• Journal of Microbiology and Biotechnology
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• v.22 no.3
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• pp.378-384
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• 2012

In aquatic invertebrates, particularly marine gastropods, organotin compounds induce irreversible sexual abnormality in females, which is termed imposex, at very low concentrations. Organotin compounds are agonists for nuclear receptors such as RXRs and $PPAR{\gamma}$. However, the imposex phenomenon has not been reported to act as an antagonist on estrogen receptors in other species, including vertebrates and invertebrates. In order to gain insights into the antagonistic activity of organotin compounds on estrogen receptors (ERs), we examined the inhibitive effect of these compounds on estradiol-dependent ${\beta}$-galactosidase activity using the yeast two-hybrid detection system consisting of a combination of the human estrogen receptor ($hER{\beta}$) ligand-binding domain and the co-activator steroid receptor co-activator-1 (SRC1). Tributyltin-hydroxide (TBT-OH) and triphenyltin-chlorine (TPT-Cl) exhibited an inhibitive effect on $E_2$-dependent transcriptional activity, similar to antagonistic chemicals such as 4-hydroxytamoxifen (OHT) or ICI 182,780, at a very low concentration of $10^{-14}$ M TBT or $10^{-10}$ M TPT, respectively. The yeast growth and transcriptional activity with transcriptional factor GAL4 did not exhibit any effect at the tested concentration of TBT or TPT. Moreover, the yeast two-hybrid system using the interaction between p53 and the T antigen of SV40 large did not describe any effect at the tested concentration of OHT or ICI 182,780. However, the interaction between p53 and T antigen was inhibited at a TBT or TPT concentration of $10^{-9}$ M, respectively. These results indicate that TBT and TPT act as inhibitors of ER-dependent reporter gene transcriptional activation and of the interaction between $hER{\beta}$ LBD and the co-activator SRC1 in the yeast two-hybrid system. Consequently, our data could partly explain the occurrence of organotin compound-induced imposex on the endocrine system of mammals, including humans.

• Journal of the Korean Institute of Landscape Architecture
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• v.32 no.4
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• pp.7-20
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• 2004

This study was executed to find out how to improve the planting and use of landscaping plants in Chuncheon. The number of street trees was 17,877 in 2003. The major species of street trees were Ginkgo biloba(52.7％), Prunus sargentii(15.3％), Zelkova serrata(8.9％), Platanus occidentalis(7.3％). Salix babylonica and Platanus occidentalis were decreased, while Prunus sargentii and Zelkova serrata were increased. Salix babylonica is a good species for a lakeside city, but its seeds cause allergies to some people. Most of the trees have been removed in Chuncheon. The planting of Salix babylonica(♂) resulted in no problems, and it should be propagated to plant. The soil of several areas was analysed to investigate soil conditions. The outskirts of city had good conditions in pH, organic matter and minerals, but the downtown areas had high alkalic, due to alkali from footpath concrete blocks. Appropriate pruning adds to the aesthetic and prolongs the useful life; it also requires less managing of insects and diseases to maintain good healthy of street trees. Street trees were not properly pruned due to electric lines and shortage of pruning information. The pruning was controlled by Korea Electric Power Co, which has no pruning information. Pruning must be maintained by a professional landscape company to maintain good shape such as with Bonsai. The Shrubs planting zone between street trees and other trees, and preservation plates were established for healthy of street trees. They have to be repaired and maintained well to keep better environmental conditions. The number of tree and flower species of 68 schools in Chuncheon were 12 and 16, respectively. The species that showed high preference were Juniperus chinensis, Pinus koraiensis, Pinus densiflora, Rosa centifolia, Forsythia koreana, and Rhododendron schlippenbachii. The high frequency of the protection trees designated by Chuncheon were Pinus densiflora, Ginko biloba, Zelkova serrata, Quercus species. It was thought that the diversification of street tree species, the selection of street trees suitable to each space, the generalization of use of native species, the appropriate pruning and proper fertilization, the control of pests and diseases, and the opinions of citizens concerning landscape plants were needed to improve the planting, use and maintenance of landscaping plants in Chuncheon.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.28 no.4
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• pp.847-857
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• 2018

