙에 관한 교사의 인식을 묻는 설문지였다. 연구 결과는 다음과 같다. 첫째, 교사는 흥미영역 중 미술영역에 대한 제한 규칙의 필요성을 가장 높게 인식하였다. 둘째, 교사는 세 가지 유형의 제한 규칙 중 인원수 제한 규칙의 필요성을 가장 높게 인식하였다. 셋째, 제한 규칙의 필요 이유에 대한 교사 인식은 다음과 같았다. 인원수 제한 규칙 필요 이유는 일부 영역으로 쏠리는 현상을 예방하기 위해서였다. 시간 제한 규칙 필요 이유는 다양한 흥미영역에서 놀이하도록 지도하는 것이 교육적이라고 생각하기 때문이었다. 공간 제한 규칙 필요 이유는 각 흥미영역 고유의 교육목표를 확실히 할 수 있기 때문이었다. 유아의 놀이 권리와 연계하여 자유놀이 제한 규칙의 의미와 필요성을 논의하였다.

• 융합정보논문지
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• 제11권3호
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• pp.87-94
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• 2021

본 연구는 2016년~2018년도에 수집된 국민건강영양조사 7기 자료의 2차 분석을 통해 심혈관질환자의 활동 제한 여부에 의한 정신 건강과 삶의 질을 확인하였다. 연구대상자는 자료대상자 총 24,269명 중 협심증이나 심근경색 진단 병력이 있는 530명의 성인에서 변수의 누락이 없는 521명이다. SAS 9.4 version으로 활동 제한 유무에 따른 정신 건강과 삶의 질 차이를 Chi-square방법, 활동 제한에 의한 정신 건강과 삶의 질 영향을 Logistic regression 통계 방법으로 분석하였다. 분석 결과 활동 제한이 있을 때 스트레스 정도, 최근 2주간 우울감과 자살 생각 정도가 높아 정신 건강에 유의한 영향이 있었다. 활동 제한이 있을 때 운동능력, 자기관리, 일상활동에 더욱 지장이 있다고 느꼈고, 통증/불편감과 불안/우울감이 증가하여 삶의 질 역시 유의한 영향이 있었다. 따라서 심혈관질환자의 정신 건강 및 삶의 질 증진을 위해 활동 제한을 최소화할 수 있는 효과적인 신체 활동 증진프로그램의 개발 및 운영이 필요함을 제언한다.

• Journal of Animal Science and Technology
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• 제64권2호
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• pp.330-342
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• 2022

We aimed to investigate candidate proteins related to long-term caloric restriction and feed efficiency in bovine longissimus dorsi muscle (LM). A total of 31 Korean native steers were randomly distributed to ad libitum (n = 16) or caloric restriction group (n = 15) to conduct two feeding trials for 13 mon. In the first trial (10-18 mon of age), steers were fed with 100% ad libitum (NE_g = 0.63 Mcal/kg) or caloric restriction (80% of the previous day's feed intake of ad libitum group). In the second trial (18-23 mon of age), the energy value of 100% ad libitum diet was 1.13 Mcal/kg NE_g and those in caloric restriction group diet was 0.72 Mcal/kg NE_g. At the endpoint of this experiment, in each group, 6 animals were selected with high (n = 3) or low feed efficiency (n = 3) to collect muscle tissue samples (6 animals/group). From muscle tissues of 23 mo of age, we excavated 9 and 12 differentially expressed (two-fold or more) proteins in a nutritional group and feed efficiency group using two-dimensional electrophoresis, respectively. Of these proteins, heat shock protein beta-6 was up-regulated in both the caloric restriction and the low feed efficiency group. In bovine embryonic fibroblasts, the mRNA expression of heat shock protein beta-6 increased after adipogenic differentiation, however, decreased after myogenic differentiation. Our data provide that heat shock protein beta-6 may be an adipogenic protein involved in the mechanism of caloric restriction and feed efficiency in the LM of the steer.