• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.190-197
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• 2011

Background and Objective : Radiation resistance(RR) is one of main determinants of treatment outcome in oral squamous cell carcinoma(OSCC), but accurate prediction of RR is difficult. We aim to establish RR OSCC cell lines and identify genes related with RR by a measurement of altered gene expression after inducing RR. Material and Methods : OSCC cell lines, SCC15, SCC25 and QLL1, were treated with 2Gy radiation per session, and parts of them were alive in finally accumulated dosage of 60Gy through 30 times repetition of radiotherapy for inducing RR cell lines. We compared results of cDNA array and proteomics in non-radiated cell lines and RR cell lines to detect changes of gene expression. Western blot was used for the validation of results. Results : cDNA array revealed 265 commonly up-regulated genes and 268 commonly down-regulated genes in 3 RR cell lines comparing their non-radiated counterpart. Among them, 30 cancer related genes were obtained. Proteomics showed 51 commonly altered protein expressions in 3 RR cell lines and 18 cancer related proteins were obtained. Among the detected genes, we found NM23-H1 and PA2G4 were over-expressed in both cDNA array and proteomics. Western blot showed increased expression of NME1 in RR cell lines but not in PA2G4. Conclusion: We concluded that NM23-H1 may be a candidate of RR related gene and over-expression of NM23-H1 could be a biomarker to predict RR in OSCC.

• Korean Journal of Cognitive Science
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• v.23 no.4
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• pp.425-455
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• 2012

Multi-dimensional verbal short-term memory mechanisms are largely divided into the phonological channel and the lexical-semantic channel. The former is called phonological short-term memory and the latter is called semantic short-term memory. Phonological short-term memory is further segmented into the phonological input buffer and the phonological output buffer. In this study, the language performance of each of three patients with similar levels of conduction aphasia was analyzed in terms of multi-dimensional verbal short-term memory. To this end, three patients with conduction aphasia were instructed to perform four different aspects of language tasks that are spontaneous speaking, repetition, spontaneous writing, and dictation in both word and sentence level. Moreover, the patients' phonological memories and semantic short-term memories were evaluated using digit span tests and verbal learning tests. As a result, the three subjects exhibited various types of performances and error responses in the four aspects of language tests, and the short-term memory tests also did not produce identical results. The language performance of three patients with conduction aphasia can be explained according to whether the defects occurred in the semantic short-term memory, phonological input buffer and/or phonological output buffer. In this study, the relations between language and multi-dimensional verbal short-term memory were discussed based on the results of language tests and short-term memory tests in patients with conduction aphasia.

• The Journal of the Korea Contents Association
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• v.13 no.3
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• pp.141-151
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• 2013

With the spread of Personal Computers(PC) in the 1980's, many people started to deal businesses with PC. From late 1990's, the Internet age with PC have started and many people have showed keen interest in cyber-space and now they are utilizing it. Since 2000's the use of cyber-space have skyrocketed and it caused significant changes to humans' life. There was a huge prosperity to us but the new kind of crime, cyber-crime, was raised. Unlike past physical type of crimes, those cyber-crimes take place in the cyber-space and they have special features of non-facing, anonymity, specialty, technologic, repetition, continuation. Those cyber-crimes are continually growing since 2003 and in 2010 it almost doubled compared to 2003. General cyber-crimes like phishing-scam pornography circulation was most of them and notably perpetrators of them are younger generation. Recently cyber-crimes are showing the trend of advancing more and more and cyber-bullying, fraud like phishing scam are on the rise. The police are responding by making 'Cyber Terror Response Center', but it does not work effectively with the problems of breakup of prevention and investigation unit, procedure of investigation and the system itself. So, I suggest practical use of private security to remedy our police's weakness and to prevent cyber-crimes. Preventing solutions of cyber-crime with private security are physical defense of large-scale servers and vital computers, building of Back-up system to prevent vital data loss, and building of cyber-crime preventing system combining software and hardware.

