• Genomics & Informatics
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• v.14 no.4
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• pp.187-195
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• 2016

In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants are located within the same gene or genetic region. However, statistical testing procedures based on an individual test suffer from multiple testing issues such as the control of family-wise error rate and dependent tests. Moreover, detecting only a few of genes associated with a phenotype outcome among tens of thousands of genes is of main interest in genetic association studies. In this reason regularization procedures, where a phenotype outcome regresses on all genomic markers and then regression coefficients are estimated based on a penalized likelihood, have been considered as a good alternative approach to analysis of high-dimensional genomic data. But, selection performance of regularization procedures has been rarely compared with that of statistical group testing procedures. In this article, we performed extensive simulation studies where commonly used group testing procedures such as principal component analysis, Hotelling's $T^2$ test, and permutation test are compared with group lasso (least absolute selection and shrinkage operator) in terms of true positive selection. Also, we applied all methods considered in simulation studies to identify genes associated with ovarian cancer from over 20,000 genetic sites generated from Illumina Infinium HumanMethylation27K Beadchip. We found a big discrepancy of selected genes between multiple group testing procedures and group lasso.

• The Korean Journal of Air & Space Law and Policy
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• v.6
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• pp.137-147
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• 1994

Clearly there are many legal arguments and criticisms surrounding the proposals for change in the Warsaw Convention and the need for a radical review. The question remains is unlimited liability the answer or should there be some other form of supplemental compensation and if so, what limits should be applicable. It does seem that the adopted limits of the Convention are seen by many as the first line of defence, which, dependent on political and cultural differences, the legal interpretation of contractual wording and the legal system globally have resulted in enormous differences in compensation paid whether or not the Convention limits were imposed. An example of this is in the United States, which highlights the significance of the problem in that domestic travellers without Convention Limits can, through the American legal system, obtain compensation in the multi-million dollar area for a death claim, whereas a passenger t1ying internationally would in the first instance be subject to Convention Limits. expensive legal action through litigation. To date, we can advise that insurers have not charged additional premium for unlimited liability coverage. Insurance rates as we have stated are hardening considerably. To date, average rate increases have been plus 56% for aircraft hull and plus 45% for liabilities. Insurers last year suffered global losses of around US $ 1.1 Billion against a premium income of US $ 800,000. The target premium income for 1993 is believed to be in the region of US $1.4 Billion.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.6
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• pp.698-705
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• 2008

When electromagnetic waves propagate through atmosphere, waves are affected by various factors. Atmosphere normally consists of different molecular species, water vapours, rain, fog, snow and small suspended particles called aerosols. The distributions of atmosphere molecules, water vapours, rain rate, snowfall and aerosol are dependent on geometrical regions or environment. In order to predict propagation characteristics in atmospheric environment, statistical analysis of the relevant parameters such as temperature, humidity, atmospheric pressure, wind speed, areosol and rainfall is crucial. In this paper, we performed a long-term statistical analysis for the atmospheric parameters in domestic environments and analyzed the propagation characteristics through atmosphere based on that.

• BMB Reports
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• v.32 no.3
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• pp.294-298
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• 1999

Myo-inositol monophosphate phosphatase is a key enzyme in the phosphoinositide cell-signaling system. Incubation of myo-inositol monophosphate phosphatase from porcine brain with N-bromosuccinimide (NBS) resulted in a time-dependent loss of enzyme activity. The inactivation followed pseudo-first-order kinetics with the second-order rate constant of $3.8{\times}10^3\;M^{-1}min^{-1}$. The time course of the reaction was significantly affected by the substrate myo-inositol-1-phosphate, which afforded complete protection against the loss of catalytic activity. Spectrophotometric studies indicated that about one oxindole group per molecule of enzyme was formed following complete loss of enzymatic activity. It is suggested that the catalytic function of myo-inositol monophosphate phosphatase is modulated by the binding of NBS to a specific tryptophan residue at or near the substrate binding site of the enzyme.

• Composites Research
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• v.16 no.4
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• pp.51-58
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• 2003

Since the reliability of adhesively bonded joints is much dependent on the curing status of thermosetting adhesive, the on-line cure monitoring during the cure of adhesively joints could improve the quality of adhesively bonded joints. In this work, the dielectric method which measures the dissipation factor of the adhesive during the cure of joints and converts it into the degree of cure of the adhesive was devised. The relation between the dissipation factor and the degree of cure of adhesive was investigated, which could eliminate the temperature effect on the dissipation factor that is a strong function of the degree of cure and temperature of adhesive. From the investigation, it was found that the dissipation factor showed a trend similar to the cure rate of the adhesive.

