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크론병의 한약 치료에 대한 최근 국내외 임상연구 동향 (Recent Domestic and International Trends in Clinical Research of Herbal Medicine Treatment for Crohn's disease)

  • 이신희;허유진;조연수
    • 대한한방소아과학회지
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    • 제35권4호
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    • pp.56-74
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    • 2021
  • Objectives The purpose of this study is to analyze the trend of herbal medicine treatment, treatment's effect and stability for Crohn's disease by reviewing clinical studies published over the past 5 years. Methods 22 articles which were published from 2017 to August, 2021 were obtained from the ScienceON, Research information sharing service (RISS), Koreanstudies Information Service System (KISS), Oriental medicine advanced searching integrated system (OASIS), China national knowledge infrastructure (CNKI), Pubmed. We analyzed the literature in regards to the treatment methods and results. Results There were 6 case reports, 1 controlled clinical trial, and 15 randomized controlled trial and in most cases, herbal medicines and Western medicines were administered in combination. The pathology of damp-heat due to spleen deficiency was the most common, and Sijunzi-tang and Shenling Baishu san were the most commonly used. As a result of the treatment, it was found that the combined administration of the herbal medicine and the Western medicine was more effective than the administration of the Western medicine alone. Conclusions Herbal treatment of Crohn's disease induced high cure rate safely than when only western treatment was applied. Future studies on safety and studies that can suggest specific guidelines for the combined administration of western and herbal medicines are needed.

사상체질별 운동요법 관련 연구 문헌 고찰 - 데이터베이스 검색을 통해 - (Literature Review on Exercise Therapy by Sasang Constitution through Database Search)

  • 신소이;이준희
    • 사상체질의학회지
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    • 제33권3호
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    • pp.29-53
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    • 2021
  • Objective The purpose of this review was to investigate exercise therapy by sasang constitution and to offer information for further research. Method The literature was investigated from KMBASE, KISS, ScienceON, JSCM, DBpia, Pubmed. The searching term were sasang, sasang constituion, sasang type, taeyangin, taeeumin, soyangin, soeumin, exercise, physical therapy, physical activity, and so on. Studies were extracted and analyzed exercise by sasang constitution, in addition, were also collected physiological differences related to sasang constitution, exercise ability, exercise response and effects, and exercise contraindications. Result & Conclusion It is helpful for Taeyangin to lower the energy through exercises that train the lower body and deep breathing, and there is no need to exercise excessively. Taeeumin tend to be obese compared to other constitutions. In order to be physically healthy, it is good to sweat a lot through regular exercise. It is good to do aerobic exercise that burns a lot of calories every day. Soyangin has a weak lower body, so it is good to exercise to reinforce the lower body. Soyangin has weak stamina, and since static exercise easily loses interest, it is helpful to do exciting exercise, and it can be performed at normal intensity. Soeumin are statistically less physically active. So soeumin need to improve exercise habits, but because physical strength is on the weak side, it is more appropriate to do an exercise that activates the body parts evenly rather than a strong one.

갑상선기능항진증의 한약 치료에 대한 무작위 대조군 연구의 문헌 고찰 (A Review of Randomized Controlled Trials of Herbal Medicine Treatment for Hyperthyroidism)

  • 이희윤;황수인;박장경;윤영진
    • 대한한방부인과학회지
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    • 제34권3호
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    • pp.114-136
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    • 2021
  • Objectives: The purpose of this study is to analyze the effectiveness and safety of herbal medicine treatment for treating hyperthyroidism. Methods: We searched for randomized controlled trials of Hyperthyroidism treated with herbal medicine, published from January 2016 to May 2021, through electronic database such as Pubmed, EMBASE, China Academic Journal (CAJ). Interventions and results of the selected clinical studies were analyzed. Results: The 25 randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in 2 studies, and with herbal medicine and conventional medicine in 23 studies. Control group was treated with conventional medicine. Outcome measures are total efficacy rate, thyroid function test, Traditional Chinese medicine (TCM) syndrome scores, liver function test, recurrence rate, etc. Prunellae Spica (夏枯草) (60%) was the most frequently used herb in herbal medicine treatment. In all of 25 studies, treatment group was more effective and safer for hyperthyroidism than the control group. Conclusions: This study indicates that herbal medicine treatment alone or combined with conventional medicine treatment could be helpful in improving the therapeutic effect on hyperthyroidism and reducing side effects as well.