As the number of malicious code increases steeply, cyber attack victims targeting corporations, public institutions, financial institutions, hospitals are also increasing. Accordingly, academia and security industry are conducting various researches on malicious code detection. In recent years, there have been a lot of researches using machine learning techniques including deep learning. In the case of research using Convolutional Neural Network, ResNet, etc. for classification of malicious code, it can be confirmed that the performance improvement is higher than the existing classification method. However, one of the characteristics of the target attack is that it is custom malicious code that makes it operate only for a specific company, so it is not a form spreading widely to a large number of users. Since there are not many malicious codes of this kind, it is difficult to apply the previously studied machine learning or deep learning techniques. In this paper, we propose a method to classify malicious codes when the amount of samples is insufficient such as targeting type malicious code. As a result of the study, we confirmed that the accuracy of 97% can be achieved even with a small amount of data by applying the Memory Augmented Neural Networks model.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.18 no.2
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• pp.1-11
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• 2019

The accident of mass transit such as a bus could draw the large casualties and this induces social and economic losses. Recently, severe bus accidents caused by tiredness and inattention of bus drivers occurred and those lead to growing interest in bus accidents and the drivers' work environment. Therefore, this study analyzes the accident based on the work environment of bus drivers and route-bus categories. For the research, this study collected digital tachograph data and the bus company information for 271 domestic bus companies in 2017 and used ANOVA test and chi-square test as statistical methodologies. As a result, we figured out there are statistically significant differences in the accident according to the working environments. Especially, the present study confirmed the intracity bus with working every other day has the most frequent accidents. We expect that the results of this study be used as foundations for the improvement of working conditions to reduce route-bus accidents in the future.

• Geophysics and Geophysical Exploration
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• v.22 no.3
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• pp.149-159
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• 2019

Borehole elemental concentration logging, measuring neutron-induced gamma rays by inelastic scattering and neutron capture interactions between neutron and formation, delivers concentrations of the most common elements found in the minerals and fluids of subsurface formation. X-ray diffraction and X-ray fluorescence analysis from core samples are traditionally used to understand formation composition and mineralogy, but it represents only part of formations. Additionally, it is difficult to obtain elemental analysis over the whole intervals because of poor core recovery zones such as fractures or sand layers mainly responsible for groundwater flow. The development of borehole technique for in situ elemental analysis plays a key role in assessing subsurface environment. Although this technology has advanced consistently starting from conventional and unconventional resources evaluation, it has been considered as exclusive techniques of some major service company. As regards domestic research and development, it has still remained an unexplored field because of some barriers such as the deficiency of detailed information on tools and calibration facility for chemistry and mineralogy database. This article reviews the basic theory of spectroscopy measurements, system configuration, calibration facility, and current status. In addition, this article introduces the domestic researches and self-development status on borehole elemental concentration tools.

• Journal of the Korean Society of Mechanical Technology
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• v.20 no.6
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• pp.763-769
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• 2018

In this research, in order to improve the heat retention of greenhouse, comparative analysis of the heat flux of the marketed multi-later insulating curtain was carried out. Experiments is conducted by fabricating a test apparatus for investigating the heat flux characteristics. The multi-later insulating curtain used for the experiment was compared using the P, N, S, U and T company, which are commercially available, and the heat flux due to temperature difference between the experimental apparatus and the outside was compared and analyzed. When the internal temperature of the experimental result is the maximum temperature $60^{\circ}C$, the heat flux of multi-later insulating curtain is T Co.($73.1W/m^2$) > S Co.($119.5W/m^2$) > U Co.($155W/m^2$) > N Co.($163.1W/m^2$) > P Co.($177.7W/m^2$). The heat flux means the quantity of heat passing through the unit time per unit area, and the higher the numerical value, the higher the quantity of heat passing through the multi-layer insulating curtain. This can be determined that high heat fluxes produce low heat resistance. Further, it has been found that the weight of the insulating curtain is largely unrelated to the heat insulating property, and the heat insulating curtain having a thickness containing a high internal air layer is excellent in the heat insulating property. In the future when manufacturing a heat insulating curtain, It is judged that it is desirable to manufacture a combination of heat insulating materials that contain a high internal air layer content and that can maintain the air layer even for long-term use while minimizing the volume.

