• Nutrition Research and Practice
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• v.9 no.1
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• pp.79-86
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• 2015

BACKGROUND/OBJECTIVES: It is well-known that alcohol consumption is associated with stroke risk as well as with aldehyde dehydrogenase 2 gene (ALDH2) polymorphisms. However, it is unclear whether ALDH2 polymorphisms are associated with stroke risk independent of alcohol consumption and whether such association is modified by sex. We evaluated sex-specific associations of a common ALDH2 polymorphism and alcohol consumption with stroke risk in a Korean population. SUBJECTS/METHODS: We conducted a prospective cohort study involving 8,465 men and women, aged 40-69 years and free of stroke between June, 2001 and January, 2003, and followed for the development of stroke. We identified new cases of stroke, which were self-reported or ascertained from vital registration data. Based on genome-wide association data, we selected a single-nucleotide polymorphism (rs2074356), which shows high linkage disequilibrium with the functional polymorphism of ALDH2. We conducted Cox proportional hazards regression analysis considering potential risk factors collected from a baseline questionnaire. RESULTS: Over the median follow-up of 8 years, 121 cases of stroke were identified. Carrying the wild-type allele of the ALDH2 polymorphism increased stroke risk among men. The multivariate hazard ratio [95% confidence interval] of stroke was 2.02 [1.03-3.99] for the wild-type allele compared with the mutant alleles, but the association was attenuated after controlling for alcohol consumption. Combinations of the wild-type allele and other risk factors of stroke, such as old age, diabetes mellitus, and habitual snoring, synergistically increased the risk among men. Among women, however, the ALDH2 polymorphism was not associated with stroke risk. CONCLUSIONS: The prospective cohort study showed a significant association between a common ALDH2 polymorphism and stroke risk in Korean men, but not in Korean women, and also demonstrated that men with genetic disadvantages gain more risk when having risk factors of stroke. Thus, these men may need to make more concerted efforts to control modifiable risk factors of stroke.

• The Journal of the Korea Contents Association
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• v.16 no.11
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• pp.675-682
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• 2016

Design-talent donation is a new form of social contribution activities using designers' professional skill and experience. The purpose of this study is to demonstrate which causes affect the inclination to participate in design-talent donation, taking into account that the research compared prospective designers and professional designers. When it comes to research method, this study classified the capabilities of designers with professional designers and prospective designer as potential talent donation provider. The research executed questionnaires of each factors and collected data were verified by using t-test analysis. Through the survey analysis to determine the factors affecting each group validated statistical difference between the two groups. The results showed that there is a significant difference in the impact factors between professional designers and prospective designers who involve in design-talent donation. The type of compensation could be expected to know that there is no significant correlation between the two groups. The meanings of this study are value addition criteria for the design output that provided from design talent donation should be clarified and ultimately is expected to specify the design talents donations range to meet the needs of designers as potential talent donation provider.

• The Journal of Korean Medicine
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• v.31 no.5
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• pp.1-11
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• 2010

Objectives: This study aimed to evaluate any clinical studies regarding rhinitis published by the Korean Oriental Medical Society and its sub-societies for future rigorous clinical research. Methods: Every article relevant to rhinitis was initially obtained from journals of the Korean Oriental Medical Society and its sub-societies by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings, two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For prospective studies, quality assessment was also conducted. Results: From 36 initially obtained articles, 17 were finally analyzed. 2 articles were randomized controlled studies, 6 articles were prospective whereas 9 were retrospective. In the prospective articles, there were no randomized controlled trials and the other non-randomized studies had no control group with several problems of quality regarding pre-calculated study size and unbiased assessment. None of the retrospective studies described rhinitis diagnosis objectively and outcome measures were either non-relevant to rhinitis or non-validated. Conclusions: Further well-designed randomized controlled studies for rhinitis are mandatory and more rigorous non-randomized controlled studies should be conducted.

• Journal of Korea Entertainment Industry Association
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• v.15 no.4
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• pp.359-367
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• 2021

This study tried to examine the factors that affect the entrepreneurial intentions in the field of culture and tourism industry. Through this, it was attempted to present strategic implications for start-up plans to prospective entrepreneurs in the cultural tourism industry. As a result of the study, the following implications were drawn. First, prospective entrepreneurs in the field of culture and tourism industry need to analyze the start-up items they want to start and systematically design a start-up plan based on market research. Also, by analyzing various start-up cases, it is necessary to secure various prior experiences of failure and success. Second, prospective entrepreneurs in the field of culture and tourism industry will need to increase their interest in starting a business by completing various entrepreneurship education conducted by more diverse institutions and schools than now, and they will have to increase the sense of achievement and willpower that can appear in education. In addition, by making efforts to create human relationships through various entrepreneurship education, efforts should be made to show the utilization of human networks and information sharing when starting a business. Lastly, prospective entrepreneurs in the field of culture and tourism industry should visit startup-related institutions and receive education and advice from experts in order to acquire various information. In addition, efforts should be made to provide more diverse start-up support by obtaining information on start-ups implemented by the state.