• Journal of Advanced Marine Engineering and Technology
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• v.21 no.5
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• pp.564-570
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• 1997

The most important factor for the desalination system is the fresh water production cost dependent upon the possible energy source which should be obtained easily and with low price. Recently in Korea the demand of LNG, as a cheap and clean energy which does not cause an environmental problem, has sharply been increased. In general, LNG is storaged in a tank as a liquid state below -162 'C. When it is serviced, however, the LNG absorbs energy from a heating source and transforms to the gaseous state with high pressure. During this process a huge amount of cold energy accumulated in LNG is wasted. This waste cold energy can be utilized for producing fresh water from sea water using a sea water freezing desalination system. In order to develop a sea water freezing desalination system and to establish its design technique, a qualitative and quantitative data regarding the freezing behavior of sea water is needed in advance. The goal of this study, therefore, are to reveal the freezing mechanism of sea water, to measure the freezing rate, and to investigate the freezing heat-transfer characteristics. The experimental results help to provide a general understanding of the sea water freezing behavior in a Rectangular vessel cooled from below.

• Textile Coloration and Finishing
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• v.22 no.4
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• pp.325-331
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• 2010

The alkaline dissolution behavior of sea-island type ultrafine nylon fiber were dependent on the concentration of NaOH and treatment time, and the most appropriate condition for alkaline dissolution was to treat with 20g/l NaOH for 30 min at $80^{\circ}C$. The dyeing properties of sea-island type ultrafine nylon fiber and regular nylon fiber were examined with 3 different types of acid dyes in this study. The dye uptakes of ultrafine nylon fiber were higher than regular nylon fiber because of large surface area per unit mass, which increased as the dye bath pH decreased. The dyeing rates on ultrafine nylon fiber were faster and dye exhaustions were higher than regular nylon fiber, however color strength and rating of wash fastness were lower. It was also found that levelling type acid dye showed fast dyeing rate on both nylon fibers than metal-complex and milling type acid dyes.

• Applied Chemistry for Engineering
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• v.26 no.1
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• pp.67-73
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• 2015

Using a computational fluid dynamics technique, the flow characteristics and particle residence time in a Taylor reactor were studied. Since flow characteristics in a Taylor reactor are dependent on the operating conditions, effects of the inlet flow velocity and reactor rotational speed were investigated. In addition, the particle residence time of $LiNiMnCoO_2$ (NMC), which is a cathode material in lithium-ion battery, is estimated in the Taylor vortex flow (TVF) region. Without considering the complex chemical reaction at the inlet, the effect of Taylor flow was studied. The results show that the particle residence time increases as the rotating speed increased and the flow rate decreased.

• International Journal of Aeronautical and Space Sciences
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• v.12 no.2
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• pp.200-209
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• 2011

An analytical solution for rectangular laminated composite plates was obtained via a formal asymptotic method. From threedimensional static equilibrium equations, the microscopic one-dimensional and macroscopic two-dimensional equations were systematically derived by scaling of the thickness coordinate with respect to the characteristic length of the plate. The onedimensional through-the-thickness analysis was performed by applying a standard finite element method. The derived twodimensional plate equations, which take the form of recursive equations, were solved under sinusoidal loading with simplysupported boundary conditions. To demonstrate the validity and accuracy of the present method, various types of composite plates were studied, such as cross-ply, anti-symmetric angle-ply and sandwich plates. The results obtained were compared to those of the classical laminated plate theory, the first-order shear deformation theory and the three-dimensional elasticity. In the present analysis, the characteristic length of each composite was dependent upon the layup configurations, which affected the convergence rate of the method. The results shown herein are promising that it can serve as an efficient tool for the analysis and design of laminated composite plates.

• Journal of Food Hygiene and Safety
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• v.12 no.4
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• pp.310-314
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• 1997

Antithiamin activities of BHA, BHT, PG and TBHQ of synthetic antioxidants on the effect of temperature and pH was determined by means of HPLC. The influence of synthetic antioxidants on the degration of thiamin was found to be dependent on temperature and pH. The degradation of thiamin was considerably more rapid at pH 7 than pH 4. The influence on the heat of synthetic antioxidants at pH 4 and 38* was extremely slight, but the degradation of thiamin at pH 7 was much more rapid at 60* than at 38*. After 24 hours of incubation both PG and TBHQ at pH 7 and 60* nearly completely destroyed thiamin. Tests of antithiamin activities showed that TBHQ, which was decomposed completely in 72 hours, was more effective than PG at pH 7 and 38* but BHA and BHT hardly had antithiamin activities which was evaluated under various reactions of pH and temperature. Thiamin degradation, at pH 7 and 6$0^{\circ}C$, was proportional to the concentration of PG. When the ratio of PG to thiamin was increased from 0.15:1 to 2:1, the degradation rate also increased. However, the change between ratio of 1:1 and 2:1 was negligible.