• Asian-Australasian Journal of Animal Sciences
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• 제31권10호
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• pp.1550-1557
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• 2018

Objective: Circular RNAs (circRNAs) are a newfound class of non-coding RNA in animals and plants. Recent studies have revealed that circRNAs play important roles in cell proliferation, differentiation, autophagy and apoptosis during development. However, there are few reports about muscle development-related circRNAs in livestock. Methods: RNA sequencing analysis was employed to identify and annotate circRNAs from longissimus dorsi of sheep. Reverse transcription followed by real-time quantitative (q) polymerase chain reaction (PCR) analysis verified the presence of these circRNAs. Targetscan7.0 and miRanda were used to analyse the interaction of circRNA-microRNA (miRNA). To investigate the function of circRNAs, an experiment was conducted to perform enrichment analysis hosting genes of circRNAs using gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathways. Results: About 75.5 million sequences were obtained from RNA libraries of sheep skeletal muscle. These sequences were mapped to 729 genes in the sheep reference genome. We identified 886 circRNAs, including numerous circular intronic RNAs and exonic circRNAs. Reverse transcription PCR (RT-PCR) and DNA sequencing analysis confirmed the presence of several circRNAs. Real-Time RT-PCR analysis exhibited resistance of sheep circRNAs to RNase R digestion. We found that many circRNAs interacted with muscle-specific miRNAs involved in growth and development of muscle, especially circ776. The GO and KEGG enrichment analysis showed that hosting genes of circRNAs was involved in muscle cell development and signaling pathway. Conclusion: The study provides comprehensive expression profiles of circRNAs in sheep skeletal muscle. Our study offers a large number of circRNAs to facilitate a better understanding of their roles in muscle growth. Meanwhile, we suggested that circ776 could be analyzed in future study.

• 한국콘텐츠학회논문지
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• 제15권6호
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• pp.616-631
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• 2015

본 연구는 3세~5세를 대상으로 하는 모바일 AR(Augmented Reality, 증강현실) 기반의 "낱말카드" 교구를 설계 제안하고 있다. 본 연구에서는 동기유발과 몰입도 향상을 목적으로 학습구조를 도출하고, 도출된 학습구조를 적용한 사용자 인터페이스를 설계해 이를 구현한다. 그리고 콘텐츠 제작을 지원하는 콘텐츠 관리도구를 설계하여, 교수자가 여러 학습자의 콘텐츠를 관리하기 용이하도록 제안하고 있다. 이를 위해 관련 연구 분석, 학습자용 AR 유아 언어교육 콘텐츠 설계, 교수자용 AR 유아 언어교육 콘텐츠 관리도구 설계, AR기반 언어학습도구의 효과검증의 4단계로 연구를 진행하였다. 본 연구에서 제안하고 있는 AR 유아 언어 교육 콘텐츠는 몰입도 향상과 동기유발을 위한 학습구조로 설계되었고, AR 교육 콘텐츠 갱신의 어려움을 극복하기 위하여 일반 교수자가 손쉽게 AR 타겟과 교육 내용을 등록 관리할 수 있는 교수자용 AR 콘텐츠 관리 도구를 포함하고 있다. 제안 콘텐츠를 통한 학습 몰입도 향상 검증 및 콘텐츠 설계 확장을 위한 사전 실험으로 3~4세 유아 6명을 대상으로 한 실험 수업을 진행하였다. 실험결과 몰입도 향상 효과를 검증할 수 있었고, 교수자의 설문의견을 통하여 유아를 위한 차별화된 인터랙션의 설계의 필요성을 도출하였다.

• 한국학교수학회논문집
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• 제16권4호
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• pp.797-820
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• 2013

본 논문은 초등학교 예비교사 100명을 대상으로 수학적 '문제 만들기'의 문장에 나타나는 오류를 분석하고 그에 대한 간단한 예방책을 기술한 논의이다. '문제 만들기' 문장에는 '음운 오류, 단어 오류, 문장 오류, 의미 오류, 표기 오류' 등 5가지 오류 유형이 나타났다. 이를 다시 14개의 세부 유형으로 구분하여 세부적으로 논의하였다. 곧 음운 오류의 유형은 'ㄹ'첨가 오류와 조사끼리의 준말 사용 오류가 있다. 단어 오류는 크게 '부적절한 사용 오류'와 '부당한 생략 오류'로 구분하고 이를 다시 조사, 어미, 어휘의 사용 오류와 조사와 어휘의 부당한 생략 오류로 유형화하였다. 문장 오류는 '지시 대상의 오류, 문장 성분의 생략 오류, 어순 오류, 자체 비문'의 네 가지로 유형화하였다. 의미 오류는 논리적 모순 관계 오류와 중의성을 띄는 의미 오류에 대해서만 논의하였고, 표기 오류는 띄어쓰기와 문장 부호, 철자에 관한 한글 맞춤법 오류와 외래어 표기법 오류 등에 대하여 논의하였다. 또한 14개의 문법적 세부 오류 유형을 방지하기 위한 예방책을 제시하였다. 먼저 구어와 문어의 차이를 인식하고, 둘째 글을 쓰는 문어 상황에 맞도록 구어적 표현을 지양하도록 하는 것, 셋째 국어 기본 문형 학습에 대한 강조, 넷째 단어 의미의 명확한 이해를 바탕으로 한 의미의 논리적 전개 인식을 제안하였으며, 끝으로 국어 어문 규정에 대한 학습을 제안하였다. 그리고 대학생 글쓰기 교육에 대한 필요성에 대한 재인식을 결론으로 갈음하였다.