• The Journal of the Korea Contents Association
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• v.13 no.8
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• pp.266-274
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• 2013

This study was developed to provide the basis for efficient bedside training by discovering and analyzing ways to reduce stress when students are in clinical practice. The present study was conducted using a 3-part questionnaire format and was based on 253 participants who were students completing clinical practice. The results showed that environmental factors were the most stressful for students in the department of radiology. According to the questionnaire, the highest factor relating to stress was 'standing for long durations' with a value of $3.27{\pm}1.04$, and values were respectively high in the sections on' disregard when students have a lack of knowledge' and 'repetition in simple tasks'. Students who had a good training atmosphere, good relationships with clinical radiological technologists and other students, and students who had high self-esteem showed low stress levels. The effect on BEPSI scale increased as interpersonal relationships and performance declined. Therefore, training institutions should consider relaxation areas for students, radiological technologists should not ignore the reality that students do not have substantial knowledge in clinical practice and comparisons made between students should not exist. In addition, there is the need to make an effort to reduce stress experienced by students in clinical practice through the use of positive communication and encouragement by assigning various training opportunities, providing areas to sit and initiating relaxation periods for students to reduce fatigue, as well as challenging students rather than restricting them to the simple and repetitive routines they encounter in clinical practice.

• The Korean Journal of Physiology
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• v.5 no.2
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• pp.45-54
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• 1971

That different mechanisms are involved in the secretory processes by the liver and the kidney of various dyes has been indicated by Sporter (1959), Kim and Hong (1963). Andrews (1958). suggested that a striking difference in the dye-secretory mechanism existed even in the same organ from species to species. Hence, the attempt has been made to study in the rabbit the secretory processes by the live. and the kidney of either phenol red (PSP), bromsulfalein (BSP) or green in the presence of Na-acetate, Na-taurocholate, P-Aminohippurate (PAH) or Benemid. In 37 rabbits, weighing about 2kg., anesthetized with ether, a dye was administered in such 8 manner that the plasma concentration was kept at a relatively constant level throughout the whole experimental period. Hepatic bile sad urine samples were quantitatively collected through the canulae which were previously inserted into the common bile duct (with the cystic duct ligated) and the urinary bladder, respectively, while arterial samples were taken from a femoral artery. After 50 min from the onset of dye administration, these samples were obtained every 10 mit for a period of 40 min. This was followed by the administration of either Na-acetate, Na-tauro-cholate, PAH or Benemid with a repetition of the same sample collecting procedures just stated. The results may be summarized as follows: 1) Na·acetate augmented urinary clearance of PSP by nearly 300 per cent, but lowered urinary BSP clearance by about 50 per cent. It enhanced biliary BSP clearance by 40% and had no effect on biliary psp clearance. 2) Na-taurocholate lowered biliary and urinary clearance of PSP by 10 per cent and 30 per cent respectively, and had no effect on both biliary and urinary clearance of BSP. 3) PAH lowered both biliary and urinary excretion of BSP and PSP, while it lowered the biliary excretion of indocyanine green which was excreted only in the bile. 4) Benemid suppressed BSP excretion by the liver and the kidney. 5) raper chromatographic analysis of PSP and of BSP in the bile and urine samples gave the following results: a) PSP Ivas excreted in the urine and bile only in free forms, and no modification in the excretory pattern was brought about by Na-taurocholate. b) BSP was excreted in the urine in 4 different conjugated froms and in the bile in both 3 different conjugated forms and in a free form. Na-taurocholate modified the excretory pattern of the urinary BSP.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.8
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• pp.4033-4038
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• 2013

Sedimentary rocks from construction waste are discarded through open storage and landfilling, which causes an increase in construction cost and inefficient of execution of works. Some sandstone are selected and utilized as aggregates, but shale is buried as industrial waste. Therefore, in this research, we evaluated weathering properties of shale aggregate that is widely distributed throughout Daegu-Kyeongbuk region and freeze-thaw characteristics of concrete according to the replacement ratio of shale aggregate, in an effort to stabilize aggregate supply-demand in Daegu-Kyeongbuk region and develop alternative aggregates. We used red shale and black shale in the experiment, which were exported from a construction site in Deagu. We verified the usage of shale as a concrete aggregate by comparing andesite, which is broadly used as a thick aggregate for concrete, to hornfels, which is a metamorphic sedimentary rock. As a result of the experiment, we observed no degradation phenomenon for andesite and hornfels. However, a part of country rock containing black shale was found to be exfoliated. Red shale started having cracks in the direction of stratification after 1.5 months of direct exposure, and it broke into smaller pieces after approximately 4 months. After 300 cycles of freeze-thaw process on the concrete manufactured according to the replacement ratio of shale aggregate, the modulus of elasticity was 97% for plain and 95% for hornfels. In the case of RS_100, it was 57% after 210 cycles, and for BS_100, it was 54% after 240 cycles. Therefore, we established that, as the number of repetition increases, the freeze-thaw resistance decreases dramatically.