• Korean Journal of Biological Psychiatry
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• v.28 no.1
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• pp.13-22
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• 2021

Objectives Despite growing attention to anxiety in bipolar disorder (BD), little research has assessed anxiety symptoms in the course of BD. The current prospective follow-up study examines the influence of subjectively and objectively measured anxiety symptoms on the course of BD. Methods A total of 49 patients with BD were followed-up prospectively for average of one year at an average of four months interval. The Korean version of the Beck Anxiety Inventory (K-BAI), the Hamilton Anxiety Rating Scale, heart rate variability (HRV) were used to measure anxiety subjectively, objectively and physiologically. Participants were divided into high and low anxiety groups based on their K-BAI scores. Kaplan-Meier survival analysis was performed to compare the recurrence of mood episode, suicide attempt, emergency room visit, and psychiatric hospitalization between two groups. Mediators were investigated with Cox proportional hazards models. Results Compared to the low anxiety group, the high anxiety group reported significantly higher impulsiveness (p = 0.016) and lower high frequency component on HRV (p = 0.007) after controlling for severity of BD. Regarding survival analysis, the high anxiety group showed hastened depressive episode recurrence (p = 0.048) and suicidal ideation was the mediator of the hazard ratio (HR) 1.089 (p = 0.029) in the Cox model. Moreover, the high anxiety group showed a tendency of accelerated suicide attempt (p = 0.12) and impulsivity was the risk factor of suicide attempt (HR = 1.089, p = 0.036). Conclusions This interim analysis of prospective study suggests that high anxiety level in BD may anticipate unfavorable course. Further studies are needed to understand the multifactorial mechanism of anxious bipolar patients.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.119-131
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• 2021

The purpose of this study is to improve the curriculum of major subjects by constructing and applying design thinking centered 'early childhood language education' for prospective kindergarten teachers, and to cultivate their teaching ability in the classroom. As a result of the study, it is as follows. First, in the improvement of 'early childhood language education' subjects centered on design thinking, the "plan" stage recognizes the problem of interest in language education and the execution of language areas. In the "action" step, they created a interesting stationery for plays that can be actively expressed for young children who are hard to write. In the "re-action after reflection" steps, they have developed creative writing based on the diverse experience of the who have been working on a kindergarten field practice, Second, The meaning of the implementation for the major classes based on the design thinking is listening to young children than given practice, and self-reflection and growth through sympathy and cooperation. The implications of this study are needed to change the various major classes and the experience of problem solving is that it is also helpful for the autonomy and expertise of prospective kindergarten teachers.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.4
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• pp.649-660
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• 2023

The study aims to identify the complex effects of information security (IS) environments and individuals' IS-related perceptions and value dissimilarity that negatively affect insiders' IS compliance activities. In detail, the study aimed to confirm the roles of prospective and inhibitory anxiety, and value dissimilarity in the process in which a competitive psychological climate negatively affects IS compliance intentions. The study obtained 387 samples from the firm's workers with IS-related regulations and verified the research hypotheses established using the AMOS 22.0 and Process 3.1 tools. As a result, the competitive psychological climate negatively affected IS compliance intention by increasing individual's IS-related prospective and inhibitory anxiety. In addition, IS-related value dissimilarity had an interactive effect with prospective and inhibitory anxiety and had a negative effect on IS compliance intention. This study has practical implications in terms of presenting information and values to be provided to employees to achieve internal IS goals and has academic implications in terms of applying the complex effects of IS-related anxiety and value dissimilarity.

• The Journal of Advanced Prosthodontics
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• v.15 no.4
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• pp.202-213
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• 2023

PURPOSE. This prospective clinical study was conducted to evaluate the clinical usefulness of the freely detachable zirconia ball- and spring-retained implant prosthesis (BSRP) through a comparative analysis of screw- and cement-retained implant prosthesis (SCRP). MATERIALS AND METHODS. A multi-center, randomized, prospective clinical study evaluating the clinical usefulness of the detachable zirconia ball- and spring-retained implant prostheses was conducted. Sixty-four implant prostheses in 64 patients were examined. Periodic observational studies were conducted at 0, 3, 6, and 12 months after delivery of the implant prosthesis. Factors such as implant success rate, marginal bone resorption, periodontal pocket depth, plaque and bleeding index, and prosthetic complications were evaluated, respectively. RESULTS. During the 1-year observation period, all implants survived without functional problems and clinical mobility, showing a 100% implant success rate. Marginal bone resorption was significantly higher in the SCRP group than in the BSRP group only at the time of implant prosthesis delivery (P = .043). In all observation periods, periodontal pocket depth was slightly higher in the BSRP group than in the SCRP group, but there was no significant difference (P > .05). The modified plaque index (mPI) scores of both groups were moderate. Higher ratio of a score 2 in modified sulcus bleeding index (mBI) was observed in the BSRP group in the 6- and 12-months observation. CONCLUSION. Within the limitations of this study, the newly developed zirconia ball- and spring-retained implant prosthesis could be considered as an applicable and predictable treatment method along with the existing screw- and cement-retained prosthesis.

• 대한정형외과스포츠의학회:학술대회논문집
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• 2001.11a
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• pp.1-2
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• 2001

• 대한예방의학회:학술대회논문집
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• 2001.10a
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• pp.231-232
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• 2001