• 보건행정학회지
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• 제22권2호
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• pp.163-182
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• 2012

This study was performed to identify the difference of the area-based deprivation and the educational level on the cerebrovascular mortality in Korea. Data used in this study was obtained from the Death Certificate Data 2000 and the 2000 Census produced by Korean National Statistics(NSO). We classified the whole country into 246 areas based on the administrative districts. Then, the Standardized Mortality Ratio (SMR) in cerebrovascular disease was calculated according to the sex, education level and 246 areas. Its Predicted SMR was calculated by the Empirical Bayes Methods to reduce the variation of the SMR values. The area-based deprivation of 246 areas were measured using the modified Carstairs index in which the 5 indicators consisted of overcrowding, the unemployment ratio of men, the percentage of households classified low social class, the percentage of non home owners, and finally those houses lacking basic amenities. The correlation between the area-based deprivation and the SMR of the whole country and the correlation between the area-based deprivation and the SMR of each metropolitan cities or provinces was analyzed by the Pearson correlation analysis method. After classifying the deprivation of 246 areas into 5 levels, we performed the random intercept Poisson regression analysis after adjusting education level and age using Empirical Bayes Method to investigate the relationship between the 5 deprivation levels and the cerebrovascular mortality. The SMR was increased in lower education level. Each 246 areas had different values in SMR, Predicted SMR and area-based deprivation. The area-based deprivation and the SMR of the whole country was not correlated in both sexes. The education level of an individual was associated the risk of cerebrovascular mortality in men. The risk of cerebrovascular mortality increased with age compared to the reference(<30). The area-based deprivation was not associated with the risk of cerebrovascular in both sexes. The findings of this study suggest that the SMR had positive and negative correlations with area-based deprivation depending on the metropolitan cities or province. It also suggests that the individual education level and age were related with mortality and finally that the area-based deprivation was not associated to the cerebrovascular mortality in Korea.

• 대한지역사회영양학회지
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• 제13권6호
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• pp.922-933
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• 2008

The purpose of this study was to investigate the effects of nutrition education using Food Exchange System on elementary students' nutrition knowledge, dietary attitude and nutrients intake. Nutrition education lessons (40 min /lesson, 4 times), '5 major nutrients and functions', '6 food groups and sources of 6 food groups', 'good choice of snacks and eating out' as class lesson, 'daily needed energy and food exchange units' as individual lesson, were provided to 70 elementary students (4th grade 33 students, 5th grade 37 students) in Jeonbuk Province. We assessed the changes in nutrition knowledge, dietary attitude, food habit using a questionnaire and nutrient intake using 24 hr recall method by nutrition education. In nutrition knowledge, there were significant increases in scores of 'functions of carbohydrate', 'functions of protein', 'functions of lipid', 'foods of carbohydrate', and 'foods of lipid'. In dietary attitude, there were significant increases in scores of 'taking a meal with joy', 'taking a meal at ease', 'taking a meal with sufficient protein intake' and 'taking a meal without spicy foods' by nutrition education. There were significant changes in the type of breakfast and in the frequency of snacks. After education, in type of breakfast, it showed higher number of students ate rice oriented meal than they did before education. and in frequency of snacks, it showed lower number of students ate snacks 'over 3 times' than they did before education. In Carbohydrate : Protein : Fat (CPF) ratio (%), it was significantly changed from 55.8 : 17.7 : 26.6 to 63.6 : 15.3 : 21.1. In evaluation of nutrient intake by Dietary Reference Intakes for Koreans (KDRIs), vitamin A, thiamin, niacin, vitamin $B_6$, calcium, phosphate, iron and zinc showed positive changes in distribution of number of children by intake level. That is, there were significant improvements in intakes of vitamin A, thiamin, niacin, vitamin $B_6$, calcium, phosphate, iron and zinc. These results showed that nutrition education using Food Exchange System for elementary students improved nutrition knowledge, dietary attitude and nutrients intake. It suggest that nutrition education using Food Exchange System may improve dietary behaviors and reduce an incidence of obesity in elementary students.