척추측만증 평가 척도에 관한 문헌 고찰: 비방사선 방법을 중심으로 (Review Study on the Measurement Tools of Scoliosis: Mainly on Non-radiological Methods)

  • 김동주;최성경;조효림;하유빈;최성환;박서현;이승덕;금동호;성원석;김은정
    • 대한한의학회지
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    • 제42권1호
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    • pp.75-98
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    • 2021
  • Objectives: The purpose of this study is to investigate the characteristics, validity, and reliability of non-radiological assessment tools of scoliosis that have been studied so far. Methods: Electronic databases including Pubmed, Cochrane Library, CNKI, Science On, RISS, OASIS were searched by keywords including 'scoliosis assessment', 'scoliosis screening', 'physical examination', 'functional measurement', 'photography', and 'smartphone'. Results: 32 articles using radiation-free assessments were identified from 1,011 records. The mostly used non-radiological methods were Surface topography, Scoliometer, Ultrasound, Digital Infrared Thermal Imaging, and Photography. The other methods were Gait analysis, 3D depth sensor imaging, and Low intensity electromagnetic scan. Conclusions: It was found that non-radiological assessment tools might reduce the number of radiographs taken in scoliosis patients. To increase the reliability and validity, further research on the measurement tools of scoliosis will be needed.

암 환자 대상 변증 설문지 활용 현황에 대한 문헌고찰 (A Review of Studies Using Syndrome Differentiation Questionnaire in Cancer Patients)

  • 박수빈;윤지현;김은혜;이지영;윤성우
    • 대한암한의학회지
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    • 제26권1호
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    • pp.1-15
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    • 2021
  • Objective: The aim of this review is to analyze the studies using syndrome differentiation questionnaire in cancer patients. Methods: We searched electronic databases including Pubmed, google scholar, Cochrane library, CNKI, KISS, RISS and OASIS. Key words used for searching were cancer, Korean medicine, pattern identification, and questionnaire. Studies using a symptom differentiation questionnaire to cancer patients were selected. Results: 35 studies were enrolled. A total of 17 questionnaires was used. Most of the types of included studies were observational studies, followed by randomized controlled trials (RCTs) and validation studies. The purposes of using questionnaires were rrelation analysis, outcome measurement, evaluating adverse events, subgroup analysis, and questionnaire development. The most used questionnaire was Body Constitution Questionnaire (BCQ), and it was used 8 times, Questionnaire for the Sasang Constitution Classification II (QSCC II) was used 5 times, Constitution in Chinese Medicine Questionnaire (CCMQ), TCM-Symptom Complex Differentiation Questionnaire (TCM-SCDQ), Yin Deficiency Questionnaire were used 4 times, and Qi Blood Yin Yang Deficiency Questionnaire was used twice. BCQ is a questionnaire diagnosing and evaluating yang deficiency, yin deficiency, and blood stasis. It has high reliability, validity, and optimal cut-off value. Conclusion: BCQ is the most used syndrome differentiation questionnaire in cancer-related studies. So, BCQ could be recommended in syndrome differentiation-related cancer studies.

오령산에 대한 임상연구 분석 (An analysis of Clinical Studies on Oryeong-San)

  • 석은주;전수연;김원배;김도현;이숭인
    • 대한한의학방제학회지
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    • 제26권4호
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    • pp.341-362
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    • 2018
  • Objective : This study's purpose was to review the clinical studies of Oryeong-San. Method : We searched papers about Oryeong-San using KISS, KTKP, PUBMED, Embase, Science Direct, and the key words "Goreisan", "Goreito", "Wu Ling San", "Oryeongsan", "Poria Five Powder" were used. Papers not matched with inclusion criteria were excluded. Results : Until today, there have been 133 studies on the effects of head diseases, urinary system diseases, edema, and other various effects of Oryeong-San. Of these, 23 studies were classified as clinical research papers. There were 8 cases of head diseases, 5 cases of urinary system diseases, 3 cases of edema, 2 cases of adjuvant, 1 case of Dysmenorrhea, 1 case of Primary Hypertension, 1 case of Primary Insomnia, 1 case of hydrocele, 1 case of side effects causing TINU syndrome. Conclusion : It can be seen that Oryeong-San has established the basis for application to the purpose of head disease(chronic subdural hematoma, hydrocephalus, hearing loss), urinary system disease(stone, urinary tract infection), edema, adjuvant, other hypertension and insomnia. On the other hand, considering one case that causes side effect of TINU syndrome, caution should be exercised when observing the progress of the patient taking the Oryeong-San.

소아 알레르기 비염에 대한 추나요법의 효과 : 체계적 문헌 고찰과 메타분석 (Chuna Manual Therapy for Pediatric Allergic Rhinitis : A Systematic Review and meta-analysis)

  • 박선영;박인화;이상현;황만석;황의형;신병철
    • 척추신경추나의학회지
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    • 제14권1호
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    • pp.25-37
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    • 2019
  • Objectives : This review determines the evidence of effectiveness and safety of Chuna manual therapy (CMT) for pediatric allergic rhinitis. Methods : We searched 12 electronic databases (Pubmed, EMBASE, Cochrane Library, Web of Science, CAJ, J-STAGE, RISS, DBpia, NDSL, KISTI, KISS, and KMBASE) and two related journals up to the end of April, 2019. We only included randomized controlled trials (RCTs) investigating CMT for the treatment of pediatric allergic rhinitis. The methodological quality of the included RCTs was evaluated using the Cochrane risk of bias tool 1.0. Results : Twelve RCTs were eligible in our inclusion criteria. A meta-analysis of five studies demonstrated positive results for the using CMT for the treatment of pediatric allergic rhinitis. When used in conjunction with traditional Chinese medicine, CMT treatment significantly improved total efficacy rate compared with traditional Chinese medicine alone (P<0.02, n=5). Conclusions : Based on a published meta-analysis, there is reliable evidence for the use of CMT in treating pediatric allergic rhinitis. However, it should be noted that the studies included in this systematic review were heterogeneous and were of low quality, warranting further investigation using well-designed RCTs.