• Journal of Distribution Science
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• v.12 no.11
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• pp.67-76
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• 2014

Purpose - PB (Private Brand) refers to the product for which the distribution company plans the production independently, consigns the production to the manufacturer, or attaches the self-developed trademark and sells it. To reinforce competitiveness in such a market environment, diverse products development, systematic management activities, and marketing efforts to analyze and understand the consumers' behavior regarding PB products are emphasized. Therefore, this study aims to investigate the relationships among PB product attributes, consumption emotion, brand attitude, and brand loyalty in general supermarkets. First, PB product attributes were defined using the five categories of perceived price, store image, familiarity, perceived service, and perceived quality, based on preceding studies. This study examined the influence of PB product attributes on consumption. Further, this study examined the relation among consumption emotion, brand attitude, and brand loyalty. This study provides more detailed and concentrated strategic implications. Research design, data, and methodology - In this study, the research model was designed to examine the relation among PB product attributes, consumption emotion, brand attitude, and brand loyalty. For the data collection method, the questionnaire survey comprised multiple items for each component and the direct interview method was employed. To collect data, the questionnaire survey was conducted for customers who personally visited the general supermarket after verifying the PB product purchase experience. The questionnaire survey was performed for one month, May 2014. A total of 300 questionnaires were distributed and 240 questionnaires were used for the analysis, excluding the unanswered and insincere questionnaires. The data were analyzed using SPSS ver. 20.0. Results - First, PB product attributes had a significantly positive effect on consumption emotion. The PB product attributes perceived by the customer at the point of service contact are important to form the positive consumption emotion. Second, consumption emotion had a significantly positive effect on brand attitude. Third, the consumption emotion had a significantly positive effect on brand loyalty. Such consumption emotion is an important factor in causing the positive evaluation on the brand attitude perceived by the customer. Fourth, brand attitude had a significantly positive effect on brand loyalty. The consumption emotion was positively represented to invoke the relational continuance behavior. The relational continuance behavior accompanies the repetition of purchase, word of mouth, and recommendation activities, and influences trust regarding the brand, for which the customer maintains the transaction continuously. Conclusions - The PB product attributes perceived by the customer at the point of service contact are important factors to form the positive consumption emotion. Based on this result, the discount store service provider would prepare the measures that can make the customer recognize the positive value, and make more detailed efforts. Consumption emotion is an important factor to cause the positive evaluation on the brand attitude perceived by the customer. Based on this result, the general supermarket must make efforts to provide fun or convenience in the purchase process for consumers.

• Cartoon and Animation Studies
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• s.47
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• pp.273-294
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• 2017

Korea has suffered numerous casualties due to a lot of accidents caused by safety insufficiency in recent years. Therefore, safety education is more important than ever before, and 'how to educate with what contents' is an important subject. Especially, experience education is effective rather than theoretical education because of the nature of safety education. However, it is not easy to design and develop these safety education programs. There is not much opportunity to access first-aid training, which is a part of safety education, unless it is compulsory to learn through public institutions. As a result, program utilization on safety education in Korea is still insufficient to what it should be. With that taken into account, this study proposed an effective serious game with fun and immersion for medical first-aid education. To do this, we analyzed five medical games through 20 cases of first-aid applications and elicited five factors that enhance the usability of serious games. With an analysis of five medical games, we selected one game to borrow the game rules, and applied the elicited five elements in the forms of level-up structure, iterative learning, compensation outcomes, competition system, and information transfer. The proposed medical education functional games should have 1) a character that plays a role of a patient, 2) a narrative flow that shows the situation, 3) the user should judge the situation and induce first aid. 4) compensation, levels, and simple repetition should be designed, and 5) information should be shared with the others in the given community. The results of this study is believed to contribute to enhance the medical emergency education in Korea.