• Journal of the Korean Wood Science and Technology
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• v.49 no.6
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• pp.574-590
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• 2021

International efforts to prevent illegally logged wood are expanding around the world. The "Legal Wood Trade Promotion System" was enacted in Korea in 2019 to strengthen the legal import and distribution of commercial wood in Korea. Since then, this system has promoted and ensured that the imported wood and wood products are legal with respect to the country of origin, wood species, and harvested area. As verification methods, DNA analysis technology and anatomical analysis using a microscope are mainly used in conjunction. Therefore, in this study, wood species of plywood were identified by analyzing the anatomical characteristics of various wood products for the first time. Douglas fir (Pseudotsuga menziesii (Mirb.) Franco.) and larch (Larix kaempferi (Lamb.) Carriere) plywoods (7, 9 ply) were obtained from four companies that supply plywood in Korea. After cutting each company's plywood to a size of about 1 cm³, the layers from top to bottom were separated into single layers, and three sections were observed using an optical microscope. The results revealed that the plywood was composed of a mixture of softwood and hardwood wood species, pine wood species, poplar wood species, or a mixture of larch and pine wood species. Identification of wood species using microscopy is important and can enable the scientific analysis and verification of various wood products, including plywood, imported from countries where the likelihood of indiscriminate distribution of illegal wood and illegal logging is high.

• Journal of the Economic Geographical Society of Korea
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• v.24 no.3
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• pp.313-329
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• 2021

This study analyzed the characteristics of the management crisis, the level of resilience, and the alternatives based on the companies' self-evaluation of the game industry in Daegu. The Daegu game industry, which started spontaneously in the late 1990s, grew rapidly until the late 2000s with the support of the government and supporting organizations. However, from the mid-2010s, it has entered a period of recession due to the number of companies that failed to respond to the saturation of the mobile game market and fierce competition at home and abroad. In response, some game companies turned the crisis into an opportunity to strengthen their competitiveness by pursuing challenging strategies for product differentiation and pioneering new markets. On the other hand, companies that were passive in responding to the crisis have not get out of the management crisis. In addition, in terms of the resilience level of game companies in Daegu, the level of immediate response to shock(rapidity) and replacement of the damaged part(redundancy) was low, but the level of mobilizing sufficient resources internally(resourcefulness) was high. However, as the Daegu game industry is facing more complex multi-spatial-scale environmental changes than in the past, its resilience should be strengthened through strategies that can compensate for weaknesses in terms of the game industry ecosystem beyond individual company-level efforts.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.5
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• pp.25-32
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• 2019

The purpose of this study is to investigate how to make a proper investment in ICO in the market. Previously, companies used to borrow money from banks or to obtain investments from venture capital (VC) and angel investors, but now ICOs are used as a new type of funding and financing model. The ICO sells the tokens or coins created on the blockchain openly online to raise the necessary funds, and provides the market value by paying the tokens or coins as much as the investment amount. According to this study, the limitations of the ICO market are (1) difficulties in evaluating the company, (2) uncertainties in investments, (3) lack of legal safeguards, and (4) measures to secure corporate stability after recruitment. At present, there is no way to cope with this systematically since the ICO is not protected in the legal framework. Nevertheless, we investigated the ways to make proper investment in the existing ICO market. In investing in ICO, investors should (1) consider investment methods and profitability, and (2) verify and judge investment fraud through various channels (ex. Homepage, composition team profile, etc.) and make investments based on this. This study will contribute to the formation of a healthy ICO market by understanding the newly emerged ICO market and studying the considerations when investing in it, thereby contributing to the right investor training and reducing the mass production of consumer damages caused by fraud. The limitation of this study is that the domestic ICO has not yet been examined in the legal framework, so further research is needed when policy changes occur in the future.

• FLOWER RESEARCH JOURNAL
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• v.26 no.4
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• pp.187-194
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• 2018

This study was conducted to investigate the facilities, cultivation, postharvest management, and distribution status of 27 cut chrysanthemum farms in Korea. The 60% of farms have cultivated the cut chrysanthemum using soil fertigation system in the PE plastic house. In Jeonnam and Busan provinces, Standard type of chrysanthemum was cultivated mainly than spray type of chrysanthemumJeoas. Most farms have been producing the rooted cuttings by plug system using cuttings self-propagated or purchased from the company, but farms in Jeonnam have been planting cuttings directly on cultivation bed. And the 66.6% of cut chrysanthemum farms have been pretreating with dipping in hot water or tap water after harvesting. Precooling was not performed on 70.4% of the farms, and precooling farms have been mainly conducted at temperature of $2-4^{\circ}C$. After harvesting, 70.4% of the farms stored the cut flowers at $2-4^{\circ}C$ for more than 48 hours to control the distribution volume. Cut chrysanthemum was graded mainly by individuals before distribution, and some export farmers have been conducting the cooperative grading. In distribution, all farms have distributed the cut flowers to the domestic markets, and 44.4% of these farms have been also exporting. The 63.0% of farms distributed to domestic market have been trading with flower auction sites.