미세먼지 관련 호흡기질환 임상연구 동향 (Clinical Research Trends in Respiratory Diseases Related to Particulate Matter)

  • 유이란;김진후;양원경;김승형;박양춘
    • 대한한방내과학회지
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    • 제40권3호
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    • pp.443-457
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    • 2019
  • Objectives: This study aimed to review the clinical research trends in respiratory diseases related to particulate matter (PM) to help design clinical studies on herbal medicine that protects against PM. Methods: We searched three international databases (Pubmed, EMBASE, and CENTRAL) to investigate clinical studies on respiratory diseases related to PM and to analyze their study design, respiratory-related disease, inclusion/exclusion criteria, study period, outcome measure, study results, measurement method of PM and range of PM. Results: A total of 18 studies were finally selected, including 13 observational studies and 5 randomized controlled trials. The selected studies showed an increasing trend from 1985 to 2018 and were conducted mostly in North America, followed by Europe and Asia. Subject disease and age were decided in variety by each study objective, although asthma accounted for the majority. For the outcome assessment, pulmonary function test was mostly used for lung function. Quality of life questionnaires and biomarkers in blood and sputum were also used. Conclusion: A well-designed clinical study on herbal medicine that protects against PM is needed, and this study is expected to be used as base data.

소아 말초성 안면마비에 대한 추나요법의 효과 : 체계적 문헌고찰 (Effect of Chuna Manual Therapy for Peripheral Facial Paralysis in Children : A Systematic Review)

  • 김의별;강기완;김민우;고연석
    • 척추신경추나의학회지
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    • 제14권1호
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    • pp.1-11
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    • 2019
  • Objectives : The purpose of this study is to review clinical studies about the effect of chuna manual therapy (CMT) for peripheral facial paralysis in children. Methods : In this review, we searched 11 electronic databases (Pubmed, Cochrane Library, EMBASE, CINAHL, CAJ, Oasis, NDSL, KISS, RISS, KISTI, Dbpia); We concluded our literature search in April 23, 2019. We included only randomized controlled trials (RCTs) of testing CMT for peripheral facial paralysis in children. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. The meta-analysis was performed by synthesizing outcome data of total efficacy rate (TER). Results : After screening papers, a total of 6 RCTs were selected and analyzed. In the 6 RCTs, patients(n=15-60 per study) were randomized into groups for treatment and control. Specifically, the treatment group received CMT, while the control group was concurrently given usual care, such as acupuncture and medicine. The meta-analysis showed that the treatment group receiving CMT alone showed significant improvement in TER, compared to the control group receiving acupuncture therapy alone(P<0.05). And the treatment group receiving CMT combined with usual care showed positive results, in terms of TER, compared to the control group receiving usual care, but was not statistically significant(P>0.05). Conclusions : Our analysis suggests that CMT has therapeutic effects for peripheral facial paralysis in children. However, to confirm this result, further investigation accompanied by high quality studies is required.

불안장애의 추나 치료에 대한 중의학 최신임상연구 동향 (Review of Current Research Trends in Chuna Manual Therapy for Anxiety Disorders in China.)

  • 이지은;최진봉;김지훈
    • 척추신경추나의학회지
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    • 제14권1호
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    • pp.119-134
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    • 2019
  • Objectives : This study was conducted to investigate current research trends in Chuna manual therapy for the treatment of anxiety disorders in China. Methods : Using China Academic Journal and Pubmed, we performed a literature search of studies that were published from 2010 onwards. In total, 15 published studies were included in our analysis. Results : Of the 15 analyzed studies, nine were randomized controlled trials, two were non-randomized controlled trials, and four were case reports. Of the total patients, 80% were treated daily and received ${\leq}30$ treatments in total (excluding one study). In most studies(11 out of 15, 73.33%), the total effective rate of treatment was used to measure the outcome, with the Hamilton Anxiety Rating Scale being used most frequently. The case report demonstrated a therapeutic effect > 90%. In the control study, except for the two studies that reported significant improvement in the follow-up period, all of the measures were significantly improved (P<0.05) after treatment compared with before treatment. The An(按) and Rou(?) methods were the most frequently used. The Chuna method is categorized into four types: 1) It is performed around shoulders, neck, and face; 2) performed around abdomen, back, and neck; 3) performed on the whole body; 4) performed at the simply-stimulated acupoints. The most commonly used acupoint was Taiyang (Ex-HN 5), and the most frequently used acupoints were predominantly distributed in the head, face, and neck. Conclusions : This study demonstrated that Chuna manual therapy has significant effects when used as a treatment for anxiety disorder, warranting further investigation.