• 한국초등수학교육학회지
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• 제19권4호
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• pp.457-484
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• 2015

본 연구에서는 초등학생들이 다양한 비례 추론 과제를 해결할 때 사용하는 비례 추론 전략과 정답률을 분석하여 비례 추론 능력 지도를 위한 시사점을 제공하고자 하였다. 이를 위해 비례식을 학습한 6학년 173명을 대상으로 조사 연구를 실시하였다. 비례 추론 과제는 대수 기하, 양적 질적 추론, 미지값 비교 과제로 구분하고, 선행 연구에서 사용된 비례 추론 문항을 참조하여 다양한 과제 유형을 고려한 문항으로 검사지를 구성하였다. 과제 유형별로 정답률을 살펴보면, 기하 과제보다는 대수 과제, 질적 추론 과제보다는 양적 추론 과제, 비교 과제보다는 미지값 과제의 정답률이 상대적으로 높게 나타났다. 학생들이 사용한 비례 추론 전략을 살펴보면 비례식을 학습하였음에도 불구하고 형식적 전략보다는 인수 전략, 단위 비율 전략과 같은 비형식적 전략을 사용하는 비율이 상대적으로 높게 나타났다. 이와 같은 결과를 바탕으로 비례 추론 능력 지도를 위한 시사점으로 형식적 전략의 약화와 비형식적 전략의 명시적 지도, 질적 추론의 강화 및 질적 양적 추론의 결합, 다양한 과제 유형의 균형있는 취급 등을 제안하였다.

• 한국의료질향상학회지
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• 제9권2호
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• pp.176-197
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• 2002

Backgound : This study is to suggest the standardized format of the clinical sheets and the standardized items of every clinical sheet. The standardization of the medical records will increase the faithfullnes of the contents in them and it will contribute to construct the good health information system. Method : From Jan. 1st. 2001 to March 31st 2001, we gathered as many paper clinical sheets as possible by every class of institutions to review the faithfulness of the clinical contents in them. Clinical sheets of 9 tertiary care hospitals, 6 general hospitals and 56 clinics were gathered. Two experienced medical record administrators reviewed them. The review focus was to check whether the items recommend by the hospital standardization review criteria and hospital service evaluation organization were appeared in the clinical sheets and whether the contents of every item were written. Results : Tertiary care hospitals; In case of administrative data, the contents were filled well if the items were fixed. The clinical data like C.C, history,physical examiniation were filled well, but if the items were not fixed, some items were omitted. The result is that more items are to be filled if they are fixed. General hospitals Administrative data were filled more than 50%. Final diagnosis was filled about 66.7%.But other clinical data were not filled well and not many clinical related items were appeared in the sheets.In the legal point of view, the reason for visiting hosptals or the right diagnosis, patient condition at discharge could not be confirmed well.In surgery cases, surgical procedures could not be confirmed well as many surgical related information(surgery time, fluids and blood, number of sponges, biopsy, etc) were omitted. Clinics More than 70% administrative data were filled and fixed as items. Among the clinical related data, laboratory result was the most credible data. But without the right diagnosis, drug orders were given and doctors' written signatures were not appeared over 96.4%. So the clinical sheets cannot be used as a legal document. Conculusion : There was a tendency that the contents were filled well if the items were fixed in the documents, We also suggest a clinical check list to review the completeness and faithfulness of the clinical sheets. If many hospitals use the suggested clincal check list and if they make the necessary items fixed in the clinical sheets, the quality of the medical record will increase dramatically.

• 건축역사연구
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• 제15권4호
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• pp.37-56
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• 2006