• Korean Security Journal
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• no.7
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• pp.233-285
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• 2004

‘Defined legally as a violation of law' (Sutherland, E. H. Principles of Criminology, Lippincott, Chicago, 1939) Crime within the group is essentially and primarily antisocial in that the criminal who is welfare of his group acts instead against it and breaks the principles of social solidarity not merely by not doing what these principles prescribe, but by doing something exactly opposites. Any program set up to attack crime and delinquent behavior at their sources. A program of his nature needs the constant and comprehensive collaboration of psychiatrists, social works, educations, lawmakers, and public officials, since crime is a social problem and it should be treated as such. Some crime preventives which should be mentioned are as follows, (1) The insurance that every child will be decently born and that his home life be socially and economically adequate; without socially mature parents the chid is handicapped at the start; thus parental education, integrated with the public school system, should be developed now. (2) A more meaningful educational program which would emphasize ideals of citizenship, moral integrity, and respect for the law and the police. (3) A periodic check made for potential delinquents throughout the public schools and treatment provided if possible; and if not, proper segregation in institutions. (4) Careful attention paid to press, movies, and radio so that crime may no longer appear to be glamorous. This can be done by women's clubs, civic bodies, and other educational groups exerting pressure on the movie syndicates and broadcasting companies to free their productions of the tawdry and lurid characteristics of crime and criminals. Aggression associated with the phallic stage of development, The child ordinarily comprehends sexual intercourse as an aggressive and sadistic act on the part of the male, and specifically on the part of the penis. Evidence that the penis is phantasied as a weapon of violence and destruction come from unconscious productions of normal adults. Limerick, for instance, often refer to the penis as square, or too large, etc., so that intercourse is dangerous and painful for the partner, This may wall be a projection of the male's own fear of coitus. A certain portion of the death-instinct always remains within the person; it is called 'primal sadism' and according to Freud is identical with masochism. 'After the chief part of it(the death instinct) has been directed outwards towards objects, there remains as a residuum within the organism the true erotogenic masochism, which on the one hand becomes a component of the libido and on the other still has the subject itself for a object.' Criminalism, compulsive-neurotic frequent repetition of criminal acts in a compulsive manner. Like most symptoms of the compulsive-neurotic, such antisocial act are closely rated to feelings of hostility and aggression, often against the father. Because these acts are symptomatic, they afford only temporary relief and are therefore repeated. One patient with compulsive-neurotic criminalism was apprehended after breaking into hardware store and stealing money. He later confessed to many similar incidents over the preceding two years. At the same time it was apparent that he stole only for the sake of stealing. He did not need the money he thus obtained and had no special plans for using it.

• Journal of Korea Water Resources Association
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• v.49 no.11
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• pp.931-939
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• 2016

Bangudae Petroglopys of the national treasure No. 285 located in elevation of 53 m to 57 m have been damaged by repetition of submergence and exposure due to the Sayeon-dam of EL.60 m constructed in down stream. In this study, as a preservation plan of the petroglyphs from the contact with water, the construction of eco-levee was suggested and its effect was investigated in the views of hydraulic engineering. It was designed to be located aside of 80 m from Bangudae Petroglyphs with the length of 440 m in streamwise direction, and it was need to construct a new channel maintaining the original hydraulic capacity and conveyance. Hydraulic characteristics such as water surface elevations and velocities near Bangudae Petroglyphs were measured after the eco-levee was installed in the hydraulic model with the scale of 1:50. It showed that there were not much changes of water surface elevations and velocities between sayeon-dam spillway EL. 60 m (Suggestion 1) and EL. 54 m (Suggestion 2). It was concluded the eco-levee could be made of natural materials like soil, pebble, gravel in terms of allowable velocity and shear stresses. The slope of water surface at Suggestion 2 was steeper, and velocities near Bangudae Petroglyphs were also faster than Suggestion 1. As the vorties occured at the left side in Suggestion 2, more detailed study is required.