Introducing International Style, P. Johnson and H. R. Hitchcock gave three standards to be the Modern, volume and surface, regularity, and exclusion of applied decoration. In spite of the negation of stylistic, formal approach in the Modernist Manifestoes, one usually have understood Modernity in Architecture with its formal character, especially with no ornament and flat, abstract, white surface. Modernism as a new paradigm in architecture have emphasized that there is no representation of anything outside and only present architecture in itself. They said that Modernism only cared about the language of Architecture without figural reference. So apparently there is no way to prove to its Modernity with formal condition. Modernity is in Spirit and contents. But actually we understand well its existence by visual communication This study deals with this difficult situation how Modernity represents itself without visual media and asks the question how simultaneously it presents its thingness and materiality In order to analyse contradictory situation between representation and presentation in Modern Architecture we need to survey the historical process of changing position of ornaments and its meaning in time. With the crisis of representation the role of ornament have seriously changed and divided. It caused the two situation in pre-Modern Architecture. Firstly, Architecture tend to be a high art and formal expression became important much more. The Use of Ornament became a kind of fashion to show the power, class, money. Secondly, Ornament lost its cultural weight and the structure and material aspect became the central in architecture. Rational Structuralism would be the essential character in Modern Architecture. Here the theory of G. Semper and A. Loos on cladding(dressing) and Ornament can help its problems and limits. In the situation without conventional ornament Modernists need to present modernity with new media that only show the thing itself and by that it does not represent any thing else as like the value, idea outside buildings. They believed that only it concerned esthetics and morality in architecture. But in reality it referred to art and machines as like ships, aircraft, and cars. By excluding Ornament and showing the process of clearing, abstract, flat, white surface 'represent' Modernity by the indirect way referring the concept of transparency, reason, sanitation, tectonics, etc. An Ideology and myth intervened architectural discourse to make the doxa about the representation in Architecture. Surface must be a different kind of media and message that can communicate in different way with compared to conventional Ornament. Decorated Shed by R. Venturi and Post-Functionalism by P. Eisenman, that are the most famous post-modern discourse, shows well difficult and contradictory condition in contemporary architecture concerning representation and form, meaning and form.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권3호
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• pp.152-159
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• 2017

Objectives: The aim of this study was to investigate the effects of advancement magnitude and changes in mandibular plane angle on the stability of mandibular advancement. Materials and Methods: This retrospective cohort study evaluated the postoperative stability of mandibular advancement in class II skeletal subjects who underwent bilateral sagittal split osteotomy. Radiographs taken preoperatively, immediately postoperatively and 1 year postoperatively were traced and analyzed using linear and angular measurements. To determine horizontal and vertical relapse, an X-Y coordinate system was established in which the X-axis was constructed by rotating S-N downward by $7^{\circ}$ (approximation of the Frankfort horizontal plane) and the Y-axis was defined as a line perpendicular to the X-axis and passing through the point Sella. For certain reference points including point A, point B, pogonion and menton, the perpendicular distance between each point and both axes was determined and cephalometric variables were recorded as X and Y coordinates. Results: Twenty-five subjects were studied. A significant correlation between the amount of mandibular advancement and relapse in the B point (vertical and horizontal) and the pogonion point was observed (vertical and horizontal, P<0.001). Evaluation of data demonstrated a positive correlation between the mandibular plane angle (SN/ML) change and vertical relapse in the B point (P<0.05). A simple regression model demonstrated that 74% of horizontal relapse and 42.3% of vertical relapse in the B point was related to the amount of mandibular advancement. The receiver operating characteristic test showed that 8.5 mm mandibular advancement is related to a relapse rate of 1 mm or more in the pogonion, vertically or horizontally. Conclusion: The magnitude of mandibular advancement is a stronger surgical predictor for horizontal rather than vertical relapse at the B point. Changes in mandibular plane angle (SN/ML) during surgery affect vertical, but not horizontal relapse at the B point.

• 전기전자학회논문지
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• 제14권2호
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• pp.51-57
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• 2010

대형 TFT LCD 판넬의 감마보정전압을 구동하기 위한 레일-투-레일 고전압 CMOS 완충 증폭기를 제안하였다. 이 회로는 단일 전압하에서 동작하고 18V 전압원에서 0.5mA 의 전류소비특성을 나타내며 8비트/10비트 고해상도 TFT LCD 판넬의 감마보정 전압 구동을 위하여 설계하였다. 이 회로는 높은 slew rate, 0.5mA의 정적 전류특성을 나타내며 1k$\Omega$의 저항성/용량성 부하구동 능력을 가지고 있다. 또한 넓은 출력 공급범위를 지니며, 5mA의 출력 정전류를 내보낼 경우 50mV미만의 옵셋전압 특성을 가진다. 또한, 용량성 부하 구동시 입력기준 옵셋전압이 2.5mV 미만인 좋은 특성을 나타낸다. 본 논문에서는 넓은 스윙입력범위와 출력 동작 범위을 얻기 위해 전류미러형 n-채널 차동증폭기, p-채널 차동증폭기, AB-급 푸쉬-풀 출력단, 히스테리시스 비교기를 사용한 입력레벨 검출기 등을 사용하였다. 제안된 회로는 고전압 디스플레이 구동 IC에 사용하기 위해 0.18um 18V 고전압 CMOS 공정기술에 의해 제작되었다. 제안된 회로는 8~18V의 공급 전압 범위에서 동작한다.